LOCUS       NM_001033699            3007 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase assembly homolog COX15
            (Cox15), mRNA.
ACCESSION   NM_001033699 XM_219882
VERSION     NM_001033699.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3007)
  AUTHORS   Oquendo,C.E., Antonicka,H., Shoubridge,E.A., Reardon,W. and
            Brown,G.K.
  TITLE     Functional and genetic studies demonstrate that mutation in the
            COX15 gene can cause Leigh syndrome
  JOURNAL   J Med Genet 41 (7), 540-544 (2004)
   PUBMED   15235026
REFERENCE   2  (bases 1 to 3007)
  AUTHORS   Vitt,U., Gietzen,D., Stevens,K., Wingrove,J., Becha,S., Bulloch,S.,
            Burrill,J., Chawla,N., Chien,J., Crawford,M., Ison,C., Kearney,L.,
            Kwong,M., Park,J., Policky,J., Weiler,M., White,R., Xu,Y.,
            Daniels,S., Jacob,H., Jensen-Seaman,M.I., Lazar,J., Stuve,L. and
            Schmidt,J.
  TITLE     Identification of candidate disease genes by EST alignments,
            synteny, and expression and verification of Ensembl genes on rat
            chromosome 1q43-54
  JOURNAL   Genome Res 14 (4), 640-650 (2004)
   PUBMED   15060005
REFERENCE   3  (bases 1 to 3007)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   4  (bases 1 to 3007)
  AUTHORS   Antonicka,H., Mattman,A., Carlson,C.G., Glerum,D.M., Hoffbuhr,K.C.,
            Leary,S.C., Kennaway,N.G. and Shoubridge,E.A.
  TITLE     Mutations in COX15 produce a defect in the mitochondrial heme
            biosynthetic pathway, causing early-onset fatal hypertrophic
            cardiomyopathy
  JOURNAL   Am J Hum Genet 72 (1), 101-114 (2003)
   PUBMED   12474143
REFERENCE   5  (bases 1 to 3007)
  AUTHORS   Petruzzella,V., Tiranti,V., Fernandez,P., Ianna,P., Carrozzo,R. and
            Zeviani,M.
  TITLE     Identification and characterization of human cDNAs specific to
            BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the
            formation and function of the mitochondrial respiratory chain
  JOURNAL   Genomics 54 (3), 494-504 (1998)
   PUBMED   9878253
REFERENCE   6  (bases 1 to 3007)
  AUTHORS   Kennaway,N.G., Carrero-Valenzuela,R.D., Ewart,G., Balan,V.K.,
            Lightowlers,R., Zhang,Y.Z., Powell,B.R., Capaldi,R.A. and
            Buist,N.R.
  TITLE     Isoforms of mammalian cytochrome c oxidase: correlation with human
            cytochrome c oxidase deficiency
  JOURNAL   Pediatr Res 28 (5), 529-535 (1990)
   PUBMED   2175025
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 16, 2014 this sequence version replaced NM_001033699.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The exon combination used for the transcript
            record was based on alignment to full-length human mRNA BT007129.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.3919.1,
                                           SRR26643295.6736.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000001.1  252571326-252571471 c
            147-340             JAXUCZ010000001.1  252570007-252570200 c
            341-463             JAXUCZ010000001.1  252568173-252568295 c
            464-650             JAXUCZ010000001.1  252566387-252566573 c
            651-818             JAXUCZ010000001.1  252563174-252563341 c
