LOCUS       NM_019300               1441 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus carboxypeptidase A3 (Cpa3), mRNA.
ACCESSION   NM_019300 XM_001056211 XM_001056274 XM_342219
VERSION     NM_019300.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1441)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 1441)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 1441)
  AUTHORS   Xing,D., Zhang,R., Li,S., Huang,P., Luo,C., Hei,Z., Xia,Z. and
            Gan,X.
  TITLE     Pivotal role of mast cell carboxypeptidase A in mediating
            protection against small intestinal ischemia-reperfusion injury in
            rats after ischemic preconditioning
  JOURNAL   J Surg Res 192 (1), 177-186 (2014)
   PUBMED   24953986
  REMARK    GeneRIF: These data suggest that ischemic preconditioning protected
            against reperfusion injury via the mast cell degranulation-mediated
            release of MC-CPA.
REFERENCE   4  (bases 1 to 1441)
  AUTHORS   Taketomi,Y., Ueno,N., Kojima,T., Sato,H., Murase,R., Yamamoto,K.,
            Tanaka,S., Sakanaka,M., Nakamura,M., Nishito,Y., Kawana,M.,
            Kambe,N., Ikeda,K., Taguchi,R., Nakamizo,S., Kabashima,K.,
            Gelb,M.H., Arita,M., Yokomizo,T., Nakamura,M., Watanabe,K.,
            Hirai,H., Nakamura,M., Okayama,Y., Ra,C., Aritake,K., Urade,Y.,
            Morimoto,K., Sugimoto,Y., Shimizu,T., Narumiya,S., Hara,S. and
            Murakami,M.
  TITLE     Mast cell maturation is driven via a group III phospholipase
            A2-prostaglandin D2-DP1 receptor paracrine axis
  JOURNAL   Nat Immunol 14 (6), 554-563 (2013)
   PUBMED   23624557
REFERENCE   5  (bases 1 to 1441)
  AUTHORS   Lundequist,A., Tchougounova,E., Abrink,M. and Pejler,G.
  TITLE     Cooperation between mast cell carboxypeptidase A and the chymase
            mouse mast cell protease 4 in the formation and degradation of
            angiotensin II
  JOURNAL   J Biol Chem 279 (31), 32339-32344 (2004)
   PUBMED   15173164
REFERENCE   6  (bases 1 to 1441)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 1441)
  AUTHORS   Kayashima,T., Yamasaki,K., Yamada,T., Sakai,H., Miwa,N., Ohta,T.,
            Yoshiura,K., Matsumoto,N., Nakane,Y., Kanetake,H., Ishino,F.,
            Niikawa,N. and Kishino,T.
  TITLE     The novel imprinted carboxypeptidase A4 gene (CPA4) in the 7q32
            imprinting domain
  JOURNAL   Hum Genet 112 (3), 220-226 (2003)
   PUBMED   12552318
REFERENCE   8  (bases 1 to 1441)
  AUTHORS   Lutzelschwab,C., Pejler,G., Aveskogh,M. and Hellman,L.
  TITLE     Secretory granule proteases in rat mast cells. Cloning of 10
            different serine proteases and a carboxypeptidase A from various
            rat mast cell populations
  JOURNAL   J Exp Med 185 (1), 13-29 (1997)
   PUBMED   8996238
REFERENCE   9  (bases 1 to 1441)
  AUTHORS   Cole,K.R., Kumar,S., Trong,H.L., Woodbury,R.G., Walsh,K.A. and
            Neurath,H.
  TITLE     Rat mast cell carboxypeptidase: amino acid sequence and evidence of
            enzyme activity within mast cell granules
  JOURNAL   Biochemistry 30 (3), 648-655 (1991)
   PUBMED   1988052
REFERENCE   10 (bases 1 to 1441)
  AUTHORS   Goldstein,S.M., Kaempfer,C.E., Kealey,J.T. and Wintroub,B.U.
  TITLE     Human mast cell carboxypeptidase. Purification and characterization
  JOURNAL   J Clin Invest 83 (5), 1630-1636 (1989)
   PUBMED   2708524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM101110.1 and U67914.1.
            
            On or before Nov 21, 2008 this sequence version replaced
            XM_342219.3, XM_001056274.1, XM_001056211.1.
