LOCUS       NM_001401216            4506 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus cleavage and polyadenylation specific factor 1
            (Cpsf1), mRNA.
ACCESSION   NM_001401216 XM_006241853
VERSION     NM_001401216.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4506)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 4506)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   3  (bases 1 to 4506)
  AUTHORS   Laishram,R.S. and Anderson,R.A.
  TITLE     The poly A polymerase Star-PAP controls 3'-end cleavage by
            promoting CPSF interaction and specificity toward the pre-mRNA
  JOURNAL   EMBO J 29 (24), 4132-4145 (2010)
   PUBMED   21102410
REFERENCE   4  (bases 1 to 4506)
  AUTHORS   Murthy,K.G. and Manley,J.L.
  TITLE     The 160-kD subunit of human cleavage-polyadenylation specificity
            factor coordinates pre-mRNA 3'-end formation
  JOURNAL   Genes Dev 9 (21), 2672-2683 (1995)
   PUBMED   7590244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 4, 2022 this sequence version replaced XM_006241853.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168713.1, SRR26360172.1609373.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000007.1  110210396-110210644 c
            250-277             JAXUCZ010000007.1  110208065-110208092 c
            278-411             JAXUCZ010000007.1  110207849-110207982 c
            412-492             JAXUCZ010000007.1  110207642-110207722 c
            493-644             JAXUCZ010000007.1  110207373-110207524 c
            645-791             JAXUCZ010000007.1  110207130-110207276 c
            792-931             JAXUCZ010000007.1  110206863-110207002 c
            932-1042            JAXUCZ010000007.1  110206675-110206785 c
            1043-1136           JAXUCZ010000007.1  110206482-110206575 c
            1137-1224           JAXUCZ010000007.1  110206141-110206228 c
            1225-1347           JAXUCZ010000007.1  110205947-110206069 c
            1348-1399           JAXUCZ010000007.1  110205795-110205846 c
            1400-1488           JAXUCZ010000007.1  110205630-110205718 c
            1489-1563           JAXUCZ010000007.1  110205489-110205563 c
            1564-1644           JAXUCZ010000007.1  110205332-110205412 c
            1645-1734           JAXUCZ010000007.1  110205165-110205254 c
            1735-1845           JAXUCZ010000007.1  110204909-110205019 c
            1846-1987           JAXUCZ010000007.1  110204692-110204833 c
            1988-2166           JAXUCZ010000007.1  110204432-110204610 c
            2167-2303           JAXUCZ010000007.1  110204214-110204350 c
            2304-2478           JAXUCZ010000007.1  110203967-110204141 c
            2479-2685           JAXUCZ010000007.1  110203689-110203895 c
            2686-2775           JAXUCZ010000007.1  110203505-110203594 c
            2776-2919           JAXUCZ010000007.1  110203270-110203413 c
            2920-3072           JAXUCZ010000007.1  110203039-110203191 c
            3073-3189           JAXUCZ010000007.1  110202244-110202360 c
            3190-3280           JAXUCZ010000007.1  110202078-110202168 c
            3281-3365           JAXUCZ010000007.1  110201909-110201993 c
            3366-3507           JAXUCZ010000007.1  110201695-110201836 c
            3508-3660           JAXUCZ010000007.1  110201459-110201611 c
            3661-3837           JAXUCZ010000007.1  110201202-110201378 c
            3838-3904           JAXUCZ010000007.1  110201062-110201128 c
            3905-3952           JAXUCZ010000007.1  110200936-110200983 c
            3953-4108           JAXUCZ010000007.1  110200701-110200856 c
