LOCUS       NM_012812                493 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase subunit 6A2 (Cox6a2),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012812
VERSION     NM_012812.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 493)
  AUTHORS   Mell,O.C., Seibel,P. and Kadenbach,B.
  TITLE     Structural organisation of the rat genes encoding liver- and
            heart-type of cytochrome c oxidase subunit VIa and a pseudogene
            related to the COXVIa-L cDNA
  JOURNAL   Gene 140 (2), 179-186 (1994)
   PUBMED   8144025
REFERENCE   4  (bases 1 to 493)
  AUTHORS   Kadenbach,B., Stroh,A., Becker,A., Eckerskorn,C. and Lottspeich,F.
  TITLE     Tissue- and species-specific expression of cytochrome c oxidase
            isozymes in vertebrates
  JOURNAL   Biochim Biophys Acta 1015 (2), 368-372 (1990)
   PUBMED   2153407
REFERENCE   5  (bases 1 to 493)
  AUTHORS   Schlerf,A., Droste,M., Winter,M. and Kadenbach,B.
  TITLE     Characterization of two different genes (cDNA) for cytochrome c
            oxidase subunit VIa from heart and liver of the rat
  JOURNAL   EMBO J 7 (8), 2387-2391 (1988)
   PUBMED   2461293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM058713.1 and BQ782365.1.
            
            On Dec 29, 2010 this sequence version replaced NM_012812.2.
            
            Transcript Variant: This variant (1) encodes the longer transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF558749.1, FQ224196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               FM058713.1         55-525
            472-493             BQ782365.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..493
                     /gene="Cox6a2"
                     /gene_synonym="COX6AH"
                     /note="cytochrome c oxidase subunit 6A2"
                     /db_xref="GeneID:25278"
                     /db_xref="RGD:2385"
     exon            1..143
                     /gene="Cox6a2"
                     /gene_synonym="COX6AH"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..364
                     /gene="Cox6a2"
                     /gene_synonym="COX6AH"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit 6A2, mitochondrial;
                     cytochrome c oxidase subunit VIa polypeptide 2 (heart);
                     COXVIAH; cytochrome c oxidase polypeptide VIa-heart"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 6A2, mitochondrial
                     precursor"
                     /protein_id="NP_036944.2"
                     /db_xref="GeneID:25278"
                     /db_xref="RGD:2385"
                     /translation="MALPLKVLSRSMASASKGDHGGAGANTWRLLTFVLALPSVALCS
                     LNCWMHAGHHERPEFIPYHHLRIRTKPFSWGDGNHTLFHNPHVNPLPTGYEQP"
     exon            144..280
                     /gene="Cox6a2"
                     /gene_synonym="COX6AH"
                     /inference="alignment:Splign:2.1.0"
     exon            281..475
                     /gene="Cox6a2"
                     /gene_synonym="COX6AH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      457..462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cox6a2"
                     /gene_synonym="COX6AH"
     polyA_site      475
                     /gene="Cox6a2"
                     /gene_synonym="COX6AH"
ORIGIN      
        1 gggaggagat cccctagact gagtgaagga gacagagaag gacagtgcca ttcctagcct
       61 cccttcaaca atggctctgc ctcttaaggt cctcagtcgg agcatggcca gcgcatccaa
      121 aggagaccac ggaggcgcag gagccaacac ttggcgcctc ctgacctttg tgctggctct
      181 ccccagcgta gctctctgct cgcttaactg ctggatgcac gctggccacc atgagcgccc
      241 agaattcatc ccctatcacc acctccgcat ccgaaccaag cccttctcct ggggggatgg
      301 gaaccacacg cttttccaca atccccacgt caatcctttg cccaccggct acgagcagcc
      361 ttgaagactc agcagacgta ctctgccaca gtctccaaac tgacctccat accggctcta
      421 agggcccctg aggttccagt ggacagttcc aagcgcaata aaggtgtgaa actttaaaaa
      481 aaaaaaaaaa aaa
//