            
            Sequence Note: This RefSeq record was created from transcripts from
            mixed strains because no data from the same strain was available
            for the full length of the gene. The extent of the transcript
            record is supported by alignment data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U67914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                FM101110.1         1-14
            15-1441             U67914.1           1-1427
FEATURES             Location/Qualifiers
     source          1..1441
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..1441
                     /gene="Cpa3"
                     /note="carboxypeptidase A3"
                     /db_xref="GeneID:54242"
                     /db_xref="RGD:2390"
     exon            1..69
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1255
                     /gene="Cpa3"
                     /EC_number="3.4.17.1"
                     /note="mast cell carboxypeptidase A; R-CPA; RMC-CP;
                     carboxypeptidase A3, mast cell"
                     /codon_start=1
                     /product="mast cell carboxypeptidase A precursor"
                     /protein_id="NP_062173.1"
                     /db_xref="GeneID:54242"
                     /db_xref="RGD:2390"
                     /translation="MRSFLLMGVIYSTLAIAPVQFDREKVFRVKLQDEKQASILKNLT
                     QTIELDFWYPDAIHDIAVNMTVDFRVTEKESQTIQSTLEQHKMDYEILINDLQEEIDK
                     QFDVKEEIAGRHSYAKYNDWNKIVSWTEKMVEKHPEMVSRIKIGSTVEDNPLYVLKIG
                     RKDGERKAIFMDCGIHAREWVSPAFCQWFVYQAAKSYGKNKIMTKLLDRMNFYVLPVF
                     NVDGYIWSWTKDRMWRKNRSKNPNSTCIGTDLNRNFDVSWDSSPNTDNPCLSVYRGPA
                     PESEKETKAVTNFIRSHLNSIKAYITFHSYSQMLLFPYGYTIKLPPNHQDLLKVARIA
                     TDVLSSRYETRYIYGPIASTIYKTSGSSLDWAYDLGIKHTFAFELRDKGKSGFLLPES
                     RIKPTCKETMLSVKFIAKYILKHTS"
     exon            70..145
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
     exon            146..270
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
     exon            271..373
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
     exon            374..475
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
     exon            476..577
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
     exon            578..688
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
     exon            689..779
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..982
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1067
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1435
                     /gene="Cpa3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catgaggtcc ttcttgctta tgggggtcat ctattccaca cttgcaattg ctcctgttca
       61 gtttgacagg gagaaggtat tccgtgtgaa actccaggat gaaaagcaag caagtatctt
      121 gaagaacttg acccaaacca ttgagcttga cttctggtat ccagatgcta tccatgatat
      181 tgctgttaat atgactgtgg atttccgagt tactgagaag gaatctcaga ctatccagtc
      241 taccttggaa caacataaaa tggactatga aattctgata aatgacctac aagaagagat
      301 agacaaacag tttgatgtga aagaggaaat cgcaggcagg cacagttatg caaaatacaa
      361 tgactggaac aagattgttt cttggactga aaaaatggta gaaaaacatc ctgaaatggt
      421 ttcaaggatt aaaattggat caactgttga agataatcca ttatatgttc tcaagattgg
      481 gagaaaagat ggagaaagaa aggctatctt tatggactgt ggcatccatg ctcgtgaatg
      541 ggtttcccca gctttctgtc agtggtttgt ctatcaggca gccaagagtt atggaaaaaa
      601 taaaatcatg accaaacttt tggaccggat gaatttttat gttctgcccg tattcaatgt
      661 agatggatac atttggtcat ggacaaagga tcgaatgtgg agaaaaaacc gttccaagaa
      721 cccaaattca acctgcattg gcactgacct caacaggaac ttcgatgtct catgggactc
      781 ttccccaaac accgacaacc catgcctcag tgtctacagg ggacctgcac cagagtccga
      841 gaaagagaca aaagctgtca ctaacttcat tcgaagtcat ctgaactcaa tcaaggctta
      901 tatcaccttc cattcctact ctcagatgct gttatttcct tatggctaca caatcaaact
      961 gccacccaac caccaggacc tgctgaaggt tgcgaggatt gccactgatg ttctctcaag
     1021 tagatatgaa acccgttata tctacggccc aatagcatcc acaatttaca agacatcagg
     1081 ttcttcttta gactgggctt atgacctggg catcaaacac acatttgcct ttgagcttcg
     1141 tgataaagga aaatctggtt tccttcttcc agaatctcgg ataaagccaa catgtaaaga
     1201 aaccatgctt tctgtcaaat ttattgccaa gtatatcctc aagcatactt cctaataagt
     1261 tgcccttggt ttgaaatgtg ctaattaatc cttgggtgga gcctttccct ggaaagacaa
     1321 ccttctgcat cacctggatc catcctgctc ttattcatga agtcctgcat tattttctac
     1381 ttattcttat ttacacccaa tagccccaca acaataaagc tttaagtaaa tccaaaaaaa
     1441 a
//