            4109-4238           JAXUCZ010000007.1  110200505-110200634 c
            4239-4377           JAXUCZ010000007.1  110200284-110200422 c
            4378-4506           JAXUCZ010000007.1  110200078-110200206 c
FEATURES             Location/Qualifiers
     source          1..4506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4506
                     /gene="Cpsf1"
                     /note="cleavage and polyadenylation specific factor 1"
                     /db_xref="GeneID:366952"
                     /db_xref="RGD:1306406"
     exon            1..249
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..4425
                     /gene="Cpsf1"
                     /EC_number="2.4.2.30"
                     /note="cleavage and polyadenylation specific factor 1,
                     160kDa"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 1"
                     /protein_id="NP_001388145.1"
                     /db_xref="GeneID:366952"
                     /db_xref="RGD:1306406"
                     /translation="MYAVYKQAHPPTGLEFAMYCNFFNNSERNLVVAGTSQLYVYRLN
                     RDAEALTKNDGSTEGKAHREKLELVASFSFFGNVMSMASVQLAGAKRDALLLSFKDAK
                     LSVVEYDPGTHDLKTLSLHYFEEPELRDGFVQNVHTPRVRVDPDGRCAAMLIYGTRLV
                     VLPFRRESLAEEHEGLMGEGQRSSFLPSYIIDVRALDEKLLNIIDLQFLHGYYEPTLL
                     ILFEPNQTWPGRVAVRQDTCSIVAISLNITQKVHPVIWSLTSLPFDCTQALAVPKPIG
                     GVVIFAVNSLLYLNQSVPPYGVALNSLTTGTTAFPLRTQEGVRITLDCAQAAFISYDK
                     MVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTSMVTMEPGYLFLGSRLGNSL
                     LLKYTEKLQEPPASSVREAADKEEPPSKKKRVDPTVGWTGGKTQDEVDEIEVYGSEAQ
                     SGTQLATYSFEVCDSMLNIGPCANAAVGEPAFLSEEFQNSPEPDLEIVVCSGYGKNGA
                     LSVLQKSIRPQVVTTFELPGCYDMWTVIAPVRKEEEETPKAESTEQEPSAPKAEEDGR
                     RHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVFAGNIGDNRYIVQVSPLGIRL
                     LEGVNQLHFIPVDLGAPIVQCAVADPYVVIMSAEGHVTMFLLKSDSYGGRHHRLALHK
                     PPLHHQSKVIALCLYRDVSGMFTTESRLGGARDELGGRSGSEAEGLGSETSPTVDDEE
                     EMLYGDSSSLFSPSKEEARRSNQPPADRDPAPFRADPTHWCLLVRENGTMEIYQLPDW
                     RLVFLVKNFPVGQRVLVDSSFGQPTTQGEVRKEEATRQGELPLVKEVLLVALGSRQSR
                     PYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKPKPSKKKAEGCST
                     EEGSGVRGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMGIDGPIDSFA
                     PFHNVNCPRGFLYFNRQGELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVY
                     AVATSTNTPCTRIPRMTGEEKEFEAIERDDRYIHPQQEAFSIQLISPVSWEAIPNARI
                     ELEEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPE
                     PGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDT
                     QLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQ
                     LGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGAAEGPS
                     KKSVMWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFR
                     MLHVDRRILQNAVRNVLDGELLNRYLYLSTMERSELAKKIGTTPDIILDDLLETDRVT
                     AHF"
     exon            250..277
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..411
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..492
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..644
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..791
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..931
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1042
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1136
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1224
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1347
