LOCUS       NM_001107917            5580 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus copine 3 (Cpne3), mRNA.
ACCESSION   NM_001107917 XM_001057562 XM_006237932 XM_232809
VERSION     NM_001107917.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5580)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 5580)
  AUTHORS   Perestenko,P.V., Pooler,A.M., Noorbakhshnia,M., Gray,A., Bauccio,C.
            and Jeffrey McIlhinney,R.A.
  TITLE     Copines-1, -2, -3, -6 and -7 show different calcium-dependent
            intracellular membrane translocation and targeting
  JOURNAL   FEBS J 277 (24), 5174-5189 (2010)
   PUBMED   21087455
REFERENCE   3  (bases 1 to 5580)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 5580)
  AUTHORS   Heinrich,C., Keller,C., Boulay,A., Vecchi,M., Bianchi,M., Sack,R.,
            Lienhard,S., Duss,S., Hofsteenge,J. and Hynes,N.E.
  TITLE     Copine-III interacts with ErbB2 and promotes tumor cell migration
  JOURNAL   Oncogene 29 (11), 1598-1610 (2010)
   PUBMED   20010870
REFERENCE   5  (bases 1 to 5580)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 5580)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 5580)
  AUTHORS   Cowland,J.B., Carter,D., Bjerregaard,M.D., Johnsen,A.H.,
            Borregaard,N. and Lollike,K.
  TITLE     Tissue expression of copines and isolation of copines I and III
            from the cytosol of human neutrophils
  JOURNAL   J Leukoc Biol 74 (3), 379-388 (2003)
   PUBMED   12949241
REFERENCE   8  (bases 1 to 5580)
  AUTHORS   Caudell,E.G., Caudell,J.J., Tang,C.H., Yu,T.K., Frederick,M.J. and
            Grimm,E.A.
  TITLE     Characterization of human copine III as a phosphoprotein with
            associated kinase activity
  JOURNAL   Biochemistry 39 (42), 13034-13043 (2000)
   PUBMED   11041869
REFERENCE   9  (bases 1 to 5580)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Aug 29, 2022 this sequence version replaced
            XM_006237932.3, NM_001107917.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.20710.1,
                                           SRR26643289.14823.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000005.1  37860758-37860840   c
            84-223              JAXUCZ010000005.1  37846171-37846310   c
            224-403             JAXUCZ010000005.1  37845294-37845473   c
            404-478             JAXUCZ010000005.1  37842564-37842638   c
            479-550             JAXUCZ010000005.1  37840875-37840946   c
            551-634             JAXUCZ010000005.1  37836243-37836326   c
            635-724             JAXUCZ010000005.1  37833645-37833734   c
            725-823             JAXUCZ010000005.1  37828964-37829062   c
            824-910             JAXUCZ010000005.1  37827628-37827714   c
            911-970             JAXUCZ010000005.1  37825422-37825481   c
            971-1104            JAXUCZ010000005.1  37824780-37824913   c
            1105-1159           JAXUCZ010000005.1  37819920-37819974   c
            1160-1211           JAXUCZ010000005.1  37819793-37819844   c
            1212-1345           JAXUCZ010000005.1  37818055-37818188   c
            1346-1582           JAXUCZ010000005.1  37816785-37817021   c
