LOCUS       NM_001106000            1338 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase assembly factor COX18
            (Cox18), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106000 XM_001072704 XM_214011
VERSION     NM_001106000.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1338)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1338)
  AUTHORS   Bourens,M. and Barrientos,A.
  TITLE     Human mitochondrial cytochrome c oxidase assembly factor COX18 acts
            transiently as a membrane insertase within the subunit 2 maturation
            module
  JOURNAL   J Biol Chem 292 (19), 7774-7783 (2017)
   PUBMED   28330871
REFERENCE   3  (bases 1 to 1338)
  AUTHORS   Gaisne,M. and Bonnefoy,N.
  TITLE     The COX18 gene, involved in mitochondrial biogenesis, is
            functionally conserved and tightly regulated in humans and fission
            yeast
  JOURNAL   FEMS Yeast Res 6 (6), 869-882 (2006)
   PUBMED   16911509
REFERENCE   4  (bases 1 to 1338)
  AUTHORS   Sacconi,S., Trevisson,E., Pistollato,F., Baldoin,M.C.,
            Rezzonico,R., Bourget,I., Desnuelle,C., Tenconi,R., Basso,G.,
            DiMauro,S. and Salviati,L.
  TITLE     hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase
            assembly
  JOURNAL   Biochem Biophys Res Commun 337 (3), 832-839 (2005)
   PUBMED   16212937
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474060.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214011.4, XM_001072704.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132295 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1338
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1338
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="cytochrome c oxidase assembly factor COX18"
                     /db_xref="GeneID:289522"
                     /db_xref="RGD:1559547"
     exon            1..389
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1061
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /note="COX18 cytochrome c oxidase assembly homolog;
                     cytochrome c oxidase assembly homolog 18; cytochrome c
                     oxidase assembly protein 18; COX18, cytochrome c oxidase
                     assembly factor"
                     /codon_start=1
                     /product="mitochondrial inner membrane protein COX18"
                     /protein_id="NP_001099470.1"
                     /db_xref="GeneID:289522"
                     /db_xref="RGD:1559547"
                     /translation="MLCGSCAGLLRSLRTLQLRAPGSLPAWSSARLPTLPVWAAASVS
                     AASPGGWYEALAASAPVHAAEEMLLSAQETTGLPWWGNILLSTVVLRGAVTLPLAAYQ
                     HYILAKVENLQPEIKDIAKRLNQEVAVCARQFGWSKRVARLTYLKNIRRLVSELYVRD
                     NCHPFKATVLVWVQLPMWVFISVALRNLSTGATHSDGISVQDQLAAGGTLWFPDLTAV
                     DSTWILPVSVGVVNLLIVEIFALQKIGKSRFQMYVTNFVRAVSVLMVPVAATVPSALV
                     LYWLCSSLMGLSQNLLLRSPGFRQLCRIPPSRSDSETPYRDLSAAFCAKFLSRKR"
     exon            390..490
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            491..654
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            655..776
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            777..884
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1338
                     /gene="Cox18"
                     /gene_synonym="RGD1559547"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagcctcct gatggccaag gtctaggtgt cttcctcgct gacctgccgc ccgtcgtgtc
       61 tagccatgct atgcggatcg tgtgccgggt tgctccggtc gctgcgcacc ttgcagctcc
      121 gggcaccggg atcactgccc gcctggagca gcgcgcggct cccaaccctt ccggtatggg
      181 cggccgcgtc ggtttcggcg gcctctccgg gtggctggta tgaggccctg gcagcgtcgg
      241 cgcccgtgca tgcggcggag gaaatgctgc tgagcgcgca ggagaccaca ggcctccctt
      301 ggtggggtaa catcttactc agcaccgttg tcctgcgtgg tgctgtcact ctgcccctgg
      361 ccgcctatca acattacatc cttgctaagg tggaaaactt gcaaccagaa ataaaagaca
      421 tcgccaagcg ccttaaccaa gaagttgcag tctgtgcacg tcagtttggt tggtccaaga
      481 gagtggccag actcacttac ctgaagaaca ttcgcagact tgtgtcggag ctgtacgttc
      541 gtgacaactg ccatcctttc aaagccacgg tcctagtctg ggtccagctt ccaatgtggg
      601 tcttcatatc cgtcgccctc cggaacctta gcacaggggc cacacattca gacggcattt
      661 ctgttcagga ccagttagct gccggcggga ccctgtggtt tcctgacctc actgcagtgg
      721 attccacctg gattctgcct gtctctgttg gtgttgtcaa cttactgata gtggagattt
      781 ttgctcttca aaaaatcggg aagtcacgtt ttcaaatgta tgttacgaat tttgttcgag
      841 ccgtctcggt gttgatggtc ccagtggctg ccacagtacc ctcggcgctt gttctctact
      901 ggctgtgctc cagcctcatg ggcctctctc agaaccttct gctgcgctcc cctggcttcc
      961 gacagctgtg ccggatacca ccaagcaggt cagactcgga gaccccgtac agagacctct
     1021 ctgctgcctt ttgcgccaag ttcctttcaa gaaaacgatg agttcgctcc cagttccgtg
     1081 aaaaaattac agatgtcact gtcagcttca tgcactgaat tttgaagctt ttatttaaat
     1141 atcatgaagc acagtgggaa agatgtaatt tggatgtatt tgacatttag tattaaaaac
     1201 taaatgttca gttgtaagag tgtaaaaata agacaggatg cctggccttg ttcataaaaa
     1261 tcatagtttt gctgagaaca ggattagatc ctgtgtaatc tctgtgccca actgtccaca
     1321 aataaaggtt tataaatt
//
