LOCUS       NM_001108727            1287 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus coenzyme Q10A (Coq10a), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001108727 XM_001067009 XM_343138
VERSION     NM_001108727.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1287)
  AUTHORS   Srivastava,P., Verma,A.K., Arya,J.K. and Rizvi,S.I.
  TITLE     Modulatory effect of exogenous Coenzyme Q10 on redox and
            inflammatory biomarkers during aging in rats
  JOURNAL   Biol Futur 73 (4), 473-481 (2022)
   PUBMED   36443592
  REMARK    GeneRIF: Modulatory effect of exogenous Coenzyme Q10 on redox and
            inflammatory biomarkers during aging in rats.
REFERENCE   2  (bases 1 to 1287)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1287)
  AUTHORS   Arany,I., Carter,A., Hall,S., Fulop,T. and Dixit,M.
  TITLE     Coenzyme Q10 protects renal proximal tubule cells against
            nicotine-induced apoptosis through induction of p66shc-dependent
            antioxidant responses
  JOURNAL   Apoptosis 22 (2), 220-228 (2017)
   PUBMED   27770269
  REMARK    GeneRIF: Our studies revealed that Coenzyme Q10 strongly inhibits
            nicotine-mediated production of reactive oxygen species and
            consequent apoptosis that requires serine36 phosphorylation but not
            mitochondrial translocation/cytochrome c binding of p66(shc).
REFERENCE   4  (bases 1 to 1287)
  AUTHORS   Kucharska,J., Gvozdjakova,A. and Simko,F.
  TITLE     Simvastatin decreased coenzyme Q in the left ventricle and skeletal
            muscle but not in the brain and liver in L-NAME-induced
            hypertension
  JOURNAL   Physiol Res 56 Suppl 2, S49-S54 (2007)
   PUBMED   17824807
  REMARK    GeneRIF: Administration of simvastatin under the condition of
            nitric oxide-deficiency reduced the level of coenzyme Q9/10 in the
            heart and skeletal muscle.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474104.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343138.3, XM_001067009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB586137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1287
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1287
                     /gene="Coq10a"
                     /gene_synonym="RGD1562447"
                     /note="coenzyme Q10A"
                     /db_xref="GeneID:362810"
                     /db_xref="RGD:1562447"
     exon            1..122
                     /gene="Coq10a"
                     /gene_synonym="RGD1562447"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..732
                     /gene="Coq10a"
                     /gene_synonym="RGD1562447"
                     /note="coenzyme Q10 homolog A"
                     /codon_start=1
                     /product="coenzyme Q-binding protein COQ10 homolog A,
                     mitochondrial"
                     /protein_id="NP_001102197.1"
                     /db_xref="GeneID:362810"
                     /db_xref="RGD:1562447"
                     /translation="MELWGYVCKFDAPGGFLISCNLLLPRAAQVLAAEVGLPPSRSFM
                     GFAAPFTNKRKAYSERRIMGYSMQEMFEVVSNVQEYREFVPWCKKSLVVSSRKGHLKA
                     QLEVGFPPVLERYTSAVSMVKPHMVKAVCTDGKLFNHLETIWRFSPGIPAYPRTCTVD
                     FSISFEFRSLLHSQLATMFFDEVVKQNVAAFERRAATKFGPETAIPRELMFHEVHQT"
     exon            123..269
                     /gene="Coq10a"
                     /gene_synonym="RGD1562447"
                     /inference="alignment:Splign:2.1.0"
     exon            270..462
                     /gene="Coq10a"
                     /gene_synonym="RGD1562447"
                     /inference="alignment:Splign:2.1.0"
     exon            463..564
                     /gene="Coq10a"
                     /gene_synonym="RGD1562447"
                     /inference="alignment:Splign:2.1.0"
     exon            565..1287
                     /gene="Coq10a"
                     /gene_synonym="RGD1562447"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccggcacc ctgagtttct gtggtgaagg gtggcaggcc ggagaagggc tagcattggt
       61 ggtgccctag gagctcgaat ggagctctgg ggatacgtgt gcaaatttga tgctccgggc
      121 gggtttctta tttcctgtaa cctcctcttg cctcgcgctg cccaggtctt ggcggctgag
      181 gttggccttc ctcctagtcg ttccttcatg ggctttgctg cccccttcac caacaagcga
      241 aaggcttact cagagcgtag gatcatgggg tactcaatgc aggaaatgtt tgaggtggtg
      301 tccaatgtcc aggagtaccg agagtttgtg ccgtggtgta agaagtcact ggtggtatcc
      361 agccgtaagg gtcacctgaa agcccagttg gaagtcgggt tcccacctgt cttggaacgt
      421 tacacctctg cagtctccat ggtcaaacca cacatggtca aggctgtctg cactgatggc
      481 aagctcttta accacttaga gactatttgg cgattcagcc ctggtattcc cgcctaccct
      541 cgaacctgca ctgtggactt ctcgatttcc tttgaatttc gttctctgct ccactcccag
      601 ctggcgacca tgttttttga tgaggttgta aagcagaacg ttgctgcctt tgagcgccgg
      661 gcagcaacca agtttggccc agaaacagcc atcccccgtg agctcatgtt ccatgaagtg
      721 caccagactt gagacaagga ttgtttcctt gcctctaacc cctcttccca cccaatttta
      781 tttatttggt ttggctctga gagaggtcta agtttcacct ctcaagtctt cctaaactgg
      841 gctgcatgct gtctggacac aggaaagata gcagatatga agtgagatgg atacatagga
      901 aagggtcaag cacattctga aagcctcaca tgcccatggc cgttgcacac cagataaaaa
      961 gcagggctgt agctgtctct gggcctggtc aagaaacctt actactcagt tgatgaaatt
     1021 tagaaggaac tttctcacac agagagactg gctggcaagt aacttttacc ctgctaagat
     1081 ttctcaggag aaaaggcaac ctgccccagt ttaggaacat gtccatgctg tctgacaggt
     1141 aggaagtgag gagctgcttt accatagtgc cacagagcaa gggggagaag tcactagaca
     1201 gtgttgttca tattgtggga tgtacctttt ttctcccatg tggcctgagt ttttataaaa
     1261 ctttaataaa tggtgacagt gtgaatt
//
