LOCUS       NM_001270961            3607 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus ceruloplasmin (Cp), transcript variant 2, mRNA.
ACCESSION   NM_001270961
VERSION     NM_001270961.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3607)
  AUTHORS   Sun,Q., Hackler,J., Hilger,J., Gluschke,H., Muric,A., Simmons,S.,
            Schomburg,L. and Siegert,E.
  TITLE     Selenium and Copper as Biomarkers for Pulmonary Arterial
            Hypertension in Systemic Sclerosis
  JOURNAL   Nutrients 12 (6), 1894 (2020)
   PUBMED   32630589
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3607)
  AUTHORS   Kenawi,M., Rouger,E., Island,M.L., Leroyer,P., Robin,F., Remy,S.,
            Tesson,L., Anegon,I., Nay,K., Derbre,F., Brissot,P., Ropert,M.,
            Cavey,T. and Loreal,O.
  TITLE     Ceruloplasmin deficiency does not induce macrophagic iron overload:
            lessons from a new rat model of hereditary aceruloplasminemia
  JOURNAL   FASEB J 33 (12), 13492-13502 (2019)
   PUBMED   31560858
REFERENCE   3  (bases 1 to 3607)
  AUTHORS   Gudehithlu,K.P., Hart,P., Joshi,A., Garcia-Gomez,I., Cimbaluk,D.J.,
            Dunea,G., Arruda,J.A.L. and Singh,A.K.
  TITLE     Urine exosomal ceruloplasmin: a potential early biomarker of
            underlying kidney disease
  JOURNAL   Clin Exp Nephrol 23 (8), 1013-1021 (2019)
   PUBMED   30955187
  REMARK    GeneRIF: Urine exosomal CP, observed to increase prior to
            proteinuria, makes it a potential urinary biomarker to diagnose
            early kidney disease.
REFERENCE   4  (bases 1 to 3607)
  AUTHORS   Liu,H., Hua,Y., Keep,R.F. and Xi,G.
  TITLE     Brain Ceruloplasmin Expression After Experimental Intracerebral
            Hemorrhage and Protection Against Iron-Induced Brain Injury
  JOURNAL   Transl Stroke Res 10 (1), 112-119 (2019)
   PUBMED   30315404
  REMARK    GeneRIF: This study found that CP was expressed on neurons and
            astrocytes in both cortex and basal ganglia after Intracerebral
            Hemorrhage.
REFERENCE   5  (bases 1 to 3607)
  AUTHORS   El-Koofy,N., Fouad,H.M., Fahmy,M.E., Helmy,H., Shaker,O.,
            El-Karaksy,H.M. and Mohsen,N.
  TITLE     Copper concentrations in Egyptian infants with cholestasis: A
            single center study
  JOURNAL   Arab J Gastroenterol 19 (1), 21-25 (2018)
   PUBMED   29523470
REFERENCE   6  (bases 1 to 3607)
  AUTHORS   Battiston,L., Passamonti,S., Macagno,A. and Sottocasa,G.L.
  TITLE     The bilirubin-binding motif of bilitranslocase and its relation to
            conserved motifs in ancient biliproteins
  JOURNAL   Biochem Biophys Res Commun 247 (3), 687-692 (1998)
   PUBMED   9647754
REFERENCE   7  (bases 1 to 3607)
  AUTHORS   Yoshida,K., Furihata,K., Takeda,S., Nakamura,A., Yamamoto,K.,
            Morita,H., Hiyamuta,S., Ikeda,S., Shimizu,N. and Yanagisawa,N.
  TITLE     A mutation in the ceruloplasmin gene is associated with systemic
            hemosiderosis in humans
  JOURNAL   Nat Genet 9 (3), 267-272 (1995)
   PUBMED   7539672
REFERENCE   8  (bases 1 to 3607)
  AUTHORS   Fleming,R.E. and Gitlin,J.D.
  TITLE     Structural and functional analysis of the 5'-flanking region of the
            rat ceruloplasmin gene
  JOURNAL   J Biol Chem 267 (1), 479-486 (1992)
   PUBMED   1730611
REFERENCE   9  (bases 1 to 3607)
  AUTHORS   Fleming,R.E. and Gitlin,J.D.
