LOCUS       NM_001037095            2810 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus coproporphyrinogen oxidase (Cpox), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001037095 XM_221545
VERSION     NM_001037095.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Loskove,Y., Yasuda,M., Chen,B., Nazarenko,I., Cody,N. and
            Desnick,R.J.
  TITLE     Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane
            synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen
            oxidase novel mutations
  JOURNAL   Mol Genet Metab 128 (3), 352-357 (2019)
   PUBMED   30385147
REFERENCE   2  (bases 1 to 2810)
  AUTHORS   Barupala,D.P., Dzul,S.P., Riggs-Gelasco,P.J. and Stemmler,T.L.
  TITLE     Synthesis, delivery and regulation of eukaryotic heme and Fe-S
            cluster cofactors
  JOURNAL   Arch Biochem Biophys 592, 60-75 (2016)
   PUBMED   26785297
  REMARK    Review article
REFERENCE   3  (bases 1 to 2810)
  AUTHORS   Mortensen,M., Ferguson,D.J., Edelmann,M., Kessler,B., Morten,K.J.,
            Komatsu,M. and Simon,A.K.
  TITLE     Loss of autophagy in erythroid cells leads to defective removal of
            mitochondria and severe anemia in vivo
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 832-837 (2010)
   PUBMED   20080761
REFERENCE   4  (bases 1 to 2810)
  AUTHORS   Sopena,Y.E., Ferramola de Sancovich,A.M. and Sancovich,H.A.
  TITLE     Hexachlorobenzene treatment on hepatic mitochondrial function
            parameters and intracellular coproporphyrinogen oxidase location
  JOURNAL   Int J Toxicol 27 (6), 455-465 (2008)
   PUBMED   19482825
REFERENCE   5  (bases 1 to 2810)
  AUTHORS   Ajioka,R.S., Phillips,J.D. and Kushner,J.P.
  TITLE     Biosynthesis of heme in mammals
  JOURNAL   Biochim Biophys Acta 1763 (7), 723-736 (2006)
   PUBMED   16839620
  REMARK    Review article
REFERENCE   6  (bases 1 to 2810)
  AUTHORS   Li,F., Lim,C.K. and Peters,T.J.
  TITLE     Coproporphyrinogen oxidase, protoporphyrinogen oxidase and
            ferrochelatase activities in iron-overloaded and ethanol-treated
            rats
  JOURNAL   Biomed Chromatogr 4 (6), 253-256 (1990)
   PUBMED   2289051
REFERENCE   7  (bases 1 to 2810)
  AUTHORS   Adjarov,D.G.
  TITLE     Decreased activity of liver coproporphyrinogen oxidase in
            hexachlorobenzene-induced porphyria
  JOURNAL   Exp Pathol 40 (2), 117-122 (1990)
   PUBMED   2079105
REFERENCE   8  (bases 1 to 2810)
  AUTHORS   Woods,J.S. and Southern,M.R.
  TITLE     Studies on the etiology of trace metal-induced porphyria: effects
            of porphyrinogenic metals on coproporphyrinogen oxidase in rat
            liver and kidney
  JOURNAL   Toxicol Appl Pharmacol 97 (1), 183-190 (1989)
   PUBMED   2916235
REFERENCE   9  (bases 1 to 2810)
  AUTHORS   Grandchamp,B., Phung,N. and Nordmann,Y.
  TITLE     The mitochondrial localization of coproporphyrinogen III oxidase
  JOURNAL   Biochem J 176 (1), 97-102 (1978)
   PUBMED   31872
REFERENCE   10 (bases 1 to 2810)
  AUTHORS   Goldberg,A., Meredith,P.A., Miller,S., Moore,M.R. and Thompson,G.G.
  TITLE     Hepatic drug metabolism and haem biosynthesis in lead-poisoned rats
  JOURNAL   Br J Pharmacol 62 (4), 529-536 (1978)
   PUBMED   656697
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107664.1.
            
            On Nov 5, 2005 this sequence version replaced XM_221545.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2810
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..2810
                     /gene="Cpox"
                     /note="coproporphyrinogen oxidase"
                     /db_xref="GeneID:304024"
                     /db_xref="RGD:1311817"
     exon            1..604
                     /gene="Cpox"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1413
                     /gene="Cpox"
                     /EC_number="1.3.3.3"
                     /note="coproporphyrinogen-III oxidase, mitochondrial; COX;
                     coprogen oxidase; coproporphyrinogenase; oxygen-dependent
                     coproporphyrinogen-III oxidase, mitochondrial"
                     /codon_start=1
                     /product="oxygen-dependent coproporphyrinogen-III oxidase,
                     mitochondrial precursor"
                     /protein_id="NP_001032172.1"
                     /db_xref="GeneID:304024"
                     /db_xref="RGD:1311817"
                     /translation="MALRLGQLGSGPWWRAVRGDYAQLRAPSPRSASACVCRLPGTAG
                     TQPRRGLGHGSSAGGGSRLGTGLAAALAGMAGLAAAVLGHVQRAEMVPKSSGARSPSP
