LOCUS       NM_001108098            5450 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus carboxypeptidase M (Cpm), mRNA.
ACCESSION   NM_001108098 XM_001080977 XM_235168
VERSION     NM_001108098.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5450)
  AUTHORS   Teckchandani A, Toida N, Goodchild J, Henderson C, Watts J,
            Wollscheid B and Cooper JA.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
REFERENCE   2  (bases 1 to 5450)
  AUTHORS   Moreau ME, Garbacki N, Molinaro G, Brown NJ, Marceau F and Adam A.
  TITLE     The kallikrein-kinin system: current and future pharmacological
            targets
  JOURNAL   J Pharmacol Sci 99 (1), 6-38 (2005)
   PUBMED   16177542
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080977.1, XM_235168.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5450
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..5450
                     /gene="Cpm"
                     /note="carboxypeptidase M"
                     /db_xref="GeneID:314855"
                     /db_xref="RGD:1310532"
     exon            1..30
                     /gene="Cpm"
                     /inference="alignment:Splign:2.1.0"
     exon            31..193
                     /gene="Cpm"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1365
                     /gene="Cpm"
                     /EC_number="3.4.17.12"
                     /codon_start=1
                     /product="carboxypeptidase M precursor"
                     /protein_id="NP_001101568.1"
                     /db_xref="GeneID:314855"
                     /db_xref="RGD:1310532"
                     /translation="MDGARLWLGLLLPVVAALDFRYHHQEGMEAFLKSVAQNYSSITH
                     LHSIGKSVRGRNLWVLVVGQSPKEHRVGIPEFKYVANMHGDETVGRELLLHLIDYLVT
                     SYGKDAEMTRLIDSTRIHIMPSMNPDGFEAVKKPDCYYSNGRENYNNYDLNRNFPDAF
                     ENNSVTKQPETLAVMTWLQTETFVLSANLHGGALVASYPFDNGVQATGTLLSRSLTPD
                     DDVFQHLAYTYASRNPNMTKGDQCKNKRSFPNGIINGYSWYPLQGGMQDYNYIWAQCF
                     EITLELSCCKYPREEKLPFFWNDNKASLIEYIKQVHLGVKGQVFDQSGNPLPNVIVEA
                     QDRKHICPFRTNKLGEYYLLLLPGSYVINVTVPGHDSHLTKLTIPSKSQPFSALKKDF
                     HLPLRWQPDSVSVSNPSCPMIPLYKLKPSHSAATKPSLFVFFVTLLHIFFK"
     exon            194..291
                     /gene="Cpm"
                     /inference="alignment:Splign:2.1.0"
     exon            292..464
                     /gene="Cpm"
                     /inference="alignment:Splign:2.1.0"
     exon            465..649
                     /gene="Cpm"
                     /inference="alignment:Splign:2.1.0"
     exon            650..820
                     /gene="Cpm"
                     /inference="alignment:Splign:2.1.0"
     exon            821..973
                     /gene="Cpm"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1122
                     /gene="Cpm"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..5450
                     /gene="Cpm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcgggcg gagacgcgcg cctggcactg gacatggacg gcgcgcgcct gtggctgggg
       61 cttctgctgc ccgtggtggc cgccttggat ttccgatacc accaccagga agggatggag
      121 gctttcctaa agagcgtggc tcagaactac agttcgatca cgcacttgca cagcatcggg
      181 aaatcggtga gaggtagaaa cttgtgggtt cttgttgtgg ggcagtctcc aaaggagcac
