LOCUS       NM_053526               1780 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus carboxypeptidase N subunit 1 (Cpn1), mRNA.
ACCESSION   NM_053526 XM_345036
VERSION     NM_053526.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1780)
  AUTHORS   Moreau,M.E., Garbacki,N., Molinaro,G., Brown,N.J., Marceau,F. and
            Adam,A.
  TITLE     The kallikrein-kinin system: current and future pharmacological
            targets
  JOURNAL   J Pharmacol Sci 99 (1), 6-38 (2005)
   PUBMED   16177542
  REMARK    Review article
REFERENCE   2  (bases 1 to 1780)
  AUTHORS   Dendorfer,A., Wolfrum,S., Wagemann,M., Qadri,F. and Dominiak,P.
  TITLE     Pathways of bradykinin degradation in blood and plasma of
            normotensive and hypertensive rats
  JOURNAL   Am J Physiol Heart Circ Physiol 280 (5), H2182-H2188 (2001)
   PUBMED   11299220
REFERENCE   3  (bases 1 to 1780)
  AUTHORS   Sato,T., Miwa,T., Akatsu,H., Matsukawa,N., Obata,K., Okada,N.,
            Campbell,W. and Okada,H.
  TITLE     Pro-carboxypeptidase R is an acute phase protein in the mouse,
            whereas carboxypeptidase N is not
  JOURNAL   J Immunol 165 (2), 1053-1058 (2000)
   PUBMED   10878383
REFERENCE   4  (bases 1 to 1780)
  AUTHORS   Kato,T., Akatsu,H., Sato,T., Matsuo,S., Yamamoto,T., Campbell,W.,
            Hotta,N., Okada,N. and Okada,H.
  TITLE     Molecular cloning and partial characterization of rat
            procarboxypeptidase R and carboxypeptidase N
  JOURNAL   Microbiol Immunol 44 (8), 719-728 (2000)
   PUBMED   11021404
REFERENCE   5  (bases 1 to 1780)
  AUTHORS   Rajashree,S. and Puvanakrishnan,R.
  TITLE     Dexamethasone induced alterations in the levels of proteases
            involved in blood pressure homeostasis and blood coagulation in
            rats
  JOURNAL   Mol Cell Biochem 197 (1-2), 203-208 (1999)
   PUBMED   10485340
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088124.1.
            
            On Jun 10, 2007 this sequence version replaced NM_053526.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088124.1, AB042599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1780
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1780
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /note="carboxypeptidase N subunit 1"
                     /db_xref="GeneID:365466"
                     /db_xref="RGD:70931"
     exon            1..419
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1570
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /EC_number="3.4.17.3"
                     /note="carboxypeptidase N catalytic chain;
                     carboxypeptidase N, polypeptide 1, 50kD; carboxypeptidase
                     N small subunit; carboxypeptidase N catalytic chain-like"
                     /codon_start=1
                     /product="carboxypeptidase N catalytic chain precursor"
                     /protein_id="NP_445978.1"
                     /db_xref="GeneID:365466"
                     /db_xref="RGD:70931"
                     /translation="MPDLPSAFLPLLLLSKFVTPVTFRHHRYDDLVRTLYKVHNQCPD
                     ITRLYNIGRSVKGRYLYVLEFSDYPGTHEPLEPEVKYVGNMHGNEVLGRELLLQLSEF
                     LCEEFRNRNQRILRLIQDTRIHILPSMNPDGYEVAAAQGPNTSGYLVGRNNANGVDLN
                     RNFPDLNTYFYYNSKYGGPNHHLPLPDNWKSQVEPETRAVIQWIRSLNFVLSANMHGG
