LOCUS       NM_001035257            1729 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus coenzyme Q9 (Coq9), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001035257 XM_574198
VERSION     NM_001035257.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1729)
  AUTHORS   Lohman,D.C., Forouhar,F., Beebe,E.T., Stefely,M.S., Minogue,C.E.,
            Ulbrich,A., Stefely,J.A., Sukumar,S., Luna-Sanchez,M., Jochem,A.,
            Lew,S., Seetharaman,J., Xiao,R., Wang,H., Westphall,M.S.,
            Wrobel,R.L., Everett,J.K., Mitchell,J.C., Lopez,L.C., Coon,J.J.,
            Tong,L. and Pagliarini,D.J.
  TITLE     Mitochondrial COQ9 is a lipid-binding protein that associates with
            COQ7 to enable coenzyme Q biosynthesis
  JOURNAL   Proc Natl Acad Sci U S A 111 (44), E4697-E4705 (2014)
   PUBMED   25339443
REFERENCE   2  (bases 1 to 1729)
  AUTHORS   Garcia-Corzo,L., Luna-Sanchez,M., Doerrier,C., Garcia,J.A.,
            Guaras,A., Acin-Perez,R., Bullejos-Peregrin,J., Lopez,A.,
            Escames,G., Enriquez,J.A., Acuna-Castroviejo,D. and Lopez,L.C.
  TITLE     Dysfunctional Coq9 protein causes predominant encephalomyopathy
            associated with CoQ deficiency
  JOURNAL   Hum Mol Genet 22 (6), 1233-1248 (2013)
   PUBMED   23255162
REFERENCE   3  (bases 1 to 1729)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   4  (bases 1 to 1729)
  AUTHORS   Kucharska,J., Gvozdjakova,A. and Simko,F.
  TITLE     Simvastatin decreased coenzyme Q in the left ventricle and skeletal
            muscle but not in the brain and liver in L-NAME-induced
            hypertension
  JOURNAL   Physiol Res 56 Suppl 2, S49-S54 (2007)
   PUBMED   17824807
  REMARK    GeneRIF: Administration of simvastatin under the condition of
            nitric oxide-deficiency reduced the level of coenzyme Q9/10 in the
            heart and skeletal muscle.
REFERENCE   5  (bases 1 to 1729)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK600220.1 and BC104702.1.
            
            On Oct 31, 2005 this sequence version replaced XM_574198.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127449.1, SRR8487226.40572.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CK600220.1         21-34
            15-1729             BC104702.1         1-1715
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     gene            1..1729
                     /gene="Coq9"
                     /note="coenzyme Q9"
                     /db_xref="GeneID:498909"
                     /db_xref="RGD:1586040"
     exon            1..85
                     /gene="Coq9"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..948
                     /gene="Coq9"
                     /note="ubiquinone biosynthesis protein COQ9,
                     mitochondrial; coenzyme Q9 homolog"
                     /codon_start=1
                     /product="ubiquinone biosynthesis protein COQ9,
                     mitochondrial precursor"
                     /protein_id="NP_001030334.1"
                     /db_xref="GeneID:498909"
                     /db_xref="RGD:1586040"
                     /translation="MAATAAVSGVLRRLGWRLLQLRCLPVARCQSPLMPRAFHTAVGF
                     RSSEEQRQQPPHSSQQHSETQGPEFSRPPPRYTDQSGEEEEDYESEEQIQHRILTAAL
                     EFVPDHGWTAEAIAEGAQSLGLSSAAASMFGSDGSELILHFVTQCNARLNHVLEEEQK