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1399
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1488
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1563
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1644
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1734
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1845
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1987
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2166
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2303
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2478
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2685
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2775
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2919
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3072
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3189
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3280
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3365
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..3507
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3660
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..3837
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..3904
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3905..3952
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4108
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..4238
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            4239..4377
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            4378..4506
                     /gene="Cpsf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaaactc ggaactcggt ggcgggtttg cgcgcgccgc cggaccgagt ccgctggcgt
       61 ccctgtcccc tgagtcggcg gctccggcgt gacagtggcg gcgacatgta cgcggtgtac
      121 aagcaggcgc acccgcccac cgggctcgag tttgccatgt actgcaactt cttcaacaac
      181 agtgagcgca acctcgtggt ggccggcacc tcgcagctct atgtgtaccg cctgaaccgc
      241 gacgctgagg ctctgaccaa gaatgatggg agcacagagg gaaaggccca tcgagagaaa
      301 ctagagctgg tagcctcctt ctcttttttt ggcaatgtca tgtccatggc cagcgtgcag
      361 ctcgcaggtg ccaaacgcga tgctttgctt ctcagcttca aagacgctaa gctgtctgtg
      421 gtggagtacg acccaggcac tcatgacctg aagaccctgt ctctgcacta ctttgaggag
      481 cctgaacttc gggatggatt tgtgcagaac gtgcatacgc cccgtgtgcg ggtggaccct
      541 gacgggcgct gtgcggcaat gctcatctat ggcacaagac tggtagttct gcctttccgc
      601 agagagagcc tggctgagga gcatgaaggg ctcatgggtg aggggcagag gtccagcttc
      661 ctgcccagct acatcatcga tgtgcgggct ctggatgaga agctgctcaa catcattgac
      721 ctgcagttcc tacacggcta ctatgagccc accctgctta tcctgtttga gcccaaccag
      781 acctggccag ggcgggtggc tgtgaggcag gacacgtgct ccattgtggc tatctcgctg
      841 aacatcacac agaaagtcca tccagtcatc tggtccctca ccagcttgcc ttttgactgt
      901 acccaggccc tggctgtgcc caagcccata ggtggggtag tgatcttcgc tgtcaactcc
      961 ctgttgtacc tgaaccagag tgttccccca tatggcgtgg ctctcaacag ccttaccacg
     1021 ggcaccactg cttttccatt acgtacccaa gaaggtgtaa ggatcaccct ggactgtgca
     1081 caggcggcct tcatctctta tgacaagatg gtcatctccc tcaagggtgg tgagatttat
     1141 gtgctgaccc tcatcactga cggcatgcga agtgtccgag catttcactt tgacaaggca
     1201 gctgctagtg tcctcaccac cagcatggtc acaatggagc ctggatacct gttcctaggc
     1261 tctcgcctgg gcaattccct cctcctcaag tacacggaga agctgcagga acccccagcc
     1321 agctctgttc gtgaggctgc tgacaaggaa gaacctccct caaagaagaa gcgagtggac
     1381 cctacagtgg gctggacagg aggcaagaca caggatgagg tggatgaaat tgaagtttat
     1441 ggcagtgagg cccagtcagg cacacagtta gctacttact cttttgaggt atgtgatagc
     1501 atgctcaaca ttggaccctg tgccaatgct gctgtgggcg agcctgcctt cctctccgaa
     1561 gagtttcaga acagccctga gccagacctg gagattgtgg tttgttccgg ctacgggaaa
