LOCUS       NM_182473               3640 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus corin, serine peptidase (Corin), mRNA.
ACCESSION   NM_182473
VERSION     NM_182473.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3640)
  AUTHORS   Zhang,J., Yin,Y., Chen,L., Chu,C., Wang,Y., Lv,Y., He,M.,
            Martin,M., Huang,P.H., Mu,J.J., Shyy,J.Y. and Yuan,Z.Y.
  TITLE     Short-Term High-Salt Diet Increases Corin Level to Regulate the
            Salt-Water Balance in Humans and Rodents
  JOURNAL   Am J Hypertens 31 (2), 253-260 (2018)
   PUBMED   28985241
  REMARK    GeneRIF: Enhanced serum corin level in humans and rodents is
            positively correlated with high salt diet-induced systolic blood
            pressure and 24-hour urinary Na+ and albumin excretion, which
            suggests that corin is involved in the salt-water balance in
            response to HS intake.
REFERENCE   2  (bases 1 to 3640)
  AUTHORS   Wang,J., Mi,Y., Yuan,F., Wu,S., You,X., Dai,F., Huang,Y., Cao,J.,
            Zhu,J., Xue,B. and Zhu,L.
  TITLE     The Involvement of Corin in the Progression of Diabetic Erectile
            Dysfunction in a Rat Model by Down-Regulating ANP /NO/cGMP Signal
            Pathway
  JOURNAL   J Cell Biochem 118 (8), 2325-2332 (2017)
   PUBMED   28106289
  REMARK    GeneRIF: Corin contributes to the progression of diabetic ED and
            the underlying mechanism is associated with the down-regulation of
            ANP /NO/cGMP signal pathway.
REFERENCE   3  (bases 1 to 3640)
  AUTHORS   Pang,A., Hu,Y., Zhou,P., Long,G., Tian,X., Men,L., Shen,Y., Liu,Y.
            and Cui,Y.
  TITLE     Corin is down-regulated and exerts cardioprotective action via
            activating pro-atrial natriuretic peptide pathway in diabetic
            cardiomyopathy
  JOURNAL   Cardiovasc Diabetol 14, 134 (2015)
   PUBMED   26446774
  REMARK    GeneRIF: Corin mRNA and protein are downregulated in diabetic
            cardiomyopathy (DCM). Corin plays an important role in
            cardioprotection by activating pro-atrial natriuretic peptide
            pathway in DCM.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3640)
  AUTHORS   Wang,W., Shen,J., Cui,Y., Jiang,J., Chen,S., Peng,J. and Wu,Q.
  TITLE     Impaired sodium excretion and salt-sensitive hypertension in
            corin-deficient mice
  JOURNAL   Kidney Int 82 (1), 26-33 (2012)
   PUBMED   22418978
REFERENCE   5  (bases 1 to 3640)
  AUTHORS   Cui,Y., Wang,W., Dong,N., Lou,J., Srinivasan,D.K., Cheng,W.,
            Huang,X., Liu,M., Fang,C., Peng,J., Chen,S., Wu,S., Liu,Z.,
            Dong,L., Zhou,Y. and Wu,Q.
  TITLE     Role of corin in trophoblast invasion and uterine spiral artery
            remodelling in pregnancy
  JOURNAL   Nature 484 (7393), 246-250 (2012)
   PUBMED   22437503
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3640)
  AUTHORS   Chan,J.C., Knudson,O., Wu,F., Morser,J., Dole,W.P. and Wu,Q.
  TITLE     Hypertension in mice lacking the proatrial natriuretic peptide
            convertase corin
  JOURNAL   Proc Natl Acad Sci U S A 102 (3), 785-790 (2005)
   PUBMED   15637153
REFERENCE   7  (bases 1 to 3640)
  AUTHORS   Tran,K.L., Lu,X., Lei,M., Feng,Q. and Wu,Q.
  TITLE     Upregulation of corin gene expression in hypertrophic
            cardiomyocytes and failing myocardium
  JOURNAL   Am J Physiol Heart Circ Physiol 287 (4), H1625-H1631 (2004)
   PUBMED   15191894
  REMARK    GeneRIF: corin gene is upregulated in hypertrophic cardiomyocytes
            and failing myocardium and may contribute to elevation of ANP in
            the setting of cardiac hypertrophy and heart failure.
REFERENCE   8  (bases 1 to 3640)
  AUTHORS   Langenickel,T.H., Pagel,I., Buttgereit,J., Tenner,K., Lindner,M.,
            Dietz,R., Willenbrock,R. and Bader,M.
