LOCUS       NM_001256465            3531 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus copine 1 (Cpne1), mRNA.
ACCESSION   NM_001256465
VERSION     NM_001256465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3531)
  AUTHORS   Lu,X., Xie,H., Ju,Y., Fu,Y., Liu,S. and Zhao,S.
  TITLE     Role of CPNE1 in Odontoblastic Differentiation of Rat Stem Cells
            from Apical Papilla
  JOURNAL   Adv Biol (Weinh) 7 (7), e2300054 (2023)
   PUBMED   37132099
  REMARK    GeneRIF: Role of CPNE1 in Odontoblastic Differentiation of Rat Stem
            Cells from Apical Papilla.
REFERENCE   2  (bases 1 to 3531)
  AUTHORS   Choi,H.Y., Park,N., Lee,B., Choe,Y.I., Woo,D.K., Park,J.Y. and
            Yoo,J.C.
  TITLE     CPNE1-mediated neuronal differentiation can be inhibited by HAX1
            expression in HiB5 cells
  JOURNAL   Biochem Biophys Res Commun 533 (3), 319-324 (2020)
   PUBMED   32958249
  REMARK    GeneRIF: CPNE1-mediated neuronal differentiation can be inhibited
            by HAX1 expression in HiB5 cells.
REFERENCE   3  (bases 1 to 3531)
  AUTHORS   Park,N., Yoo,J.C., Lee,Y.S., Choi,H.Y., Hong,S.G., Hwang,E.M. and
            Park,J.Y.
  TITLE     Copine1 C2 domains have a critical calcium-independent role in the
            neuronal differentiation of hippocampal progenitor HiB5 cells
  JOURNAL   Biochem Biophys Res Commun 454 (1), 228-233 (2014)
   PUBMED   25450385
  REMARK    GeneRIF: the C2 domains of CPNE1 play a calcium-independent role in
            regulating the neuronal differentiation of HiB5 hippocampal
            progenitor cells
REFERENCE   4  (bases 1 to 3531)
  AUTHORS   Park,N., Yoo,J.C., Ryu,J., Hong,S.G., Hwang,E.M. and Park,J.Y.
  TITLE     Copine1 enhances neuronal differentiation of the hippocampal
            progenitor HiB5 cells
  JOURNAL   Mol Cells 34 (6), 549-554 (2012)
   PUBMED   23263657
  REMARK    GeneRIF: Copine 1 enhances neuronal differentiation of HiB5 cells
            not through the PI3K-Akt pathway, but by using another Akt
            activated signal pathway.
REFERENCE   5  (bases 1 to 3531)
  AUTHORS   Perestenko,P.V., Pooler,A.M., Noorbakhshnia,M., Gray,A., Bauccio,C.
            and Jeffrey McIlhinney,R.A.
  TITLE     Copines-1, -2, -3, -6 and -7 show different calcium-dependent
            intracellular membrane translocation and targeting
  JOURNAL   FEBS J 277 (24), 5174-5189 (2010)
   PUBMED   21087455
REFERENCE   6  (bases 1 to 3531)
  AUTHORS   Ramsey,C.S., Yeung,F., Stoddard,P.B., Li,D., Creutz,C.E. and
            Mayo,M.W.
  TITLE     Copine-I represses NF-kappaB transcription by endoproteolysis of
            p65
  JOURNAL   Oncogene 27 (25), 3516-3526 (2008)
   PUBMED   18212740
REFERENCE   7  (bases 1 to 3531)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   8  (bases 1 to 3531)
  AUTHORS   Tomsig,J.L., Sohma,H. and Creutz,C.E.
  TITLE     Calcium-dependent regulation of tumour necrosis factor-alpha
            receptor signalling by copine
  JOURNAL   Biochem J 378 (Pt 3), 1089-1094 (2004)
   PUBMED   14674885
REFERENCE   9  (bases 1 to 3531)
  AUTHORS   Cowland,J.B., Carter,D., Bjerregaard,M.D., Johnsen,A.H.,
            Borregaard,N. and Lollike,K.
  TITLE     Tissue expression of copines and isolation of copines I and III
            from the cytosol of human neutrophils
  JOURNAL   J Leukoc Biol 74 (3), 379-388 (2003)
   PUBMED   12949241
REFERENCE   10 (bases 1 to 3531)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000119.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001256465.3.