                     AVVANYPYDKSLEHRFRSPHRTSNSPTPDDELFQTLAKVYSYAHGWMHQGWNCGDYFP
                     DGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCNKFPRQEELQREWLGNREALIQF
                     LEQVHQGIKGMVLDENYNNLTGAVISVTGINHDVTSGEHGDYFRLLLPGTYSVTAKAS
                     GYEPKTVTVTVGPAGPTLVDFQLKRSTTQVHPVQKAPGRGQGSRAKQPRTSRKKDQAA
                     KRHRGPA"
     exon            420..616
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /inference="alignment:Splign:2.1.0"
     exon            617..772
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /inference="alignment:Splign:2.1.0"
     exon            773..955
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1067
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1207
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1307
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1426
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1754
                     /gene="Cpn1"
                     /gene_synonym="Cpn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaaggga aatgagtccg gagggcaacg tggctatccc ggggccacag aaataattcc
       61 cagtgtagca gaggcgggtc cccagcctcc tgcaggtgcg gcgggtgcga ggcggctact
      121 ctggatccca acaggcaaag gattgcttgg agagagcggg aaggcacatt ttagagccgc
      181 ttagaagctc ctcgagatgc cagacctgcc ctcagccttc ctgcccctcc tcctcctctc
      241 caagtttgtt accccggtga cctttcgtca ccaccgctac gacgacctcg tgcggacgct
      301 gtacaaggtg cacaaccaat gcccggacat cacgcggctc tacaacatcg ggcgcagcgt
      361 gaaggggagg tacctctacg tgctggagtt tagcgactat cctgggaccc atgaaccctt
      421 ggaaccggaa gtcaagtacg tggggaacat gcacgggaac gaggtgctgg gccgcgaact
      481 gctgctgcag ctgtcggaat tcctctgcga ggagttccgg aaccggaacc agcgcatcct
      541 gcgcctcatc caggacaccc gcattcacat ccttccatcc atgaaccctg acggctacga
      601 ggtggctgct gcccagggcc caaacacgtc tgggtatctg gttggtagga acaatgcaaa
      661 tggggtggac ctgaaccgaa acttcccgga tctcaacacc tatttctact acaattcgaa
      721 gtatggcggc cccaaccacc acctgcccct ccctgacaac tggaaaagtc aggtggaacc
      781 agagacccgg gcagtgatcc agtggattcg atccttaaac ttcgttctct cagccaatat
      841 gcacggcggg gctgtggtgg ccaattaccc atatgacaag tcactggaac acaggttccg
      901 aagtccccat cgcacctcca attcccccac accggatgac gagctcttcc agacgctggc
      961 caaggtctac tcctacgcac atggatggat gcaccaaggt tggaactgtg gggactactt
     1021 tccagacggc atcaccaatg gggcatcctg gtattctcta agcaagggaa tgcaagactt
     1081 caattatctc cataccaact gctttgagat caccctagag ctgagttgca acaagtttcc
     1141 ccggcaagaa gagctgcaaa gggagtggct gggtaaccgg gaagccttaa tccagttctt
     1201 ggaacaggtt caccagggca tcaagggaat ggtgcttgac gagaactata acaacctcac
     1261 aggggctgtc atttccgtca ccggcatcaa ccacgatgtc acttcaggtg aacacgggga
     1321 ttatttccgg ctgctgcttc caggtactta ctcagtcact gccaaggcat cagggtatga
     1381 gcccaaaaca gtgactgtga ccgtggggcc tgcgggacca acactggttg acttccagct
     1441 caagcgaagc acgactcagg tgcaccctgt gcagaaagct cctggccgag gacagggaag
     1501 cagggcaaag cagccccgga catccagaaa gaaagaccag gcagcaaagc ggcacagggg
     1561 ccctgcatga agcccagcac ccagggccac acacagcgag gctatccctg ctctcaaacc
     1621 cccatggcca cacttctctt ttcttatctg ggacatatgt agacgcaggc acgtaccgaa
     1681 cagttctgag tgtttctgtc tgtcccagga tcaagccttc cttgggccag cattaaagga
     1741 gtccgaacct tccaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