            819-900             JAXUCZ010000001.1  252561857-252561938 c
            901-1055            JAXUCZ010000001.1  252560150-252560304 c
            1056-1169           JAXUCZ010000001.1  252558601-252558714 c
            1170-3007           JAXUCZ010000001.1  252554811-252556648 c
FEATURES             Location/Qualifiers
     source          1..3007
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3007
                     /gene="Cox15"
                     /note="cytochrome c oxidase assembly homolog COX15"
                     /db_xref="GeneID:309391"
                     /db_xref="RGD:1312043"
     exon            1..146
                     /gene="Cox15"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1301
                     /gene="Cox15"
                     /note="COX15 homolog, cytochrome c oxidase assembly
                     protein; cytochrome c oxidase assembly homolog 15; COX15
                     cytochrome c oxidase assembly homolog; cytochrome c
                     oxidase assembly protein COX15 homolog"
                     /codon_start=1
                     /product="COX15 homolog"
                     /protein_id="NP_001028871.2"
                     /db_xref="GeneID:309391"
                     /db_xref="RGD:1312043"
                     /translation="MQRLFLPPLKALMGSRNVGLLVPKAASRAQCGGGSYGGRRPLRP
                     GQYGTITEVALQSGKGTVSLPSRAAERAVGRWLLVCSGTVAGAVILGGVTRLTESGLS
                     MVDWHLIKEMKPPTSQEEWEAEFQKYQQFPEFKILNHDMTLAEFKFIWYMEYSHRMWG
                     RAVGLAYILPAAYFWRKGWLNRGMKGRVLALCGLVCFQGLLGWYMVKSGLEEKPESYD
                     IPRVSQYRLAAHLGSALILYCGSLWTSLSLLLPQHKIPETRQLLWLRRFAGGTAGLVF
                     LTALSGAFVAGLDAGLVYNSFPKMGESWIPEDLLTFSPILKNVFENPTMVQFDHRLLG
                     VTSVTAITMLYFLSRRIPLPRRTKMAAVTLLALAYAQVALGISTLLMYVPTPLAATHQ
                     SGSLALLSGALWLMNELRRVPK"
     exon            147..340
                     /gene="Cox15"
                     /inference="alignment:Splign:2.1.0"
     exon            341..463
                     /gene="Cox15"
                     /inference="alignment:Splign:2.1.0"
     exon            464..650
                     /gene="Cox15"
                     /inference="alignment:Splign:2.1.0"
     exon            651..818
                     /gene="Cox15"
                     /inference="alignment:Splign:2.1.0"
     exon            819..900
                     /gene="Cox15"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1055
                     /gene="Cox15"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1169
                     /gene="Cox15"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..3007
                     /gene="Cox15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagcgga ccgcagatcg ctggctggtg cgttccgcag aggctgtact gtcagtatgc
       61 aacggttgtt cctcccgccc ctcaaggcct tgatggggag ccgcaatgtc gggctcctgg
      121 tccctaaggc ggcatctaga gcacagtgtg gcggcggcag ctatggcggc aggcgtcctc
      181 tgaggccagg gcagtacggc accatcactg aagtggcttt gcaatctgga aaaggcacag
      241 tgtcccttcc ttcgagggca gccgagcggg cagtgggccg atggctcctg gtgtgcagtg
      301 gaacagtggc tggagcagtt attcttggag gagtgaccag gctgacggag tctggcctct
      361 caatggtaga ctggcattta ataaaggaga tgaagccacc cacaagccag gaagaatggg
