LOCUS       NP_001032172             443 aa            linear   ROD 03-APR-2024
DEFINITION  oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
            precursor [Rattus norvegicus].
ACCESSION   NP_001032172 XP_221545
VERSION     NP_001032172.1
DBSOURCE    REFSEQ: accession NM_001037095.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 443)
  AUTHORS   Loskove,Y., Yasuda,M., Chen,B., Nazarenko,I., Cody,N. and
            Desnick,R.J.
  TITLE     Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane
            synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen
            oxidase novel mutations
  JOURNAL   Mol Genet Metab 128 (3), 352-357 (2019)
   PUBMED   30385147
REFERENCE   2  (residues 1 to 443)
  AUTHORS   Barupala,D.P., Dzul,S.P., Riggs-Gelasco,P.J. and Stemmler,T.L.
  TITLE     Synthesis, delivery and regulation of eukaryotic heme and Fe-S
            cluster cofactors
  JOURNAL   Arch Biochem Biophys 592, 60-75 (2016)
   PUBMED   26785297
  REMARK    Review article
REFERENCE   3  (residues 1 to 443)
  AUTHORS   Mortensen,M., Ferguson,D.J., Edelmann,M., Kessler,B., Morten,K.J.,
            Komatsu,M. and Simon,A.K.
  TITLE     Loss of autophagy in erythroid cells leads to defective removal of
            mitochondria and severe anemia in vivo
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 832-837 (2010)
   PUBMED   20080761
REFERENCE   4  (residues 1 to 443)
  AUTHORS   Sopena,Y.E., Ferramola de Sancovich,A.M. and Sancovich,H.A.
  TITLE     Hexachlorobenzene treatment on hepatic mitochondrial function
            parameters and intracellular coproporphyrinogen oxidase location
  JOURNAL   Int J Toxicol 27 (6), 455-465 (2008)
   PUBMED   19482825
REFERENCE   5  (residues 1 to 443)
  AUTHORS   Ajioka,R.S., Phillips,J.D. and Kushner,J.P.
  TITLE     Biosynthesis of heme in mammals
  JOURNAL   Biochim Biophys Acta 1763 (7), 723-736 (2006)
   PUBMED   16839620
  REMARK    Review article
REFERENCE   6  (residues 1 to 443)
  AUTHORS   Li,F., Lim,C.K. and Peters,T.J.
  TITLE     Coproporphyrinogen oxidase, protoporphyrinogen oxidase and
            ferrochelatase activities in iron-overloaded and ethanol-treated
            rats
  JOURNAL   Biomed Chromatogr 4 (6), 253-256 (1990)
   PUBMED   2289051
REFERENCE   7  (residues 1 to 443)
  AUTHORS   Adjarov,D.G.
  TITLE     Decreased activity of liver coproporphyrinogen oxidase in
            hexachlorobenzene-induced porphyria
  JOURNAL   Exp Pathol 40 (2), 117-122 (1990)
   PUBMED   2079105
REFERENCE   8  (residues 1 to 443)
  AUTHORS   Woods,J.S. and Southern,M.R.
  TITLE     Studies on the etiology of trace metal-induced porphyria: effects
            of porphyrinogenic metals on coproporphyrinogen oxidase in rat
            liver and kidney
  JOURNAL   Toxicol Appl Pharmacol 97 (1), 183-190 (1989)
   PUBMED   2916235
REFERENCE   9  (residues 1 to 443)
  AUTHORS   Grandchamp,B., Phung,N. and Nordmann,Y.
  TITLE     The mitochondrial localization of coproporphyrinogen III oxidase
  JOURNAL   Biochem J 176 (1), 97-102 (1978)
   PUBMED   31872
REFERENCE   10 (residues 1 to 443)
  AUTHORS   Goldberg,A., Meredith,P.A., Miller,S., Moore,M.R. and Thompson,G.G.
  TITLE     Hepatic drug metabolism and haem biosynthesis in lead-poisoned rats
  JOURNAL   Br J Pharmacol 62 (4), 529-536 (1978)
   PUBMED   656697
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107664.1.
            
            On Nov 5, 2005 this sequence version replaced XP_221545.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     Protein         1..443
                     /product="oxygen-dependent coproporphyrinogen-III oxidase,
                     mitochondrial precursor"
                     /EC_number="1.3.3.3"
                     /note="coproporphyrinogen-III oxidase, mitochondrial; COX;
                     coprogen oxidase; coproporphyrinogenase; oxygen-dependent
                     coproporphyrinogen-III oxidase, mitochondrial"
                     /calculated_mol_wt=39549
     transit_peptide 1..98
                     /note="Mitochondrion.
                     /evidence=ECO:0000250|UniProtKB:P36552; propagated from
                     UniProtKB/Swiss-Prot (Q3B7D0.1)"
                     /calculated_mol_wt=9747
     Region          90..111
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7D0.1)"
     mat_peptide     99..443
                     /product="Oxygen-dependent coproporphyrinogen-III oxidase,
                     mitochondrial. /id=PRO_0000293624"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7D0.1)"
                     /calculated_mol_wt=39549
     Site            101
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q3B7D0.1)"
     Region          140..441
                     /region_name="Coprogen_oxidas"
                     /note="Coproporphyrinogen III oxidase; pfam01218"
                     /db_xref="CDD:460116"
     Region          182..191
                     /region_name="Important for dimerization.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7D0.1)"
     Site            316
                     /site_type="other"
                     /note="Important for dimerization. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q3B7D0.1)"
     Region          381..417
                     /region_name="Important for dimerization.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3B7D0.1)"
     Site            393
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P36552; propagated from
                     UniProtKB/Swiss-Prot (Q3B7D0.1)"
     CDS             1..443
                     /gene="Cpox"
                     /coded_by="NM_001037095.1:82..1413"
                     /db_xref="GeneID:304024"
                     /db_xref="RGD:1311817"
ORIGIN      
        1 malrlgqlgs gpwwravrgd yaqlrapspr sasacvcrlp gtagtqprrg lghgssaggg
       61 srlgtglaaa lagmaglaaa vlghvqraem vpkssgarsp spgrleedgd elarrcstfm
      121 sspvtelrel grrpddmktk melmimetqa qvcralaqvd gvadfsvdrw erkeggggit
      181 cvlqdgrvfe kagvnisvvh gnlseeaanq mrsrgkalkk kdgklpftam gissvihpkn
      241 pyaptmhfny ryfeveeadg kmhwwfgggc dltptylnre davhfhrtlk eacdqhgpdi
      301 ypkfkkwcdd yffiahrger rgiggiffdd ldspskeeaf rfvktcaeav vpsyvpivkk
      361 hcddsytpqd klwqqlrrgr yvefnlvydr gtkfglftpg sriesilmsl pltarweymh
      421 sppenskeae ilevlrhpkd wvh
//
