LOCUS       NM_012835                438 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cortistatin (Cort), mRNA.
ACCESSION   NM_012835
VERSION     NM_012835.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 438)
  AUTHORS   Liu,Y., Lin,F., Fu,Y., Chen,W., Liu,W., Chi,J., Zhang,X. and Yin,X.
  TITLE     Cortistatin inhibits arterial calcification in rats via
            GSK3beta/beta-catenin and protein kinase C signalling but not c-Jun
            N-terminal kinase signalling
  JOURNAL   Acta Physiol (Oxf) 223 (3), e13055 (2018)
   PUBMED   29436118
  REMARK    GeneRIF: inhibits aortic calcification and osteogenic
            differentiation of vascular smooth muscle cells likely via the
            GSK3beta/beta-catenin and PKC signalling pathways, but not JNK
            signalling pathway
REFERENCE   2  (bases 1 to 438)
  AUTHORS   Yue,M., Xia,Y., Shi,C., Guan,C., Li,Y., Liu,R., Wei,Z. and Dai,Y.
  TITLE     Berberine ameliorates collagen-induced arthritis in rats by
            suppressing Th17 cell responses via inducing cortistatin in the gut
  JOURNAL   FEBS J 284 (17), 2786-2801 (2017)
   PUBMED   28636167
  REMARK    GeneRIF: Oral berberine exerted anti-arthritic effect through
            inhibiting the Th17 cell response, which was closely associated
            with the induction of cortistatin generation from gut through
            augmenting autocrine/paracrine action between enteric nerve cells
            and endocrine cells.
REFERENCE   3  (bases 1 to 438)
  AUTHORS   Liu,Y., Lin,F., Fu,Y., Chen,W., Liu,W., Chi,J., Zhang,X. and Yin,X.
  TITLE     Cortistatin inhibits calcification of vascular smooth muscle cells
            by depressing osteoblastic differentiation and endoplasmic
            reticulum stress
  JOURNAL   Amino Acids 48 (11), 2671-2681 (2016)
   PUBMED   27480534
  REMARK    GeneRIF: CST directly inhibited beta-GP-induced calcification of
            VSMCs in vitro, probably by suppressing ERS and phenotypic
            transformation of VSMCs into osteoblastic cells.
REFERENCE   4  (bases 1 to 438)
  AUTHORS   Chen,X.M., Xia,J., Zhou,T., Yuan,Q., Zhang,W.F., Hu,C.P., Li,Y.J.
            and Jiang,J.L.
  TITLE     Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid
            arthritis in rats
  JOURNAL   Int Immunopharmacol 16 (2), 322-331 (2013)
   PUBMED   23619555
  REMARK    GeneRIF: The DDAH/asymmetric dimethylarginine pathway participates
            in the pathogenesis of rheumatoid arthritis and may be mediated by
            cortistatin.
REFERENCE   5  (bases 1 to 438)
  AUTHORS   Buga,A.M., Scholz,C.J., Kumar,S., Herndon,J.G., Alexandru,D.,
            Cojocaru,G.R., Dandekar,T. and Popa-Wagner,A.
  TITLE     Identification of new therapeutic targets by genome-wide analysis
            of gene expression in the ipsilateral cortex of aged rats after
            stroke
  JOURNAL   PLoS One 7 (12), e50985 (2012)
   PUBMED   23251410
REFERENCE   6  (bases 1 to 438)
  AUTHORS   Xidakis,C., Mastrodimou,N., Notas,G., Renieri,E., Kolios,G.,
            Kouroumalis,E. and Thermos,K.
  TITLE     RT-PCR and immunocytochemistry studies support the presence of
            somatostatin, cortistatin and somatostatin receptor subtypes in rat
            Kupffer cells
  JOURNAL   Regul Pept 143 (1-3), 76-82 (2007)
   PUBMED   17481746
  REMARK    GeneRIF: RT-PCR and immunocytochemistry studies support the
            presence of cortistatin in rat Kupffer cells.
REFERENCE   7  (bases 1 to 438)
  AUTHORS   Robas,N., Mead,E. and Fidock,M.
  TITLE     MrgX2 is a high potency cortistatin receptor expressed in dorsal
            root ganglion
  JOURNAL   J Biol Chem 278 (45), 44400-44404 (2003)
   PUBMED   12915402
REFERENCE   8  (bases 1 to 438)
  AUTHORS   Deghenghi,R., Avallone,R., Torsello,A., Muccioli,G., Ghigo,E. and
            Locatelli,V.
  TITLE     Growth hormone-inhibiting activity of cortistatin in the rat
  JOURNAL   J Endocrinol Invest 24 (11), RC31-RC33 (2001)
   PUBMED   11817718
REFERENCE   9  (bases 1 to 438)
  AUTHORS   Fukusumi,S., Kitada,C., Takekawa,S., Kizawa,H., Sakamoto,J.,
            Miyamoto,M., Hinuma,S., Kitano,K. and Fujino,M.
  TITLE     Identification and characterization of a novel human
            cortistatin-like peptide
  JOURNAL   Biochem Biophys Res Commun 232 (1), 157-163 (1997)
   PUBMED   9125122
REFERENCE   10 (bases 1 to 438)
  AUTHORS   de Lecea,L., Criado,J.R., Prospero-Garcia,O., Gautvik,K.M.,
            Schweitzer,P., Danielson,P.E., Dunlop,C.L., Siggins,G.R.,
            Henriksen,S.J. and Sutcliffe,J.G.
  TITLE     A cortical neuropeptide with neuronal depressant and
            sleep-modulating properties
  JOURNAL   Nature 381 (6579), 242-245 (1996)
   PUBMED   8622767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U51919.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51919.1, BI281700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..438
                     /gene="Cort"
                     /note="cortistatin"
                     /db_xref="GeneID:25305"
                     /db_xref="RGD:2383"
     exon            1..155
                     /gene="Cort"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..368
                     /gene="Cort"
                     /note="Preprocortistatin"
                     /codon_start=1
                     /product="cortistatin preproprotein"
                     /protein_id="NP_036967.1"
                     /db_xref="GeneID:25305"
                     /db_xref="RGD:2383"
                     /translation="MGGCSTRGKRPSALSLLLLLLLSGIAASALPLESGPTGQDSVQD
                     ATGGRRTGLLTFLAWWHEWASQDSSSTAFEGGTPELSKRQERPPLQQPPHRDKKPCKN
                     FFWKTFSSCK"
     exon            156..438
                     /gene="Cort"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcacaga cttcaggtct ccaaggagga tgggtggctg cagcacaaga ggcaagcggc
       61 cgtcagccct cagtctgctg ctgctgctgc tgctctcggg gatcgcagcc tctgccctcc
      121 ccctggagag cggtcccacc ggccaggaca gtgtgcagga tgccacaggc gggaggagga
      181 ccggccttct gactttcctt gcctggtggc atgagtgggc ttcccaagac agctccagca
      241 ccgctttcga agggggtacc ccggagctgt ctaagcggca ggaaagacca cccctccagc
      301 agcccccaca ccgggataaa aagccctgca agaacttctt ctggaaaacc ttctcctcgt
      361 gcaagtagcc cgagcctgac cggagcctga ccggccaccc tgtgaatgca gccgtggcct
      421 gaataaagag tgtcaagt
//
