LOCUS       NM_012785                887 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus coenzyme Q7, hydroxylase (Coq7), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_012785
VERSION     NM_012785.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 887)
  AUTHORS   Monaghan,R.M., Barnes,R.G., Fisher,K., Andreou,T., Rooney,N.,
            Poulin,G.B. and Whitmarsh,A.J.
  TITLE     A nuclear role for the respiratory enzyme CLK-1 in regulating
            mitochondrial stress responses and longevity
  JOURNAL   Nat Cell Biol 17 (6), 782-792 (2015)
   PUBMED   25961505
REFERENCE   2  (bases 1 to 887)
  AUTHORS   Garcia-Corzo,L., Luna-Sanchez,M., Doerrier,C., Garcia,J.A.,
            Guaras,A., Acin-Perez,R., Bullejos-Peregrin,J., Lopez,A.,
            Escames,G., Enriquez,J.A., Acuna-Castroviejo,D. and Lopez,L.C.
  TITLE     Dysfunctional Coq9 protein causes predominant encephalomyopathy
            associated with CoQ deficiency
  JOURNAL   Hum Mol Genet 22 (6), 1233-1248 (2013)
   PUBMED   23255162
REFERENCE   3  (bases 1 to 887)
  AUTHORS   Wang,D., Wang,Y., Argyriou,C., Carriere,A., Malo,D. and Hekimi,S.
  TITLE     An enhanced immune response of Mclk1/ mutant mice is associated
            with partial protection from fibrosis, cancer and the development
            of biomarkers of aging
  JOURNAL   PLoS One 7 (11), e49606 (2012)
   PUBMED   23166727
REFERENCE   4  (bases 1 to 887)
  AUTHORS   Natarajaseenivasan,K., Shanmughapriya,S., Velineni,S.,
            Artiushin,S.C. and Timoney,J.F.
  TITLE     Cloning, expression, and homology modeling of GroEL protein from
            Leptospira interrogans serovar autumnalis strain N2
  JOURNAL   Genomics Proteomics Bioinformatics 9 (4-5), 151-157 (2011)
   PUBMED   22196358
  REMARK    GeneRIF: groEL gene encodes a protein of 60 kDa with a high degree
            of homology (99% similarity) to those of other leptospiral serovar
REFERENCE   5  (bases 1 to 887)
  AUTHORS   Zheng,H., Lapointe,J. and Hekimi,S.
  TITLE     Lifelong protection from global cerebral ischemia and reperfusion
            in long-lived Mclk1(+/)(-) mutants
  JOURNAL   Exp Neurol 223 (2), 557-565 (2010)
   PUBMED   20170652
REFERENCE   6  (bases 1 to 887)
  AUTHORS   Silvestri,E., de Lange,P., Moreno,M., Lombardi,A., Ragni,M.,
            Feola,A., Schiavo,L., Goglia,F. and Lanni,A.
  TITLE     Fenofibrate activates the biochemical pathways and the de novo
            expression of genes related to lipid handling and uncoupling
            protein-3 functions in liver of normal rats
  JOURNAL   Biochim Biophys Acta 1757 (5-6), 486-495 (2006)
   PUBMED   16595124
REFERENCE   7  (bases 1 to 887)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 887)
  AUTHORS   Levavasseur,F., Miyadera,H., Sirois,J., Tremblay,M.L., Kita,K.,
            Shoubridge,E. and Hekimi,S.
  TITLE     Ubiquinone is necessary for mouse embryonic development but is not
            essential for mitochondrial respiration
  JOURNAL   J Biol Chem 276 (49), 46160-46164 (2001)
   PUBMED   11585841
REFERENCE   9  (bases 1 to 887)
  AUTHORS   Nakai,D., Yuasa,S., Takahashi,M., Shimizu,T., Asaumi,S., Isono,K.,
            Takao,T., Suzuki,Y., Kuroyanagi,H., Hirokawa,K., Koseki,H. and
            Shirsawa,T.
  TITLE     Mouse homologue of coq7/clk-1, longevity gene in Caenorhabditis
            elegans, is essential for coenzyme Q synthesis, maintenance of
            mitochondrial integrity, and neurogenesis
  JOURNAL   Biochem Biophys Res Commun 289 (2), 463-471 (2001)
   PUBMED   11716496
REFERENCE   10 (bases 1 to 887)
  AUTHORS   Jonassen,T., Marbois,B.N., Kim,L., Chin,A., Xia,Y.R., Lusis,A.J.
            and Clarke,C.F.
