LOCUS       NM_017202                696 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase subunit 4i1 (Cox4i1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_017202
VERSION     NM_017202.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 696)
  AUTHORS   Kumar,V., A,A.K., Sanawar,R., Jaleel,A., Santhosh Kumar,T.R. and
            Kartha,C.C.
  TITLE     Chronic Pressure Overload Results in Deficiency of Mitochondrial
            Membrane Transporter ABCB7 Which Contributes to Iron Overload,
            Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac
            Function
  JOURNAL   Sci Rep 9 (1), 13170 (2019)
   PUBMED   31511561
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 696)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 696)
  AUTHORS   Kar,A.N., Vargas,J.N.S., Chen,C.Y., Kowalak,J.A., Gioio,A.E. and
            Kaplan,B.B.
  TITLE     Molecular determinants of cytochrome C oxidase IV mRNA axonal
            trafficking
  JOURNAL   Mol Cell Neurosci 80, 32-43 (2017)
   PUBMED   28161363
  REMARK    GeneRIF: The results provided in this communication indicate that a
            multi-protein ribonucleoprotein complex is formed in association
            with the COXIV 38 nt zipcode.
REFERENCE   4  (bases 1 to 696)
  AUTHORS   Martin,J., Balmer,M.L., Rajendran,S., Maurhofer,O., Dufour,J.F. and
            St-Pierre,M.V.
  TITLE     Nutritional stress exacerbates hepatic steatosis induced by
            deletion of the histidine nucleotide-binding (Hint2) mitochondrial
            protein
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 310 (7), G497-G509 (2016)
   PUBMED   26767982
REFERENCE   5  (bases 1 to 696)
  AUTHORS   Iwao,B., Yara,M., Hara,N., Kawai,Y., Yamanaka,T., Nishihara,H.,
            Inoue,T. and Inazu,M.
  TITLE     Functional expression of choline transporter like-protein 1 (CTL1)
            and CTL2 in human brain microvascular endothelial cells
  JOURNAL   Neurochem Int 93, 40-50 (2016)
   PUBMED   26746385
REFERENCE   6  (bases 1 to 696)
  AUTHORS   Virbasius,J.V. and Scarpulla,R.C.
  TITLE     The rat cytochrome c oxidase subunit IV gene family:
            tissue-specific and hormonal differences in subunit IV and
            cytochrome c mRNA expression
  JOURNAL   Nucleic Acids Res 18 (22), 6581-6586 (1990)
   PUBMED   2174541
REFERENCE   7  (bases 1 to 696)
  AUTHORS   Amuro,N., Yamada,M., Goto,Y. and Okazaki,T.
  TITLE     Complete nucleotide sequence of the gene encoding rat cytochrome c
            oxidase subunit IV
  JOURNAL   Nucleic Acids Res 18 (13), 3992 (1990)
   PUBMED   2165254
REFERENCE   8  (bases 1 to 696)
  AUTHORS   Yamada,M., Amuro,N., Goto,Y. and Okazaki,T.
  TITLE     Structural organization of the rat cytochrome c oxidase subunit IV
            gene
  JOURNAL   J Biol Chem 265 (13), 7687-7692 (1990)
   PUBMED   2159010
REFERENCE   9  (bases 1 to 696)
  AUTHORS   Gopalan,G., Droste,M. and Kadenbach,B.
  TITLE     Nucleotide sequence of cDNA encoding subunit IV of cytochrome c
            oxidase from fetal rat liver
  JOURNAL   Nucleic Acids Res 17 (11), 4376 (1989)
   PUBMED   2544859
REFERENCE   10 (bases 1 to 696)
  AUTHORS   Goto,Y., Amuro,N. and Okazaki,T.
  TITLE     Nucleotide sequence of cDNA for rat brain and liver cytochrome c
            oxidase subunit IV
  JOURNAL   Nucleic Acids Res 17 (7), 2851 (1989)
   PUBMED   2541414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X54081.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB569108.1, X14209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..696
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..696
                     /gene="Cox4i1"
                     /gene_synonym="Cox4; Cox4a"
                     /note="cytochrome c oxidase subunit 4i1"
                     /db_xref="GeneID:29445"
                     /db_xref="RGD:68374"
     exon            1..88
                     /gene="Cox4i1"
                     /gene_synonym="Cox4; Cox4a"
                     /inference="alignment:Splign:2.1.0"
     exon            89..162
                     /gene="Cox4i1"
                     /gene_synonym="Cox4; Cox4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..599
                     /gene="Cox4i1"
                     /gene_synonym="Cox4; Cox4a"
                     /EC_number="7.1.1.9"
                     /note="COX IV-1; cytochrome c oxidase polypeptide IV;
                     cytochrome c oxidase, subunit 4a; cytochrome c oxidase,
                     subunit IVa"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit 4 isoform 1,
                     mitochondrial precursor"
                     /protein_id="NP_058898.1"
                     /db_xref="GeneID:29445"
                     /db_xref="RGD:68374"
                     /translation="MLATRALSLIGKRAISTSVCLRAHGSVVKSEDYALPSYVDRRDY
                     PLPDVAHVKLLSASQKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNKGTNEWKT
                     VVGLAMFFIGFTALVLIWEKSYVYGPIPHTFDRDWVAMQTKRMLDMKVNPIQGFSAKW
                     DYNKNEWKK"
     exon            163..330
                     /gene="Cox4i1"
                     /gene_synonym="Cox4; Cox4a"
                     /inference="alignment:Splign:2.1.0"
     exon            331..462
                     /gene="Cox4i1"
                     /gene_synonym="Cox4; Cox4a"
                     /inference="alignment:Splign:2.1.0"
     exon            463..696
                     /gene="Cox4i1"
                     /gene_synonym="Cox4; Cox4a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      696
                     /gene="Cox4i1"
                     /gene_synonym="Cox4; Cox4a"
ORIGIN      
        1 gctcttccgg tgcgggaccc gctcttccgg tcgcgagcac ccggggtgta gagggcggtc
       61 gcggcggtcg cctgggcagc agtggcagaa tgttggctac cagggcactt agcctaattg
      121 gcaagagagc catttctact tcggtgtgcc ttcgggcaca tgggagtgtt gtgaagagtg
      181 aagactatgc tctcccatct tatgttgatc ggcgtgacta ccccttgcct gatgtggccc
      241 acgtcaagct gctgtctgcc agccagaagg ccctgaagga gaaggagaag gccgactgga
      301 gcagcctttc cagggatgag aaagtccaat tgtaccgcat ccagtttaac gagagcttcg
      361 ctgagatgaa caagggcacc aatgagtgga agacagtggt gggcctggcc atgttcttca
      421 tcggcttcac tgcgcttgtg ctgatctggg agaagagcta cgtgtatggc cccatccctc
      481 atacctttga tcgtgactgg gtggccatgc agaccaagcg gatgctggac atgaaggtca
      541 accccattca gggcttctcc gccaagtggg actacaacaa gaatgaatgg aagaagtgag
      601 agcctgctgc tgtgggctcc tccctccctc cctccctcag catgctggaa gctgctgtgt
      661 ccaatggtcc atgttaataa atgaccagtt tacgtg
//