  TITLE     Primary structure of rat ceruloplasmin and analysis of
            tissue-specific gene expression during development
  JOURNAL   J Biol Chem 265 (13), 7701-7707 (1990)
   PUBMED   2332446
REFERENCE   10 (bases 1 to 3607)
  AUTHORS   Aldred,A.R., Grimes,A., Schreiber,G. and Mercer,J.F.
  TITLE     Rat ceruloplasmin. Molecular cloning and gene expression in liver,
            choroid plexus, yolk sac, placenta, and testis
  JOURNAL   J Biol Chem 262 (6), 2875-2878 (1987)
   PUBMED   3818625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            Transcript Variant: This variant (2) lacks an exon and contains two
            alternate 3' exons compared to variant 1. The resulting protein
            (isoform 2), which is longer and has a distinct C-terminus compared
            to isoform 1, is a glycosylphosphatidylinositol-anchored form.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF202115.1, SRR26643290.7845.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000002.1  104368670-104368848
            180-427             JAXUCZ010000002.1  104375826-104376073
            428-637             JAXUCZ010000002.1  104377793-104378002
            638-811             JAXUCZ010000002.1  104378748-104378921
            812-1066            JAXUCZ010000002.1  104380714-104380968
            1067-1238           JAXUCZ010000002.1  104381836-104382007
            1239-1378           JAXUCZ010000002.1  104385140-104385279
            1379-1531           JAXUCZ010000002.1  104386242-104386394
            1532-1728           JAXUCZ010000002.1  104387457-104387653
            1729-1879           JAXUCZ010000002.1  104396440-104396590
            1880-2092           JAXUCZ010000002.1  104398124-104398336
            2093-2300           JAXUCZ010000002.1  104400032-104400239
            2301-2440           JAXUCZ010000002.1  104401407-104401546
            2441-2569           JAXUCZ010000002.1  104402800-104402928
            2570-2676           JAXUCZ010000002.1  104405617-104405723
            2677-2893           JAXUCZ010000002.1  104407502-104407718
            2894-3033           JAXUCZ010000002.1  104408076-104408215
            3034-3196           JAXUCZ010000002.1  104409226-104409388
            3197-3301           JAXUCZ010000002.1  104423957-104424061
            3302-3607           JAXUCZ010000002.1  104426814-104427119
FEATURES             Location/Qualifiers
     source          1..3607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..3607
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /note="ceruloplasmin"
                     /db_xref="GeneID:24268"
                     /db_xref="RGD:2387"
     exon            1..179
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..3288
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /EC_number="1.11.1.9"
                     /EC_number="1.16.3.1"
                     /EC_number="1.11.1.27"
                     /EC_number="1.16.3.4"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; bilitranslocase; ceruloplasmin (ferroxidase);
                     cuproxidase ceruloplasmin; ferroxidase ceruloplasmin;
                     glutathione peroxidase ceruloplasmin;
                     glutathione-dependent peroxiredoxin ceruloplasmin"
                     /codon_start=1
                     /product="ceruloplasmin isoform 2 precursor"
                     /protein_id="NP_001257890.1"
                     /db_xref="GeneID:24268"
                     /db_xref="RGD:2387"
                     /translation="MKFLLLSALLFLHSSLAWTREKHYYIGITEAVWDYASGSEEKEL
