LOCUS       NM_145783                600 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase subunit 5A (Cox5a), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_145783
VERSION     NM_145783.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 600)
  AUTHORS   Jung,S.E., Kim,S.W., Jeong,S., Moon,H., Choi,W.S., Lim,S., Lee,S.,
            Hwang,K.C. and Choi,J.W.
  TITLE     MicroRNA-26a/b-5p promotes myocardial infarction-induced cell death
            by downregulating cytochrome c oxidase 5a
  JOURNAL   Exp Mol Med 53 (9), 1332-1343 (2021)
   PUBMED   34518647
  REMARK    GeneRIF: MicroRNA-26a/b-5p promotes myocardial infarction-induced
            cell death by downregulating cytochrome c oxidase 5a.
REFERENCE   2  (bases 1 to 600)
  AUTHORS   Jiang,Y., Bai,X., Li,T.T., Al-Hawwas,M., Jin,Y., Zou,Y., Hu,Y.,
            Liu,L.Y., Zhang,Y., Liu,Q., Yang,H., Ma,J., Wang,T.H., Liu,J. and
            Xiong,L.L.
  TITLE     COX5A over-expression protects cortical neurons from hypoxic
            ischemic injury in neonatal rats associated with TPI up-regulation
  JOURNAL   BMC Neurosci 21 (1), 18 (2020)
   PUBMED   32349668
  REMARK    GeneRIF: COX5A over-expression protects cortical neurons from
            hypoxic ischemic injury in neonatal rats associated with TPI
            up-regulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 600)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   4  (bases 1 to 600)
  AUTHORS   Zong,S., Wu,M., Gu,J., Liu,T., Guo,R. and Yang,M.
  TITLE     Structure of the intact 14-subunit human cytochrome c oxidase
  JOURNAL   Cell Res 28 (10), 1026-1034 (2018)
   PUBMED   30030519
REFERENCE   5  (bases 1 to 600)
  AUTHORS   Gong,Y.Y., Liu,Y.Y., Li,J., Su,L., Yu,S., Zhu,X.N., Cao,X.P. and
            Xiao,H.P.
  TITLE     Hypermethylation of Cox5a promoter is associated with mitochondrial
            dysfunction in skeletal muscle of high fat diet-induced insulin
            resistant rats
  JOURNAL   PLoS One 9 (12), e113784 (2014)
   PUBMED   25436770
  REMARK    GeneRIF: Novel observations indicate that Cox5a hypermethylation is
            associated with mitochondrial dysfunction in skeletal muscle of
            high-fat diet-induced insulin resistant rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 600)
  AUTHORS   Abmayr,S., Crawford,R.W. and Chamberlain,J.S.
  TITLE     Characterization of ARC, apoptosis repressor interacting with CARD,
            in normal and dystrophin-deficient skeletal muscle
  JOURNAL   Hum Mol Genet 13 (2), 213-221 (2004)
   PUBMED   14645204
REFERENCE   7  (bases 1 to 600)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 600)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 600)
  AUTHORS   Schagger,H., Noack,H., Halangk,W., Brandt,U. and von Jagow,G.
  TITLE     Cytochrome-c oxidase in developing rat heart. Enzymic properties
            and amino-terminal sequences suggest identity of the fetal heart
            and the adult liver isoform
  JOURNAL   Eur J Biochem 230 (1), 235-241 (1995)
   PUBMED   7601105
REFERENCE   10 (bases 1 to 600)
  AUTHORS   Droste,M., Schon,E. and Kadenbach,B.
  TITLE     Nucleotide sequence of cDNA encoding subunit Va from rat heart
            cytochrome c oxidase
  JOURNAL   Nucleic Acids Res 17 (11), 4375 (1989)
   PUBMED   2544858
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X15030.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X15030.1, FQ217304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..600
                     /gene="Cox5a"
                     /note="cytochrome c oxidase subunit 5A"
                     /db_xref="GeneID:252934"
                     /db_xref="RGD:620607"
     exon            1..100
                     /gene="Cox5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..453
                     /gene="Cox5a"
                     /EC_number="7.1.1.9"
                     /note="cytochrome c oxidase subunit 5A, mitochondrial;
                     cytochrome c oxidase polypeptide Va; cytochrome c oxidase,
                     subunit Va"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 5A, mitochondrial
                     precursor"
                     /protein_id="NP_665726.1"
                     /db_xref="GeneID:252934"
                     /db_xref="RGD:620607"
                     /translation="MLAAALRRCTAAAAARGLLHPVSAPSPAAAVCSIRCYSHGSHET
                     DEEFDARWVTYFNKPDIDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLNDFASAV
                     RILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV"
     exon            101..217
                     /gene="Cox5a"
                     /inference="alignment:Splign:2.1.0"
     exon            218..339
                     /gene="Cox5a"
                     /inference="alignment:Splign:2.1.0"
     exon            340..463
                     /gene="Cox5a"
                     /inference="alignment:Splign:2.1.0"
     exon            464..600
                     /gene="Cox5a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      600
                     /gene="Cox5a"
                     /note="polyA site"
ORIGIN      
        1 gtggtcgccg tcatgctcgc cgctgccctc cgtcgctgta ccgcagccgc ggccgcccga
       61 ggccttctgc accccgtctc ggctcccagc cccgctgccg ctgtctgttc cattcgctgc
      121 tattctcatg ggtcacatga gacagatgag gagtttgatg ctcgctgggt gacatacttc
      181 aacaagccag acattgatgc ctgggagttg cgtaaaggga tgaatacact tgttggctat
      241 gatctggttc ctgagcccaa aatcattgat gctgctttga gggcatgtag acggttaaat
      301 gattttgcta gtgctgttcg catcttggag gttgttaagg acaaagcagg acctcataag
      361 gaaatctacc cctatgtcat ccaggaactt agaccaactt taaatgaatt gggaatctcc
      421 actccagagg aactgggcct tgacaaagtg taaactccct tcgatgggct tcccaaggac
      481 ttaactgcta ttgctacttg attgaaacag ttgcctggaa atgttttatt tgaacaaatt
      541 ttcctttgag tatcaaacca tgtaacttgg actttaataa agggaaatga gtttgacccg
//
