LOCUS       XM_008770139            5322 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus corin, serine peptidase (Corin),
            transcript variant X1, mRNA.
ACCESSION   XM_008770139
VERSION     XM_008770139.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051349.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_008770139.4.
            
            On Jan 21, 2021 this sequence version replaced XM_008770139.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5322
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5322
                     /gene="Corin"
                     /note="corin, serine peptidase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 13
                     ESTs, 5 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 7 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:289596"
                     /db_xref="RGD:727887"
     CDS             704..3841
                     /gene="Corin"
                     /codon_start=1
                     /product="atrial natriuretic peptide-converting enzyme
                     isoform X1"
                     /protein_id="XP_008768361.1"
                     /db_xref="GeneID:289596"
                     /db_xref="RGD:727887"
                     /translation="MFTKRPPALAPEEHSRRADAPKRVLRADSSVGEGCPQKLVTANL
                     LRFLLLVLIPCICALIVLLAILLSFVGTLKKVYFKSNDSEPLVTDGEVRVPGVIHVNR
                     YENTGAPSMPPSQSIPAWTPRAPSLEDQSHGNTSTCVNITHRQCQILPYHSTLAPLLP
                     IVKNMDTEKFLKFFTYLHRLGCYQHILLFGCSLAFPKCIVDGDDRHGLLPCRSFCEAA
                     KEGCESVLGMVNSSWPDSLRCSQFRYHTENNSDASRICFSLQQEHGKQSLCGGGESFL
                     CTSGLCISKKLQCNGYNDCDDWSDEAHCNCSEDLFHCGTGKCLHHSLVCDGYDDCGDL
                     SDEQNCDCNLTKEHRCGDGRCIAAEWVCDGDHDCVDKSDEVNCSCPSQGLVECRSGQC
                     IPSTFQCDGDEDCKDGSDEENCSDRPTPCPGGDRGCLDSSCVESCAGSSLCDSDSSLS
                     NCSHCEPITLELCMNLPYNLTHYPNYLGHRTQKEASISWESALFPALVQTNCYKYLMF
                     FACTILVPKCDVNTGQRVPPCRLLCEHSKERCESVLGIVGLQWPEDTDCSQFPEQSSD
                     NQTCLLPNEDVEECSPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGCKERDLWEC
                     PLNKQCLKHTLICDGFPDCSDSMDEKNCSFCQDDELECANHECVPRDLWCDGWTDCSD
                     SSDEWGCVTLSKNGNSSSFLTVHRSARDHHVCADGWQETLSQLACRQMGLGEPSVTEL
                     VQGQEGQQWLRLHSSWENLNGSTLQELLVHRRSCPSGSEISLLCTKQDCGRRPAARMN
                     KRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGREDADVWKVV
                     FGINNLDHPSGFMQTRFVKTILLHPRYSRAVVDYDISVVELSDDINETSYVRPVCLPS
                     PREFLEPDTYCYITGWGHMGNKMPFKLQEGEVRIIPLEQCQSYFDMKTITNRMICAGY
                     ESGTVDSCMGDSGGPLVCERPGGQWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVDWIE
                     RQIYIQTFLQKKSQG"
ORIGIN      
        1 gtctgacagg cacaaatttg ccggtccctg atttcagcct tgttcttgtc cggcaatgcc
       61 aggctggagt tctggcccat agggcttgag cagccaagct ggctcgcaaa tgcagttttc
      121 cccctaaacc tgtagcagaa gacagattta caatttgtgt aacgcagata atgtctgcct
      181 tcaaaacctt acgtctcttc caacacaaca aacaacattg gattgccagt gcccggaggc
      241 agtcattttg atacttgcct ggttagattc ctgtttgggg ggatagagca ttctaggatg
