LOCUS       NM_001398997            2850 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus cytochrome c oxidase assembly factor heme
            A:farnesyltransferase COX10 (Cox10), mRNA.
ACCESSION   NM_001398997 XM_006246833
VERSION     NM_001398997.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2850)
  AUTHORS   Diaz,F., Fukui,H., Garcia,S. and Moraes,C.T.
  TITLE     Cytochrome c oxidase is required for the assembly/stability of
            respiratory complex I in mouse fibroblasts
  JOURNAL   Mol Cell Biol 26 (13), 4872-4881 (2006)
   PUBMED   16782876
REFERENCE   2  (bases 1 to 2850)
  AUTHORS   Diaz,F., Thomas,C.K., Garcia,S., Hernandez,D. and Moraes,C.T.
  TITLE     Mice lacking COX10 in skeletal muscle recapitulate the phenotype of
            progressive mitochondrial myopathies associated with cytochrome c
            oxidase deficiency
  JOURNAL   Hum Mol Genet 14 (18), 2737-2748 (2005)
   PUBMED   16103131
REFERENCE   3  (bases 1 to 2850)
  AUTHORS   Williams,S.L., Valnot,I., Rustin,P. and Taanman,J.W.
  TITLE     Cytochrome c oxidase subassemblies in fibroblast cultures from
            patients carrying mutations in COX10, SCO1, or SURF1
  JOURNAL   J Biol Chem 279 (9), 7462-7469 (2004)
   PUBMED   14607829
REFERENCE   4  (bases 1 to 2850)
  AUTHORS   Antonicka,H., Leary,S.C., Guercin,G.H., Agar,J.N., Horvath,R.,
            Kennaway,N.G., Harding,C.O., Jaksch,M. and Shoubridge,E.A.
  TITLE     Mutations in COX10 result in a defect in mitochondrial heme A
            biosynthesis and account for multiple, early-onset clinical
            phenotypes associated with isolated COX deficiency
  JOURNAL   Hum Mol Genet 12 (20), 2693-2702 (2003)
   PUBMED   12928484
REFERENCE   5  (bases 1 to 2850)
  AUTHORS   Valnot,I., von Kleist-Retzow,J.C., Barrientos,A., Gorbatyuk,M.,
            Taanman,J.W., Mehaye,B., Rustin,P., Tzagoloff,A., Munnich,A. and
            Rotig,A.
  TITLE     A mutation in the human heme A:farnesyltransferase gene (COX10)
            causes cytochrome c oxidase deficiency
  JOURNAL   Hum Mol Genet 9 (8), 1245-1249 (2000)
   PUBMED   10767350
REFERENCE   6  (bases 1 to 2850)
  AUTHORS   Glerum,D.M. and Tzagoloff,A.
  TITLE     Isolation of a human cDNA for heme A:farnesyltransferase by
            functional complementation of a yeast cox10 mutant
  JOURNAL   Proc Natl Acad Sci U S A 91 (18), 8452-8456 (1994)
   PUBMED   8078902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 29, 2021 this sequence version replaced XM_006246833.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2758450.1,
                                           SRR26643289.28029.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000010.1  49241883-49242009   c
            128-261             JAXUCZ010000010.1  49236208-49236341   c
            262-577             JAXUCZ010000010.1  49234447-49234762   c
            578-702             JAXUCZ010000010.1  49209283-49209407   c
            703-773             JAXUCZ010000010.1  49159864-49159934   c
            774-1006            JAXUCZ010000010.1  49142613-49142845   c
            1007-2850           JAXUCZ010000010.1  49130209-49132052   c
FEATURES             Location/Qualifiers
     source          1..2850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q23"
     gene            1..2850
                     /gene="Cox10"
                     /note="cytochrome c oxidase assembly factor heme
                     A:farnesyltransferase COX10"
                     /db_xref="GeneID:691853"
                     /db_xref="RGD:1594623"
     exon            1..127
                     /gene="Cox10"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1413
                     /gene="Cox10"
                     /note="COX10 homolog, cytochrome c oxidase assembly
                     protein, heme A: farnesyltransferase; cytochrome c oxidase
                     assembly homolog 10; protoheme IX farnesyltransferase,
                     mitochondrial; COX10 heme A:farnesyltransferase cytochrome
                     c oxidase assembly factor"
                     /codon_start=1
                     /product="cytochrome c oxidase assembly factor heme
                     A:farnesyltransferase COX10"
                     /protein_id="NP_001385926.1"
                     /db_xref="GeneID:691853"
                     /db_xref="RGD:1594623"
                     /translation="MAASPHTISSRLLTGSVGRSVWYLERRAIQGLPHRVTRLFRNVT
                     NQWVTVQHLSFLKRMYVTQLHRGLNQRVKPKPAPPASPLLEHTSSGQARAEVDELPPF
                     PAPSLPLSQKPNELMELEATSIVDHSLDTAKEQKEERQWKEMKLHTDDLPGILARLSK
