LOCUS       NM_053878                901 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus complexin 2 (Cplx2), mRNA.
ACCESSION   NM_053878
VERSION     NM_053878.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 901)
  AUTHORS   Mingardi,J., Paoli,C., La Via,L., Carini,G., Misztak,P., Cifani,C.,
            Popoli,M., Barbon,A. and Musazzi,L.
  TITLE     Involvement of miR-135a-5p Downregulation in Acute and Chronic
            Stress Response in the Prefrontal Cortex of Rats
  JOURNAL   Int J Mol Sci 24 (2), 1552 (2023)
   PUBMED   36675068
  REMARK    GeneRIF: Involvement of miR-135a-5p Downregulation in Acute and
            Chronic Stress Response in the Prefrontal Cortex of Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 901)
  AUTHORS   Pavarotti,M.A., Tokarz,V., Frendo-Cumbo,S., Bilan,P.J., Liu,Z.,
            Zanni-Ruiz,E., Mayorga,L.S. and Klip,A.
  TITLE     Complexin-2 redistributes to the membrane of muscle cells in
            response to insulin and contributes to GLUT4 translocation
  JOURNAL   Biochem J 478 (2), 407-422 (2021)
   PUBMED   33393983
  REMARK    GeneRIF: Complexin-2 redistributes to the membrane of muscle cells
            in response to insulin and contributes to GLUT4 translocation.
REFERENCE   3  (bases 1 to 901)
  AUTHORS   Chang,S., Reim,K., Pedersen,M., Neher,E., Brose,N. and
            Taschenberger,H.
  TITLE     Complexin stabilizes newly primed synaptic vesicles and prevents
            their premature fusion at the mouse calyx of held synapse
  JOURNAL   J Neurosci 35 (21), 8272-8290 (2015)
   PUBMED   26019341
REFERENCE   4  (bases 1 to 901)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   5  (bases 1 to 901)
  AUTHORS   Hazell,A.S. and Wang,D.
  TITLE     Identification of complexin II in astrocytes: a possible regulator
            of glutamate release in these cells
  JOURNAL   Biochem Biophys Res Commun 404 (1), 228-232 (2011)
   PUBMED   21110949
  REMARK    GeneRIF: These findings point to Cpx II being a likely key
            modulator of synaptic activity at the level of astrocytes.
REFERENCE   6  (bases 1 to 901)
  AUTHORS   Ishizuka,T., Saisu,H., Odani,S., Kumanishi,T. and Abe,T.
  TITLE     Distinct regional distribution in the brain of messenger RNAs for
            the two isoforms of synaphin associated with the docking/fusion
            complex
  JOURNAL   Neuroscience 88 (1), 295-306 (1999)
   PUBMED   10051208
REFERENCE   7  (bases 1 to 901)
  AUTHORS   Yamada,M., Saisu,H., Ishizuka,T., Takahashi,H. and Abe,T.
  TITLE     Immunohistochemical distribution of the two isoforms of
            synaphin/complexin involved in neurotransmitter release:
            localization at the distinct central nervous system regions and
            synaptic types
  JOURNAL   Neuroscience 93 (1), 7-18 (1999)
   PUBMED   10430466
REFERENCE   8  (bases 1 to 901)
  AUTHORS   Ono,S., Baux,G., Sekiguchi,M., Fossier,P., Morel,N.F.,
            Nihonmatsu,I., Hirata,K., Awaji,T., Takahashi,S. and Takahashi,M.
  TITLE     Regulatory roles of complexins in neurotransmitter release from
            mature presynaptic nerve terminals
  JOURNAL   Eur J Neurosci 10 (6), 2143-2152 (1998)
   PUBMED   9753100
REFERENCE   9  (bases 1 to 901)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   10 (bases 1 to 901)
  AUTHORS   Ishizuka,T., Saisu,H., Odani,S. and Abe,T.
  TITLE     Synaphin: a protein associated with the docking/fusion complex in
            presynaptic terminals
  JOURNAL   Biochem Biophys Res Commun 213 (3), 1107-1114 (1995)
   PUBMED   7654227
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000284.1.
            
            [WARNING] On Mar 29, 2024 this sequence was replaced by
            NM_053878.3.
            
            On Nov 26, 2020 this sequence version replaced NM_053878.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D70816.1, FQ097495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132293, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JACYVU010000284.1  10231467-10231666   c
            201-319             JACYVU010000284.1  10224587-10224705   c
            320-495             JACYVU010000284.1  10224308-10224483   c
            496-901             JACYVU010000284.1  10223357-10223762   c
FEATURES             Location/Qualifiers
     source          1..901
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..901
                     /gene="Cplx2"
                     /note="complexin 2"
                     /db_xref="GeneID:116657"
                     /db_xref="RGD:70945"
     exon            1..200
                     /gene="Cplx2"
                     /inference="alignment:Splign:2.1.0"
     exon            201..319
                     /gene="Cplx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..693
                     /gene="Cplx2"
                     /note="CPX II; synaphin-1; complexin II"
                     /codon_start=1
                     /product="complexin-2"
                     /protein_id="NP_446330.1"
                     /db_xref="GeneID:116657"
                     /db_xref="RGD:70945"
                     /translation="MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQ
                     EEERKAKHARMEAEREKVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIP
                     AGCGDEEEEEEESILDTVLKYLPGPLQDMFKK"
     exon            320..495
                     /gene="Cplx2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..901
                     /gene="Cplx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtacggc gtcagggcct ggctgagggg cgtgattgga gggcgccttc ggcatccgcc
       61 cgcccgcggc agcagcctcg gtcccagctc gcctggcgga gttacaccag gcagcggcgc
      121 gagctggctg agcacaccgc actgcctgct ggagtcagcc ggagccctgc agtggcttag
      181 acggttgctg ggaccaccag gcgagctcat tccccgaagg cagaccagcc aggagtgctg
      241 aatgcgaatt cagtcacggg ctagggagca ctaaccaaag cctgtaggat ggacttcgtc
      301 atgaagcaag ccctcggagg ggccaccaag gacatgggga agatgctggg gggagaggag
      361 gagaaggacc cagatgcaca gaagaaggag gaggagcggc aggaggccct gaggcagcag
      421 gaggaagagc gcaaggccaa acatgcccgc atggaagcgg aacgtgagaa ggtccggcag
      481 cagattcgag ataagtatgg gctgaagaag aaagaagaga aggaggcaga ggagaaggca
      541 gccctggaac agccctgcga gggaagcctg accagaccca agaaggccat ccctgcaggc
      601 tgtggggacg aggaggagga agaagaggag agcatcctgg acacggtgct caaatatctg
      661 ccggggccac tgcaggacat gttcaagaag taacctgtcc tcttccggcc ccgtccacgt
      721 tatgactttt tttttttttt ttttttggtg ttcctagttt ttcttttctt tttttattca
      781 gttaagtctc agttccaaag gggaaaacct cagtcggcct ctgccccctt tccctcagca
      841 acccttcaca agcccttcat ccagggtttc tagttctgtt tcactcccaa gtagcttgga
      901 g
//