      241 agagtcggga ttccagagtt caaatacgtg gctaatatgc acggcgatga gactgtgggg
      301 cgagaactgc tgctccactt gatcgactat ctggtaacca gttatgggaa ggacgccgaa
      361 atgacacgcc tgatcgacag cacccggatc cacatcatgc cttccatgaa cccagatgga
      421 ttcgaagccg tcaagaagcc cgactgttac tacagtaatg gaagggaaaa ctacaataat
      481 tatgacctga acagaaactt ccctgatgcc tttgaaaata acagtgtaac caagcagccc
      541 gagaccctgg cggtcatgac gtggctgcaa accgagacat ttgtcctctc tgcgaatctc
      601 catgggggtg ccctggtggc cagttacccc tttgataatg gcgtgcaagc cacggggaca
      661 ctgttgtccc gaagcctgac tccagatgac gatgtttttc aacacctggc gtacacctat
      721 gcctcacgga atcccaacat gacaaaaggg gatcagtgta aaaacaagag gagcttcccc
      781 aacgggatca tcaacgggta ctcctggtat ccactgcaag ggggaatgca agattacaac
      841 tacatctggg cccagtgctt tgaaatcacc ctggagctgt cctgctgtaa ataccctcgg
      901 gaggagaagc taccgttctt ttggaatgat aacaaagcct ctttgatcga gtacataaaa
      961 caggtgcacc taggtgtaaa gggtcaagtg tttgatcaga gtggaaatcc attgccgaat
     1021 gtaattgtgg aagcccaaga cagaaaacat atctgcccgt tcagaaccaa caagcttgga
     1081 gagtattacc tgcttctctt gcctgggtcc tacgtgataa atgttacagt ccctggacat
     1141 gactcacacc tcacgaagct tacaattcca tcgaaatccc agcccttcag tgctcttaaa
     1201 aaggattttc acctcccgtt gcgatggcag ccagattccg tctccgtatc aaatccttcg
     1261 tgcccaatga ttcctctgta caaattaaag ccaagccact ctgctgcaac aaagcctagt
     1321 ttgtttgtat ttttcgtgac tcttttgcac atatttttca aataaagcaa aatgtgaaac
     1381 tcaacccccg tgaccccgtg gaatcgggga tcggttaccc caggttatgg caactctccc
     1441 tcttgtgcga ctacagtagg atggactcca ctgttctcct taagaagaaa gccggatgtc
     1501 tccaaacctg gcctagagca acctgtaact acaaaatcat tcttcagtct ggataaaatg
     1561 gagtcactgc ctagcaaatg ctgcccatgg aaactccatc ccaaaggagt cccaaacact
     1621 gtaagaaagt tcagaagccg aacagacaca tccctataag aaaaacaatt tgtgtacgga
     1681 gagccacgtg gatcaaaacc agacactttc tgattgcctg ctgcggacga cccttcctga
     1741 gggttatctg tagagagctg atactgcaca taagtggttc tccccaaagg aaggaatttc
     1801 tagatagcag aactaagaac atttactctt gccaacgttc taaggacgaa tgacagaaag
     1861 tgggcaaacg tgtctgatgt ggctgcagag cccaacagat gacgtggcct ctgtctcctg
     1921 tgccattgtc cttgcctccc tgcatctgat gccacggtcc tatgaagatg gcccctcctg
     1981 tgtaacccta gtctcttgcc tgagcctcag aggcagctgc tcgccagaca cgcccacctc
     2041 aatacaacac ataggaacat ggactcaccc tgttgacagt tgagaggctg ttcgcttccc
     2101 atattcagtc actgaaagct gctctactga tccttgccaa cctctccagg ccagttagca
     2161 ccccctcact gctgacccag ctgctactca cgggtacctt tgccaagtcc atcatccacc
     2221 agcatctggg gagttggact gcccaaagcc ctcccgctcc ctaaacacaa cacagtgctc
     2281 gaaattccag gtctggatgc cattctgatt gtgccacttc ctgctcaata aaactccatt
     2341 ccatgagggt taagagcact gactgctctt ccagaggtcc tgagttcaaa tcccagtcac
     2401 cacatagaag ctcacaacca tctgtaatgg gatccgaggc cctctcctgc tgtgtgtgaa
     2461 gacagcaaca atgtattcat acttagaata aattgttaaa gagaagattc cagtaccgac
     2521 ttcaaccgga agcccatgga gttccaggcg gtcgagttca aagaagctgg tcctaaccag
     2581 tgagtttaca gcactgcggt gtggaactac tccatgctga ccttctctag tacgccatga
     2641 gctctttcac accaaccagg atctacttga gaaactacaa accttccaga actccatata
     2701 agttttatgt ttggcaacat tcggctacac acacacacac acacacacac acacacacac
     2761 acacacacac acacttttca tgttgcatca aaaaaacagt ccaaagacaa ctgcgagtga