     1621 aacggggccc tgtctgtgtt gcagaagagt atccggcccc aggtggtgac aacctttgaa
     1681 cttcctggat gctatgatat gtggacagtc attgctcctg tgcggaaaga ggaggaagaa
     1741 acacccaaag cagagagcac agagcaggaa cctagtgccc ctaaagcaga ggaggatggg
     1801 cgaagacatg gattccttat tcttagccga gaagactcaa ccatgatcct acagactggc
     1861 caggagatca tggagctgga caccagtggc tttgccacac agggtcctac tgtctttgct
     1921 ggaaacattg gggacaatcg ttatattgtc caagtctcgc cattgggcat tcgcctgttg
     1981 gaaggtgtga atcagctgca cttcatccct gtggacctgg gcgcccccat cgtgcagtgt
     2041 gctgtggctg atccctatgt ggtcatcatg agtgctgagg gacacgttac catgttccta
     2101 ctcaagagcg attcctatgg tggccgccac caccggctgg cactacacaa gcctccacta
     2161 catcatcagt ctaaggtgat tgcgctctgc ctgtaccgag atgtcagtgg catgttcacc
     2221 actgagagcc gcctgggtgg ggcccgtgat gaactgggtg gccgaagtgg ctcagaggct
     2281 gaaggcctgg gctcagaaac aagccccaca gtggacgatg aggaagagat gctatatggg
     2341 gactccagtt ccctcttcag tcccagcaaa gaggaggccc gaaggagcaa ccagccacca
     2401 gctgatcgtg accctgcacc cttcagggct gaccccactc actggtgcct gctggtgcgg
     2461 gagaatggca ccatggagat ctaccagctc ccagactggc ggctggtatt cctagttaag
     2521 aacttccctg tgggacagcg ggttctggtg gatagttcat ttggacagcc cactacacaa
     2581 ggtgaagtcc gaaaggagga ggccacacgc cagggggagc tgcctttggt caaggaggtg
     2641 ttattggttg ctctgggaag ccggcagagc aggccctacc tgctggtaca tgtggaccag
     2701 gagttgctta tctatgaagc ctttccccat gactctcagc ttggccaggg aaaccttaaa
     2761 gtccgtttca agaaggtccc ccacaacatc aacttccgtg aaaagaagcc aaagccatcc
     2821 aagaagaagg cagaaggttg cagcactgag gagggatctg gagtccgggg ccgtgtggca
     2881 cgtttccgct actttgagga catttatggc tattcggggg tctttatctg tggaccctca
     2941 cctcactggc tcctggtaac tggccgtggg gctctgcgtc tgcaccccat gggcattgat
     3001 ggccccatcg actcctttgc tccattccac aacgtgaact gcccccgtgg tttcctgtac
     3061 ttcaacagac agggagagct gaggatcagt gtcctgcctg cctacctgtc ctatgatgcc
     3121 ccatggccgg tcaggaagat tccactccga tgcacagccc actatgtagc ctaccacgtg
     3181 gaatccaagg tatatgctgt ggccaccagc accaacacac cttgcactag aatcccacgc
     3241 atgactggtg aggagaaaga atttgaggcc attgagagag atgacagata catccacccc
     3301 cagcaggaag ccttctccat ccagctcatc tccccagtca gctgggaggc catccccaat
     3361 gccaggatcg agctagagga atgggagcat gtcacgtgca tgaagacagt gtcactgcgc
     3421 agtgaggaga ccgtgtcagg cctaaagggc tatgtggctg ctgggacctg cctcatgcag
     3481 ggggaggagg tcacgtgccg tgggcggatc ctgatcatgg atgtgattga agtggtgcct
     3541 gagccggggc agcccctgac caagaacaag ttcaaagtcc tgtatgagaa ggaacagaaa
     3601 gggcccgtga ctgcgctgtg ccactgcaat ggccacctgg tgtcagccat tggccaaaaa
     3661 atcttcctgt ggagcctgcg ggctagcgag ctgactggca tggccttcat cgacacccag
     3721 ctgtacatcc accagatgat cagcgtcaag aacttcatcc tggcagcaga cgtcatgaag
     3781 agcatctcac tgctgcgcta ccaggaggag agcaaaacgc tcagcctggt gtcccgggat
     3841 gccaagcctt tggaggtata cagcgtggac ttcatggtgg acaatgccca gctgggcttc
     3901 ttggtgtctg accgagaccg caatcttatg gtgtatatgt atctgccaga agccaaagag
     3961 agttttgggg gcatgcgcct gctgcgccga gcagacttcc atgtgggtgc ccacgtgaac
     4021 acgttctgga ggaccccatg ccgaggtgct gctgaggggc ccagcaagaa gtcggtcatg
     4081 tgggaaaaca agcatatcac atggtttgca acccttgatg gtggcattgg gctcctgctg
     4141 cccatgcaag agaagacata cagacgactg ctgatgctgc agaatgcact gaccaccatg
     4201 ctaccccacc acgctggcct caacccccga gccttccgaa tgctgcatgt agaccggcgc
     4261 atcctgcaga atgctgtacg caacgtcctc gatggagaac tgctgaaccg ttacctatac
     4321 ctcagcacca tggagcgcag tgagctggcc aagaagatag gcaccacacc tgacatcatc
     4381 ctggacgact tgctggagac agaccgcgtc acggctcact tctaactcta ggatgccaca
     4441 ccctgctgtt gtatacctcc ctcttcccgt tttgtataaa acacaaagaa aacaatttct
     4501 ttcaga
//