      421 aagcggagtt ccaaaagtac cagcaatttc cggaatttaa aatcctgaat catgacatga
      481 cactggcgga attcaagttt atctggtaca tggaatactc acaccggatg tggggtcgag
      541 ctgtaggcct tgcatacatc ctgcctgctg cctacttttg gagaaagggt tggctcaacc
      601 gtggcatgaa aggacgtgtt cttgccctct gtggcttagt ctgtttccag ggtctgttgg
      661 gttggtatat ggtgaaaagt ggattagaag aaaaaccaga gtcctatgac atccctcggg
      721 tcagtcagta ccgcctcgca gcccacctgg ggtcagcact gattctctac tgtggcagcc
      781 tgtggacctc cctgtcactg ctactgcctc agcacaagat accggaaacc cgacagctcc
      841 tgtggctgag acgctttgct ggtggaacag caggcctggt gttcctcaca gctctctcag
      901 gggcttttgt ggcagggctg gatgctgggc tcgtttacaa ctccttcccc aaaatgggag
      961 aatcttggat cccagaggac ctcctgacct tctctcccat cctgaagaat gtttttgaga
     1021 atcctactat ggttcagttt gatcaccggc ttctgggagt cacgtctgtc actgccatta
     1081 caatgctcta tttcctgtcc cggagaatcc cccttcctcg aagaaccaag atggcagcgg
     1141 tgactctgct agctttggca tatgcacagg tggccttggg catcagcact ctgcttatgt
     1201 atgtgccaac tccgctggct gccacacacc agtcaggctc cttggctctg ctcagtggtg
     1261 ccctttggct catgaatgaa ctccgaagag ttccaaaata attctccaag gatcgtttcc
     1321 taggactgga actgccctgg gaattcatca ccaagaacaa gaccttttcg ggtcttttca
     1381 ggacggtggt attgacaggc cacggtttcc aaattggtca ggtcattcag aacttttaag
     1441 gtgggcactg aatcaagaat gtcactaagg tgttcttata ccagaggttt cctttaaaac
     1501 aactgttgca taaacaagca tctgtcattt gctgcttaat atgcagtctg atgtcttaga
     1561 gctcggtttc tatgtgctgc agactcctgt ccacttgtca agctggtggt gacagtgaca
     1621 gactcaagaa cacaagcccc aatggagtta ctcaaccaat ggaatggtga ctgaatgttg
     1681 gtttgttacc aaggtgtagg gttgtcattg tttctggttt ttataagcag ctaactagct
     1741 aactagctaa ctagctaggt ttttgaagtg aacattctct tatgtatatg tgtgtttgta
     1801 ttaatatatg ccatgtgtat gaaggagccc atggaggcca aggaaggtac tgggtcccta
     1861 gagctggagt tataggtgac tttgacatgc ctgatgtggg tgctagtaac caagcacagt
     1921 cctctggaag agcagcaggc acttctaact gagccatctc tccagccctg gagtaaatat
     1981 catgaaaatt acatgttgac aatttcaatt tttttttttt tttttttttt tttggttctt
     2041 tttttcggag ctggggaccg aacccagggc cttgtgcttc ctaggcaagc gctcaaccac
     2101 tgagctaaat ccccaacccg acaatttcaa tttttaaaaa acatgtctga cctgaggttg
     2161 cacatttgca gtttttgaac aagataatca ggtttttatg gtttttgggt tttttgtttt
     2221 tgtttttaac tctaataatt attctgagtc tcagtgtatc ctaaagagta ctgatcttag
     2281 ctagttttag caaaaacaat gacataggca ttttactctc cgagtcccag gccctgttgg
     2341 gctgtgttat tgcacaaaag aggctccctt cacctcagaa ctcaggactc ctcctagacc
     2401 ccacgaaatc accaggcctc atctaacctg ttagccctgt ctgttggccg gcagggtaga
     2461 cgctcttcta gacagaaccc cttcgaggag aggaccaggg cagcttgcag accacctgct
     2521 tcccatctct aaatccagtc ttcggtgaga agcagacagc agagggaagg agggaccaac
     2581 caaagatcac atgacggttt tatggccacc ccaagcacgt ggcaacccga gttggctcaa
     2641 gtctcagatg ttttgctgca tttatttttg actacagtta agcatgttca gaacagatcc
     2701 agtatttagc tgtttaactg gattatggtt tctgtatggt cctggtgaag agagatcatc
     2761 gtaactattt ttgttatctg tataattcac tgacaccatt tatataccaa atactgaatg
     2821 aagaaagcat gaattggtgg aaatatatga ttattgattt atgccccaaa tgtctatttc
     2881 agaaaaagcc attgcacact taaaggatta aataatttcc tttaatgttt tcaacagtct
     2941 gtcaacagtt ctgtcaattg tttttaaatt ataaaggtaa ttaaaatatg tattttcagt
     3001 cagctaa
//
