LOCUS       NM_001012065            2145 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus coenzyme Q8B (Coq8b), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001012065 XM_218358
VERSION     NM_001012065.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Stefely,J.A., Licitra,F., Laredj,L., Reidenbach,A.G.,
            Kemmerer,Z.A., Grangeray,A., Jaeg-Ehret,T., Minogue,C.E.,
            Ulbrich,A., Hutchins,P.D., Wilkerson,E.M., Ruan,Z., Aydin,D.,
            Hebert,A.S., Guo,X., Freiberger,E.C., Reutenauer,L., Jochem,A.,
            Chergova,M., Johnson,I.E., Lohman,D.C., Rush,M.J.P., Kwiecien,N.W.,
            Singh,P.K., Schlagowski,A.I., Floyd,B.J., Forsman,U.,
            Sindelar,P.J., Westphall,M.S., Pierrel,F., Zoll,J., Dal Peraro,M.,
            Kannan,N., Bingman,C.A., Coon,J.J., Isope,P., Puccio,H. and
            Pagliarini,D.J.
  TITLE     Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of
            Unorthodox Kinase Activity
  JOURNAL   Mol Cell 63 (4), 608-620 (2016)
   PUBMED   27499294
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079227.1.
            
            On Feb 11, 2005 this sequence version replaced XM_218358.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079227.1, SRR8487227.182781.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2145
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /note="coenzyme Q8B"
                     /db_xref="GeneID:308453"
                     /db_xref="RGD:1311356"
     exon            1..73
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            74..181
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1663
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /note="aarF domain-containing protein kinase 4; aarF
                     domain containing kinase 4; coenzyme Q protein 8B"
                     /codon_start=1
                     /product="atypical kinase COQ8B, mitochondrial"
                     /protein_id="NP_001012065.1"
                     /db_xref="GeneID:308453"
                     /db_xref="RGD:1311356"
                     /translation="MWLELGAMLRTTCGPLGRAVRLPCAGALRLRPHWWGPCRDCLAQ
                     RVHQDQPGRGLTEDEIRRAREARLRKAPRPQLSDRSRERKVPASRISRLASFGGLAVG
                     LGLGALAEVTKKSLPGGSLQHEGSSPFLTEANAERIVQTLCTVRGAALKIGQMLSIQD
                     NSLISPQLQRVFERVRQSADFMPRWQMMKVLEEELGKDWQDKVASLEEVPFAAASIGQ
                     VHQGVLKDGTEVAVKIQYPGVAESIQSDVQNLLALLKMSVGLPEGLFAEQSLQTLQQE
                     LAWECDYRREAACAQTFKKLLADDPFFRVPAVVEELCTTRVLGMELAGGIPLDQCQGL
                     SQDIRNQICFQLLRLCLRELFEFRFMQTDPNWANFLYDASSHKVTLLDFGASRAFGTE
                     FTDHYIEVVKAAADGDRDRVLQKSQDLKFLTGFETKAFSDAHVEAVMILGEPFAASGS
                     YDFGAGETARRIQGLIPVLLRHRLRPPPEETYALHRKLAGAFLACARLHAHIACRDLF
                     QDTYHRYWASRQTLPLPAAS"
     exon            182..301
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            302..368
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            369..446
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            447..554
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            555..640
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            641..781
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            782..863
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            864..957
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1099
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1207
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1273
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1360
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..2096
                     /gene="Coq8b"
                     /gene_synonym="Adck4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgtaacgg ggttgtaacg gggtgttggg aggagggggc agcacaggaa ttgtggatgc
       61 ttaacagtcc aaggcaatgt ggctggagct aggagctatg ctgcgcacga cctgtggacc
      121 gctgggcagg gctgttcgtc tgccctgtgc gggggccctg agacttaggc cccactggtg
      181 ggggccatgt agggattgtt tggcccaaag ggttcatcaa gaccagcccg gaagaggcct
      241 aactgaagat gaaattcgta gggcccggga ggccaggctc aggaaggcac cccggcccca
      301 gctgagtgat cgctctcgtg aacgcaaggt gcctgcctcc cgcatcagtc gcttggccag
      361 ctttgggggg ctggctgtgg gcttgggcct gggagcactg gccgaggtga ccaagaagtc
      421 cctgccaggt ggaagtctgc agcatgaggg ctccagtcct ttccttaccg aggccaatgc
      481 tgagaggatc gtacagacct tatgtacagt ccggggagct gccctcaaga tcggccaaat
      541 gctcagcatc caggacaaca gcctcatcag cccccagctt cagcgagtct tcgagagggt
      601 ccggcagagt gctgacttta tgccccgctg gcagatgatg aaagttctag aagaggagct
      661 aggcaaggac tggcaggaca aggtggcctc cctggaggag gtgccctttg ctgctgcctc
      721 catcgggcag gtacaccaag gcgtgctgaa ggacgggact gaggtggctg tgaagatcca
      781 gtacccaggt gttgccgaga gcatccagag tgacgtgcag aacctgctgg ccctgctcaa
      841 gatgagtgtg ggactaccag agggcctgtt tgctgagcag agcctgcaga ccttgcagca
      901 agagctggct tgggaatgtg actaccgcag agaagccgcc tgtgcccaga ccttcaagaa
      961 gctcttggct gatgacccct tcttccgagt accagctgtg gtagaggagt tatgcaccac
     1021 acgggtgctg ggcatggagc tggctggggg aatccctcta gaccagtgcc agggcctgag
     1081 ccaggacatc cggaatcaga tttgcttcca gctcctgagg ctgtgtctgc gggagctgtt
     1141 tgagttcaga ttcatgcaaa cagatcccaa ctgggccaac ttcctgtatg atgcctccag
     1201 ccacaaggtg actctactgg actttggtgc aagccgggcc tttggaacag agttcacgga
     1261 ccattacatt gaggtggtga aggctgcagc agatggggac agagatcgag ttctccagaa
     1321 atcccaggac ctcaaattcc ttacaggctt tgaaaccaag gcattctctg acgcccacgt
     1381 cgaggcagtg atgatccttg gggagccctt tgctgcttca ggctcctatg acttcggtgc
     1441 tggagagact gctcgccgaa tacagggcct catcccagtg ttgcttcggc accggcttcg
     1501 cccaccgcct gaggagacct atgctctaca ccgcaagcta gctggggctt tcttagcctg
     1561 tgcccgtctc cacgcccaca tcgcctgccg ggacctcttc caagatacct accaccgcta
     1621 ctgggccagt cgccagacat tgccactgcc agcagcctcc tgactaggga cctctctgcc
     1681 gacccaccat gacagattcc agtgggggag accagctcca cagcgggcgg tcccctccta
     1741 tgtcctagtc ccagagctta gttttttgcc ttggatcttc atacccctgg agttagctcc
     1801 ctgatccaaa gtgagcatcc ttaaattctg aggctgagag tcagcagaat cctgccacca
     1861 tctaagtgag cccttggcct cttcataggg tccactcgca tgtggaggag gcgcccctcg
     1921 gccccaggtc ttccaggatc cgcaggcaaa aggggagata gctattggag gcggtcctca
     1981 cctttgcctc ccttgcttct ctaccagctg ccttcttccc gggttccagc ctgtgtattg
     2041 gaggatgggg gtgggtgctg atccttccct ccgaataaag gcaccctttc cctaccaaaa
     2101 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
