LOCUS       NM_001013185            2515 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus coenzyme Q8A (Coq8a), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001013185 XM_341162
VERSION     NM_001013185.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2515)
  AUTHORS   Stefely,J.A., Licitra,F., Laredj,L., Reidenbach,A.G.,
            Kemmerer,Z.A., Grangeray,A., Jaeg-Ehret,T., Minogue,C.E.,
            Ulbrich,A., Hutchins,P.D., Wilkerson,E.M., Ruan,Z., Aydin,D.,
            Hebert,A.S., Guo,X., Freiberger,E.C., Reutenauer,L., Jochem,A.,
            Chergova,M., Johnson,I.E., Lohman,D.C., Rush,M.J.P., Kwiecien,N.W.,
            Singh,P.K., Schlagowski,A.I., Floyd,B.J., Forsman,U.,
            Sindelar,P.J., Westphall,M.S., Pierrel,F., Zoll,J., Dal Peraro,M.,
            Kannan,N., Bingman,C.A., Coon,J.J., Isope,P., Puccio,H. and
            Pagliarini,D.J.
  TITLE     Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of
            Unorthodox Kinase Activity
  JOURNAL   Mol Cell 63 (4), 608-620 (2016)
   PUBMED   27499294
REFERENCE   2  (bases 1 to 2515)
  AUTHORS   Stefely,J.A., Reidenbach,A.G., Ulbrich,A., Oruganty,K., Floyd,B.J.,
            Jochem,A., Saunders,J.M., Johnson,I.E., Minogue,C.E., Wrobel,R.L.,
            Barber,G.E., Lee,D., Li,S., Kannan,N., Coon,J.J., Bingman,C.A. and
            Pagliarini,D.J.
  TITLE     Mitochondrial ADCK3 employs an atypical protein kinase-like fold to
            enable coenzyme Q biosynthesis
  JOURNAL   Mol Cell 57 (1), 83-94 (2015)
   PUBMED   25498144
REFERENCE   3  (bases 1 to 2515)
  AUTHORS   Gerards,M., van den Bosch,B., Calis,C., Schoonderwoerd,K., van
            Engelen,K., Tijssen,M., de Coo,R., van der Kooi,A. and Smeets,H.
  TITLE     Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar
            ataxia and atrophy
  JOURNAL   Mitochondrion 10 (5), 510-515 (2010)
   PUBMED   20580948
  REMARK    GeneRIF: These results indicate that CABC1 is an important
            candidate for mutation analysis in progressive cerebellar ataxia
            and atrophy on MRI to identify those patients who may benefit from
            CoQ10 treatment.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC091388.1.
            
            On Apr 20, 2005 this sequence version replaced XM_341162.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..2515
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /note="coenzyme Q8A"
                     /db_xref="GeneID:360887"
                     /db_xref="RGD:1308245"
     exon            1..27
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            28..213
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1986
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /note="chaperone activity of bc1 complex-like,
                     mitochondrial; aarF domain-containing protein kinase 3;
                     chaperone, ABC1 activity of bc1 complex like; atypical
                     kinase ADCK3, mitochondrial; aarF domain containing kinase
                     3; coenzyme Q protein 8A"
                     /codon_start=1
                     /product="atypical kinase COQ8A, mitochondrial"
                     /protein_id="NP_001013203.1"
                     /db_xref="GeneID:360887"
                     /db_xref="RGD:1308245"
                     /translation="MAAMLGDAIMVAKGLAKLTQAAVETHLQNLGLGGELILAARALQ
                     STAVEQISMVFGKVQGQDKHEDSYATENFEDLEAEVQFSTPQAAGSSPDFSTASSLDQ
                     PLSSSLGHAHREGPAPAYVSSGPFREAGLSGQATSPLGRVNGRLFVDCRDLFLANSIQ
                     RRFFHQDQAPVGGLTAEDIEKARQAKARPESKPHKQMLSERARERKVPVTRIGRLANF
                     GGLAVGLGFGALAEVAKKSLRSENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAAL
                     KLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMTKTLNNDLGPHWRDKLEYFEE
                     RPFAAASIGQVHLARLKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFP
                     EHLIDVLRRELTLECDYQREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELIT
                     GFPLDQAEGLSQEVRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLD
                     FGATREYDRSFTDLYIQVIRAAADQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILI
