LOCUS       NM_031640               1778 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus carboxypeptidase Q (Cpq), mRNA.
ACCESSION   NM_031640
VERSION     NM_031640.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1778)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   2  (bases 1 to 1778)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 1778)
  AUTHORS   Suban,D., Zajc,T., Renko,M., Turk,B., Turk,V. and Dolenc,I.
  TITLE     Cathepsin C and plasma glutamate carboxypeptidase secreted from
            Fischer rat thyroid cells liberate thyroxin from the N-terminus of
            thyroglobulin
  JOURNAL   Biochimie 94 (3), 719-726 (2012)
   PUBMED   22127294
REFERENCE   4  (bases 1 to 1778)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   5  (bases 1 to 1778)
  AUTHORS   Dolenc,I. and Mihelic,M.
  TITLE     Purification and primary structure determination of human lysosomal
            dipeptidase
  JOURNAL   Biol Chem 384 (2), 317-320 (2003)
   PUBMED   12675526
REFERENCE   6  (bases 1 to 1778)
  AUTHORS   Della Fazia,M.A., Piobbico,D., Bartoli,D., Castelli,M.,
            Brancorsini,S., Viola Magni,M. and Servillo,G.
  TITLE     lal-1: a differentially expressed novel gene during proliferation
            in liver regeneration and in hepatoma cells
  JOURNAL   Genes Cells 7 (11), 1183-1190 (2002)
   PUBMED   12390252
  REMARK    GeneRIF: lal-1 is involved in liver regeneration and its expression
            is finely regulated during proliferative process {Liver Annexin
            Like-1 (lal-1)
REFERENCE   7  (bases 1 to 1778)
  AUTHORS   Gingras,R., Richard,C., El-Alfy,M., Morales,C.R., Potier,M. and
            Pshezhetsky,A.V.
  TITLE     Purification, cDNA cloning, and expression of a new human blood
            plasma glutamate carboxypeptidase homologous to
            N-acetyl-aspartyl-alpha-glutamate
            carboxypeptidase/prostate-specific membrane antigen
  JOURNAL   J Biol Chem 274 (17), 11742-11750 (1999)
   PUBMED   10206990
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF097723.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF097723.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1778
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /note="carboxypeptidase Q"
                     /db_xref="GeneID:58952"
                     /db_xref="RGD:628610"
     exon            1..37
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            38..99
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            100..553
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1539
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /EC_number="3.4.17.-"
                     /note="liver annexin like-1; hls2-rp; liver annexin-like
                     protein 1; hematopoietic lineage switch 2 related protein;
                     plasma glutamate carboxypeptidase"
                     /codon_start=1
                     /product="carboxypeptidase Q precursor"
                     /protein_id="NP_113828.1"
                     /db_xref="GeneID:58952"
                     /db_xref="RGD:628610"
                     /translation="MRFLFFLFVAVVHLFSLGSGKAIYKSGVSQRTFQEIKEEIANYE
                     DVAKAIINLAVYGKYQNRSYERLGLLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLEN
                     VHLEQVRIPHWGRGEESAVMVVPRIHKLAILGLGGSIGTPPEGITAEVLVVASFVELQ
                     RRASEARGKIVVYNQPYTDYGKTVQYRERGAVEAAKVGAVASLIRSVASFSIYSPHTG
                     HQGYQDGVPKIPTACITIEDAEMMSRMASRGDKIVIHLKMGAKTYPDTDSFNTVAEIT
                     GSKYPEEVVLVSGHLDSWDVGQGALDDGGGAFISWEALSLVKDLGLRPKRTLRLVLWT
                     AEEQGGVGASQYYELHKANISKYSLVMEADSGTFLPTGLQFTGSDKARAIMKEVMSLL
                     QPLNITKVFNDAEGTDINFWIQAGVPGASLRDDLYKYFFFHHSHGDTMTAMDPKQMNV
                     AAAVWAVVAYVVADMEEMLPRS"
     exon            554..761
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            762..969
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1081
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1173
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1375
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1778
                     /gene="Cpq"
                     /gene_synonym="LAL; lal-1; Pgcp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttgcggt tgctgctctg cagaacctcg tgaccaggta ttccgatttg gagtccttga
       61 attaaaaaca accatggagc atgtcattgg agacagcaag aagaaaagaa actagggaca
      121 atgaggttcc ttttcttcct gttcgttgct gttgttcacc ttttctcctt gggctctgga
      181 aaagctatat acaagagtgg tgtttctcag cgaacatttc aagaaataaa agaagaaata
      241 gccaactatg aagatgttgc taaagcaatt atcaaccttg ctgtttatgg aaaataccag
      301 aaccggtcgt atgagcgttt gggacttcta gttgatactg ttggacccag actgagtggc
      361 tctaagaacc tagagaaagc tatccaaatc atgtaccaaa acctgcaaca agatgggctg
      421 gaaaacgtcc acctggagca ggtcagaata cctcactggg ggaggggcga agaatctgca
      481 gtgatggtgg tgcctcgaat tcacaagttg gctattttag gccttggcgg cagcattggg
      541 actcctcctg aaggtatcac agcagaagta ctcgtggtgg cctcttttgt tgaacttcaa
      601 agaagggcat cagaggcaag agggaagatt gttgtttata accagcctta cactgactat
      661 gggaaaactg tgcagtaccg ggagcgcgga gctgtggaag ctgccaaggt gggggccgtg
      721 gcatccctca tccgatcagt agcttctttt tccatctaca gtcctcacac aggtcatcaa
      781 ggatatcaag atggtgtgcc caagattcca acagcctgta tcacaataga agatgcagaa
      841 atgatgtctc gaatggcttc tcgtggggac aaaattgtca ttcatctgaa aatgggagca
      901 aagacctatc cagatacaga ttccttcaac actgttgcag agatcactgg gagcaagtat
      961 ccagaggaag ttgtcctggt cagtggacat ctggacagct gggacgtcgg gcagggtgca
     1021 ctggatgatg gcggtggagc cttcatatca tgggaagcac tctcacttgt taaagatctt
     1081 gggctgcgtc caaagaggac tctgcgcttg gtgctctgga ccgcagaaga acaaggaggg
     1141 gttggtgcct cccagtatta tgagctacat aaggcaaata tttccaagta cagtttggtg
     1201 atggaggctg actcaggaac cttcttaccc actgggctgc agttcaccgg cagtgacaag
     1261 gccagggcta tcatgaagga agtcatgagt ctcctgcaac ccctcaatat caccaaggtc
     1321 tttaatgatg cagaaggaac tgacattaac ttctggatcc aagctggagt gcctggagcc
     1381 agtctgcgag atgacttgta caagtatttc tttttccatc attcccatgg agacaccatg
     1441 actgccatgg atccaaagca gatgaatgtt gctgctgctg tttgggctgt tgtcgcttac
     1501 gttgtggcag acatggagga aatgctgccc aggtcctaag gaaaacaaga aggaagaacc
     1561 ttgttctctg cagctgggaa tccccattcg ggattttcac agcagccatc ttcacagcac
     1621 cttgttatac actcaatccc cgtggcacag tttctttata ccttctgtta accatctttc
     1681 cttgatacgc ttttacctgt tctagaataa gtaatcatca ctactgtacc accttgaaaa
     1741 tactgtttcc agtttaaaaa taaacaataa atatatga
//
