LOCUS       NM_001109346            2781 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus carboxypeptidase A4 (Cpa4), mRNA.
ACCESSION   NM_001109346 XM_001065041 XM_578236
VERSION     NM_001109346.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2781)
  AUTHORS   Gao,W., Guo,N., Zhao,S., Chen,Z., Zhang,W., Yan,F., Liao,H. and
            Chi,K.
  TITLE     Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through
            activating PI3K-AKT-mTOR signaling
  JOURNAL   Biosci Rep 40 (5) (2020)
   PUBMED   32347291
  REMARK    GeneRIF: Carboxypeptidase A4 promotes cardiomyocyte hypertrophy
            through activating PI3K-AKT-mTOR signaling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 20, 2012 this sequence version replaced NM_001109346.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.17838.1,
                                           SRR26643294.17580.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000004.1  60155675-60155760
            87-168              JAXUCZ010000004.1  60161224-60161305
            169-303             JAXUCZ010000004.1  60161724-60161858
            304-399             JAXUCZ010000004.1  60163471-60163566
            400-501             JAXUCZ010000004.1  60167053-60167154
            502-609             JAXUCZ010000004.1  60168346-60168453
            610-720             JAXUCZ010000004.1  60169080-60169190
            721-811             JAXUCZ010000004.1  60170517-60170607
            812-1011            JAXUCZ010000004.1  60172286-60172485
            1012-1096           JAXUCZ010000004.1  60173222-60173306
            1097-2781           JAXUCZ010000004.1  60177960-60179644
FEATURES             Location/Qualifiers
     source          1..2781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2781
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /note="carboxypeptidase A4"
                     /db_xref="GeneID:502736"
                     /db_xref="RGD:1563619"
     exon            1..86
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1284
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /EC_number="3.4.17.15"
                     /codon_start=1
                     /product="carboxypeptidase A4 precursor"
                     /protein_id="NP_001102816.1"
                     /db_xref="GeneID:502736"
                     /db_xref="RGD:1563619"
                     /translation="MKWLLFFGALIGTGICGRDKFFGDQVFRINVRNGDEIRKLTELV
                     NSDHFKLNVWKSPSTFDRPVDILVPSVSLLPVKSFLKSQGLDYSVTIDNLQALLDIED
                     EEMQHNEGRERSGDFNYGSYHSPEAIYHEMDSIATDFPDLASRVKIGETFEKRPMYVL
                     KFSTGGGGKKRPAIWLNAGIHAREWISQATAIWTARKIVTDYQKDPAVTSILEKMDIF
                     LLPVANPDGYVYTQNQNRLWRKTRSRNPGSRCIGADPNRNWNASFAGEGASNNPCSEV
                     YHGSHPNSEVEVKSVVDFIQKHGNFKCFIDLHSYSQLLMYPYGYSVKKAPDAEELDDV
                     ARSAAKALASLSGTKYQVGPTCTTVYPASGSSVDWAYDNGIKYAFTFELRDTGHYGFL
                     LPASQIIPTAEETWQGLKVIMEHVRDNLY"
     exon            87..168
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
     exon            169..303
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
     exon            304..399
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
     exon            400..501
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
     exon            502..609
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
     exon            610..720
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
     exon            721..811
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1011
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1096
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..2781