            1583-5580           JAXUCZ010000005.1  37811566-37815563   c
FEATURES             Location/Qualifiers
     source          1..5580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..5580
                     /gene="Cpne3"
                     /note="copine 3"
                     /db_xref="GeneID:313087"
                     /db_xref="RGD:1310178"
     exon            1..83
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            84..223
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1693
                     /gene="Cpne3"
                     /note="copine III"
                     /codon_start=1
                     /product="copine-3"
                     /protein_id="NP_001101387.2"
                     /db_xref="GeneID:313087"
                     /db_xref="RGD:1310178"
                     /translation="MAAQCVTKVELNISCNSLLDTDLTSKSDPLCVLFLNTSGQQWYE
                     VERTERIKNSLNPKFSKTFVIDYYFEVVQKLKFGIYDIDNKTIELSDDDFLGECEVTL
                     GQIVSSKKLTRPLVLKNGKPAGQGSITILAEEIKDNRVVLFEMEARKLDNKDLFGKSD
                     PYLEFHKQTSDGHWLMVHRTEVIKNNLNPMWKPFKISLNSLCYGDMDKTIKVECYDYD
                     NDGSHDLIGTFQTTMTKLKEASRSSPVEFECINEKKRQKKKSYKNSGVIVVKHCEITV
                     ECTFLDYIMGGCQLNFTVGVDFTGSNGDPSSPDSLHYISPNGVNEYLTAIWSVGLVVQ
                     DYDADKMFPAFGFGAQVPPQWQVSHEFPMNFNPSNPYCNGIQGIIEAYRTCLPQIRLY
                     GPTNFSPIINHVARFAAAATQQQTASQYFVLLIITDGVITDLDQTRQAIVSAAKLPMS
                     IIIVGVGGADFSAMEFLDGDNGSLRAPSGEVAIRDIVQFVPFRQFQNAPKEALAQCVL
                     AEIPQQVVGYFNTYRLLPPKNPAVK"
     exon            224..403
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            404..478
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..550
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..634
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..724
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            725..823
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            824..910
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            911..970
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1104
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1159
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1211
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1345
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1582
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..5580
                     /gene="Cpne3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtaaagccc ctgcggtccc accgccttgc ggtactcctt gctggctctc caccctcact
       61 ggacttcctc ggcgacctag tagctgaaga catggctgcg cagtgcgtca cgaaggtgga
      121 gctaaatatt tcctgtaaca gccttttgga tactgatcta acgtcaaagt ccgacccttt
      181 atgtgtgttg tttttgaaca ccagtggtca acagtggtat gaggttgaac gcacagaaag
      241 gattaagaat tctttgaatc ccaaattttc taagacattt gtcattgatt actactttga
      301 agtggttcag aaattgaagt ttggaatcta tgatattgac aacaaaacta tcgagctgag
      361 tgatgatgac ttcttgggag aatgtgaagt cacccttgga caaattgttt ccagtaagaa
      421 gctgactcga ccactggtgc tcaaaaatgg caaacctgca gggcaaggga gtattacgat
      481 tttagcagaa gaaataaagg ataacagagt ggtactgttt gaaatggaag ccagaaaact
