LOCUS       NM_012786                332 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase, subunit VIIIb (Cox8b),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012786
VERSION     NM_012786.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Oana,F., Homma,T., Takeda,H., Matsuzawa,A., Akahane,S., Isaji,M.
            and Akahane,M.
  TITLE     DNA microarray analysis of white adipose tissue from obese (fa/fa)
            Zucker rats treated with a beta3-adrenoceptor agonist, KTO-7924
  JOURNAL   Pharmacol Res 52 (5), 395-400 (2005)
   PUBMED   16027000
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Li,P., Li,J., Feng,X., Li,Z., Hou,R., Han,C. and Zhang,Y.
  TITLE     Gene expression profile of cardiomyocytes in hypertrophic heart
            induced by continuous norepinephrine infusion in the rats
  JOURNAL   Cell Mol Life Sci 60 (10), 2200-2209 (2003)
   PUBMED   14618266
REFERENCE   3  (bases 1 to 332)
  AUTHORS   Lenka,N., Basu,A., Mullick,J. and Avadhani,N.G.
  TITLE     The role of an E box binding basic helix loop helix protein in the
            cardiac muscle-specific expression of the rat cytochrome oxidase
            subunit VIII gene
  JOURNAL   J Biol Chem 271 (47), 30281-30289 (1996)
   PUBMED   8939982
REFERENCE   4  (bases 1 to 332)
  AUTHORS   Schagger,H., Noack,H., Halangk,W., Brandt,U. and von Jagow,G.
  TITLE     Cytochrome-c oxidase in developing rat heart. Enzymic properties
            and amino-terminal sequences suggest identity of the fetal heart
            and the adult liver isoform
  JOURNAL   Eur J Biochem 230 (1), 235-241 (1995)
   PUBMED   7601105
REFERENCE   5  (bases 1 to 332)
  AUTHORS   Scheja,K. and Kadenbach,B.
  TITLE     Nucleotide sequence of cDNA encoding subunit VIII of cytochrome c
            oxidase from rat heart
  JOURNAL   Biochim Biophys Acta 1132 (1), 91-93 (1992)
   PUBMED   1324738
REFERENCE   6  (bases 1 to 332)
  AUTHORS   Kadenbach,B., Stroh,A., Becker,A., Eckerskorn,C. and Lottspeich,F.
  TITLE     Tissue- and species-specific expression of cytochrome c oxidase
            isozymes in vertebrates
  JOURNAL   Biochim Biophys Acta 1015 (2), 368-372 (1990)
   PUBMED   2153407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM054348.1 and X64827.1.
            
            On Dec 29, 2010 this sequence version replaced NM_012786.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217043.1, FQ217767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               FM054348.1         1-318
            319-332             X64827.1           314-327
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..332
                     /gene="Cox8b"
                     /gene_synonym="CCO8A; Cox8h; COXVIII-H"
                     /note="cytochrome c oxidase, subunit VIIIb"
                     /db_xref="GeneID:25250"
                     /db_xref="RGD:2386"
     exon            1..168
                     /gene="Cox8b"
                     /gene_synonym="CCO8A; Cox8h; COXVIII-H"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..270
                     /gene="Cox8b"
                     /gene_synonym="CCO8A; Cox8h; COXVIII-H"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit 8B, mitochondrial;
                     cytochrome c oxidase subunit 8-1; cytochrome c oxidase
                     subunit 8H; cytochrome c oxidase polypeptide VIII-heart;
                     Cytochrom c oxidase subunit VIII-H (heart/muscle);
                     cytochrome c oxidase, subunit 8B; cytochrome c oxidase,
                     subunit VIIIb, muscle; Cytochrome c oxidase subunit VIII-H
                     (heart/muscle)"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 8B, mitochondrial
                     precursor"
                     /protein_id="NP_036918.2"
                     /db_xref="GeneID:25250"
                     /db_xref="RGD:2386"
                     /translation="MPRLPPILRLLQAPEKYTVIPKARISSKPAKSPTSAMDQAVGMS
                     VIIAGFMVPAGWVLSHLESYKRSSAA"
     exon            169..319
                     /gene="Cox8b"
                     /gene_synonym="CCO8A; Cox8h; COXVIII-H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      298..303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox8b"
                     /gene_synonym="CCO8A; Cox8h; COXVIII-H"
     polyA_site      319
                     /gene="Cox8b"
                     /gene_synonym="CCO8A; Cox8h; COXVIII-H"
ORIGIN      
        1 cagcagacat tcagggtgcc tctttggggc caaggaaaga gtgcgacccc gagaatcatg
       61 ccaaggcttc cccctatcct gcggctgctc caagcgcccg agaagtacac agtgattcct
      121 aaagcccgta tctcttccaa gccagccaaa tctcccactt ctgccatgga tcaggctgtg
      181 gggatgtcag tcataatcgc tggcttcatg gttccagcag gatgggtctt atcccacttg
      241 gagagctata agagaagctc cgcagcatga ggagctcggc gcatccctga gaggccaatt
      301 aaacgcttcc agtacctcca aaaaaaaaaa aa
//
