LOCUS       NM_053540                440 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase copper chaperone COX17
            (Cox17), mRNA.
ACCESSION   NM_053540
VERSION     NM_053540.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Zhu,S.Y., Zhou,W.Q., Niu,Y.Y., Zheng,C., Liu,X., Zhang,Y.Y. and
            Yu,C.
  TITLE     COX17 restricts renal fibrosis development by maintaining
            mitochondrial copper homeostasis and restoring complex IV activity
  JOURNAL   Acta Pharmacol Sin 44 (10), 2091-2102 (2023)
   PUBMED   37217601
  REMARK    GeneRIF: COX17 restricts renal fibrosis development by maintaining
            mitochondrial copper homeostasis and restoring complex IV activity.
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 440)
  AUTHORS   Oswald,C., Krause-Buchholz,U. and Rodel,G.
  TITLE     Knockdown of human COX17 affects assembly and supramolecular
            organization of cytochrome c oxidase
  JOURNAL   J Mol Biol 389 (3), 470-479 (2009)
   PUBMED   19393246
REFERENCE   4  (bases 1 to 440)
  AUTHORS   Banci,L., Bertini,I., Ciofi-Baffoni,S., Janicka,A., Martinelli,M.,
            Kozlowski,H. and Palumaa,P.
  TITLE     A structural-dynamical characterization of human Cox17
  JOURNAL   J Biol Chem 283 (12), 7912-7920 (2008)
   PUBMED   18093982
REFERENCE   5  (bases 1 to 440)
  AUTHORS   Banci,L., Bertini,I., Ciofi-Baffoni,S., Leontari,I., Martinelli,M.,
            Palumaa,P., Sillard,R. and Wang,S.
  TITLE     Human Sco1 functional studies and pathological implications of the
            P174L mutant
  JOURNAL   Proc Natl Acad Sci U S A 104 (1), 15-20 (2007)
   PUBMED   17182746
REFERENCE   6  (bases 1 to 440)
  AUTHORS   Takahashi,Y., Kako,K., Kashiwabara,S., Takehara,A., Inada,Y.,
            Arai,H., Nakada,K., Kodama,H., Hayashi,J., Baba,T. and Munekata,E.
  TITLE     Mammalian copper chaperone Cox17p has an essential role in
            activation of cytochrome C oxidase and embryonic development
  JOURNAL   Mol Cell Biol 22 (21), 7614-7621 (2002)
   PUBMED   12370308
REFERENCE   7  (bases 1 to 440)
  AUTHORS   Kako,K., Tsumori,K., Ohmasa,Y., Takahashi,Y. and Munekata,E.
  TITLE     The expression of Cox17p in rodent tissues and cells
  JOURNAL   Eur J Biochem 267 (22), 6699-6707 (2000)
   PUBMED   11054125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ195675.1, AB032178.1 and BI293817.1.
            
            On Dec 23, 2009 this sequence version replaced NM_053540.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR756052.1, BP500515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132296, SAMD00132300
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BQ195675.1         358-413             c
            57-285              AB032178.1         1-229
            286-440             BI293817.1         1-155               c
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..440
                     /gene="Cox17"
                     /note="cytochrome c oxidase copper chaperone COX17"
                     /db_xref="GeneID:89786"
                     /db_xref="RGD:620548"
     exon            1..200
                     /gene="Cox17"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..285
                     /gene="Cox17"
                     /note="cytochrome c oxidase, subunit XVII assembly protein
                     homolog; COX17 cytochrome c oxidase assembly homolog;
                     COX17 cytochrome c oxidase copper chaperone; cytochrome c
                     oxidase assembly homolog 17"
                     /codon_start=1
                     /product="COX17 homolog, cytochrome c oxidase assembly
                     protein"
                     /protein_id="NP_445992.1"
                     /db_xref="GeneID:89786"
                     /db_xref="RGD:620548"
                     /translation="MPGLAAASPAPPEAQEKKPLKPCCACPETKKARDACIIEKGEEH
                     CGHLIEAHKECMRALGFKI"
     exon            201..289
                     /gene="Cox17"
                     /inference="alignment:Splign:2.1.0"
     exon            290..425
                     /gene="Cox17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgactgc ggaagtggat acagacagct cgggttggtc tgagttttgg gagctttgcg
       61 cgtgtgcgat cgttactgct ttcctctgga aagatgccgg gactggctgc cgctagccct
      121 gccccgcccg aggctcagga gaagaagcct ctgaagccct gctgtgcctg cccggagacc
      181 aagaaggcgc gtgatgcgtg catcattgag aaaggagaag aacactgtgg acatctcatc
      241 gaggcccaca aggagtgcat gagagcgctg ggatttaaga tatgacatgg tggcccactt
      301 tgtgaatgaa taagccctga agaatgaaga agagtaaata ttttggaagt tctttgatga
      361 actttgataa gtggataaag tatttataat ttattaaaaa acaaaaggaa agaaaatgtg
      421 gtaaaaaaaa aaaaaaaaaa
//
