LOCUS       NM_019222               1796 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus coronin 1B (Coro1b), mRNA.
ACCESSION   NM_019222
VERSION     NM_019222.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1796)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1796)
  AUTHORS   Usatyuk,P.V., Burns,M., Mohan,V., Pendyala,S., He,D.,
            Ebenezer,D.L., Harijith,A., Fu,P., Huang,L.S., Bear,J.E.,
            Garcia,J.G. and Natarajan,V.
  TITLE     Coronin 1B regulates S1P-induced human lung endothelial cell
            chemotaxis: role of PLD2, protein kinase C and Rac1 signal
            transduction
  JOURNAL   PLoS One 8 (5), e63007 (2013)
   PUBMED   23667561
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1796)
  AUTHORS   Williams,H.C., San Martin,A., Adamo,C.M., Seidel-Rogol,B.,
            Pounkova,L., Datla,S.R., Lassegue,B., Bear,J.E. and Griendling,K.
  TITLE     Role of coronin 1B in PDGF-induced migration of vascular smooth
            muscle cells
  JOURNAL   Circ Res 111 (1), 56-65 (2012)
   PUBMED   22619279
  REMARK    GeneRIF: Suggest that phosphorylation of Coro1B and the subsequent
            reduced interaction with ARP2/3 complex participate in PDGF-induced
            VSMC migration, an important step in vascular lesion formation.
REFERENCE   4  (bases 1 to 1796)
  AUTHORS   Chan,K.T., Roadcap,D.W., Holoweckyj,N. and Bear,J.E.
  TITLE     Coronin 1C harbours a second actin-binding site that confers
            co-operative binding to F-actin
  JOURNAL   Biochem J 444 (1), 89-96 (2012)
   PUBMED   22364218
REFERENCE   5  (bases 1 to 1796)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 1796)
  AUTHORS   Cai,L., Makhov,A.M., Schafer,D.A. and Bear,J.E.
  TITLE     Coronin 1B antagonizes cortactin and remodels Arp2/3-containing
            actin branches in lamellipodia
  JOURNAL   Cell 134 (5), 828-842 (2008)
   PUBMED   18775315
REFERENCE   7  (bases 1 to 1796)
  AUTHORS   Cai,L., Makhov,A.M. and Bear,J.E.
  TITLE     F-actin binding is essential for coronin 1B function in vivo
  JOURNAL   J Cell Sci 120 (Pt 10), 1779-1790 (2007)
   PUBMED   17456547
  REMARK    GeneRIF: F-actin binding is absolutely required for coronin 1B to
            exert its effects on whole-cell motility and lamellipodial
            dynamics.
REFERENCE   8  (bases 1 to 1796)
  AUTHORS   Cai,L., Marshall,T.W., Uetrecht,A.C., Schafer,D.A. and Bear,J.E.
  TITLE     Coronin 1B coordinates Arp2/3 complex and cofilin activities at the
            leading edge
  JOURNAL   Cell 128 (5), 915-929 (2007)
   PUBMED   17350576
  REMARK    GeneRIF: Study concludes that Coronin 1B's coordination of filament
            formation by Arp2/3 complex and filament turnover by Cofilin is
            required for effective lamellipodial protrusion and cell migration.
REFERENCE   9  (bases 1 to 1796)
  AUTHORS   Cai,L., Holoweckyj,N., Schaller,M.D. and Bear,J.E.
  TITLE     Phosphorylation of coronin 1B by protein kinase C regulates
            interaction with Arp2/3 and cell motility
  JOURNAL   J Biol Chem 280 (36), 31913-31923 (2005)
   PUBMED   16027158
REFERENCE   10 (bases 1 to 1796)
  AUTHORS   Gatfield,J., Albrecht,I., Zanolari,B., Steinmetz,M.O. and
            Pieters,J.