  TITLE     Rat corin gene: molecular cloning and reduced expression in
            experimental heart failure
  JOURNAL   Am J Physiol Heart Circ Physiol 287 (4), H1516-H1521 (2004)
   PUBMED   15155264
  REMARK    GeneRIF: Downregulation of atrial corin mRNA expression may be a
            novel mechanism for the blunted ANP release in heart failure.
REFERENCE   9  (bases 1 to 3640)
  AUTHORS   Wu,F., Yan,W., Pan,J., Morser,J. and Wu,Q.
  TITLE     Processing of pro-atrial natriuretic peptide by corin in cardiac
            myocytes
  JOURNAL   J Biol Chem 277 (19), 16900-16905 (2002)
   PUBMED   11884416
REFERENCE   10 (bases 1 to 3640)
  AUTHORS   Yan,W., Wu,F., Morser,J. and Wu,Q.
  TITLE     Corin, a transmembrane cardiac serine protease, acts as a
            pro-atrial natriuretic peptide-converting enzyme
  JOURNAL   Proc Natl Acad Sci U S A 97 (15), 8525-8529 (2000)
   PUBMED   10880574
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 27, 2020 this sequence version replaced NM_182473.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY251285.1, SRR26643289.34873.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               JAXUCZ010000014.1  36035566-36035857
            293-434             JAXUCZ010000014.1  36083136-36083277
            435-629             JAXUCZ010000014.1  36098209-36098403
            630-837             JAXUCZ010000014.1  36115159-36115366
            838-1022            JAXUCZ010000014.1  36142286-36142470
            1023-1136           JAXUCZ010000014.1  36193093-36193206
            1137-1244           JAXUCZ010000014.1  36203825-36203932
            1245-1355           JAXUCZ010000014.1  36205997-36206107
            1356-1472           JAXUCZ010000014.1  36208025-36208141
            1473-1580           JAXUCZ010000014.1  36211880-36211987
            1581-1812           JAXUCZ010000014.1  36219905-36220136
            1813-1958           JAXUCZ010000014.1  36224178-36224323
            1959-2066           JAXUCZ010000014.1  36225044-36225151
            2067-2180           JAXUCZ010000014.1  36231166-36231279
            2181-2291           JAXUCZ010000014.1  36232968-36233078
            2292-2421           JAXUCZ010000014.1  36234086-36234215
            2422-2535           JAXUCZ010000014.1  36244523-36244636
            2536-2585           JAXUCZ010000014.1  36248298-36248347
            2586-2760           JAXUCZ010000014.1  36248491-36248665
            2761-3032           JAXUCZ010000014.1  36259813-36260084
            3033-3166           JAXUCZ010000014.1  36261760-36261893
            3167-3640           JAXUCZ010000014.1  36262996-36263469
FEATURES             Location/Qualifiers
     source          1..3640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..3640
                     /gene="Corin"
                     /note="corin, serine peptidase"
                     /db_xref="GeneID:289596"
                     /db_xref="RGD:727887"
     exon            1..292
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..3361
                     /gene="Corin"
                     /note="pro-ANP-converting enzyme"
                     /codon_start=1
                     /product="atrial natriuretic peptide-converting enzyme"
                     /protein_id="NP_872279.2"
                     /db_xref="GeneID:289596"
                     /db_xref="RGD:727887"
                     /translation="MGRVSFNVRVSSVRRARCSCPGRCYLSCRVPPTTALHALNGFGR
                     AGVLGETAGGTVGLGPSGTRGFLSGSKFQASGSLKDCFGAPPAPDVLRADSSVGEGCP
                     QKLVTANLLRFLLLVLIPCICALIVLLAILLSFVGTLKKVYFKSNDSEPLVTDGEVRV