  TITLE     Isolation and sequencing of the rat Coq7 gene and the mapping of
            mouse Coq7 to chromosome 7
  JOURNAL   Arch Biochem Biophys 330 (2), 285-289 (1996)
   PUBMED   8660658
  REMARK    Erratum:[Arch Biochem Biophys 1996 Nov 1;335(1):227]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ225865.1, BF558335.1 and AI711299.1.
            
            On Mar 29, 2013 this sequence version replaced NM_012785.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225865.1, SRR8487231.173007.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               FQ225865.1         1-516
            517-865             BF558335.1         26-374              c
            866-887             AI711299.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..887
                     /gene="Coq7"
                     /note="coenzyme Q7, hydroxylase"
                     /db_xref="GeneID:25249"
                     /db_xref="RGD:2381"
     exon            1..133
                     /gene="Coq7"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..714
                     /gene="Coq7"
                     /EC_number="1.14.99.60"
                     /note="ubiquinone biosynthesis protein COQ7 homolog;
                     coenzyme Q7 homolog, ubiquinone; timing protein clk-1
                     homolog; coenzyme Q biosynthesis protein 7 homolog;
                     demethyl-Q 7; Coenzyme q (ubiquinone) biosynthetic enzyme
                     (DHPB methyltransferase) 7; DMQ hydroxylase; ubiquinone
                     biosynthesis monooxygenase COQ7"
                     /codon_start=1
                     /product="5-demethoxyubiquinone hydroxylase,
                     mitochondrial"
                     /protein_id="NP_036917.2"
                     /db_xref="GeneID:25249"
                     /db_xref="RGD:2381"
                     /translation="MSGAGAIAAASVGCLRTGVPRPFSAYGRGLIIRCHSTGMTLDNI
                     NRAAVDQIIRVDHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKNHLKKFNELMV
                     AFRVRPTVLMPLWNVAGFALGAGTALLGKEGAMACTVAVEESIAHHYNNQIRMLMEED
                     AEKYEELLQVIKQFRDEELEHHDTGLEHDAELAPAYTLLKRLIQAGCSAAIYLSERF"
     exon            134..312
                     /gene="Coq7"
                     /inference="alignment:Splign:2.1.0"
     exon            313..427
                     /gene="Coq7"
                     /inference="alignment:Splign:2.1.0"
     exon            428..567
                     /gene="Coq7"
                     /inference="alignment:Splign:2.1.0"
     exon            568..636
                     /gene="Coq7"
                     /inference="alignment:Splign:2.1.0"
     exon            637..870
                     /gene="Coq7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctgagtc gagagcgcga ttggcgggac gcttggactg tggctgcact gtcaccagcg
       61 atgagcggcg cgggagcgat agcggccgct tccgtgggat gcctgcgcac tggtgtcccg
      121 aggcctttct cagcttatgg gagaggcctt atcatcaggt gtcacagcac aggaatgacc
      181 ttagacaata ttaaccgggc agccgtggat cagataatcc gggtggatca cgctggtgaa
      241 tatggagcaa accgcatcta tgcagggcag atggctgtgc ttggacggac cagtgttggc
      301 cctgtcattc agaaaatgtg ggatcaagaa aagaaccatt tgaaaaagtt caacgagttg
      361 atggttgcgt tcagggtccg acctacggtt ttgatgccct tgtggaacgt ggcagggttt
      421 gccctggggg caggaactgc cttgctgggg aaggaaggag caatggcctg caccgtggca
      481 gtagaagagt ctatcgctca tcactacaac aaccagatcc gcatgctgat ggaggaggac
      541 gctgagaagt acgaggagct gctgcaggtc attaagcagt ttcgagatga ggagcttgag
      601 caccacgaca caggcctgga acatgatgca gagctggctc ccgcatacac cttgttgaag
      661 agacttatcc aggccggatg cagtgcagcc atatacttat cagaaaggtt ttaaagtacg
      721 actactgagc catctcaaga aaagatggcc gtaactcaag gtgtttgtgg aggaagaact
      781 gcagttatca ctgtgtgtga tttgttaata caagaggcgg tgtttggggt tgtgtcactg
      841 ttgtcaataa aactcctcgg tgctggtttc aaaaaaaaaa aaaaaaa
//