  TITLE     Association of the leukocyte plasma membrane with the actin
            cytoskeleton through coiled coil-mediated trimeric coronin 1
            molecules
  JOURNAL   Mol Biol Cell 16 (6), 2786-2798 (2005)
   PUBMED   15800061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019222.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ006064.1, SRR26360176.784634.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                JAXUCZ010000001.1  210872561-210872580
            21-223              JAXUCZ010000001.1  210873218-210873420
            224-346             JAXUCZ010000001.1  210873739-210873861
            347-476             JAXUCZ010000001.1  210873966-210874095
            477-658             JAXUCZ010000001.1  210874311-210874492
            659-778             JAXUCZ010000001.1  210874578-210874697
            779-883             JAXUCZ010000001.1  210875243-210875347
            884-1029            JAXUCZ010000001.1  210875428-210875573
            1030-1087           JAXUCZ010000001.1  210876366-210876423
            1088-1351           JAXUCZ010000001.1  210877062-210877325
            1352-1796           JAXUCZ010000001.1  210877432-210877876
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1796
                     /gene="Coro1b"
                     /note="coronin 1B"
                     /db_xref="GeneID:29474"
                     /db_xref="RGD:2382"
     exon            1..20
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
     exon            21..223
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1477
                     /gene="Coro1b"
                     /note="coronin-2; coronin, actin-binding protein, 1B"
                     /codon_start=1
                     /product="coronin-1B"
                     /protein_id="NP_062095.2"
                     /db_xref="GeneID:29474"
                     /db_xref="RGD:2382"
                     /translation="MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVN
                     PKFLAVIVEASGGGAFMVLPLNKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGS
                     EDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIITWHPTARNVLLSAGCDNVVLIW
                     NVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEREKAH
                     EGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENFEEPMALQELDSSNGALLPFYD
                     PDTSVVYVCGKGDSSIRYFEITDEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEI
                     ARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTAGPDAALEAEDWVSGQDADPILISL
                     REAYVPSKQRDLKVSRRNVLSDSKPAGYSRSGVSTATAITDIPSGNLAGSGEAGKLEE
                     VMQELRALRVLVKEQGERISRLEEHLGRMENGDT"
     exon            224..346
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
     exon            347..476
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
     exon            477..658
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
     exon            659..778
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
     exon            779..883
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1029
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1087
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1351
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1796
                     /gene="Coro1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcggaga gcggtgagcg acatgtcctt ccgaaaagtt gtgcggcaga gcaaattccg
       61 gcatgtattt ggtcagccag tcaagaatga ccagtgctat gaggacattc gagtctcccg
      121 agttacctgg gacagtacct tctgcgcagt caaccccaag ttcctggcag tgattgtgga
      181 agccagtggt gggggtgcct ttatggtgct ccctctaaac aagacaggcc gcattgacaa
      241 ggcctaccca acagtgtgtg ggcacacagg acctgttctg gatattgact ggtgccccca
      301 caatgacgaa gtcattgcca gtggatcaga ggactgcact gtcatggtgt ggcagattcc
      361 agagaatggg ctgacctccc ctctgacaga gccagtagtg gtgcttgagg ggcataccaa
      421 gcgtgtgggc atcatcacct ggcaccccac agcccgaaat gtgcttctca gtgcaggttg
      481 tgacaatgtg gtgcttatct ggaatgtggg cactgcagag gagctgtacc gcctagacag
      541 cttgcaccct gacctcatct acaatgtgag ctggaaccac aacggcagcc tcttttgcac
      601 agcttgcaag gacaagagtg tccgaatcat cgatcccagg cggggcaccc tggtggcaga
      661 acgggagaag gctcatgagg gggctcggcc catgcgggcc atctttctgg ctgatgggaa
      721 ggtgttcacc actggtttca gccgcatgag tgaacggcaa ctggcactct gggacccaga
      781 aaactttgag gagcccatgg ccctgcagga gctggattca agcaatgggg ctctactgcc
      841 tttctatgac ccggacacca gtgtggtcta cgtctgtggc aagggtgatt ccagcatccg
      901 gtactttgag atcacagatg aacctcccta catccacttt ctgaatacct ttaccagcaa
      961 agaaccccag aggggtatgg gcagcatgcc taagaggggc ttggaggtca gcaagtgtga
     1021 aattgccagg ttctacaaac tgcatgaacg caagtgtgag cccatagtaa tgactgtgcc
     1081 aagaaagtct gacctctttc aggatgatct gtaccctgac acagccggac ccgatgctgc
     1141 tcttgaggca gaggattggg ttagtggtca ggatgctgat ccaatcctca tctcactacg
     1201 ggaagcctat gtgcccagta aacaacggga cctgaaggtc agccggcgca acgtgctatc
     1261 ggacagcaag cctgccggtt acagccgctc cggagtctcc acagctactg caattactga
     1321 cattcccagt ggcaaccttg ctgggtctgg tgaagctggg aagctggaag aggtgatgca
     1381 ggagcttcgg gcacttcggg tgctggtcaa ggaacaaggg gagcgtatca gccgcctgga
     1441 ggagcatctg ggccgcatgg agaatgggga tacataggac caccagggac ctgctcccga
     1501 tactgcctcc ttctcctcca acccttccca cctagcttct gtggccaggt cacaccaggc
     1561 agtttgctgc tcagtgcctc tgtggcaggt catggccagt ttgcacctct ccacagcctg
     1621 gggcccaggt tggaagcacc acctggcttt tggaagattt ttgtaccaag gcaaattccc
     1681 aagtactcta agggaccatc tcctcgactt gcccaaccca ctgccccctc actagaaaaa
     1741 gcagcagaga tgggttctat attttcattc caaataaaat gctctttcta aagcca
//