                     PGVIHVNRYENTGAPSMPPSQSIPAWTPRAPSLEDQSHGNTSTCVNITHRQCQILPYH
                     STLAPLLPIVKNMDTEKFLKFFTYLHRLGCYQHILLFGCSLAFPKCIVDGDDRHGLLP
                     CRSFCEAAKEGCESVLGMVNSSWPDSLRCSQFRYHTENNSDASRICFSLQQEHGKQSL
                     CGGGESFLCTSGLCISKKLQCNGYNDCDDWSDEAHCNCSEDLFHCGTGKCLHHSLVCD
                     GYDDCGDLSDEQNCDCNLTKEHRCGDGRCIAAEWVCDGDHDCVDKSDEVNCSCPSQGL
                     VECRSGQCIPSTFQCDGDEDCKDGSDEENCSDRPTPCPGGDRGCLDSSCVESCAGSSL
                     CDSDSSLSNCSHCEPITLELCMNLPYNLTHYPNYLGHRTQKEASISWESALFPALVQT
                     NCYKYLMFFACTILVPKCDVNTGQRVPPCRLLCEHSKERCESVLGIVGLQWPEDTDCS
                     QFPEQSSDNQTCLLPNEDVEECSPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGC
                     KERDLWECPLNKQCLKHTLICDGFPDCSDSMDEKNCSFCQDDELECANHECVPRDLWC
                     DGWTDCSDSSDEWGCVTLSKNGNSSSFLTVHRSARDHHVCADGWQETLSQLACRQMGL
                     GEPSVTELVQGQEGQQWLRLHSSWENLNGSTLQELLVHRRSCPSGSEISLLCTKQDCG
                     RRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRE
                     DADVWKVVFGINNLDHPSGFMQTRFVKTILLHPRYSRAVVDYDISVVELSDDINETSY
                     VRPVCLPSPREFLEPDTYCYITGWGHMGNKMPFKLQEGEVRIIPLEQCQSYFDMKTIT
                     NRMICAGYESGTVDSCMGDSGGPLVCERPGGQWTLFGLTSWGSVCFSKVLGPGVYSNV
                     SYFVDWIERQIYIQTFLQKKSQG"
     exon            293..434
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            435..629
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            630..837
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1022
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1136
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1244
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1355
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1472
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1580
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1812
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1958
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2066
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2180
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2291
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2421
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2535
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2585
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2760
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..3032
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3166
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3640
                     /gene="Corin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttggagtcg gaggctcgga cagtcatggg cagggtttct ttcaacgttc gggtcagctc
       61 tgtgaggaga gcccgctgct cttgtcctgg gcgatgctac ctgtcctgca gagtccctcc
      121 aaccaccgcc ctccatgcac tgaacgggtt tggccgcgcg ggggttctgg gggagactgc
      181 aggtggaacc gtcggactcg gcccctcggg gacccgtggc ttcctctccg ggtccaagtt
      241 ccaggcttcg ggcagcttga aggattgctt tggagccccg cctgctccag acgtcttgag
      301 agcagacagc agcgtgggcg agggctgtcc tcagaagctg gtgacagcaa atttgctacg
      361 cttcctcctg cttgtgctca tcccctgcat ctgcgccctt atcgtgctgc tggccatcct
      421 gctgtccttc gtgggaacat taaagaaggt ttatttcaaa tcaaatgaca gtgaaccttt
      481 ggtcactgat ggtgaagttc gagtgcctgg tgttatccat gtaaatagat atgagaacac
      541 aggggcgccc tctatgcccc ccagccaatc cattcctgcc tggacaccta gagctccttc
      601 tctagaggac cagagtcacg gaaatacaag cacctgcgtg aacatcactc acagacagtg
      661 tcaaattctg ccctaccaca gcacgctggc acccctcttg ccaattgtca aaaatatgga
      721 cacggagaag ttcctcaagt tcttcacgta cctccatcgc ctcggttgct atcaacacat