     2821 gctcactaca aggctggtgg gaaaggcata gctggctgtt aaccagcacc cgcactgcct
     2881 tccagaccag ataatcaatt ccgagtagaa gtgtcccccg tgaaagtaac ttttttctag
     2941 cacagcctaa gaagagaaag ctgggcatgg tggcccacac ctttaatccc aacactcagg
     3001 aggcagaggc aggggcatgt cttagcgcta ggccagctgg gctacacagc cagaccctat
     3061 ctcaaagggt aaatgtcaaa caggaaaatc tgctgcaact ccgaggtgca ggtttctgag
     3121 tgccgtgcat tttccacagg aagtgaggac acacagtgtt cagcaggcaa tgaaggcttg
     3181 agactctaaa gggatatatg ggcatcctgg tgccctttct tggtgccaaa cctagtctat
     3241 caatcgtatg catagctttt taaccacttc taaattggga aatagcctga atatcttgat
     3301 cattttattt aaacaagcat taacttatat taatagttca ggaggggatc tgagtatgtt
     3361 acatttgaag tatataagac taagccaggt gtggtggctg atcacctgtt atcccagctc
     3421 ttgggaggcc gaggcaagat tgacccagtt caaggctggc ctggactaca agtgaggccc
     3481 atcttagaaa aacaaaaaca ataaaatatg taggagagaa cttggtttgc catcagctgg
     3541 gtattctgag ttctgactga ccctttccta agattgcgtg aaaggaaacg agctgtttgc
     3601 tgaattggct cttgggccta acaggagact tgtcactgga agaacttacg tgtgcacatg
     3661 tcttacggga gactggccca gggctttgca caaggccatt gaaccagagt ctttactttg
     3721 ttacttcgtt actttttgtt cagacacagc acctcactaa attgtgtagg ctgggcttga
     3781 aactcactgt aatcttaact ggctttggat ctacctgcct tagccacccg agtagctact
     3841 ataggcttgg gccactgtgt ccatcttaag gtaacattac ttaaattaga aatctgtatc
     3901 aaggggctgg agaaatggtt gggcagttaa gagcagtgag ggctcttcca gaggacctga
     3961 gttcaattcc cagcaaccac atggtggctc acaaccatct gtaatgggat ctgatgccct
     4021 cttctggtgt gtctgaagac agctagtgta ctcatataca taaaataaat aaatttttaa
     4081 aaaatcaaat ctgtatcaaa acccagtgta aaatcactta aacagggtga gggggtatga
     4141 ctcagtgaca gtactcagca tatacaaagg cttgggttca atctccatta actactcccg
     4201 gtcacaagac aaaacatgac caggaaatta ttctatggcc cggatcctca agacttctgt
     4261 tgccctctgc caggtagaga aagcacagga gtacttgggt tggtaactat tttgaaggcg
     4321 gtaggtatac ctaattaaag gagacctgaa aatggagatg ccagtgacca agaatcactt
     4381 tctttccaag gaaatgttca caaagtgcct agtttacatg tttgccactt ttgaactgag
     4441 atggtaaaat cccagcactc gggaggcaga ggcatgtgga tctctgtgag ttcaagggca
     4501 gtctttccta cagagttcca ggatagccag ggcaatgcag aaaaatccta tcttgtaaag
     4561 aatccaggtt tcggggctgg ggatttagct cagcggtaga gcgcttacct aggaagcgca
     4621 aggccctggg ttcggtcccc agctccgaaa aaaagaacca caaaaaaaaa aaaaaaaaaa
     4681 aaaaaaaaaa aaaaaaaaag aatccaggtt tctcaaactt gaactctgcc tgcattaaaa
     4741 cggtgcacac cagctctgct ctccagggta tgagctgctg ctgtcacgag acgtatctgt
     4801 ttctaggaaa agtatacaca gcatgcctgt tctcccactg caacaggagt ttgatctcat
     4861 tctgaggggc acctagagat gtttgtgagc tcagttctgc cttcctggtg acctcaggta
     4921 agggagcgtg atgctggatc aggtgaagaa catcgtgttc ttgatgccta tgacagattc
     4981 tacaccgagt ttgttctaga cttacaccac taatacgcag acactggact gtgtctcaca
     5041 gaccatttaa tcatagttta gctcacaagc caacccatag ctctttgcaa gaggcttcat
     5101 gctggttttt gttttacaag ccctctaagc gattcttgta ttaaaagcac aggagcaata
     5161 gctattaaag atgctcagat cgagtggggg cagcgttgac ccacgccttt catcccagca
     5221 ctccagaggc aaaggcagac agatctcttg agttcaagac caccctggtc tacagagtga
     5281 gttccaagat agccagggct acacagagaa accttgtctc agaaaaataa atgaataaat
     5341 tctcagatta tctaagattt aacatttgct tgggaggggc catgactacc tctgagctcg
     5401 ttttatttta cattatctga ttatcaataa agaatattca tagagtgaat
//