                     IKLTALVVSTTSAGFALAPCPFDWSCFLLTSLGTGLASCAANSINQFFEVPFDSNMSR
                     TKNRPLVRGQISPLLAVSFATCCAVPGVALLTWGVNPLTGALGVFNIFLYTCCYTPLK
                     RVSIANTWVGAVVGAIPPVMGWTAATGSLDAGALLLGGILYSWQFPHFNALSWGLRED
                     YSRGGYCMMSVTHPALCRRVALRHCLALIALSTTAPVLDITTWVFPVISLPINLYISY
                     LGFRFYVDADRKSSRKLFFCSLWHLPLLLLLMLTCKQRPGQEGDKGEAPS"
     exon            128..261
                     /gene="Cox10"
                     /inference="alignment:Splign:2.1.0"
     exon            262..577
                     /gene="Cox10"
                     /inference="alignment:Splign:2.1.0"
     exon            578..702
                     /gene="Cox10"
                     /inference="alignment:Splign:2.1.0"
     exon            703..773
                     /gene="Cox10"
                     /inference="alignment:Splign:2.1.0"
     exon            774..1006
                     /gene="Cox10"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..2850
                     /gene="Cox10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgggcta acaagatggc ggcgcccagg agccggtgag gtgagaggac gctggggtcc
       61 tggggactgc tgcaccagtg cgttatggcc gcgtccccgc acactatttc ctcgcgcctc
      121 ctcacaggct cagtaggacg aagtgtctgg tatttagaga gaagagctat acagggattg
      181 ccacacaggg tcacacgtct gttcaggaat gtcactaatc agtgggtcac ggttcagcac
      241 ttgagcttcc tcaagcgcat gtatgtcaca cagctgcaca ggggccttaa ccagcgagtc
      301 aaaccaaaac cagcgccgcc ggcttctcct cttcttgagc acacatcttc agggcaggct
      361 agagcagaag tggatgagct gccacctttc ccagcaccca gtctgcctct gtcccagaag
      421 ccaaatgagt tgatggagct ggaggcgacc tccatagtgg accattccct cgacacagcc
      481 aaagagcaaa aggaagaaag gcagtggaaa gagatgaagc ttcacaccga tgatctgcct
      541 ggcattttgg cccggctgtc caagatcaaa ctcacagctc ttgtggtaag caccacttca
      601 gcaggctttg cactggctcc atgcccattc gactggtcct gcttcctgct cacttccctt
      661 ggaaccggcc tcgcatcctg tgctgccaac tccatcaatc agttttttga ggtgccgttt
      721 gactcaaaca tgagtagaac aaagaacaga cctctggttc gtggacagat cagcccactg
      781 ctagccgtgt cttttgccac ctgctgtgct gtaccaggag tggccctgtt gacctgggga
      841 gtgaatccac tgaccggggc cttgggggtc ttcaacattt tcctgtatac ttgttgttac
      901 acaccactga agagggtcag catcgccaat acctgggttg gagccgtggt tggtgccatt
      961 cctcctgtca tgggctggac agctgccact ggaagcctcg atgctggagc acttcttctg
     1021 ggagggatcc tgtactcctg gcagttcccc cacttcaacg ccctgagctg gggcctccgt
     1081 gaagactact cccgaggagg ctactgcatg atgtctgtca cccacccagc cctctgccgg
     1141 cgggtggccc tgcgccactg cctggccctg attgctttgt cgactactgc ccctgtcctg
     1201 gacatcacca catgggtctt ccctgtcatc tccctcccta tcaacctgta catctcctac
     1261 ctcggcttcc gcttctatgt ggacgcggac cgcaagagct caaggaaact gttcttctgt
     1321 agcctgtggc acctgcccct gctcctgctg ctcatgctca cctgtaagca gcggccaggt
     1381 caggaggggg acaagggaga ggctccgagc tgaaaggcag ccagtctgtg gggaccatga
     1441 gagcagacac atgcagacac acgcaggtac agcactgccc cgggccagca ggaagggtat
     1501 tgtggttcca gcaagagggg aactgagtgg tgtcatctgg tgctgtgtct tcacttacca
     1561 gtgcttttaa tgtcagtcag actgcttccc agataagaaa ggactagcat acggagtcag
     1621 tacagaagaa gaagatttct tctcctcaaa ggtctttatg caccttttcc tccagccctg
     1681 tgttctctcc ctcacatgat gtatatgcac atcttcctcc ccatccccac cccagtcccc
     1741 cccccacaca cacatacccc acctggaggc caccatggtc gttgctcaac caggcaagtg
     1801 cttgtgaccc caacctctga agtcctgcat cctgaaggtc ctatacactg cctcagaaga
     1861 acacatagtt tggctacagc accccttctc ggccagtgag atggggcctg actagctttc
     1921 cctacctacc agtgttctca accgtgaatt ccctcaagta tcagaactcc ttgcctgggc
     1981 tgctcaccgg gagtgaggat tccaaacagt tgcctgtgga atcccaggct gcgttgccag
     2041 cacccaccat cacttcaatc ccaccccata tcaggacttc agaaacccca ggagacacac
     2101 cgcatgttca tcattctctc aggcgtggtc taagcatttc tttgtggaag ggcatcactc
     2161 agcataatct gagggagagg gtgaactggg tcagcagcca ttttgcgccc attcttatcc
     2221 cttttgtgca aaccacattt ccacactttg cctcctgagt ccagaaattg gcctctgtgc
     2281 ccagtggtat tcagagaggg ccagctgggc tcctagtggc catgagtcca gttctgggac
     2341 ttcatggcct ctaatagaaa atgcaggtac ctgtaagtcg tcagtctgtt gtgtactccc
     2401 tcaggcccac agagaggaat gttgccttaa aattgtggag cttggcagtg tttgagtcaa
     2461 tgatctccca gggtactgtg ccctgtcagg attccttcaa ggggtggttt aaaccacgtg
     2521 aaaaacggtt cttgaatttg gactattctt aaaatgtgga aggcttgagc catggctcaa
     2581 agggagagca cttgcttagc tctggactca gggtttgaac tcaagcaaaa caaaaaagag
     2641 ggggtgggga gtaggattgt gtctagagcg actgcggaca gggtgcctgg tacctctttc
     2701 tacctattgt aaccttacct cctggctgtt tcctgtggga acagggactg aggatgtctg
     2761 caaagagcat ctaggacttg ttgtagcttt taagcctgta aagtgttgat tctcctcctc
     2821 ctgtaataaa acagttaccg gagaatacaa
//
