LOCUS       NM_001044255            1797 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus coenzyme Q2, polyprenyltransferase (Coq2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001044255 XM_001061021 XM_573556
VERSION     NM_001044255.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1797)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1797)
  AUTHORS   Desbats,M.A., Morbidoni,V., Silic-Benussi,M., Doimo,M.,
            Ciminale,V., Cassina,M., Sacconi,S., Hirano,M., Basso,G.,
            Pierrel,F., Navas,P., Salviati,L. and Trevisson,E.
  TITLE     The COQ2 genotype predicts the severity of coenzyme Q10 deficiency
  JOURNAL   Hum Mol Genet 25 (19), 4256-4265 (2016)
   PUBMED   27493029
REFERENCE   3  (bases 1 to 1797)
  AUTHORS   Sasaki,D., Kotoh,J., Watadani,R. and Matsumoto,K.
  TITLE     New animal models reveal that coenzyme Q2 (Coq2) and
            placenta-specific 8 (Plac8) are candidate genes for the onset of
            type 2 diabetes associated with obesity in rats
  JOURNAL   Mamm Genome 26 (11-12), 619-629 (2015)
   PUBMED   26296322
  REMARK    GeneRIF: coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are
            differentially expressed in obese rats, suggesting that these two
            genes are candidates for the onset of type 2 diabetes associated
            with obesity in rats.
REFERENCE   4  (bases 1 to 1797)
  AUTHORS   Lopez-Martin,J.M., Salviati,L., Trevisson,E., Montini,G.,
            DiMauro,S., Quinzii,C., Hirano,M., Rodriguez-Hernandez,A.,
            Cordero,M.D., Sanchez-Alcazar,J.A., Santos-Ocana,C. and Navas,P.
  TITLE     Missense mutation of the COQ2 gene causes defects of bioenergetics
            and de novo pyrimidine synthesis
  JOURNAL   Hum Mol Genet 16 (9), 1091-1097 (2007)
   PUBMED   17374725
REFERENCE   5  (bases 1 to 1797)
  AUTHORS   Quinzii,C., Naini,A., Salviati,L., Trevisson,E., Navas,P.,
            Dimauro,S. and Hirano,M.
  TITLE     A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2)
            causes primary coenzyme Q10 deficiency
  JOURNAL   Am J Hum Genet 78 (2), 345-349 (2006)
   PUBMED   16400613
REFERENCE   6  (bases 1 to 1797)
  AUTHORS   Forsgren,M., Attersand,A., Lake,S., Grunler,J., Swiezewska,E.,
            Dallner,G. and Climent,I.
  TITLE     Isolation and functional expression of human COQ2, a gene encoding
            a polyprenyl transferase involved in the synthesis of CoQ
  JOURNAL   Biochem J 382 (Pt 2), 519-526 (2004)
   PUBMED   15153069
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099827.1.
            
            On or before Aug 24, 2006 this sequence version replaced
            XM_573556.2, XM_001061021.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1797
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1797
                     /gene="Coq2"
                     /gene_synonym="PHB:PPT; RGD1306722"
                     /note="coenzyme Q2, polyprenyltransferase"
                     /db_xref="GeneID:498332"
                     /db_xref="RGD:1306722"
     exon            1..257
                     /gene="Coq2"
                     /gene_synonym="PHB:PPT; RGD1306722"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1129
                     /gene="Coq2"
                     /gene_synonym="PHB:PPT; RGD1306722"
                     /EC_number="2.5.1.39"
                     /note="para-hydroxybenzoate--polyprenyltransferase,
                     mitochondrial; 4-hydroxybenzoate polyprenyltransferase,
                     mitochondrial; coenzyme Q2 4-hydroxybenzoate
                     polyprenyltransferase; coenzyme Q2 homolog,
                     prenyltransferase; 4-HB polyprenyltransferase;
                     PHB:polyprenyltransferase"
                     /codon_start=1
                     /product="4-hydroxybenzoate polyprenyltransferase,
                     mitochondrial precursor"
                     /protein_id="NP_001037720.1"