      301 ttataatgac agttcggagg agagcagccc tttacacggc tcaactaagt tctggccttt
      361 gctgctcctg tcccatagtt taagggtttg tttgtttcct ggtgtggggg atgggggcag
      421 gagactcttg gctctccatc tgccatagaa aatgaacttt tttgaaggca gggctgggta
      481 tggaggagct gtctcattaa gggttatggg taggacccag agacgtgagt gaagggaggg
      541 agtggtctga gggtggggtc tgcccagcaa caaaatatgg ggctcctgtc ccctgactac
      601 aacttcactc cgagtgagga gaaagacacc cgtagttgcc tctcctagag atccatagag
      661 cagagaagag cgaccgagat aagagtggac agaggataaa gatatgttca cgaaacggcc
      721 ccccgccctt gctccggagg agcacagtcg ccgagccgac gccccaaaga gggtcttgag
      781 agcagacagc agcgtgggcg agggctgtcc tcagaagctg gtgacagcaa atttgctacg
      841 cttcctcctg cttgtgctca tcccctgcat ctgcgccctt atcgtgctgc tggccatcct
      901 gctgtccttc gtgggaacat taaagaaggt ttatttcaaa tcaaatgaca gtgaaccttt
      961 ggtcactgat ggtgaagttc gagtgcctgg tgttatccat gtaaatagat atgagaacac
     1021 aggggcgccc tctatgcccc ccagccaatc cattcctgcc tggacaccta gagctccttc
     1081 tctagaggac cagagtcacg gaaatacaag cacctgcgtg aacatcactc acagacagtg
     1141 tcaaattctg ccctaccaca gcacgctggc acccctcttg ccaattgtca aaaatatgga
     1201 cacggagaag ttcctcaagt tcttcacgta cctccatcgc ctcggttgct atcaacacat
     1261 cctgctcttt ggctgtagcc tcgccttccc caagtgcatt gttgatggcg atgacaggca
     1321 tggcctccta ccctgtagat ctttctgtga ggctgcaaaa gaaggatgtg aatcagtcct
     1381 gggaatggtg aactcctcct ggccagattc cctcagatgc tctcagttta gataccacac
     1441 tgagaataac agcgacgcca gcaggatctg cttctcactg cagcaggagc atggaaagca
     1501 atcgctctgt ggaggaggtg agagcttcct gtgtaccagc gggctctgca tctccaagaa
     1561 gctgcagtgt aacggctaca atgactgtga tgactggagc gacgaggctc actgcaactg
     1621 cagcgaggat ctgtttcact gtggaacagg caagtgcctc caccacagcc ttgtgtgcga
     1681 tgggtatgat gactgtgggg acctgagcga cgagcaaaac tgtgattgca atctcacaaa
     1741 agagcatcgc tgtggagacg ggcgctgcat cgcggctgag tgggtgtgtg atggggacca
     1801 tgactgtgtg gacaagtctg acgaggtcaa ctgctcttgt cccagccagg gccttgtgga
     1861 atgcagaagt ggacagtgca tccctagcac cttccagtgt gatggggacg aagactgtaa
     1921 ggacgggagt gacgaggaga actgcagtga ccgtccgaca ccgtgtcctg gaggagatcg
     1981 gggttgcctt gacagttcct gtgtcgaatc ctgtgctggt agctctctgt gtgactcaga
     2041 cagcagcctg agtaactgca gtcactgtga gcccatcact ttggaactct gcatgaattt
     2101 gccctacaac cttacacatt atccaaatta ccttggccac agaactcaaa aggaagcgtc
     2161 catcagctgg gagtcagctc tcttccctgc ccttgtacaa accaactgtt acaaatacct
     2221 catgtttttc gcttgcacca ttttggttcc aaagtgtgat gtgaatacag gccagcgcgt
     2281 cccgccttgc agactcctgt gtgagcactc caaagagcgc tgtgagtctg ttctggggat
     2341 cgtaggcctc cagtggcctg aagacacaga ttgcagtcaa tttccagagc aaagttcaga
     2401 caatcaaact tgcctcctgc ccaatgaaga cgtggaagaa tgctctccga gtcacttcaa
     2461 gtgccgctcg ggacgatgcg ttctgggttc cagaagatgc gacggccagg ctgactgtga
     2521 tgacgacagt gacgaagaga actgtggttg taaagagaga gatctttggg aatgtccact
     2581 caataagcaa tgtctgaagc atacattaat ctgtgatggg tttccagact gttcagatag
     2641 tatggatgaa aaaaactgct cattttgcca ggacgatgag ctggaatgtg ccaaccatga
     2701 gtgtgtgcca cgcgacctgt ggtgcgatgg atggacagat tgctcagaca gttcagatga
     2761 atggggctgt gtgaccctct ctaaaaatgg gaactcctcc tcattcctga ctgttcacag
