LOCUS       NM_001108452            1618 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus coactosin-like F-actin binding protein 1 (Cotl1),
            mRNA.
ACCESSION   NM_001108452 XM_001078708 XM_341700
VERSION     NM_001108452.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Xia,L., Xiao,X., Liu,W.L., Song,Y., Liu,T.J.J., Li,Y.J.,
            Zacksenhaus,E., Hao,X.J. and Ben-David,Y.
  TITLE     Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth
            through activation of IL-24/PERP and inhibition of non-canonical
            TGFbeta signaling
  JOURNAL   Oncogene 37 (3), 323-331 (2018)
   PUBMED   28925397
  REMARK    GeneRIF: Study uncovers a novel tumor-suppressor role for CLP/Cotl1
            and identify the downstream effectors interleukin 24 (IL-24)/PERP
            and IL-24/MAPK/ERK/TGF-beta.
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Doucet,J., Provost,P., Samuelsson,B. and Radmark,O.
  TITLE     Molecular cloning and functional characterization of mouse
            coactosin-like protein
  JOURNAL   Biochem Biophys Res Commun 290 (2), 783-789 (2002)
   PUBMED   11785969
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Provost,P., Doucet,J., Stock,A., Gerisch,G., Samuelsson,B. and
            Radmark,O.
  TITLE     Coactosin-like protein, a human F-actin-binding protein: critical
            role of lysine-75
  JOURNAL   Biochem J 359 (Pt 2), 255-263 (2001)
   PUBMED   11583571
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   Provost,P., Doucet,J., Hammarberg,T., Gerisch,G., Samuelsson,B. and
            Radmark,O.
  TITLE     5-Lipoxygenase interacts with coactosin-like protein
  JOURNAL   J Biol Chem 276 (19), 16520-16527 (2001)
   PUBMED   11297527
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341700.3, XM_001078708.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158746.1, FQ232981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155323, SAMN06680423
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1618
                     /gene="Cotl1"
                     /gene_synonym="Clp"
                     /note="coactosin-like F-actin binding protein 1"
                     /db_xref="GeneID:361422"
                     /db_xref="RGD:1305498"
     exon            1..242
                     /gene="Cotl1"
                     /gene_synonym="Clp"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..594
                     /gene="Cotl1"
                     /gene_synonym="Clp"
                     /note="coactosin-like 1"
                     /codon_start=1
                     /product="coactosin-like protein"
                     /protein_id="NP_001101922.1"
                     /db_xref="GeneID:361422"
                     /db_xref="RGD:1305498"
                     /translation="MATKIDKEACRAAYNLVRDDGSSVIWVTFKYDGATIVPGDQGAD
                     YQHFIQQCTDDVRLFAFVRFTTGDAMSKRSKFALITWIGEDVSGLQRAKTGTDKTLVK
                     EVVQNFAKEFVISDRKELEEDFIRSELKKAGGANYDAQSE"
     exon            243..325
                     /gene="Cotl1"
                     /gene_synonym="Clp"
                     /inference="alignment:Splign:2.1.0"
     exon            326..483
                     /gene="Cotl1"
                     /gene_synonym="Clp"
                     /inference="alignment:Splign:2.1.0"
     exon            484..1618
                     /gene="Cotl1"
                     /gene_synonym="Clp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccggcgcg cgctccggct ctgcagtaac cgcgggcccc tctccgagga ccttagcttg
       61 caattgcgag cggccaccac cccctgctca ctctcggagc ccgctcgacc ctcgcagcgg
      121 atcagggacg cattcactgg ttccggcagt gtcctcgcgg cggccatggc cacgaagatc
      181 gacaaggagg cgtgtcgcgc ggcgtacaac ttagtgcggg acgacggctc gtcggtcatc
      241 tgggtgactt ttaaatacga cggtgccacc attgtccccg gcgatcaggg agcggattac
      301 cagcacttca tccagcagtg cacagatgac gtccggctgt tcgccttcgt gcgcttcacc
      361 accggcgacg ccatgagcaa aaggtccaag tttgccctca tcacgtggat cggagaggac
      421 gtgagtgggc tgcagcgtgc caagacgggg acagacaaga cgctggtgaa ggaggtggtc
      481 cagaattttg ccaaggagtt tgtgatcagc gatcggaagg agctagagga agacttcatc
      541 aggagcgagc tgaagaaggc tggaggagcc aattacgatg ctcagtcaga gtagctgcag
      601 ccccacaccc cagagccatc tgcctgctcc accgaggagg agactgccac ctcacgtcac
      661 cagcccaccg gggaggagaa gccatgagag gcaccagtgc caccattgtg tccagccccc
      721 tccctctccc ctctccccct cccttccctc ctcccctctg tggcccctct caggctcaca
      781 gagcatcatt ctttgagacc ccgccccctt tttgttttaa aggaaagtcc ttttggtgcc
      841 agggtcacac acatcatcat atcccgggtg cctctctgtc actagccctt gacctggcat
      901 tacccctgcc ttcagtggct tgcctggtct aagctaccct ggccttgagt tacctggtgc
      961 catcccagct taccctggct gtttcctgct agccccatgc cggccaccat gccaggcgct
     1021 gtgcacactc cacagccttc atgagctcac gcatgctcct cagaacccgt ggacttggct
     1081 ccaggcccca cccctgccct gttcagagtg gcctaagctc taagtctggt agatactgct
     1141 tggcaataac agatttaggt ctggcgtgga ccgaatatga agtgacaaat ttgccttaaa
     1201 tcttgcctgg cagtggctcc gcccacgtgg tctaaactac ccttttggtg aagcccttct
     1261 gaagcatgag aggtctgagt ccggctgtgg tgagagtttc agggtcaacc tcagggcctc
     1321 aaggatgaca aaggatggaa aggtcccctg cagacaggga ggctggcaca ggcctcaggg
     1381 cacctggaag gcagctacgg ttggaatctt agtctgcaaa ttccaaagat ggcttcgttt
     1441 gcttttaaag aaagctgagg cgggcttggc tcctcaggag caggtgaaga cggttctttt
     1501 ccttcctcct cgctcttact actctgggga agaatgctgc accgggctgg gctgtgagga
     1561 ccgcctctgg cattccaaca gtttacagaa gtaaatgtgt ttttcaagaa aaatgaat
//
