LOCUS       NM_013128               2089 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus carboxypeptidase E (Cpe), mRNA.
ACCESSION   NM_013128 XM_224778
VERSION     NM_013128.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2089)
  AUTHORS   Bosch,E., Hebebrand,M., Popp,B., Penger,T., Behring,B., Cox,H.,
            Towner,S., Kraus,C., Wilson,W.G., Khan,S., Krumbiegel,M.,
            Ekici,A.B., Uebe,S., Trollmann,R., Woelfle,J., Reis,A. and
            Vasileiou,G.
  TITLE     BDV Syndrome: An Emerging Syndrome With Profound Obesity and
            Neurodevelopmental Delay Resembling Prader-Willi Syndrome
  JOURNAL   J Clin Endocrinol Metab 106 (12), 3413-3427 (2021)
   PUBMED   34383079
REFERENCE   2  (bases 1 to 2089)
  AUTHORS   Li,N., Teng,S.W., Zhao,L., Li,J.R., Xu,J.L., Li,N., Shuai,J.C. and
            Chen,Z.Y.
  TITLE     Carboxypeptidase E Regulates Activity-Dependent TrkB Neuronal
            Surface Insertion and Hippocampal Memory
  JOURNAL   J Neurosci 41 (33), 6987-7002 (2021)
   PUBMED   34266900
  REMARK    GeneRIF: Carboxypeptidase E Regulates Activity-Dependent TrkB
            Neuronal Surface Insertion and Hippocampal Memory.
REFERENCE   3  (bases 1 to 2089)
  AUTHORS   Liang,C., Carrel,D., Omelchenko,A., Kim,H., Patel,A., Fanget,I. and
            Firestein,B.L.
  TITLE     Cortical Neuron Migration and Dendrite Morphology are Regulated by
            Carboxypeptidase E
  JOURNAL   Cereb Cortex 29 (7), 2890-2903 (2019)
   PUBMED   29982499
REFERENCE   4  (bases 1 to 2089)
  AUTHORS   Rinne,P., Lyytikainen,L.P., Raitoharju,E., Kadiri,J.J., Kholova,I.,
            Kahonen,M., Lehtimaki,T. and Oksala,N.
  TITLE     Pro-opiomelanocortin and its Processing Enzymes Associate with
            Plaque Stability in Human Atherosclerosis - Tampere Vascular Study
  JOURNAL   Sci Rep 8 (1), 15078 (2018)
   PUBMED   30305673
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2089)
  AUTHORS   Chen,G., Zhang,F., Xue,W., Wu,R., Xu,H., Wang,K. and Zhu,J.
  TITLE     An association study revealed substantial effects of dominance,
            epistasis and substance dependence co-morbidity on alcohol
            dependence symptom count
  JOURNAL   Addict Biol 22 (6), 1475-1485 (2017)
   PUBMED   27151647
REFERENCE   6  (bases 1 to 2089)
  AUTHORS   Castano,L., Russo,E., Zhou,L., Lipes,M.A. and Eisenbarth,G.S.
  TITLE     Identification and cloning of a granule autoantigen
            (carboxypeptidase-H) associated with type I diabetes
  JOURNAL   J Clin Endocrinol Metab 73 (6), 1197-1201 (1991)
   PUBMED   1955501
REFERENCE   7  (bases 1 to 2089)
  AUTHORS   Jung,Y.K., Kunczt,C.J., Pearson,R.K., Dixon,J.E. and Fricker,L.D.
  TITLE     Structural characterization of the rat carboxypeptidase-E gene
  JOURNAL   Mol Endocrinol 5 (9), 1257-1268 (1991)
   PUBMED   1770952
REFERENCE   8  (bases 1 to 2089)
  AUTHORS   Manser,E., Fernandez,D., Loo,L., Goh,P.Y., Monfries,C., Hall,C. and
            Lim,L.
  TITLE     Human carboxypeptidase E. Isolation and characterization of the
            cDNA, sequence conservation, expression and processing in vitro
  JOURNAL   Biochem J 267 (2), 517-525 (1990)
   PUBMED   2334405
REFERENCE   9  (bases 1 to 2089)
  AUTHORS   Rodriguez,C., Brayton,K.A., Brownstein,M. and Dixon,J.E.
  TITLE     Rat preprocarboxypeptidase H. Cloning, characterization, and
            sequence of the cDNA and regulation of the mRNA by
            corticotropin-releasing factor
  JOURNAL   J Biol Chem 264 (10), 5988-5995 (1989)
   PUBMED   2784437
REFERENCE   10 (bases 1 to 2089)
  AUTHORS   Fricker,L.D., Adelman,J.P., Douglass,J., Thompson,R.C., von
            Strandmann,R.P. and Hutton,J.
