LOCUS       NM_053586                486 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase subunit 5B (Cox5b), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_053586
VERSION     NM_053586.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Zong,S., Wu,M., Gu,J., Liu,T., Guo,R. and Yang,M.
  TITLE     Structure of the intact 14-subunit human cytochrome c oxidase
  JOURNAL   Cell Res 28 (10), 1026-1034 (2018)
   PUBMED   30030519
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Hinkelbein,J., Bohm,L., Braunecker,S., Adler,C., De Robertis,E. and
            Cirillo,F.
  TITLE     Decreased Tissue COX5B Expression and Mitochondrial Dysfunction
            during Sepsis-Induced Kidney Injury in Rats
  JOURNAL   Oxid Med Cell Longev 2017, 8498510 (2017)
   PUBMED   28246552
  REMARK    GeneRIF: Decreased Tissue COX5B Expression is associated with
            Mitochondrial Dysfunction during Sepsis-Induced Kidney Injury
REFERENCE   3  (bases 1 to 486)
  AUTHORS   Yu,Q., Nguyen,T., Ogbi,M., Caldwell,R.W. and Johnson,J.A.
  TITLE     Differential loss of cytochrome-c oxidase subunits in
            ischemia-reperfusion injury: exacerbation of COI subunit loss by
            PKC-epsilon inhibition
  JOURNAL   Am J Physiol Heart Circ Physiol 294 (6), H2637-H2645 (2008)
   PUBMED   18408135
  REMARK    GeneRIF: Report loss of Cox5b subunits in ischemia-reperfusion
            injury and exacerbation of subunit loss by PKC-epsilon inhibition.
REFERENCE   4  (bases 1 to 486)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   5  (bases 1 to 486)
  AUTHORS   Kuo,W.W., Chu,C.Y., Wu,C.H., Lin,J.A., Liu,J.Y., Ying,T.H.,
            Lee,S.D., Hsieh,Y.H., Chu,C.H., Lin,D.Y., Hsu,H.H. and Huang,C.Y.
  TITLE     The profile of cardiac cytochrome c oxidase (COX) expression in an
            accelerated cardiac-hypertrophy model
  JOURNAL   J Biomed Sci 12 (4), 601-610 (2005)
   PUBMED   16132109
REFERENCE   6  (bases 1 to 486)
  AUTHORS   Wu,H., Owlia,A. and Singh,P.
  TITLE     Precursor peptide progastrin(1-80) reduces apoptosis of intestinal
            epithelial cells and upregulates cytochrome c oxidase Vb levels and
            synthesis of ATP
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 285 (6), G1097-G1110 (2003)
   PUBMED   12881229
REFERENCE   7  (bases 1 to 486)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 486)
  AUTHORS   Schagger,H., Noack,H., Halangk,W., Brandt,U. and von Jagow,G.
  TITLE     Cytochrome-c oxidase in developing rat heart. Enzymic properties
            and amino-terminal sequences suggest identity of the fetal heart
            and the adult liver isoform
  JOURNAL   Eur J Biochem 230 (1), 235-241 (1995)
   PUBMED   7601105
REFERENCE   9  (bases 1 to 486)
  AUTHORS   Hoshinaga,H., Amuro,N., Goto,Y. and Okazaki,T.
  TITLE     Molecular cloning and characterization of the rat cytochrome c
            oxidase subunit Vb gene
  JOURNAL   J Biochem 115 (2), 194-201 (1994)
   PUBMED   8206867
REFERENCE   10 (bases 1 to 486)
  AUTHORS   Goto,Y., Amuro,N. and Okazaki,T.
  TITLE     Nucleotide sequence of cDNA for rat liver and brain cytochrome c
            oxidase subunit VIa (Vb)
  JOURNAL   Nucleic Acids Res 17 (15), 6388 (1989)
   PUBMED   2549512
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053586.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10952.1, FQ108951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000009.1  46417837-46417955
            120-193             JAXUCZ010000009.1  46418478-46418551
            194-293             JAXUCZ010000009.1  46418714-46418813
            294-486             JAXUCZ010000009.1  46419471-46419663
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..486
                     /gene="Cox5b"
                     /note="cytochrome c oxidase subunit 5B"
                     /db_xref="GeneID:94194"
                     /db_xref="RGD:620608"
     exon            1..119
                     /gene="Cox5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..406
                     /gene="Cox5b"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit 5B, mitochondrial;
                     cytochrome c oxidase subunit VIA*; cytochrome c oxidase
                     polypeptide Vb; cytochrome c oxidase subunit Vb"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 5B, mitochondrial
                     precursor"
                     /protein_id="NP_446038.1"
                     /db_xref="GeneID:94194"
                     /db_xref="RGD:620608"
                     /translation="MASRLLRGVGALAAQALRAHGPRGVAATRSMASGGGVPTDEEQA
                     TGLEREIMIAAQRGLDPYNMLPPKAASGTKEDPNLVPSVSNKRIVGCICEEDNCTVIW
                     FWLHQGESQRCPNCGTHYKLVPYQMVH"
     exon            120..193
                     /gene="Cox5b"
                     /inference="alignment:Splign:2.1.0"
     exon            194..293
                     /gene="Cox5b"
                     /inference="alignment:Splign:2.1.0"
     exon            294..486
                     /gene="Cox5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgtctcg agcgagatgg cttcaaggtt acttcgcgga gtaggcgctt tggcggctca
       61 ggccctgagg gcccacggac cccgtggcgt ggccgctacc cgctccatgg cttctggagg
      121 tggtgtccct actgatgagg agcaggctac cgggctggag agggagatca tgatagcagc
      181 acagagggga ctggatccat acaatatgct acctccaaag gcagcttcgg gcaccaagga
      241 agaccccaat ctagtcccat ccgttagcaa caagagaata gtgggctgca tctgtgaaga
      301 ggacaactgc actgtcatct ggttctggct gcaccaaggc gagagccagc gatgccccaa
      361 ctgtggaaca cattacaagt tggtgcccta ccaaatggtc cactgagccc acccctggtt
      421 taacatttca gaatgtaaag gaaaacgtct ctctaataaa gactagccaa cgcactggct
      481 ccttcc
//
