LOCUS       NM_001106992            2830 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cytoplasmic polyadenylation element binding
            protein 4 (Cpeb4), mRNA.
ACCESSION   NM_001106992 XM_001064017 XM_220269
VERSION     NM_001106992.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2830)
  AUTHORS   Calderone,V., Gallego,J., Fernandez-Miranda,G., Garcia-Pras,E.,
            Maillo,C., Berzigotti,A., Mejias,M., Bava,F.A., Angulo-Urarte,A.,
            Graupera,M., Navarro,P., Bosch,J., Fernandez,M. and Mendez,R.
  TITLE     Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic
            Expression of Vascular Endothelial Growth Factor and Angiogenesis
            in Chronic Liver Disease
  JOURNAL   Gastroenterology 150 (4), 982-97 (2016)
   PUBMED   26627607
  REMARK    GeneRIF: Identify a mechanism of VEGF overexpression in liver and
            mesentery that promotes pathologic, but not physiologic,
            angiogenesis, via sequential and nonredundant functions of CPEB1
            and CPEB4.
REFERENCE   2  (bases 1 to 2830)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2830)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2830)
  AUTHORS   Kan,M.C., Oruganty-Das,A., Cooper-Morgan,A., Jin,G., Swanger,S.A.,
            Bassell,G.J., Florman,H., van Leyen,K. and Richter,J.D.
  TITLE     CPEB4 is a cell survival protein retained in the nucleus upon
            ischemia or endoplasmic reticulum calcium depletion
  JOURNAL   Mol Cell Biol 30 (24), 5658-5671 (2010)
   PUBMED   20937770
  REMARK    GeneRIF: Data show that treatment of neurons with ionotropic
            glutamate receptor agonists causes CPEB4 to accumulate in the
            nucleus.
REFERENCE   5  (bases 1 to 2830)
  AUTHORS   Peng,S.C., Lai,Y.T., Huang,H.Y., Huang,H.D. and Huang,Y.S.
  TITLE     A novel role of CPEB3 in regulating EGFR gene transcription via
            association with Stat5b in neurons
  JOURNAL   Nucleic Acids Res 38 (21), 7446-7457 (2010)
   PUBMED   20639532
REFERENCE   6  (bases 1 to 2830)
  AUTHORS   Huang,Y.S., Kan,M.C., Lin,C.L. and Richter,J.D.
  TITLE     CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and
            translational control of AMPA receptor GluR2 mRNA
  JOURNAL   EMBO J 25 (20), 4865-4876 (2006)
   PUBMED   17024188
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001064017.1, XM_220269.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2830
                     /gene="Cpeb4"
                     /note="cytoplasmic polyadenylation element binding protein
                     4"
                     /db_xref="GeneID:303010"
                     /db_xref="RGD:1311931"
     CDS             1..2166
                     /gene="Cpeb4"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 4"
                     /protein_id="NP_001100462.1"
                     /db_xref="GeneID:303010"
                     /db_xref="RGD:1311931"
                     /translation="MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPNPAAF
                     INNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQ
                     EAGILPETEKAKAEENPGDNSSENSNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTS
                     SASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPGASANNGALLFQNFPHHVSPGF
                     GGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLAN
                     NLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGASQGRDHRRGLNGGITPLNSISPL
                     KKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLID
                     IMRAENDSIKGRLNYSYPGSDSSLLINGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHC
                     FTHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKG
                     YAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQ
                     PLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQ
                     QSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCL
                     QYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN"
     exon            1..1125
                     /gene="Cpeb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1207
                     /gene="Cpeb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1258