  TITLE     Isolation and sequence analysis of cDNA for rat carboxypeptidase E
            [EC 3.4.17.10], a neuropeptide processing enzyme
  JOURNAL   Mol Endocrinol 3 (4), 666-673 (1989)
   PUBMED   2725530
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013128.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X51406.1, BC085762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               JAXUCZ010000016.1  29796707-29797101
            396-592             JAXUCZ010000016.1  29877433-29877629
            593-760             JAXUCZ010000016.1  29879262-29879429
            761-878             JAXUCZ010000016.1  29886687-29886804
            879-1061            JAXUCZ010000016.1  29888709-29888891
            1062-1201           JAXUCZ010000016.1  29891205-29891344
            1202-1301           JAXUCZ010000016.1  29902995-29903094
            1302-1420           JAXUCZ010000016.1  29905543-29905661
            1421-2089           JAXUCZ010000016.1  29907979-29908647
FEATURES             Location/Qualifiers
     source          1..2089
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p13"
     gene            1..2089
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /note="carboxypeptidase E"
                     /db_xref="GeneID:25669"
                     /db_xref="RGD:2394"
     exon            1..395
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1519
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /EC_number="3.4.17.10"
                     /note="carboxypeptidase H; enkephalin convertase;
                     prohormone-processing carboxypeptidase"
                     /codon_start=1
                     /product="carboxypeptidase E precursor"
                     /protein_id="NP_037260.2"
                     /db_xref="GeneID:25669"
                     /db_xref="RGD:2394"
                     /translation="MAGRGGRVLLALCAALVAGGWLLAAEAQEPGAPAAGMRRRRRLQ
                     QEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEP
                     GEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQRGNETIVNLIHSTRIHIMPSLNPD
                     GFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNLKKI
                     VDQNSKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGTAHEYSSCPDDA
                     IFQSLARAYSSFNPVMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSS
                     NCFEITVELSCEKFPPEETLKSYWEDNKNSLINYLEQIHRGVKGFVRDLQGNPIANAT
                     ISVDGIDHDVTSAKDGDYWRLLAPGNYKLTASAPGYLAITKKVAVPFSPAVGVDFELE
                     SFSERKEEEKEELMEWWKMMSETLNF"
     exon            396..592
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /inference="alignment:Splign:2.1.0"
     exon            593..760
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /inference="alignment:Splign:2.1.0"
     exon            761..878
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1061
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1201
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1301
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1420
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..2089
                     /gene="Cpe"
                     /gene_synonym="CARBE; Cph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacgagagg aggctggtgc tgagctcgcc aactccaccc gggcccgggc agacaaaaga
       61 gaccggcggt acagctcgcg gggacgcgat ggccgggcgc ggaggacggg tgctgctggc
      121 gctgtgtgcc gcgctggtgg ccggcgggtg gctgttagcg gctgaagccc aggagcccgg
      181 ggcgccagcg gctggcatgc ggcggcgccg gcggctgcag caggaggacg gcatctcctt
      241 cgagtaccac cgctatcccg agctgcgcga ggcgctggtg tcggtatggc tgcagtgcac
      301 cgccatcagc aggatctaca cggtggggcg cagcttcgag ggccgggagc tcctggtcat
      361 cgagctgtct gacaaccccg gggtccatga gcccggtgaa cctgagttta aatacattgg
      421 gaacatgcat ggtaatgagg cggttggacg ggagctgctc attttcttgg cccagtacct
      481 gtgtaacgaa taccagagag ggaatgagac aattgtcaac ctgatccaca gcacacgaat
      541 ccatatcatg ccctccttga accccgatgg ctttgagaaa gcagcatctc agcccggtga
      601 gctgaaggac tggttcgtgg gccgcagcaa tgcccaggga atagatctga accggaactt
      661 cccagacttg gataggatcg tgtatgttaa tgagaaagaa ggcggtccca acaaccacct
      721 gctgaagaat ctgaagaaaa ttgtggacca aaattcaaag cttgcccccg agaccaaggc
      781 tgtcattcac tggatcatgg acatcccatt tgtgctctct gccaacctgc acggaggaga
      841 cctcgtggct aattacccgt atgatgagac gcggagtggt actgctcatg aatacagttc
      901 ctgccctgat gacgcaattt tccaaagctt ggctcgcgca tactcttctt tcaacccagt
      961 catgtctgac cccaatcgac ctccctgtcg caagaatgat gatgacagta gctttgtaga
     1021 tggaacaacc aatggtggtg catggtacag cgtccccggt ggaatgcaag acttcaatta
     1081 cctgagcagc aactgctttg agatcactgt ggagcttagc tgtgagaagt tcccacctga
     1141 agagactctc aaaagctact gggaagataa caaaaactcc ctcatcaact acctggagca
     1201 gatacaccga ggtgttaaag ggtttgtccg tgaccttcaa ggtaatccga ttgccaacgc
     1261 aaccatttcc gtggatggga tagaccatga tgtcacctcg gctaaggatg gggattactg
     1321 gcgattgctt gcgcctggaa actataaact tacagcctca gctcccggct acctggcaat
     1381 cacaaagaaa gtggcagttc ctttcagccc tgctgttggg gtggactttg agctggagtc
     1441 tttctctgaa aggaaggagg aggagaagga agaattgatg gagtggtgga aaatgatgtc
     1501 agagactttg aatttttaag aaaggctcct aactaatggc tttaatatat ccatagacta
     1561 tagtaagatg caacgtggct cttttatttt aggttgtgtg cagttaatat ttaacatcgg
     1621 tttatttttg atcatttaag tagtagttgc taatcactta aatacacttg gacagaaccg
     1681 tagtgtctgg atcgacttca ttctttcatg aacattcgct ttaaaatcta ggaagatcct
     1741 ttaacctagt tggtgacaat gtcacatgac agatgccatg aaaaagtcaa ccgatgtagc
     1801 ttggatctgt gagcactgtg tgtatggcga gaatcacata gttccatata agttgtcctt
     1861 agtctcttgt gctgatccac tgtataagca tgatcctgtt aatgtgcttc tgagggaagg
     1921 aaaacgtacg tgctttgcaa aggggctctg agcagaagga aaacctagtt cttgcgtgta
     1981 ctttgaagaa cagaactgta ttagtcagcc tgttagtgca acttcagagt ttggggtttt
     2041 gtcttgattg cagattggcc cagaattgca ttctaaatga ataaaggat
//
