LOCUS       NM_053472                704 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase subunit 4i2 (Cox4i2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_053472
VERSION     NM_053472.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 704)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 704)
  AUTHORS   Hao,Y.H., Zhang,J., Wang,H., Wang,H.Y., Dong,J., Xu,X.P., Yao,B.W.,
            Wang,L.F., Zhou,H.M., Zhao,L. and Peng,R.Y.
  TITLE     HIF-1alpha regulates COXIV subunits, a potential mechanism of
            self-protective response to microwave induced mitochondrial damages
            in neurons
  JOURNAL   Sci Rep 8 (1), 10403 (2018)
   PUBMED   29991768
  REMARK    GeneRIF: microwave induced mitochondrial ROS production activated
            HIF-1alpha and regulated COXIV-1 expression to restore mitochondria
            functions. Therefore, HIF-1alpha might be a potential target to
            impair microwave induced injuries.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 704)
  AUTHORS   Aras,S., Pak,O., Sommer,N., Finley,R. Jr., Huttemann,M.,
            Weissmann,N. and Grossman,L.I.
  TITLE     Oxygen-dependent expression of cytochrome c oxidase subunit 4-2
            gene expression is mediated by transcription factors RBPJ, CXXC5
            and CHCHD2
  JOURNAL   Nucleic Acids Res 41 (4), 2255-2266 (2013)
   PUBMED   23303788
REFERENCE   4  (bases 1 to 704)
  AUTHORS   Acin-Perez,R., Gatti,D.L., Bai,Y. and Manfredi,G.
  TITLE     Protein phosphorylation and prevention of cytochrome oxidase
            inhibition by ATP: coupled mechanisms of energy metabolism
            regulation
  JOURNAL   Cell Metab 13 (6), 712-719 (2011)
   PUBMED   21641552
  REMARK    GeneRIF: mitochondrial energy metabolism regulation by
            phosphorylation of COXIV-1 is coupled with prevention of COX
            allosteric inhibition by ATP
REFERENCE   5  (bases 1 to 704)
  AUTHORS   Singh,S., Misiak,M., Beyer,C. and Arnold,S.
  TITLE     Cytochrome c oxidase isoform IV-2 is involved in 3-nitropropionic
            acid-induced toxicity in striatal astrocytes
  JOURNAL   Glia 57 (14), 1480-1491 (2009)
   PUBMED   19306371
REFERENCE   6  (bases 1 to 704)
  AUTHORS   Prior,L.J., Velkoska,E., Watts,R., Cameron-Smith,D. and Morris,M.J.
  TITLE     Undernutrition during suckling in rats elevates plasma adiponectin
            and its receptor in skeletal muscle regardless of diet composition:
            a protective effect?
  JOURNAL   Int J Obes (Lond) 32 (10), 1585-1594 (2008)
   PUBMED   18725894
REFERENCE   7  (bases 1 to 704)
  AUTHORS   Lombard,D.B., Alt,F.W., Cheng,H.L., Bunkenborg,J., Streeper,R.S.,
            Mostoslavsky,R., Kim,J., Yancopoulos,G., Valenzuela,D., Murphy,A.,
            Yang,Y., Chen,Y., Hirschey,M.D., Bronson,R.T., Haigis,M.,
            Guarente,L.P., Farese,R.V. Jr., Weissman,S., Verdin,E. and
            Schwer,B.
  TITLE     Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine
            acetylation
  JOURNAL   Mol Cell Biol 27 (24), 8807-8814 (2007)
   PUBMED   17923681
REFERENCE   8  (bases 1 to 704)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 704)
  AUTHORS   Putcha,G.V., Harris,C.A., Moulder,K.L., Easton,R.M., Thompson,C.B.
            and Johnson,E.M. Jr.
  TITLE     Intrinsic and extrinsic pathway signaling during neuronal
            apoptosis: lessons from the analysis of mutant mice
  JOURNAL   J Cell Biol 157 (3), 441-453 (2002)
   PUBMED   11980919
REFERENCE   10 (bases 1 to 704)
  AUTHORS   Huttemann,M., Kadenbach,B. and Grossman,L.I.
  TITLE     Mammalian subunit IV isoforms of cytochrome c oxidase
  JOURNAL   Gene 267 (1), 111-123 (2001)
   PUBMED   11311561
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF255347.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF255347.1, FM069824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..704
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /note="cytochrome c oxidase subunit 4i2"
                     /db_xref="GeneID:84683"
                     /db_xref="RGD:69422"
     exon            1..22
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..541
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /EC_number="7.1.1.9"
                     /note="COX IV-2; cytochrome c oxidase, subunit 4b;
                     cytochrome c oxidase, subunit IVb; cytochrome c oxidase
                     subunit IV"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 4 isoform 2,
                     mitochondrial isoform 2 precursor"
                     /protein_id="NP_445924.1"
                     /db_xref="GeneID:84683"
                     /db_xref="RGD:69422"
                     /translation="MFSRATRSLVMKTGGLRTQGTHSPGSAASSSQRRMTPYVDCYAQ
                     RSYPMPDEPYCTELSEEQRALKEKEKGSWAQLSQAEKVALYRLQFHETFAEMNHRSNE
                     WKTVMGCVFFFIGFTALVIWWQRVYVFPKKVVTLTEERKAQQLQRLLDMKSNPIQGLS
                     AHWDYEKKEWKK"
     exon            23..104
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            105..272
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            273..404
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..704
                     /gene="Cox4i2"
                     /gene_synonym="Cox4b; CoxIV-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccgtctt cagcttgcaa ctatgttttc cagagctacc cggagtctgg taatgaagac
       61 aggaggactc agaactcaag ggacacacag cccaggaagt gctgctagca gcagccagcg
      121 gaggatgacc ccctatgttg actgctatgc tcagcgctcc tatcccatgc cggatgagcc
      181 ttactgcaca gagctcagcg aggagcagcg ggccctgaag gagaaagaga agggcagctg
      241 ggctcagctg agccaagcag agaaggtggc cttgtaccgg ctccagttcc acgagacctt
      301 cgcagagatg aaccatcgct ccaacgaatg gaagacagta atgggctgcg tcttcttctt
      361 cattggattc acggctctgg tgatttggtg gcagcgggtc tatgtgttcc ctaagaaggt
      421 tgtcaccctg acggaagaac ggaaagccca gcagctccag cgcctcctgg acatgaagag
      481 caaccccata cagggcctgt ctgcccactg ggattacgag aagaaagagt ggaaaaagtg
      541 accaacatca cagtctgctg cctgcccttg caaaccgatt ccgcttccgc agcctaggag
      601 accctcctct cctctcttct cctcccttcc cctcccccac ctcctgtctt gtctcctcca
      661 ttcccttctg ctccaataaa agcagcctgc attgttctgc ctgc
//