                     /gene="Cpa4"
                     /gene_synonym="RGD1563619"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactggagcc cttgagacat gaagtggtta ctgttctttg gggcccttat cgggacaggc
       61 atctgcggcc gagacaagtt ctttggggac caagttttta ggattaatgt cagaaatgga
      121 gacgagatca ggaaactgac cgagctagtg aattcggacc actttaagct caatgtctgg
      181 aaatctccct ccacttttga tcggcctgtg gatattctcg tcccttctgt cagcttgctg
      241 ccagtcaagt ccttcctgaa gtcccagggt ttagactact cagtgacaat tgacaaccta
      301 caggctctct tagatattga agatgaagaa atgcaacaca atgaagggag agaacggagt
      361 ggtgacttca actacggatc ttaccattcc ccggaggcta tttaccacga gatggacagt
      421 attgccacag acttccctga cctggcaagc cgagtgaaga tcggagagac attcgaaaag
      481 cggcccatgt atgttctcaa gttcagcacg ggaggaggag gcaagaaacg gccagccatt
      541 tggctgaatg caggcatcca tgcccgtgag tggatctcac aggccactgc catctggaca
      601 gcaaggaaga ttgtgactga ttatcagaag gacccagctg tcacctccat tttagagaaa
      661 atggatattt tcttattgcc tgtggccaat cctgacggat atgtgtacac acaaaaccaa
      721 aaccgattgt ggaggaagac acggtcccgg aacccaggaa gccgctgtat tggagctgat
      781 ccaaacagaa actggaatgc tagttttgca ggagaggggg ccagcaataa cccttgctct
      841 gaagtatacc atggctccca ccccaattct gaagtggagg tgaaatcggt ggtggacttt
      901 attcaaaagc atgggaactt caaatgcttc attgacctgc atagctactc acagctgctg
      961 atgtatccct atgggtactc ggtcaagaag gccccagatg ccgaggagct ggacgatgtg
     1021 gcgaggagtg cagccaaagc cctggcttct ctctcgggaa ccaagtacca agtgggaccg
     1081 acttgtacca ccgtctatcc agctagcggg agcagcgttg actgggcata cgacaacggc
     1141 atcaagtatg ctttcacatt tgagctgaga gacactgggc actatggctt cctcttgcca
     1201 gccagccaga tcatccccac tgcggaggag acctggcaag ggctgaaggt catcatggaa
     1261 cacgttaggg acaacctcta ctagtcagag aactctcata ttttacccct tagaccaccg
     1321 cagttaaaga tcacttcttc atgaacaggt cggagccttc tgggttggta gagaactcag
     1381 ctggctcctc tccagccttg cttccagagg tcacacatcc tggtggccag catgtgagga
     1441 acacttcctc cgtgtggtgg ttggtcctgc tgttcggctg agcctttggt atgcctctct
     1501 atgtatgcag ctggttaggc aggccacgag caagatcatt gcttcctggt agcctacggc
     1561 tacctcactt ttagatcttc gatggttctc tagtctctac atgtagcctc gggcagggct
     1621 ccatgggagg tgctgagaga ggcaatgctt gccttagaac tctgtaattt ctcctttaga
     1681 catgttctct cttttctcct ttagacaggg tcttactatt ttgcccatgc tagtctgaag
     1741 ctcctggggt caaactctac tcccatccct agtctccaca gtagtggtat gcagctcagg
     1801 aacacacttt tctttgagga acaaatccta cttgcccacc atcatagctg ttcctactct
     1861 gcttgttcct cctactccat ttcatcatat cttcttcttc atcatcaatc atcatcatca
     1921 tcatcatcat catcatcatc atcatcatca tcatcatcat caatcatcaa cactgaaaca
     1981 ggatctctat gtagacatga ctgtcctgga acttgctata tagaccaagc tggcctcaaa
     2041 cttacagaga cctgcctggc tctgccttca gcatccatta aaggaattaa agacgcctat
     2101 caccatacct ggctcatctt aattcttttc cgttggcttg cgtacacaat caagcctttg
     2161 tccattacaa ggttcagtgt tcagatgatg cccactttcg taaccctctt ttctttatat
     2221 ttggtgttgc tgggatcctc acaggggtca gttggttata ctgtaggtga tgctcacagg
     2281 gctcgtgggg aacccggggc tagactgcag ggacagatta gcaccatctg tccactggcc
     2341 tccccaccac tctgcctttt gaactcactt caaagatttt gacctcacac cacaggtcct
     2401 aaatcatcct atagcctgga taacctcagg gcctccacac attccagcca gggctctggt
     2461 gtaccctgtg gttcagtctc ctggtctctt tcctcctgtg tttaaagtta ccttctattt
     2521 tgcatcctgg gccctgagta cctacctgga acaagacttc atcatcagcc agacacttcc
     2581 tgttctcttc ctagcacaca ccatctgccc tatttgtgtt gtggttttgt ttttgttttt
     2641 gtttttgttt tgttttcttc ggcttttttt ttttttctct ctgttttcaa tcatgtctgt
     2701 aaatcttaac cttctgccta ggatttgggc agcatctagt atgtcctcct aagccaataa
     2761 atattcaata tggtctcatg a
//