                     GRLEEDGDELARRCSTFMSSPVTELRELGRRPDDMKTKMELMIMETQAQVCRALAQVD
                     GVADFSVDRWERKEGGGGITCVLQDGRVFEKAGVNISVVHGNLSEEAANQMRSRGKAL
                     KKKDGKLPFTAMGISSVIHPKNPYAPTMHFNYRYFEVEEADGKMHWWFGGGCDLTPTY
                     LNREDAVHFHRTLKEACDQHGPDIYPKFKKWCDDYFFIAHRGERRGIGGIFFDDLDSP
                     SKEEAFRFVKTCAEAVVPSYVPIVKKHCDDSYTPQDKLWQQLRRGRYVEFNLVYDRGT
                     KFGLFTPGSRIESILMSLPLTARWEYMHSPPENSKEAEILEVLRHPKDWVH"
     exon            605..748
                     /gene="Cpox"
                     /inference="alignment:Splign:2.1.0"
     exon            749..859
                     /gene="Cpox"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1001
                     /gene="Cpox"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1220
                     /gene="Cpox"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1325
                     /gene="Cpox"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..2754
                     /gene="Cpox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caataccagg gagtctcggt ctctagatcc tgggagctcc cgtggatctg caggatccgc
       61 gctgcccagt cccggcggga gatggccttg cggctgggcc agctaggctc gggcccctgg
      121 tggcgagcgg tgcgaggtga ctatgcacag ctgcgcgccc cgtcccctcg cagcgcgtcc
      181 gcctgcgtct gccggctgcc tggcaccgcc ggtacccagc ctcgccgcgg gctgggccac
      241 ggctcctcgg ctggaggcgg gtcccggctg gggaccgggc tggccgcggc gctggcgggg
      301 atggcagggc tggcagccgc cgtcttaggg cacgtgcagc gggcggagat ggtgcccaag
      361 agctcggggg cgcggagccc ctcacctgga cggctggagg aggacgggga cgagctggcc
      421 cgccgctgca gcaccttcat gtcctcgccg gtgaccgagc tgcgggagct ggggagaagg
      481 ccggatgaca tgaagaccaa gatggagctg atgattatgg agacccaggc ccaggtgtgt
      541 cgggcgctgg cacaggtaga cggagtcgct gacttctctg tggaccgatg ggagaggaag
      601 gaaggaggtg gtggcatcac ctgtgtgctt caggacgggc gtgtgtttga gaaggccggg
      661 gtgaacattt ctgtcgttca tgggaatctt tctgaggagg cagcaaacca aatgagaagc
      721 agaggaaaag ccctgaagaa gaaagatggt aaattgccgt ttactgctat gggtataagc
      781 tccgtgattc accctaagaa tccttatgca cccaccatgc atttcaacta tagatacttc
      841 gaagtagaag aagctgatgg taagatgcat tggtggtttg ggggtggatg tgacctcaca
      901 ccgacatacc tgaaccgaga ggatgccgtc catttccacc gtactctgaa ggaagcttgc
      961 gatcagcacg ggccagacat ctaccccaaa tttaaaaaat ggtgtgacga ctacttcttc
     1021 atagcacatc gcggggagcg gaggggcatc ggcggcatct ttttcgatga cctcgactct
     1081 ccatccaagg aggaggcgtt ccgctttgtg aagacgtgtg ccgaggcagt ggttccttcc
     1141 tatgttccca ttgtgaaaaa gcactgtgat gactcctaca ccccccagga taagctgtgg
     1201 cagcagctga ggagagggcg gtatgtagag tttaatctgg tgtatgatcg gggcaccaag
     1261 tttggcctct ttactccagg atccaggatc gaaagcatct tgatgtcttt acctctaaca
     1321 gcaaggtggg agtatatgca ttcccctcca gagaattcca aagaagctga aattctggaa
     1381 gtgctgcgcc atccaaagga ctgggtgcac tgatgtgcag agccttgctc cagggcctgg
     1441 tggtcgcagg tggggtcttc ctgcaccctg gccaccgtgt ggcaggcagt gtcttctgtg
     1501 ccttaccgtc cccaccttct ccaccgtggg cattcctctg tgtcaggtgg ttttggtctt
     1561 ttctagtgct gtggcaaagg tgggtgggga tataaaagtg cccaatttgt tgtccgtgaa
     1621 attcatttgt acgtttctat gcagtttcta tgaccagtca atttgacatt gggtttccag
     1681 gtcttaagtt aagggagtgt aaatactatg atacccacca ggaaactcat tttgtttgtt
     1741 gtttgaagtt ctagtttttg ctacagacat ttatcagggg atacatttta tcttcattag
     1801 ttcagtcagg ctgcccttct tgggagcttt agaatgcaat tggaagccag gcagtggtgg
     1861 tgtacgcctt taatcccagt attcaggaag aagaggttgg tggatatctg tgagtttgag
     1921 gccagcttgg tctacaaagg gcgttctagt atagccaggg ctacacagag gaaccctgtt
     1981 ttgaaaaagc caaaaacaaa acaaaaagaa aaacacaaaa aaagcaattt gaaaaaacat
     2041 gtttttcgtt atttttgatg taatttcatg tatctttctc tatagagcag aatatgataa
     2101 aagtactcat tttttttttt taaagatagc tatttaagag ctccggaaat attctttagt
     2161 cagttcttgc attatataat gttgacctag tttacagctg caaatggcat taccattatt
     2221 taaataaggg acgtcttgaa tggtgaggtt tttgtgggat tataacctgc taacattagg
     2281 attctatgta ttttttaaag caaaacttac atccctggat tctgatactt aagagtttat
     2341 tttagacatt tagatatgga agattagact aagaacaaat gaaacacatt tttctcttta
     2401 actaaaaaga acaaagatag tctaagaggg gcattttata tttttttaaa aaaatgagcc
     2461 aatagaaatt gtcttacttt tcagattaga gattcttcaa cttttacctt ttcttttaaa
     2521 agtcacagca gatttcttaa tgtgtggttt atctgtctaa ataatagtat gactgtgcta
     2581 tgttatttga tttataatat attgaatttg taaggcacaa tatattatac atagttaaat
     2641 attatcctgg aatatgttag atgtatatga ttgtgtttgg ctcttttagg gtgagaaaat
     2701 ctacaaattc ttcaacttgt cttacataga cagctaataa attttattac aaaaaaaaaa
     2761 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