                     ISVDTEQSNFYLRNGPDRIGRKYKKALYSEYTDGTFTKTIDKPAWLGLLGPVIKAEVG
                     DKVSVHVKNFASRPYTFHAHGVTYTKANEGAIYPDNTTDFQRADDKLFPGQQYLYVLR
                     ANEPSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLHKEKEENIDQEFVL
                     MFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSMCA
                     EDRVKWYLFGMGNEVDVHSALFHGQALTSKNYHTDIINLFPATLIDVSMVAQNPGVWM
                     LSCQNLNHLKAGLQAFFQVRDCNKPSPDDDIQDRHVRHYYIAAEETIWDYAPSGTDTF
                     TGENLTSLGSDSRVFFEQGATRIGGSYKKLVYREYTDDSFTNRKQRGPDEEHLGILGP
                     VIWAEVGDIIRVTFHNKGQFPLSIQPMGVRFTKENEGTYYGPDGRSSKQASHVAPKET
                     FTYEWTVPKEMGPTYADPVCLSKMYYSGVDLTKDIFTGLIGPMKICKKGSLLADGRQK
                     DVDKEFYLFATVFDENESLLLDDNIRMFTTAPENVDKEDEDFQESNKMHSMNGFMYGN
                     LPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRDTANLFPHKSLTLLMT
                     PDTEGSFDVECLTTDHYTGGMKQKYTVNQCKGQFEDVTLYQGERTYYIAAVEVEWDYS
                     PSRDWEMELHHLQEQNVSNAFLDKEEFFIGSKYKKVVYREFTDSTFREQVKRRAEEEH
                     LGILGPLIHADVGDKVKVVFKNMASRPYSIHAHGVKTKSSTVAPTLPGEVRTYIWQIP
                     ERSGAGTEDSPCIPWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFNPKKKMEFSLLF
                     LVFDENESWYLDDNINTYSDHPEKVNKDNEEFIESNKMHAINGKMFGNLQGLTMHVGD
                     EVNWYVMAMGNEIDLHTVHFHGHSFQYKHRGIHSSDVFDLFPGTYQTLEMFPQTPGTW
                     LLHCHVTDHIHAGMVTTYTVLPNQASSQSYRMTWNILYTLLISMTTLFQISTKE"
     exon            180..427
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            428..637
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            638..811
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1066
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1238
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1378
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1531
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1728
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1879
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2092
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2300
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2440
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2569
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2676
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2893
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3033
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3196
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3301
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3607
                     /gene="Cp"
                     /gene_synonym="CERP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttattgcat cgcgggctcc aagaggaaga aacatgaagt ttttgctgct tagtgcactt
       61 ttatttttgc atagttcctt agcttggaca agagaaaagc attattacat cggaattact
      121 gaagcagttt gggactatgc ttctggcagt gaagaaaagg aacttatttc agttgacacg
      181 gaacagtcca atttctatct tcgaaatggt ccagatcgta ttggaagaaa gtataagaag
      241 gccctttatt ctgagtacac agatggcacc tttacgaaga ctatagacaa accagcctgg
      301 ctagggcttt taggccctgt catcaaagct gaagttggag acaaagtttc tgttcacgta
      361 aagaactttg cctctaggcc ctacactttt catgctcatg gggtaactta caccaaggcg
      421 aacgaggggg ccatctaccc tgacaacacc actgattttc aaagagccga tgacaaactg
      481 tttcctggac agcagtattt gtacgtgctg cgtgccaatg agccaagtcc tggcgaggga
      541 gacagcaatt gtgtgaccag gatttaccac tctcatgtgg atgctccaaa agatattgca
      601 tcaggactca taggaccgtt gatactctgt aaaaaaggtt ctctgcataa ggaaaaagag
      661 gaaaatattg accaagaatt cgtactgatg ttctctgtgg tggatgaaaa tctcagctgg
      721 tatctagaag ataacatcaa aaccttctgc tcggaaccag agaaagtcga taaagacaat