      541 ggataataag gatctctttg ggaagtcaga tccatacctg gagtttcaca agcagacatc
      601 agatggccac tggctgatgg ttcaccgaac agaggttata aaaaacaacc tgaatcccat
      661 gtggaagcct tttaaaatct ctctcaactc tctgtgctat ggagatatgg acaagaccat
      721 taaggtagag tgttatgatt atgacaatga tggatcacat gatctcattg gaacatttca
      781 aaccaccatg acaaaactca aagaagcctc caggagctca cctgttgaat ttgaatgcat
      841 aaatgaaaaa aagagacaga agaaaaaaag ctacaagaat tcaggtgtta tcgttgtgaa
      901 gcattgtgag attactgtag aatgcacatt tcttgactac atcatgggag ggtgccagct
      961 gaattttact gtgggagtgg acttcactgg ctccaacggt gaccccagtt ctccagactc
     1021 cctgcattac atcagcccaa atggtgttaa tgagtatctg actgccatct ggtctgtggg
     1081 attggtagtt caagattatg atgctgataa aatgtttcca gcttttggct ttggagctca
     1141 ggttcctcct cagtggcagg tgtctcatga atttccaatg aactttaacc cctcgaaccc
     1201 ctactgtaat gggatccaag gcattataga ggcttatcgg acctgccttc ctcagataag
     1261 actctatgga ccaactaatt tttctccgat tataaatcat gtggccaggt ttgccgctgc
     1321 agccacgcaa cagcagacag cttctcagta ctttgtgctc ctcatcatca cggatggcgt
     1381 gatcacagac cttgatcaaa ccagacaggc aatcgtcagt gcggccaagc tgcccatgtc
     1441 gatcatcatt gtgggggttg ggggagctga cttcagtgcc atggaatttc tagacggtga
     1501 caatggaagc ctccgcgccc catccgggga ggtggccata agagatattg ttcagtttgt
     1561 gcctttcaga cagttccaga atgctccaaa ggaagcactt gcgcagtgtg tcttggcaga
     1621 gatcccccag caggtggtgg gttacttcaa cacatacaga ctccttcctc ccaaaaaccc
     1681 agctgtgaag tagaaggagc cgggagctac aggacgtcca aagccatgtg gagcagcgcc
     1741 atctcttaca cagaatgatg tatcgccatc tgcgcttttt accccccagg gtttctgatg
     1801 caaacccagc tttttgtata tattctatca gtttaaaaca tacattttat actttctgaa
     1861 gaggacagta gcaagtccat ttctgcccaa tgaactcagt ggctgttagt gatttataga
     1921 aattacaaga gtgcagtttg gaattgattt taatttggga aaaattggtt tgttgtatat
     1981 tttctataat gaaaatgcca ttcttaagtg ttgccagtag agtgaatgag gcattacagg
     2041 atgaagtggt atacaagttt tgctcttctg ttttagtaaa tattttgcaa gccagtgtcg
     2101 gtactgtgat ggagagagct gcttaggtca gtcacagagt tcatacctgt tactctatac
     2161 tctgtccctt tctgtgctgc agtgctacag tgtataaaac tgttttcatg tagttgctta
     2221 tgaaaaccag tggacttaac ttcgttttga aaatgtacaa tcaacctatg gagagctcct
     2281 tgtagacaag acatttttct ttgccttttg aaatcccttc actgtgaact cttgcacaca
     2341 gcgtgtcttt gctttactga gcaaacaaga cactcaaact tctgtggaca cacaatgata
     2401 ggtcatcccg gaggccacat tattagatca gcattgtcga cttaactgga actgtgttca
     2461 ctaaagcttt gagggccaaa catttaagat gaaaattcaa accagttgca gaccaggcat
     2521 ggtgacacat catgtgagca cttggaagga agaggcatga ggccagcacg agccaaccca
     2581 cctgcatagt taattccagg tctgacagct atccagtgag agtgtggttc agtacaacaa
     2641 agaaaaataa gtaattgaga aatacatttc ttctatctaa tggaataatt gcaaaaggtc
     2701 attagtattt ttttcttgct aaggtcctgt gtattgattt ttatagagtt atttagattt
     2761 ttttgtcttt ttaaaaaata gtattatttt tctttaaacc tctaattcta gttatttatt
     2821 aatcaaaatt ccattttttc atttcaataa tgtactattt ccaaagtcca gaatgtattc
     2881 tgttaagcac aaaacctgat ataacattta aaaaaagaga agaaagaaca acatatacat
     2941 accctgttct agctgctata tttacataga gtggacttag tattcttatt ttgaagaatt
     3001 gaattatttt aactttatcc tgtaggacat actgttcagt gagtacacat ttttggaata
