LOCUS       NM_001106276            2615 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cytoplasmic polyadenylation element binding
            protein 1 (Cpeb1), mRNA.
ACCESSION   NM_001106276 XM_001061933 XM_218858
VERSION     NM_001106276.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2615)
  AUTHORS   Xuan,F., Ren,Y., Lu,J., Zhou,W., Jin,R., Chen,A. and Ye,Y.
  TITLE     CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa
            cells of polycystic ovary syndrome
  JOURNAL   Mol Reprod Dev 91 (4), e23741 (2024)
   PUBMED   38616716
  REMARK    GeneRIF: CPEB1 induces autophagy and promotes apoptosis in ovarian
            granulosa cells of polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 2615)
  AUTHORS   Takahashi,K., Yi,H., Gu,J., Ikegami,D., Liu,S., Iida,T.,
            Kashiwagi,Y., Dong,C., Kunisawa,T. and Hao,S.
  TITLE     The mitochondrial calcium uniporter contributes to morphine
            tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn
  JOURNAL   Br J Anaesth 123 (2), e226-e238 (2019)
   PUBMED   31253357
  REMARK    GeneRIF: Cytoplasmic polyadenylation element-binding proteins
            (CPEB) are mRNA-binding proteins associated with protein
            translation that play an important role in development, health, and
            disease.
REFERENCE   3  (bases 1 to 2615)
  AUTHORS   Shin,J., Paek,K.Y., Ivshina,M., Stackpole,E.E. and Richter,J.D.
  TITLE     Essential role for non-canonical poly(A) polymerase GLD4 in
            cytoplasmic polyadenylation and carbohydrate metabolism
  JOURNAL   Nucleic Acids Res 45 (11), 6793-6804 (2017)
   PUBMED   28383716
REFERENCE   4  (bases 1 to 2615)
  AUTHORS   Calderone,V., Gallego,J., Fernandez-Miranda,G., Garcia-Pras,E.,
            Maillo,C., Berzigotti,A., Mejias,M., Bava,F.A., Angulo-Urarte,A.,
            Graupera,M., Navarro,P., Bosch,J., Fernandez,M. and Mendez,R.
  TITLE     Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic
            Expression of Vascular Endothelial Growth Factor and Angiogenesis
            in Chronic Liver Disease
  JOURNAL   Gastroenterology 150 (4), 982-97 (2016)
   PUBMED   26627607
  REMARK    GeneRIF: Identify a mechanism of VEGF overexpression in liver and
            mesentery that promotes pathologic, but not physiologic,
            angiogenesis, via sequential and nonredundant functions of CPEB1
            and CPEB4.
REFERENCE   5  (bases 1 to 2615)
  AUTHORS   Kim,K.C., Kim,J.W., Choi,C.S., Han,S.Y., Cheong,J.H., Han,S.H.,
            Yang,S.I., Bahn,G.H. and Shin,C.Y.
  TITLE     A role of CPEB1 in the modulation of proliferation and neuronal
            maturation of rat primary neural progenitor cells
  JOURNAL   Neurochem Res 38 (9), 1960-1972 (2013)
   PUBMED   23824559
  REMARK    GeneRIF: Increased NPCs proliferation by down-regulation of CPEB1
            resulted in eventual up-regulation of neuronal differentiation with
            increase in both pre- and post-synaptic proteins
REFERENCE   6  (bases 1 to 2615)
  AUTHORS   Alarcon,J.M., Hodgman,R., Theis,M., Huang,Y.S., Kandel,E.R. and
            Richter,J.D.
  TITLE     Selective modulation of some forms of schaffer collateral-CA1
            synaptic plasticity in mice with a disruption of the CPEB-1 gene
  JOURNAL   Learn Mem 11 (3), 318-327 (2004)
   PUBMED   15169862
REFERENCE   7  (bases 1 to 2615)
  AUTHORS   Tay,J., Hodgman,R., Sarkissian,M. and Richter,J.D.