      781 gaagacttcc aggaaagcaa caggatgtac tctataaatg gatatacatt tggaagcctc
      841 ccagggctct cgatgtgtgc agaagacaga gtgaagtggt acctttttgg gatggggaat
      901 gaagttgacg tgcattcagc gctctttcat ggtcaagccc tgaccagcaa gaactatcat
      961 actgatataa tcaacctgtt ccctgccact ctaattgatg tttctatggt ggcccagaat
     1021 cctggagtct ggatgctcag ttgccagaac ctgaaccatc tgaaagctgg tttgcaggcc
     1081 tttttccagg ttcgtgactg caacaagccc tcaccggacg acgatatcca agacagacat
     1141 gtgagacatt attacatcgc tgccgaggag accatttggg actatgctcc gtctgggaca
     1201 gacaccttca ctggagagaa cttaaccagt ctgggaagtg attcaagggt attttttgag
     1261 caaggtgcta caagaattgg tggctcttat aaaaaattgg tttatcgtga gtacacagat
     1321 gattccttca caaaccggaa gcaaagaggc cctgatgagg aacatcttgg aatccttggt
     1381 cctgtcattt gggcagaagt aggagacatc attagagtca cctttcataa caaaggacaa
     1441 tttcctctca gcattcagcc aatgggggta agattcacca aggaaaatga gggaacatac
     1501 tatggcccag atggccgttc ctcaaagcaa gcctcccatg tggctcccaa agaaaccttt
     1561 acgtatgaat ggactgtccc caaagaaatg ggacccactt atgcagatcc tgtgtgccta
     1621 tctaagatgt attattctgg agttgacctc accaaagata tatttactgg gcttattggg
     1681 ccaatgaaaa tatgcaagaa aggcagctta cttgcagatg ggagacagaa agatgtagac
     1741 aaggagttct acttgtttgc aacagtgttt gatgagaatg agagtttact cttggatgat
     1801 aatatcagaa tgttcacaac tgcacctgag aatgtggaca aggaagatga agactttcag
     1861 gagtccaaca agatgcactc catgaatgga ttcatgtatg gcaatctgcc tggcctcaat
     1921 atgtgtctag gagaatccat cgtgtggtat ttgttcagcg ctggaaatga ggcagacgtg
     1981 catgggatat acttttcagg aaatacctat ctgtccaaag gagaaagaag agacactgca
     2041 aatctatttc ctcataaaag tctcaccctt ctcatgacac ctgacacaga agggtctttt
     2101 gatgttgagt gtcttacaac agatcactac accggtggca tgaagcaaaa gtacactgtg
     2161 aaccagtgca aggggcagtt tgaagatgtc actctctacc agggagaaag gacctactat
     2221 attgcagcag tggaggtgga atgggattat tcaccaagca gggactggga aatggagctg
     2281 caccatttgc aagagcaaaa tgtttcaaat gcatttttgg ataaggaaga gtttttcata
     2341 ggctcaaagt acaagaaggt tgtgtatcga gagtttactg acagcacatt cagagaacag
     2401 gtgaagagaa gagctgaaga ggagcacttg ggcatcctcg gtccactgat tcatgcagat
     2461 gttggagaca aagttaaagt tgtctttaaa aatatggcaa gcaggccata ttcaatacat
     2521 gcccacggag tgaaaacaaa gagttctaca gttgctccaa cgttaccagg tgaagttcgc
     2581 acttatatat ggcaaattcc agaaagatca ggtgctggaa cggaggattc accttgtatc
     2641 ccatgggctt attactcaac cgtggatcga gttaaggatc tctatagtgg gctaataggc
     2701 ccattgattg tttgtcggaa atcttatgtg aaagtattca atcctaaaaa gaaaatggag
     2761 ttttcccttt tgtttctagt atttgatgag aatgaatctt ggtacttaga tgataacatc
     2821 aatacatact ctgatcaccc tgagaaagta aacaaagaca acgaggaatt catagaaagc
     2881 aataaaatgc atgctatcaa tgggaaaatg ttcggaaacc tacaaggtct cacgatgcac
     2941 gtgggagacg aggtcaactg gtatgtgatg gctatgggca atgaaataga cctgcacact
     3001 gtacacttcc acggccacag cttccaatac aagcacaggg gaattcatag ttctgatgtc
     3061 tttgaccttt ttcctggaac ataccaaacc ctagagatgt ttccccaaac gcctggaacc
     3121 tggttactcc actgccatgt gactgaccat attcatgcgg ggatggtaac tacctacact
     3181 gttttaccaa atcaagcatc gtctcagagc tacaggatga cctggaacat actctataca
     3241 ctgttaatca gcatgactac tttattccaa atatctacca aggagtagcc aggaaaataa
     3301 ggtgttttca agaacattct aaaaatgaag atggttgtac agctcatttc cctgcaacaa
     3361 gaccagtccc tcagctcagg ggcttcctcc atcaccagtt ccatccagga gccaggattc
     3421 caaagctcct aaatgtgatc aactatagac tttgcccctc aaaagctata ttctaaatta
     3481 acaagacatg tgctatcacg ccatatttaa attgtatacg atatcgaaat atattgcata
     3541 ttttaaaagt aaaagaggca tttttattta cctgtagttt caaaaggtct tctgtgtaat
     3601 ttttatc
//