     3061 gattttgtaa catttgcctg agcatctgga tgtcaaatat ttgcctatct atgcagtggc
     3121 caattattgt taacagttta acaagtagca ttgtgtatcc accacatatc ctcaagtata
     3181 tatccacaga gagcatccat gccagcgtta ccgaatcctt ctgccactgc ctgtctttgt
     3241 ttcctgcagg cttctcagga acagcttctg tcagcagaag atccacttgt cttgtttgcc
     3301 tggctcagtg agcagtggcg cctccttccc acatgggtaa ttggcatctg gattgtgctg
     3361 ttaacctgaa acagtgtacc tctgtatagc agagtttctt aaaatttatt ttcattttga
     3421 gtcctttcac ccaagaaatt ttatgtaacc ccagttttta taggtataca aagttatact
     3481 taagataggt atacaaatca aacattgcca gtaaaccaaa ttatttcagg agcctggaga
     3541 gatggctctg ggttaataat acattcactc ttgcagctgg tttctgttgc tttccagcat
     3601 gtatgtcagg cagctctact acttgactgt aactctagct tcagggggtc tggtggtctc
     3661 ctctgccctc cacgaggacc tacttttgta tgtgtgtgtg tgcgtgtgcg tgtgcgcatg
     3721 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgca cgcacacact ctcagctatt
     3781 tggtattgta gtacacagag catctttaat gtactgcaga gttgactgat attttgattt
     3841 tgtgattgcc aatactttga accccttttc acataaatac atagtacaaa atgccatcag
     3901 tgtttagagg tatttcagaa gctgcaaatt ctgtcctcat cctaagccaa aatataaagt
     3961 tttttttaat gaagcttatg ttgacagttt ttaaaatcaa actttctagc acagtacaat
     4021 ctagacataa attgatttga tattgacttg attcaggctg gcaggaaaat attgatgtct
     4081 ttcttttctg taactaagca tttatgctaa agctgagtat ggacaataaa atcactgtat
     4141 acataaaacg cacaaagtaa ccttgagtct gagctgaggt gttcaggcag tgttcactgt
     4201 tgttgggtga catggcagcc gtgtagtgca gaatgcacct gctgtctatt gacagccaag
     4261 gctgcagtga agttgagcga tacaaggtgg acaagccctg ccagaaacac ctcagagtca
     4321 ttacacattt cgttttgaat ccatttttgg ccatcgttca ttagaaagct ttactgttgt
     4381 ctggtttttc cagtcagtta catgactgcc tatgggacca gggcctgcag ttgaagaatg
     4441 tgggctttgt gggatgactc agtagtaaca actcagttat cagtagaggt gacaacatct
     4501 gatcccctcc cccccctttt tttctctctt ttgaaaccat tattattcca cggtctcagt
     4561 atcagttctc tgtggtggga agatgtcaca gtggctttca ggactttctt ttgcatacga
     4621 gggagccagg tcagaaatgg cttacaggtt ctctgtaggt tactcggtag gagagtggct
     4681 tttgactctg aagcaaggct cactaggctt gctcagcccc tgagagtacg caggactgaa
     4741 ggcccttctt catccggtag ccatcttgct tctgccactt ggtcttgaac agttttctat
     4801 tctggtttac catcactttt tcctgatgag ataacttttc tttaaatgac tcgtcttgat
     4861 ccagttttat agaaactgtg attctggcaa attaaaataa tccatagctg tctgcagttt
     4921 gaaataaaag catttccaac ttctagatta ttatgctatg aaattcttcg tctcggcact
     4981 caccttcatt ccgtattatt ttatagtggt ttgtactcaa atgtttattt tttcctgttg
     5041 tgcctcgatt tcaacaaatg ccgttcactt ttaaagaaca tctaaaataa aaatcacaga
     5101 agtgaccttc atgtctctgt aatttgtatg cacatggcca tcttgttcat tgacacacaa
     5161 tttctctcat gcatatattc aggaatggtt tttgtactgg cctagtcacc tcatcttctg
     5221 tagaagattg atttgtctga gaccattaac cctgtaaatc acctgcggga tatttacgag
     5281 tgttcacttt agacagcgct ttgttagctt ttccagaata ggcccagggc ctcactgatg
     5341 ttgggctgcc ttttacgtgc cttgcccttt tcatttcata ttagaaagcc atcttcaaga
     5401 gggctctcta ggctgatttt cttagaggtg atgtaaggta agttagcagc tgggtggaaa
     5461 ttgtgagccg ttgtcttctg gaggacagca cagtatgtgc ataacttact aaatacttaa
     5521 gtttatatta aatacattgt ccgtgtgagt tccctttaaa taaagttact cttgatgtaa
//
