LOCUS       NM_134345                495 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase subunit 8A (Cox8a), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_134345 XM_574609
VERSION     NM_134345.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Zong,S., Wu,M., Gu,J., Liu,T., Guo,R. and Yang,M.
  TITLE     Structure of the intact 14-subunit human cytochrome c oxidase
  JOURNAL   Cell Res 28 (10), 1026-1034 (2018)
   PUBMED   30030519
REFERENCE   3  (bases 1 to 495)
  AUTHORS   Sheehan,T.E., Kumar,P.A. and Hood,D.A.
  TITLE     Tissue-specific regulation of cytochrome c oxidase subunit
            expression by thyroid hormone
  JOURNAL   Am J Physiol Endocrinol Metab 286 (6), E968-E974 (2004)
   PUBMED   14970006
REFERENCE   4  (bases 1 to 495)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 495)
  AUTHORS   Huttemann,M., Schmidt,T.R. and Grossman,L.I.
  TITLE     A third isoform of cytochrome c oxidase subunit VIII is present in
            mammals
  JOURNAL   Gene 312, 95-102 (2003)
   PUBMED   12909344
REFERENCE   6  (bases 1 to 495)
  AUTHORS   Schagger,H., Noack,H., Halangk,W., Brandt,U. and von Jagow,G.
  TITLE     Cytochrome-c oxidase in developing rat heart. Enzymic properties
            and amino-terminal sequences suggest identity of the fetal heart
            and the adult liver isoform
  JOURNAL   Eur J Biochem 230 (1), 235-241 (1995)
   PUBMED   7601105
REFERENCE   7  (bases 1 to 495)
  AUTHORS   Crosignani,P.
  TITLE     [Malignant breast tumors in the population of the province of
            Varese from 01/01/76 to 12/31/87]
  JOURNAL   Pathologica 84 (1094), 1-9 (1992)
   PUBMED   1300526
REFERENCE   8  (bases 1 to 495)
  AUTHORS   Cao,X.N., Hengst,L., Schlerf,A., Droste,M., Mengel,T. and
            Kadenbach,B.
  TITLE     Complexity of nucleus-encoded genes of mammalian cytochrome c
            oxidase
  JOURNAL   Ann N Y Acad Sci 550, 337-347 (1988)
   PUBMED   2854406
REFERENCE   9  (bases 1 to 495)
  AUTHORS   Suske,G., Mengel,T., Cordingley,M. and Kadenbach,B.
  TITLE     Molecular cloning and further characterization of cDNAs for rat
            nuclear-encoded cytochrome c oxidase subunits VIc and VIII
  JOURNAL   Eur J Biochem 168 (1), 233-237 (1987)
   PUBMED   2822403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB701133.1 and L48209.1.
            
            On Oct 17, 2005 this sequence version replaced XM_574609.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210567.1, FQ213112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                CB701133.1         11-92
            83-495              L48209.1           1-413
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..495
                     /gene="Cox8a"
                     /note="cytochrome c oxidase subunit 8A"
                     /db_xref="GeneID:171335"
                     /db_xref="RGD:620638"
     exon            1..173
                     /gene="Cox8a"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..269
                     /gene="Cox8a"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit 8A, mitochondrial;
                     cytochrome c oxidase subunit 8-2; cytochrome c oxidase
                     polypeptide VIII-liver; cytochrome c oxidase subunit
                     VIIIa"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 8A, mitochondrial
                     precursor"
                     /protein_id="NP_599172.1"
                     /db_xref="GeneID:171335"
                     /db_xref="RGD:620638"
                     /translation="MSSLTPLLLRSLTGPARRLMVPRAQVHSKPPREQLGVLDITIGL
                     TSCFVCCLLPAGWVLSHLESYKKRE"
     exon            174..495
                     /gene="Cox8a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      495
                     /gene="Cox8a"
ORIGIN      
        1 tcttgacttc ctgaccttgg gcttcggctg gtccttgtcc ttggtcactc cgcgccgtca
       61 tgtcttccct gacgccgctg ctgctgagga gcctgaccgg cccggcccgg cggcttatgg
      121 tgccgcgggc tcaggtccac tcgaagccgc cgcgggagca gctcggggtc ctggatatca
      181 ccattgggct cacttcctgc ttcgtgtgtt gtcttctacc tgcgggctgg gtcctgtcac
      241 acctggaaag ctacaagaag cgggagtgaa gggagcgtct tccctcatcc tttgactaga
      301 ccactcttgc cagcccacct tgatcatgtt tcctgcattc ctggctggct taccctggga
      361 tcatgttatt caattccagt cacctcttct gcaatcatga cctctcgatg tctccatggt
      421 gacaactggg accacatata ttggttctgc ttgatggggt ccccctttgt aacaataaag
      481 tctatttaaa ccttg
//