      781 cctgctcttt ggctgtagcc tcgccttccc caagtgcatt gttgatggcg atgacaggca
      841 tggcctccta ccctgtagat ctttctgtga ggctgcaaaa gaaggatgtg aatcagtcct
      901 gggaatggtg aactcctcct ggccagattc cctcagatgc tctcagttta gataccacac
      961 tgagaataac agcgacgcca gcaggatctg cttctcactg cagcaggagc atggaaagca
     1021 atcgctctgt ggaggaggtg agagcttcct gtgtaccagc gggctctgca tctccaagaa
     1081 gctgcagtgt aacggctaca atgactgtga tgactggagc gacgaggctc actgcaactg
     1141 cagcgaggat ctgtttcact gtggaacagg caagtgcctc caccacagcc ttgtgtgcga
     1201 tgggtatgat gactgtgggg acctgagcga cgagcaaaac tgtgattgca atctcacaaa
     1261 agagcatcgc tgtggagacg ggcgctgcat cgcggctgag tgggtgtgtg atggggacca
     1321 tgactgtgtg gacaagtctg acgaggtcaa ctgctcttgt cccagccagg gccttgtgga
     1381 atgcagaagt ggacagtgca tccctagcac cttccagtgt gatggggacg aagactgtaa
     1441 ggacgggagt gacgaggaga actgcagtga ccgtccgaca ccgtgtcctg gaggagatcg
     1501 gggttgcctt gacagttcct gtgtcgaatc ctgtgctggt agctctctgt gtgactcaga
     1561 cagcagcctg agtaactgca gtcactgtga gcccatcact ttggaactct gcatgaattt
     1621 gccctacaac cttacacatt atccaaatta ccttggccac agaactcaaa aggaagcgtc
     1681 catcagctgg gagtcagctc tcttccctgc ccttgtacaa accaactgtt acaaatacct
     1741 catgtttttc gcttgcacca ttttggttcc aaagtgtgat gtgaatacag gccagcgcgt
     1801 cccgccttgc agactcctgt gtgagcactc caaagagcgc tgtgagtctg ttctggggat
     1861 cgtaggcctc cagtggcctg aagacacaga ttgcagtcaa tttccagagc aaagttcaga
     1921 caatcaaact tgcctcctgc ccaatgaaga cgtggaagaa tgctctccga gtcacttcaa
     1981 gtgccgctcg ggacgatgcg ttctgggttc cagaagatgc gacggccagg ctgactgtga
     2041 tgacgacagt gacgaagaga actgtggttg taaagagaga gatctttggg aatgtccact
     2101 caataagcaa tgtctgaagc atacattaat ctgtgatggg tttccagact gttcagatag
     2161 tatggatgaa aaaaactgct cattttgcca ggacgatgag ctggaatgtg ccaaccatga
     2221 gtgtgtgcca cgcgacctgt ggtgcgatgg atggacagat tgctcagaca gttcagatga
     2281 atggggctgt gtgaccctct ctaaaaatgg gaactcctcc tcattcctga ctgttcacag
     2341 atctgcaaga gatcaccacg tgtgtgctga tggctggcag gagacgttga gtcagctggc
     2401 ctgcaggcag atgggtttag gagaaccatc tgtgactgaa ctggtccaag ggcaggaagg
     2461 ccagcagtgg ctgaggttgc actccagctg ggagaatctc aatgggagca ccctgcagga
     2521 gctgctggtg cacaggcggt cctgcccaag cggaagtgag atttcccttc tgtgtaccaa
     2581 gcaagactgt ggtcgccgcc ctgctgcccg aatgaacaag aggatccttg ggggtcggac
     2641 tagtcgtcct gggaggtggc cgtggcagtg ttctctgcag agtgaaccca gtggacatat
     2701 ctgtggctgt gtcctcattg ccaagaagtg ggtcctgaca gttgcccatt gctttgaagg
     2761 gagagaggat gctgatgtct ggaaagtggt atttggcata aacaacctgg accatccgtc
     2821 aggcttcatg cagacccgct ttgtgaagac cattctgcta catccccgtt acagtcgagc
     2881 ggtggtagac tatgacatca gcgtggtgga gctgagtgat gatatcaatg agacaagcta
     2941 cgtcagacct gtctgcctac ccagccccag ggagttccta gaaccagata catactgcta
     3001 catcacaggc tggggccaca tgggcaataa aatgcccttt aagctgcagg agggggaagt
     3061 ccgcattatt cctctggagc agtgccagtc ctattttgac atgaagacca tcaccaatcg
     3121 gatgatatgt gctggctatg agtccggcac tgtggactca tgtatgggag acagtggtgg
     3181 tcctctggtt tgtgaacgac ccggaggaca gtggacatta tttggtttaa cttcatgggg
     3241 ctccgtctgc ttttccaaag tcctaggacc tggagtgtac agcaatgtgt cttactttgt
     3301 tgactggatc gaaagacaaa tatatatcca gacctttctc caaaagaaat cccaaggata
     3361 atcagagact ttgtgggaaa cctacacgga gaatgaccct cttgaacagg aagctgccaa
     3421 gagctgtacg aacaggcgtg tcacggacat gatgctcaac acgcactaca aggtctcctg
     3481 tttgttagtt ttcctcaggc ttcaatcctt ttcaacatta tcattcatta atttcatgga
     3541 ttcttttcaa agcacagagc aaagtaggtt ttattctttt gctaggctaa ccttgaatgt
     3601 agtgtggaat tatcaaccca cagagacatc tggagctcta
//