                     LGEAFASEEPFDFGTQSTTEKIHNLIPIMLKHRLIPPPEETYSLHRKMGGSFLICSKL
                     KACFPCKAMFEEAYSNYCRMKSGLQ"
     exon            214..627
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..694
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..769
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..892
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..978
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1119
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1201
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1295
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1437
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1545
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1611
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1698
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..2490
                     /gene="Coq8a"
                     /gene_synonym="Adck3; Cabc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagcgtgt ggactgaata tatacagccc tgaaggatgg ctgctatgtt gggggatgcc
       61 atcatggtgg ccaaaggcct tgccaagctg acccaggcag ctgtggaaac tcacctgcag
      121 aacctgggcc ttggtgggga gctcatcctg gcagccaggg ccctgcagtc tacagctgtg
      181 gagcagatca gcatggtctt tggaaaggtg cagggtcagg ataagcatga agattcatat
      241 gccactgaga acttcgaaga tctggaagcc gaagttcagt tctcaacacc acaggcagct
      301 ggaagctccc cagatttctc cacagcctcc tccctggacc agccactgtc ttcatccctg
      361 ggtcatgccc acagggaggg cccagctcct gcctatgttt ccagtggacc tttcagggaa
      421 gcagggctct ctggccaggc tacctctcct ctgggcagag tcaatggaag gctctttgta
      481 gattgtagag acttgttctt ggccaacagc atccagcgaa gattcttcca ccaggaccag
      541 gcccctgtgg gaggcctcac cgctgaagac attgaaaagg cccgtcaggc caaggctcgc
      601 ccagagagca agccacacaa gcagatgctc agtgagcggg ctcgggagcg gaaggtgcca
      661 gttacccgga ttgggcggtt ggccaacttt ggagggctgg ctgtaggtct gggctttggg
      721 gctttggctg aggttgccaa gaagagtctg cgttctgaga actccacagg gaagaaagct
      781 gtgctggatt ctagcccctt cctgtcagag gcgaatgcag agcgcattgt gagtacattg
      841 tgcaaggtgc gtggggccgc actgaagctg ggccagatgc tgagcatcca ggatgatgcc
      901 ttcatcaacc ctcacctggc caagatcttt gagcgggtga ggcagagcgc tgacttcatg
      961 ccactgaaac agatgacgaa aactctcaac aatgacctgg gcccccattg gagggacaag
     1021 ctggagtact ttgaagagcg gccctttgcg gctgcctcca tagggcaggt gcacctggcc
     1081 cgtttgaagg gtggccgtga ggtggccatg aagattcagt accctggtgt ggcccagagc
     1141 attaacagtg acgtcaacaa cctcatggct gtgctgaaca tgagtaacat gcttccagaa
     1201 ggcctgttcc cagagcacct gattgatgtg ctgaggcggg agcttaccct tgagtgtgac
     1261 taccagcggg aggctgccta tgccaagaag ttcagggagc tgctgaagga ccaccccttc
     1321 ttctatgtgc ctgagattgt ggacgagctg tgcagccccc atgtgctgac cacagagctg
     1381 ataacaggct tccccctgga ccaggcagaa gggctgagcc aggaagtgcg gaatgagatc
     1441 tgctacaaca ttttggtgct gtgcctgagg gagctgtttg agttccatgt catgcagact
     1501 gaccccaact ggtccaattt cttttatgac cctcagcagc acaaggtggc tctcctggac
     1561 tttggggcaa ctcgagaata tgaccgatcc tttactgacc tctacattca ggtcatccgg
     1621 gctgctgctg accaggacag ggaggcagtg ctgaagaagt ccatagagat gaagttcctc
     1681 actggttatg aggtcaaggc catggaggat gcccacctgg atgccattct catcctgggg
     1741 gaggcctttg cttcggaaga gccctttgac ttcggcacgc agagcaccac tgagaagatc
     1801 cataacctga tccccatcat gctgaagcac cgcctcatcc cgcctcctga ggagacctac
     1861 tctctgcacc gcaagatggg gggctctttc ctcatctgtt ccaagctgaa ggcctgcttc
     1921 ccctgcaagg ccatgtttga ggaagcgtac agtaactact gcaggatgaa gtctgggctg
     1981 cagtaggtga ggcttgggcc gggctaactg gggtcgtgcc ctccttcagg ctcagccaag
     2041 cagaggcagg atgtgggcag ggacagggac ccacagcctc catgactggg aagagagcac
     2101 tgcagactct gctgctgctg ctgctgtcca gtgcagacaa aaaggcagct gctttgccat
     2161 ctcctcctgc tgtggatgta caacaggagc atgggacaaa gcagtgctca gctcagctca
     2221 gccacctttg gggtctagtt ggccatgcag agtgaattgt gtgtttctgg gtgagcttat
     2281 gtccctgccc tttgccaccc gagctcagtc tcagcatgga caacagaccc tgttaaaagc
     2341 agggccgaca actggatgag cagcaggcct ctagcatgtc ccaggaaagg tagttactac
     2401 cccaccccag gggatcagca taggctcttt gtttgtatgt cttgtaatta cacgttcata
     2461 cctttgcatt caataaagaa gtgtgctggg aaaaaaaaaa aaaaaaaaaa aaaaa
//