            
            On Jul 8, 2022 this sequence version replaced NM_001256465.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.127460.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               JACYVU010000119.1  18284885-18285026   c
            143-224             JACYVU010000119.1  18276219-18276300   c
            225-350             JACYVU010000119.1  18251932-18252057   c
            351-530             JACYVU010000119.1  18251656-18251835   c
            531-605             JACYVU010000119.1  18251467-18251541   c
            606-677             JACYVU010000119.1  18251318-18251389   c
            678-758             JACYVU010000119.1  18251130-18251210   c
            759-848             JACYVU010000119.1  18250888-18250977   c
            849-935             JACYVU010000119.1  18250700-18250786   c
            936-1022            JACYVU010000119.1  18250482-18250568   c
            1023-1082           JACYVU010000119.1  18250306-18250365   c
            1083-1216           JACYVU010000119.1  18250088-18250221   c
            1217-1271           JACYVU010000119.1  18249932-18249986   c
            1272-1323           JACYVU010000119.1  18248754-18248805   c
            1324-1457           JACYVU010000119.1  18245433-18245566   c
            1458-1694           JACYVU010000119.1  18244636-18244872   c
            1695-3531           JACYVU010000119.1  18242646-18244482   c
FEATURES             Location/Qualifiers
     source          1..3531
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3531
                     /gene="Cpne1"
                     /note="copine 1"
                     /db_xref="GeneID:362249"
                     /db_xref="RGD:1311148"
     exon            1..142
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..224
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1835
                     /gene="Cpne1"
                     /note="copine I; copine-1-like"
                     /codon_start=1
                     /product="copine-1"
                     /protein_id="NP_001243394.2"
                     /db_xref="GeneID:362249"
                     /db_xref="RGD:1311148"
                     /translation="MAHCVTLVQLSVSCDHLIDKDIGSKSDPLCVLLQDVGGAWAELC
                     RTERVRNCSSPAFSKTLQIEYYFETVQKLRFGIYDIDNKTPELGDDDFLGGAECSLGQ
                     IVSSQTLTLPLMLKPGKPAGRGTITVSAQELKDSRVVTMEVEARNLDKKDFLGKSDPF
                     LEFFRQGDGKWHLAYRTEVVKNNLNPTWKRFSVSLQHFCGGDLNTPIQVRCSDYDSDG
                     SHDLIGTFHTTLAQLQAVPAEFECIHPEKQQRKKSYKNSGTVCVKTCRVETEYSFLDY
                     VMGGCQINFTVGVDFTGSNGDPSSPDSLHYLSPTGVNEYLTALWSVGSVVQDYDSDKL
                     FPAFGFGAQVPPDWQVSHEFALNFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAP
                     IINHVARFAAQAAQQRTASQYFVLLLLTDGAVTDVEATCKAVVEASKLPMSVIIVGVG
                     GADFEVMEQLDADGGPLRTRSGEAAARDIVQFVPYRRFQNAPRETLAMTVLAEVPTQM
                     VSYFKAQGWAPLKTLPAPAKGPAQAPQV"
     exon            225..350
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..530
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..605
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..677
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..758
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..848
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..935
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1022
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1082
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1216
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1271
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1323
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1457
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1694
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..3531
                     /gene="Cpne1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttgtgaa gcggcagcgg aggtgttggc tgcagtgggc tccgggaaag ccgttcgggc
       61 tggggctgtc ggccgcaggg ctgaggcact cgcgcggggg gtaactcggg tctgggttct
      121 ggtgccgcgc aagctctccc cgtctaaaag ttggttttaa ttggttgccc acaggattga
      181 cttggcctct acttcttaag aaaatacatc tcttgtttta caagatggcc cattgtgtga