                     LVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILLLPQNIPPSLSLLTSMV
                     DDMWHYAGDQSTDFNWYTRRAVLAGIYNTTELVMMQDSSPDFEDTWRFLDNRINDAMN
                     MGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR"
     exon            86..233
                     /gene="Coq9"
                     /inference="alignment:Splign:2.1.0"
     exon            234..369
                     /gene="Coq9"
                     /inference="alignment:Splign:2.1.0"
     exon            370..512
                     /gene="Coq9"
                     /inference="alignment:Splign:2.1.0"
     exon            513..597
                     /gene="Coq9"
                     /inference="alignment:Splign:2.1.0"
     exon            598..702
                     /gene="Coq9"
                     /inference="alignment:Splign:2.1.0"
     exon            703..858
                     /gene="Coq9"
                     /inference="alignment:Splign:2.1.0"
     exon            859..912
                     /gene="Coq9"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1704
                     /gene="Coq9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctccaaga tggcggcgac ggcagcagtg tctggtgtcc tccgccggtt gggctggagg
       61 ctcctgcagc tgcggtgcct gcctgtggcc cgctgccaat cacctctgat gccacgtgcc
      121 ttccacaccg ccgtggggtt caggtcttca gaagagcaga ggcagcagcc tccgcactct
      181 tctcagcagc attctgagac acaggggcca gagttttctc gtccaccccc caggtacaca
      241 gaccagagtg gagaggagga agaggactat gagagtgagg agcagataca gcaccgcatc
      301 ttgacggcag ccctagagtt tgtgcctgac catggctgga ctgcagaggc cattgctgaa
      361 ggagcccagt ccctgggtct ctccagcgca gcagccagca tgtttgggag cgatggcagt
      421 gaactgattc tgcactttgt gacccagtgc aatgctcgcc tcaaccatgt gctggaagag
      481 gagcagaagc tggtgcaact gggccaggca gagaagagga aaacagacca gttcctgagg
      541 gatgcagtgg aaaccagact gagaatgctg atcccctaca ttgagcactg gccgcgggcc
      601 ctcagcatcc tcctgctccc tcagaacatc ccacctagcc tgagcttgct caccagcatg
      661 gtggatgaca tgtggcatta cgctggggac cagtccactg attttaactg gtacacccgc
      721 cgcgcagtgc tggccggcat ctacaacaca acagagctgg tgatgatgca ggactcctcc
      781 ccagacttcg aagatacttg gcgtttcctg gacaaccgga tcaatgatgc aatgaacatg
      841 ggccacacgg ctaagcaggt gaagtccact ggagaggcac tggtgcaagg actgatgggt
      901 gcagcagtca cgctcaagaa cctgacaggt ctaaaccagc gccggtgaga ggaggcgaac
      961 ccacgtgcag gaaggagcat cagtagatat gaagggcttt gacaagatgc atcatccatt
     1021 gagtgagatg ttaatgagaa cacactgaag aacttggagt cgcatggcgg ccacaaggct
     1081 ggaaatcaca gtgcatttgc tacagttctg acctggaatt gggcctcttc ttcagttcct
     1141 aacaccaggc ctggccttct ggtgcctttt gcattgcagc tgtgtgtttg aaaaatgaga
     1201 ctcacatcca aggtttcaaa ccacagaaac ttggcatgac tctgccatgg tgtcacgggc
     1261 atcttgatca tgtcttgacc ttagaactgt tctctaggag tggggcatag tgacgtatac
     1321 ctgtattctc agtacgcaga agactggaga gcaggattga gagttcagag gcaggcttgt
     1381 ctatgtagag aattacaagc ctgcttgagc cacagagtgt gatcctgtcg atcaaaatcc
     1441 cctgagaaat attcttaggg gctcacaacc aaggtccaaa ggcaacacat agtgggggct
     1501 cttccccagc acagggcaga cagtgtgctc acagaggtat ttgccattgg ccactgctcc
     1561 tctggatccc ctcagaaagc tgcctcccct agacaggtgc cttttggatg gtcatgctga
     1621 acctggcatc acagacacca gtgtgcattg caggatcatt agtacattta gagtctgtaa
     1681 aaataataaa tatgtttgaa acaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
