LOCUS       NM_019187               1051 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus coenzyme Q3 methyltransferase (Coq3), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_019187 XM_346734
VERSION     NM_019187.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1051)
  AUTHORS   Jonassen,T. and Clarke,C.F.
  TITLE     Isolation and functional expression of human COQ3, a gene encoding
            a methyltransferase required for ubiquinone biosynthesis
  JOURNAL   J Biol Chem 275 (17), 12381-12387 (2000)
   PUBMED   10777520
REFERENCE   2  (bases 1 to 1051)
  AUTHORS   Poon,W.W., Barkovich,R.J., Hsu,A.Y., Frankel,A., Lee,P.T.,
            Shepherd,J.N., Myles,D.C. and Clarke,C.F.
  TITLE     Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze
            both O-methyltransferase steps in coenzyme Q biosynthesis
  JOURNAL   J Biol Chem 274 (31), 21665-21672 (1999)
   PUBMED   10419476
REFERENCE   3  (bases 1 to 1051)
  AUTHORS   Marbois,B.N., Hsu,A., Pillai,R., Colicelli,J. and Clarke,C.F.
  TITLE     Cloning of a rat cDNA encoding dihydroxypolyprenylbenzoate
            methyltransferase by functional complementation of a Saccharomyces
            cerevisiae mutant deficient in ubiquinone biosynthesis
  JOURNAL   Gene 138 (1-2), 213-217 (1994)
   PUBMED   8125303
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_019187.3.
            
            On Nov 26, 2020 this sequence version replaced NM_019187.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20427.1, SRR26643289.14852.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000005.1  40241107-40241165
            60-209              JAXUCZ010000005.1  40244129-40244278
            210-309             JAXUCZ010000005.1  40245553-40245652
            310-552             JAXUCZ010000005.1  40247137-40247379
            553-712             JAXUCZ010000005.1  40255170-40255329
            713-1051            JAXUCZ010000005.1  40257034-40257372
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..1051
                     /gene="Coq3"
                     /note="coenzyme Q3 methyltransferase"
                     /db_xref="GeneID:29309"
                     /db_xref="RGD:2380"
     CDS             1..861
                     /gene="Coq3"
                     /EC_number="2.1.1.114"
                     /EC_number="2.1.1.64"
                     /note="hexaprenyldihydroxybenzoate methyltransferase,
                     mitochondrial; DHHB-MT; DHHB-MTase; DHHB
                     methyltransferase; dihydroxyhexaprenylbenzoate
                     methyltransferase; 3,4-dihydroxy-5-hexaprenylbenzoate
                     methyltransferase; 3-demethylubiquinone-9
                     3-methyltransferase; coenzyme Q (ubiquinone);
                     2-polyprenyl-6-hydroxyphenyl methylase; coenzyme Q3
                     homolog, methyltransferase; 2-polyprenyl-6-hydroxyphenol
                     methylase; 3-demethylubiquinol 3-O-methyltransferase;
                     polyprenyldihydroxybenzoate methyltransferase"
                     /codon_start=1
                     /product="ubiquinone biosynthesis O-methyltransferase,
                     mitochondrial"
                     /protein_id="NP_062060.1"
                     /db_xref="GeneID:29309"
                     /db_xref="RGD:2380"
                     /translation="MWLRSYRITFSCLTRLKTYRSSWKKLYSTSQTVDSKEVKTFQAL
                     AHSWWDEQGKFAPLHSMNDLRVPFIRDNLLKTSTNHDPGKPLSGMKILDVGCGGGLLT
                     EPLGRLGASVVGIDPVAENIKIAQHHKSFDPVLDKRIQYRVCSLEETLNENAECFDAV
                     VASEVVEHVNNLEMFIQCCYQVLKPGGSLFITTVNKTQLSYVLGIVFSEQIAGIVPKG
                     THTWEKFVSPEKLESILEPNGLSVETVAGMVYNPFSGYWHWTENTSLNYAAHAVRARA
                     QEHLEPAESA"
     exon            1..59
                     /gene="Coq3"
                     /inference="alignment:Splign:2.1.0"
     exon            60..209
                     /gene="Coq3"
                     /inference="alignment:Splign:2.1.0"
     exon            210..309
                     /gene="Coq3"
                     /inference="alignment:Splign:2.1.0"
     exon            310..552
                     /gene="Coq3"
                     /inference="alignment:Splign:2.1.0"
     exon            553..712
                     /gene="Coq3"
                     /inference="alignment:Splign:2.1.0"
     exon            713..1051
                     /gene="Coq3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggctta gatcttacag gataacgttt tcctgtttga ccagactaaa aacttacagg
       61 tcctcttgga agaaattata cagtacttca caaacagttg acagcaagga ggtcaaaacc
      121 ttccaggccc tggctcactc atggtgggat gagcaaggga agtttgcgcc tcttcattct
      181 atgaatgacc tacgggtgcc gttcattaga gacaatcttt tgaaaacaag tactaatcat
      241 gatccaggaa agcctttatc tgggatgaag attctcgacg ttggctgtgg cggtgggtta
      301 ttaactgaac ctctagggag actgggagct tcagttgttg gaatcgatcc tgtggctgaa
      361 aacattaaga tagcacagca ccataaatca tttgatccag tcctggataa gaggatacag
      421 taccgagtgt gctccctgga ggagaccttg aatgagaatg cagagtgttt tgatgctgtc
      481 gtggcttctg aagttgtcga gcatgtgaac aaccttgaaa tgttcataca gtgctgctat
      541 caagtattga aacctggtgg ctctttattc attactacag tgaacaaaac acagctgtcc
      601 tatgtcttgg gaattgtttt ctcagagcaa attgcaggca ttgttccaaa aggcactcat
      661 acgtgggaga agtttgtttc acctgaaaag ctagaaagca tcttggaacc aaatggtctg
      721 tcagttgaaa ctgtggcagg aatggtctat aaccctttct caggttactg gcattggact
      781 gaaaatacca gccttaacta tgcagcccat gctgtgagag ccagggctca ggaacacctg
      841 gagcctgctg agtctgcttg aaagggggaa gcagaagcac cccatgccaa agtctccggc
      901 agcccaagtg tgcacgaggg gcagagaaaa tgagaaagct ctgaggacag cagtaaatat
      961 gcttgaagtt gtgttgttta caaatccaaa catcttactc cttttcggga gggattctga
     1021 agaacaaaag gtcaataaaa atatctaaat c
//