  TITLE     Regulated CPEB phosphorylation during meiotic progression suggests
            a mechanism for temporal control of maternal mRNA translation
  JOURNAL   Genes Dev 17 (12), 1457-1462 (2003)
   PUBMED   12815066
REFERENCE   8  (bases 1 to 2615)
  AUTHORS   Huang,Y.S., Carson,J.H., Barbarese,E. and Richter,J.D.
  TITLE     Facilitation of dendritic mRNA transport by CPEB
  JOURNAL   Genes Dev 17 (5), 638-653 (2003)
   PUBMED   12629046
REFERENCE   9  (bases 1 to 2615)
  AUTHORS   Tay,J. and Richter,J.D.
  TITLE     Germ cell differentiation and synaptonemal complex formation are
            disrupted in CPEB knockout mice
  JOURNAL   Dev Cell 1 (2), 201-213 (2001)
   PUBMED   11702780
REFERENCE   10 (bases 1 to 2615)
  AUTHORS   Wu,L., Wells,D., Tay,J., Mendis,D., Abbott,M.A., Barnitt,A.,
            Quinlan,E., Heynen,A., Fallon,J.R. and Richter,J.D.
  TITLE     CPEB-mediated cytoplasmic polyadenylation and the regulation of
            experience-dependent translation of alpha-CaMKII mRNA at synapses
  JOURNAL   Neuron 21 (5), 1129-1139 (1998)
   PUBMED   9856468
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218858.4, XM_001061933.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2615
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2615
                     /gene="Cpeb1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
     exon            1..44
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1715
                     /gene="Cpeb1"
                     /note="CPEB; CPEB-1; CPE-BP1; CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1"
                     /protein_id="NP_001099746.1"
                     /db_xref="GeneID:293056"
                     /db_xref="RGD:1310421"
                     /translation="MAFSLEEESGRIKDCWDNQEVPALSTCSNANIFRRINAILDDSL
                     DFSKVCTTPINRGIHDQLPDFQDSEEAITSRMLFPTSAQESPRGLPDANGLCLGLQSL
                     SLTGWDRPWSTQDSDSSAQSNTQSVLSMLQNPLGNVLGKTPLSFLSLDPLGSDLDKFP
                     APSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSMTGN
                     GPRDPLKMGVGSRMDQEQAALAAVAPSPTSAPKRWPGTSVWPSWDLLGAPKDPFSIER
                     EARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFG
                     SLSVEWPGKDGKHPRCPPKGNMPKGYVYLVFELEKSVRALLQACSHDPLSPDGLSEYY
                     FKMSSRRMRCKEVQVIPWVLADSNFVWSPSQRLDPSRTVFVGALHGMLNAEALAAILN
                     DLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVTAAFVEIKTTKFTKKVQIDPY
                     LEDSLCLICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGLRHHSPLMRNQKN"
     exon            45..219
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..408
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..632
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..885
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..999
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1104
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1241
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1440
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1535
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1616
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..2615
                     /gene="Cpeb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagtccct tagggccacg ccggacccca tggctttttc tctggaagaa gaatcaggaa
