LOCUS       NM_001145273             442 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase subunit 6B1 (Cox6b1), mRNA.
ACCESSION   NM_001145273 XM_001068644
VERSION     NM_001145273.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 442)
  AUTHORS   Yang,S., Wu,P., Xiao,J. and Jiang,L.
  TITLE     Overexpression of COX6B1 protects against I/R-induced neuronal
            injury in rat hippocampal neurons
  JOURNAL   Mol Med Rep 19 (6), 4852-4862 (2019)
   PUBMED   31059068
  REMARK    GeneRIF: COX6B1 overexpression may reverse I/R-induced neuronal
            damage by increasing the viability of neurons, by decreasing the
            cytosolic levels of Ca2+ and by suppressing apoptosis.
REFERENCE   2  (bases 1 to 442)
  AUTHORS   Zhang,W., Wang,Y., Wan,J., Zhang,P. and Pei,F.
  TITLE     COX6B1 relieves hypoxia/reoxygenation injury of neonatal rat
            cardiomyocytes by regulating mitochondrial function
  JOURNAL   Biotechnol Lett 41 (1), 59-68 (2019)
   PUBMED   30311029
  REMARK    GeneRIF: COX6B1 protected cardiomyocytes from hypoxia/reoxygenation
            injury by reducing ROS production and cell apoptosis, during which
            reduction of the release of cytochrome C from mitochondria to
            cytosol was involved.
REFERENCE   3  (bases 1 to 442)
  AUTHORS   Zong,S., Wu,M., Gu,J., Liu,T., Guo,R. and Yang,M.
  TITLE     Structure of the intact 14-subunit human cytochrome c oxidase
  JOURNAL   Cell Res 28 (10), 1026-1034 (2018)
   PUBMED   30030519
REFERENCE   4  (bases 1 to 442)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   5  (bases 1 to 442)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 442)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 19, 2009 this sequence version replaced XM_001068644.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF977389.1, BG371949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000001.1  95009732-95009852   c
            122-222             JAXUCZ010000001.1  95008713-95008813   c
            223-442             JAXUCZ010000001.1  95002513-95002732   c
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..442
                     /gene="Cox6b1"
                     /gene_synonym="Cox6b"
                     /note="cytochrome c oxidase subunit 6B1"
                     /db_xref="GeneID:688869"
                     /db_xref="RGD:1584097"
     exon            1..121
                     /gene="Cox6b1"
                     /gene_synonym="Cox6b"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..276
                     /gene="Cox6b1"
                     /gene_synonym="Cox6b"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase, subunit VIb polypeptide 1;
                     COX VIb-1; cytochrome c oxidase subunit VIb"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 6B1"
                     /protein_id="NP_001138745.1"
                     /db_xref="GeneID:688869"
                     /db_xref="RGD:1584097"
                     /translation="MAEDIKTKIKNYKTAPFDSRFPNQNQTKNCWQNYLDFHRCEKAM
                     TAKGGDVSVCEWYRRVYKSLCPVSWVSAWDDRIAEGTFPGKI"
     exon            122..222
                     /gene="Cox6b1"
                     /gene_synonym="Cox6b"
                     /inference="alignment:Splign:2.1.0"
     exon            223..442
                     /gene="Cox6b1"
                     /gene_synonym="Cox6b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catccaggag tcaggatggc cgaagacatc aagactaaaa tcaagaacta caaaaccgcc
       61 ccctttgaca gccgcttccc aaaccagaac cagactaaga actgctggca gaactacctg
      121 gacttccacc gctgtgagaa ggcaatgacg gcaaagggcg gtgacgtctc cgtgtgcgag
      181 tggtaccggc gagtgtacaa gtccctctgc cccgtctcat gggtctcagc ctgggatgac
      241 cgcatagcag aaggcacatt tcctgggaag atctgacctg gctccgccca cctctcctct
      301 gctctttgac cttctccccg atagaaaagg gggacctcag tatatgatgg tccctaccct
      361 gggaccctga atcatgatgc aactactaat aaaaactcac tggaaaggtt tcacactgtg
      421 tgtataggac agtgtctggc tc
//