                     /db_xref="GeneID:498332"
                     /db_xref="RGD:1306722"
                     /translation="MLRLGGAGLVRGLRVVSPAWLRGPGGLPLALARTTGTSGARDRR
                     APASGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAD
                     PGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSF
                     VFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGAL
                     LGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTK
                     QWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAVGAHLAHQIYTVDIHRAEDCWEKFT
                     SNRTVGLLLFLGIVLGNLYKDKPDETKGVDAVGEESERTS"
     exon            258..424
                     /gene="Coq2"
                     /gene_synonym="PHB:PPT; RGD1306722"
                     /inference="alignment:Splign:2.1.0"
     exon            425..546
                     /gene="Coq2"
                     /gene_synonym="PHB:PPT; RGD1306722"
                     /inference="alignment:Splign:2.1.0"
     exon            547..632
                     /gene="Coq2"
                     /gene_synonym="PHB:PPT; RGD1306722"
                     /inference="alignment:Splign:2.1.0"
     exon            633..766
                     /gene="Coq2"
                     /gene_synonym="PHB:PPT; RGD1306722"
                     /inference="alignment:Splign:2.1.0"
     exon            767..955
                     /gene="Coq2"
                     /gene_synonym="PHB:PPT; RGD1306722"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1777
                     /gene="Coq2"
                     /gene_synonym="PHB:PPT; RGD1306722"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcatgctg cgcttgggag gcgcggggct agtgcggggc ctgcgggtgg tgtcgcccgc
       61 atggctgcga ggtccgggtg gactcccgct ggccctggcg cgcaccacag ggacgtcggg
      121 agcgcgggac cggcgagcgc cggcctccgg gacgcagcgc gggcgcgcac tcagcctgtc
      181 cgccgcagcc gtagtgaact cggcgccccg cccgctgcag ccctacctgc ggctcatgcg
      241 cctggacaag cccatcggaa cctggctgct gtatttgcca tgcacttgga gcattggtct
      301 ggccgctgac ccgggttgtt ttcctgactg gtatatgtta tcactctttg gcactggagc
      361 tattctcatg cgtggagcag gctgtactat taatgacatg tgggaccgtg acttcgataa
      421 aaaggtcgag aggacagcaa accgcccaat cgccgcggga gacatttcag ccttccagtc
      481 cttcgtcttc cttggggcac agctgacctt ggcactgggc gttctcctgc atctgaacta
      541 ctacagtata gcaatgggag cagcatcctt acttcttgtc gtcacctacc ccctcatgaa
      601 aagagtcacg ttctggcctc agttagcctt gggcttgact tttaattggg gtgcgttact
      661 cggatggtct gctgtcaagg gctcctgtga tccagctgtg tgcctgcctc tttatttttc
      721 tggagttatg tggacactga tatatgatac tatttatgcc caccaggaca agaaagatga
      781 tgctctgatt ggcctgaagt ccacagctct gctcttcagg gagaacacca agcagtggct
      841 cagtggcttt ggggtcgcca tggtgggagc gctgagcctg gtgggagcca gcagtggtca
      901 gaccctccct tactacgctg ccgtggctgc agtgggagcc cacctggctc accagattta
      961 caccgtggac atccacagag ccgaggactg ctgggaaaag tttacctcca accgcacagt
     1021 aggcctactc ctgttcttag ggattgtgct tgggaatttg tacaaagaca agccggacga
     1081 gacgaaggga gtggacgctg ttggagagga aagtgagcgg acaagctgag cttggtgtcc
     1141 ccgggaagca ggcaggaaga ccgtgaggtc agggcattga gtgacacagt aggaccctgt
     1201 ctcaaagcag cacgccggct agagttgtag cttgtgggaa gagtgcgtgg tcaccatgcg
     1261 atacacctga gctctgggtc agcatagact cgtttgtaaa actcaggtct ggagaccaca
     1321 ttgctagatt tgaagtaaga cgcactgggg tagcatgtgc tggacctcac ggcagctgct
     1381 tcccccacct cccttccggg aacctgggct tctgcacact gtgcagcctt cgtccttgtt
     1441 cctctcacct ggagtttcag gagcttcagg aaaaccttgc ctaactcact gagttagttt
     1501 tttcttttct tttctttttt tcggagctgg ggaccgaacc cagggccttg cgcttgctag
     1561 gcaagcgctc taccactgag ctaaatcccc agccccctga gtgagttttt tatgaaaatg
     1621 gccggatact ttattttctc actaagaatc tcctgtgaga acttcctgtg atctttgctc
     1681 acttccaaag ctgaattcaa gagccattct gattctgggt gttttagaag agtatgagca
     1741 aataaatatg tttccatcca tgtgtggatg tccatgaaaa aaaaaaaaaa aaaaaaa
//