       61 ggataaagga ctgctgggac aaccaagagg ttcctgcact ctctacatgt agcaatgcca
      121 atatctttcg aaggataaat gccattttgg atgattcact ggacttcagt aaagtctgca
      181 caacacctat aaatcgagga attcatgatc agttgccaga cttccaggac tctgaagaag
      241 caattacaag caggatgctt ttccccacct ctgcgcaaga atctccccgc ggcctcccag
      301 atgcaaacgg tttgtgcctt ggcctgcagt cactcagtct gactggctgg gaccgaccct
      361 ggagcaccca ggactcagac tcctcagccc agagcaacac acagtcagta ttaagcatgc
      421 tccaaaatcc actgggaaat gtcttaggaa aaaccccctt gagcttcctg tctctggatc
      481 cccttgggtc tgacttggac aagttcccag cgccctcagt tagaggatct cgcctggaca
      541 cccggcctat cctggactcc cgttctagca gcccctctga ctcagacacg agtggcttca
      601 gctctggatc agatcatctc tcagatttga tttcaagcct tcgcatttcc cctcctctgc
      661 cctttctttc tatgacggga aatggtccca gagaccctct aaagatggga gttgggtctc
      721 gaatggacca agagcaagct gctcttgctg cagttgctcc ctctccaacc agtgctccaa
      781 agagatggcc aggaacttct gtgtggccat cttgggacct tctcggagct cctaaagacc
      841 cattcagcat agagagagag gctagactcc acaggcaggc cgcagctgtg aatgaagcta
      901 catgtacctg gagtggccag cttcctcccc ggaactacaa gaaccccatc tactcatgca
      961 aggtgttcct aggaggtgtt ccttgggaca ttacagaagc tggattggtt aacaccttcc
     1021 gtgtttttgg ctctctgagt gtggagtggc ctggtaagga tggcaagcac ccccggtgtc
     1081 ctcccaaagg taatatgcct aaagggtatg tgtatttggt gtttgaacta gagaagtccg
     1141 tccgggcctt gcttcaggct tgttctcatg acccactgag cccagatggc ctaagtgaat
     1201 attatttcaa gatgtccagc cgaaggatgc gctgcaaaga agtacaggta atcccttggg
     1261 tcttggctga cagcaacttt gtctggagcc catctcagag gctggatccc agcaggacgg
     1321 tgtttgttgg tgccttgcac gggatgctca atgctgaggc tctggctgcc atcttgaatg
     1381 acctatttgg tggagtggtg tatgctggga ttgacacaga taagcacaag taccccattg
     1441 ggtctggtcg tgtgactttc aataaccaac gtagttacct gaaagcagtc actgctgctt
     1501 ttgtggagat caaaaccacc aagtttacca agaaggttca gatcgacccc tatctagaag
     1561 attctctgtg tcttatctgc agttcacaac ctggtccttt cttctgccga gatcaggtct
     1621 gcttcaagta cttttgccga agctgctggc actggcgaca cagcatggaa ggcctacgcc
     1681 accacagccc gctaatgagg aaccagaaga actaaaattc cagctagaga agctggcctg
     1741 gcccagggcc tgtggcgcca aaggctggca agtcaggcag cagcctgttc cctgcacggg
     1801 cgcctaggag ctagctttct gcagacaagg gagaattgta ctcacctttg tacttgctga
     1861 gtctgtcttt gtttctgcac taattaatgc acaatgagtt ttgtcaggtt ttgtcttcag
     1921 cggggtgtgc cagagcaggg gcctcaggct caccctcaag caattgtagt tttcccagat
     1981 tctagttcct cattttgcaa atgaaaacaa caaaaaaaac tgtgtctaga acgcgttgac
     2041 acagatgcct acacttgggt ttatttatta aagcgcttct tacattcctt gcaatactga
     2101 tggtggtgat gcgcaggtct cattggtcca ttcttgcagt tgccatacag tgcctttcca
     2161 tttatttaac ccccacctga acggcataaa ttgagtgttc agctggtgtt ttttactgta
     2221 acaaacaaag gagactttgc tcttcattta aaccaaatca tatttcatag tttacgctcg
     2281 agggttttta ctggttcctt tttacactcc ttaaaacagt ttttaagtcg tttggaacaa
     2341 tagatttttt tttctttttt ggcagctttt aacattatag caaatttgtg tctgggggac
     2401 tgctggtcac agttgcaaat caaagcattt gtaaccaaga gaaaaattat tttatttaaa
     2461 actggatggg aggaaaaatt aggtctgagc agctgctgta tatagtttta aatggtttgt
     2521 cgcaccttat gttgcactta cgttggggga gggttgatag aagtttttaa tcacagtcac
     2581 aggacttttt cttttgtaac tgagcttaaa aatta
//