     2821 atctgcaaga gatcaccacg tgtgtgctga tggctggcag gagacgttga gtcagctggc
     2881 ctgcaggcag atgggtttag gagaaccatc tgtgactgaa ctggtccaag ggcaggaagg
     2941 ccagcagtgg ctgaggttgc actccagctg ggagaatctc aatgggagca ccctgcagga
     3001 gctgctggtg cacaggcggt cctgcccaag cggaagtgag atttcccttc tgtgtaccaa
     3061 gcaagactgt ggtcgccgcc ctgctgcccg aatgaacaag aggatccttg ggggtcggac
     3121 tagtcgtcct gggaggtggc cgtggcagtg ttctctgcag agtgaaccca gtggacatat
     3181 ctgtggctgt gtcctcattg ccaagaagtg ggtcctgaca gttgcccatt gctttgaagg
     3241 gagagaggat gctgatgtct ggaaagtggt atttggcata aacaacctgg accatccgtc
     3301 aggcttcatg cagacccgct ttgtgaagac cattctgcta catccccgtt acagtcgagc
     3361 ggtggtagac tatgacatca gcgtggtgga gctgagtgat gatatcaatg agacaagcta
     3421 cgtcagacct gtctgcctac ccagccccag ggagttccta gaaccagata catactgcta
     3481 catcacaggc tggggccaca tgggcaataa aatgcccttt aagctgcagg agggggaagt
     3541 ccgcattatt cctctggagc agtgccagtc ctattttgac atgaagacca tcaccaatcg
     3601 gatgatatgt gctggctatg agtccggcac tgtggactca tgtatgggag acagtggtgg
     3661 tcctctggtt tgtgaacgac ccggaggaca gtggacatta tttggtttaa cttcatgggg
     3721 ctccgtctgc ttttccaaag tcctaggacc tggagtgtac agcaatgtgt cttactttgt
     3781 tgactggatc gaaagacaaa tatatatcca gacctttctc caaaagaaat cccaaggata
     3841 atcagagact ttgtgggaaa cctacacgga gaatgaccct cttgaacagg aagctgccaa
     3901 gagctgtacg aacaggcgtg tcacggacat gatgctcaac acgcactaca aggtctcctg
     3961 tttgttagtt ttcctcaggc ttcaatcctt ttcaacatta tcattcatta atttcatgga
     4021 ttcttttcaa agcacagagc aaagtaggtt ttattctttt gctaggctaa ccttgaatgt
     4081 agtgtggaat tatcaaccca cagagacatc tggagctcta tggtaacaag ttatagaaag
     4141 tgccttttcg ttctattaca aaacacacac ggagatgcac gctcactgat ctccagtttc
     4201 tgctcaagca cagtggctta gggggcacat ttcagaactg atcttggaaa ctggcttttc
     4261 tttataaaaa gccaagataa tatacatgct tttactactt aatatactct tctaaataat
     4321 ttgaagaaat tatgaaagac agaaaagacc cacagtgtta atgtagacag ttgaagttgc
     4381 aaaaatgtaa aattctctag ccaacaaaac taacactcag aagtgagtat aattctacgc
     4441 tttctgtatt caaattaaga ttgtaatttc atagacaatc tccataggac tttccccatt
     4501 cctggggatt ttcgatgtat atcacttaga taactgtgct gtcaacaacc aggtcaatcc
     4561 ttgaggaaat aatttgtttg cctgtgtgga aatgaatgag aaccttttcc attctgtaaa
     4621 ccacacaagt taaaaaggag aagaaaatta aatggtatac catccccaat taaatctgaa
     4681 aattagtctg cttgtgttta cccgaaccag aaaagttaca gaactaaact tcaaagtgta
     4741 gcaaaatgtt gcatggagta taacattttg caatttcccc ctcctggtgt ctaacatctg
     4801 gtgttgccat tttgcctcat tggtaattaa aacaaaattt tagagatgct tttaagcact
     4861 gggtcacttt atggggatca atttccaaag caattagtgg ttaaaagtat ttttcccact
     4921 aaaaagcttc aaaacagaaa ccttcatatg cacctaattt aattagccag acatcaacga
     4981 tgtaacatcc agacgccttt tgaacataca gtaggatgca ctgctaaact tcaccagcaa
     5041 ccaaactgcc tcagtgttcc aaacagggac tacccgcaat tttatatgtg tattttgtac
     5101 tctttttcta gctagttcaa atgcaaaaat tgtttcaacc tttattctct atgtttttca
     5161 cctcttgtct ggaacttgtt acaaagagtg tgtagcaagt ggttgtactg tggtcatgac
     5221 tgtatgaagg tttaagaccg ttggttggtt ttgttgtaat tgttggcaca taattaataa
     5281 aatatatttt agcactggtg aacttatatt cagtaaaatg ta
//