      241 ccttggttca gctgtccgtt tcctgtgacc acctcattga caaggacatc ggctccaagt
      301 ctgacccact ctgcgtcctt ttacaggatg tgggaggtgc ctgggctgag ctttgtcgga
      361 ctgaacgtgt tcgcaactgc tcgagccctg cattctctaa gactctgcag atagaatact
      421 actttgagac tgtccagaag ttacgctttg gaatctatga catagacaac aagacacctg
      481 agctggggga tgatgacttt ctagggggag ctgaatgctc cctaggccag attgtgtcca
      541 gccagacgct gactctaccc ttgatgttga agcctgggaa acctgctgga cggggaacca
      601 ttacagtttc agctcaggag ttaaaggaca gccgtgtagt aaccatggag gtggaagcta
      661 gaaacctaga taagaaggac tttctaggaa aatctgatcc attcttggag ttcttccggc
      721 aaggtgatgg gaagtggcac ctggcatata gaactgaggt agtcaagaac aacctgaacc
      781 ctacgtggaa acgcttctca gtctctctcc agcatttctg tggcggggac ctcaacacac
      841 ccatccaggt gcgctgctca gactatgaca gtgatgggtc acatgatctc atcggtacct
      901 ttcacactac cttggcccaa ctgcaagcag tcccggctga gtttgaatgt atccaccctg
      961 agaagcagca gagaaagaaa agctacaaga actctggaac tgtctgtgtc aagacttgcc
     1021 gggtagagac agagtattcc ttcctggact atgtgatggg aggctgccaa attaacttta
     1081 ccgtgggtgt ggacttcact ggctccaacg gtgacccatc ctcacctgac tccctgcact
     1141 atctgagccc tacaggagtc aatgagtatc tgacagccct gtggagtgtg ggcagcgtgg
     1201 ttcaagacta tgactcagac aagctgtttc cagcatttgg atttggagcc caagtacccc
     1261 ctgattggca ggtctcacat gagtttgcct tgaacttcaa ccccagtaac ccatactgtg
     1321 caggcatcca gggtatcgta gacgcctacc gtcaagcact tccccaagtt cgtctctatg
     1381 gccccaccaa ctttgcaccc atcatcaacc acgtggccag gtttgcagct caggctgcac
     1441 aacagaggac tgcctcgcaa tacttcgtac tgctgctctt gactgacggc gctgtgaccg
     1501 atgtggaggc cacgtgtaag gctgtggtgg aagcctcaaa gctgcccatg tcggtgatca
     1561 tcgtgggtgt gggtggtgct gactttgagg tcatggaaca gctggatgct gatggcggcc
     1621 cacttcgtac acgctctgga gaagcagctg cccgagacat agtgcagttt gtgccttatc
     1681 gacgatttca gaatgctcca cgggagacac ttgcaatgac tgtgcttgca gaagtgccca
     1741 ctcagatggt ttcctacttc aaagcccaag gttgggcccc attaaagaca ctcccagccc
     1801 cagccaaggg ccctgcacag gccccacagg tgtaggtccc cttggaagag caggctacaa
     1861 tcaatcttca gcttgcacca tcctctgggc gtggaccaac ctgcactctt tcacttgatg
     1921 actttatatg tgcttctgct attgctgctc tttgacctgc ctgcctgcct gcctggcacc
     1981 ctcacattca ggaaagacag actagtaatt gtaaagatct attcattcca gtcacatact
     2041 ttgaaaagac agagtttgaa tataaagcaa gcatgtggtt gtccttttct tggggcgagc
     2101 tgagctggga ccgtgaatga gatggaaagt gctacctcat aggagatagc aaaggtgagg
     2161 gggaaaaaga tgttttagag caggctaagg actgctcctt agacttccta tgctagctct
     2221 gtccctctgt ttcttgggaa catttgtgta gcccaggctg gcctgcaatt tagcatcctg
     2281 ccacaacctc ttagacgcta gaattgcagg catgtactat cacgcctggt ttacagtcct
     2341 gatttttcat ttgctttttt tttttttttc ttttcttttt ttcggagctg tttcatttgc
     2401 tttttgacat atgatcttat atgttccagg ctggccctac attgtgtagc caaggataac
     2461 ctgaattctt gctcttccta ctccagcttc ccaagtgcta gcattataac caggcctcaa
     2521 gcgtgcttca cttttaacag ctcaacaatt taatagcttt tttatattaa agatttaata
     2581 agcatattca ttttgggaaa actttatagg acacatccta acccacttta gagtctttgg
     2641 actcaaggtc ctggagtagc tggactacaa ttccctcagt gcctggatga gaaaacaggt
     2701 gttgtttgca gggttatggg agggaggctc ctaaatgtag aattaaaatt tcccataacc
     2761 tgtggctcgg tcatggtaag gggaccacat tgtgaatcac agatcccagg agacaggtgt
     2821 tttaaatttt gtttgctaat ctaatgaaac attgtttcag atatcagtat tatataaaaa
     2881 taggaaatgg gaacaaagat tggtggctca tggttgtaat cccaacactc agaagtctga
     2941 ggcaggagca ttgctgtctg tgtgatgtgg acttaaggta cactgagttt cagatcagat
     3001 agaacaactt taaaaagcta gcacatgtgc tgtttgtatc tggtttgcat ttattttgga
     3061 tgccttctcc accagaactt agtctcctct ccttttcatg gctgttattc ttttgtaaga
     3121 atataccaga gtttagcaat tcccttcctt acagagactc gttttattgt gcttacacac
     3181 ccttttgaga aattggtttt taatgtggaa acggtagacc gcaggggata tttagaatgt
     3241 tagcagttat tacagagaag tgtggtcatc tcatgttagc ccgtgctcac cttccttctc
     3301 cagacctact ttccattttc ttccattatt tcacacattt ccttgtttct cagtcacctg
     3361 ttctcgagct gttagagctt ttattctgat gttcttacat gatgaaaata ttttcccctc
     3421 agctgttacc atttcatgtt tttatactcg atatgcaaat ttatttttta tatgccatcc
     3481 ttttaaaaaa tatatctgta tatgaataat aatatatacc ttcctcagtg a
//