                     /gene="Cpeb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1432
                     /gene="Cpeb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1522
                     /gene="Cpeb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1641
                     /gene="Cpeb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1756
                     /gene="Cpeb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1938
                     /gene="Cpeb4"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2830
                     /gene="Cpeb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggggatt acgggtttgg agtgctagtg caaagcaata ctgggaataa atctgctttt
       61 ccagtccgat tccatccaca tctgcagcct ccacaccatc accaaaatgc cacccccaac
      121 cctgctgctt ttataaataa taacacagct gccaacggca gcagtgctgg gtcagcttgg
      181 ctctttcctg ctccggctac ccataacatt caggatgaga tcttggggtc agaaaaagca
      241 aaaagtcaac agcaggaaca acaagaccct ttagaaaagc aacaactgtc cccgagtcca
      301 gggcaggaag ctggaatact gcctgaaact gaaaaggcaa aagccgaaga aaatccaggg
      361 gacaattctt cagagaacag caacggaaaa gaaaagatac gcattgaatc accagtgttg
      421 acaggattcg attaccaaga agccacaggc ctcgggactt ccacccaacc cttgacatcc
      481 agtgcatcat cccttactgg tttcagtaac tggtcagcag cgatagcgcc ttcttcctcc
      541 acgataatca atgaagatgc aagtttcttt caccagggag gggtccctgg cgcttcagct
      601 aataatggtg ctctcttgtt tcaaaatttc ccccatcatg tcagccctgg ctttggtggt
      661 agcttctccc ctcagatcgg gcctctctcc cagcaccatc ctcatcaccc ccatttccag
      721 caccatcaca gccagcatca gcagcagagg aggtctcctg ccagtcccca ccccccacct
      781 ttcacacata gaaatgctgc ttttaaccag ctgcctcatt tggcgaataa tcttaacaaa
      841 cctccttctc catggagtag ctaccagagt ccctctccaa ccccctcttc ttcctggagc
      901 ccgggaggtg gcggctatgg tggctgggga gcttctcaag gccgagatca ccgcagaggg
      961 ctgaacggtg gaataacacc cctgaactcc atctcacctt tgaagaaaaa ttttgcaagc
     1021 aatcatattc agctccagaa gtatgctcgc cctagctcag cctttgctcc aaaatcctgg
     1081 atggaagata gcttgaacag agctgacaac atttttcctt ttccggatcg ccccaggaca
     1141 tttgacatgc actcattgga gagctcactc attgacataa tgagagctga aaatgattcc
     1201 attaaaggtc gtctaaacta ttcataccca ggatccgata gttctctgct tattaatggt
     1261 cagtcttcat tgttcccgat ggaggatggg ttcctggatg atggccgtgg ggaccagcct
     1321 cttcacagtg gtctgggctc gcctcactgc ttcactcacc aaaacgggga gagagtggaa
     1381 cggtattccc gcaaggtgtt cgtgggtgga ttgcctcctg acattgacga agatgagatc
     1441 acggctagtt tccgtcgctt tggccctttg attgtggatt ggcctcataa agcagagagc
     1501 aaatcttatt tcccaccaaa aggctatgcc ttcctgctgt ttcaagatga aagttctgtc
     1561 caggctctca ttgatgcgtg cattgaagaa gatggaaaac tgtacctgtg tgtgtcaagt
     1621 ccaaccatca aggataaacc agtgcagatc cggccctgga atctcagtga cagtgacttt
     1681 gtgatggatg gctcacagcc acttgaccca cggaaaacga tatttgttgg tggtgttcct
     1741 cgaccattac gagctgtgga gcttgcaatg ataatggacc ggctgtatgg aggcgtctgc
     1801 tatgctggaa tcgatactga cccagagctc aaatacccaa aaggagctgg acgagtagcg
     1861 ttttctaatc aacagagtta catagctgct atcagtgctc gctttgttca gctgcagcat
     1921 ggagagatag ataaacgggt ggaggttaag ccatatgtct tggacgacca gctgtgtgat
     1981 gaatgtcagg gggcccgttg cggggggaaa tttgctccat ttttctgtgc taatgttacc
     2041 tgtctgcagt attactgtga atattgctgg gctgctattc actctcgtgc tggcagagaa
     2101 ttccacaagc ccctggtgaa ggaaggtggc gaccgccctc ggcatatctc attccgctgg
     2161 aactgaagag cgaacgactc cagggctcct ttgcaggcct cagaagaagt gcgtgccctc
     2221 ttctgttaat tccgactctt cctcagcctc ttcacgctgg catggcctgt gcagcagtgt
     2281 gtaactaaca gccgtagaat gaaaagaaca acctacaaca taggtctttt gtagactctc
     2341 gtgtcactgc aaacagtatg ttccaactcc attttcacat tgccattatg ttgcatgcaa
     2401 gtttgaattc tcttgttttg ctggaggcca agaggatcca aacttgctgt agcattttct
     2461 tagaggagag aaatattaac agagaaatga gacaatattt ttggggtttt aattgctggt
     2521 aatgatataa gaaaacttta ctgcgataac caccaacagt aacactattg tctgttctga
     2581 cacagtctcc ccagggaagg gctcttgttt cttttctttc attccttctc tctttctctc
     2641 tcttctgtcc ctttctattc tgtaacagca gtggaggaag ttagcagtta ttaacaggaa
     2701 agagtatgtc agagcgagcg aatgcatgag taagactgag cagcgtaacc gtcagagctt
     2761 tgaggccgag tatagcttga ccatgcctca aatgccttca tacatcagaa aaaataaagt
     2821 aggccagctg
//
