LOCUS       NM_001013227            1571 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus COP9 signalosome subunit 8 (Cops8), mRNA.
ACCESSION   NM_001013227 XM_343625
VERSION     NM_001013227.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1571)
  AUTHORS   Liu,C., Guo,L.Q., Menon,S., Jin,D., Pick,E., Wang,X., Deng,X.W. and
            Wei,N.
  TITLE     COP9 signalosome subunit Csn8 is involved in maintaining proper
            duration of the G1 phase
  JOURNAL   J Biol Chem 288 (28), 20443-20452 (2013)
   PUBMED   23689509
REFERENCE   2  (bases 1 to 1571)
  AUTHORS   Crone,S.G., Jacobsen,A., Federspiel,B., Bardram,L., Krogh,A.,
            Lund,A.H. and Friis-Hansen,L.
  TITLE     microRNA-146a inhibits G protein-coupled receptor-mediated
            activation of NF-kappaB by targeting CARD10 and COPS8 in gastric
            cancer
  JOURNAL   Mol Cancer 11, 71 (2012)
   PUBMED   22992343
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1571)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1571)
  AUTHORS   Sharon,M., Mao,H., Boeri Erba,E., Stephens,E., Zheng,N. and
            Robinson,C.V.
  TITLE     Symmetrical modularity of the COP9 signalosome complex suggests its
            multifunctionality
  JOURNAL   Structure 17 (1), 31-40 (2009)
   PUBMED   19141280
REFERENCE   5  (bases 1 to 1571)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
REFERENCE   6  (bases 1 to 1571)
  AUTHORS   Lykke-Andersen,K. and Wei,N.
  TITLE     Gene structure and embryonic expression of mouse COP9 signalosome
            subunit 8 (Csn8)
  JOURNAL   Gene 321, 65-72 (2003)
   PUBMED   14636993
REFERENCE   7  (bases 1 to 1571)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   8  (bases 1 to 1571)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC063182.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001013227.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063182.1, FQ215552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1571              BC063182.1         5-1575
FEATURES             Location/Qualifiers
     source          1..1571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..1571
                     /gene="Cops8"
                     /note="COP9 signalosome subunit 8"
                     /db_xref="GeneID:363283"
                     /db_xref="RGD:1311404"
     exon            1..128
                     /gene="Cops8"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..680
                     /gene="Cops8"
                     /note="SGN8; COP9 homolog; signalosome subunit 8;
                     JAB1-containing signalosome subunit 8; COP9 (constitutive
                     photomorphogenic) homolog, subunit 8"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 8"
                     /protein_id="NP_001013245.1"
                     /db_xref="GeneID:363283"
                     /db_xref="RGD:1311404"
                     /translation="MPVAVMADNAFSFRKLLDQCENQELEAPGGIATPPVYGQLLALY
                     LLQNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETV
                     QPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLEQGWQADSTTR
                     MVLPRKPAPGALDVSLNRFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN"
     exon            129..199
                     /gene="Cops8"
                     /inference="alignment:Splign:2.1.0"
     exon            200..248
                     /gene="Cops8"
                     /inference="alignment:Splign:2.1.0"
     exon            249..381
                     /gene="Cops8"
                     /inference="alignment:Splign:2.1.0"
     exon            382..489
                     /gene="Cops8"
                     /inference="alignment:Splign:2.1.0"
     exon            490..552
                     /gene="Cops8"
                     /inference="alignment:Splign:2.1.0"
     exon            553..600
                     /gene="Cops8"
                     /inference="alignment:Splign:2.1.0"
     exon            601..1541
                     /gene="Cops8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcttgtgct ttggtcaggc ggggtggcgg cggcgagagc ggccgggaag atgccagtgg
       61 cggtgatggc ggacaacgcc ttcagtttca gaaagctgtt ggatcagtgc gagaaccagg
      121 agcttgaggc tcctggagga atcgccacgc cgccagtgta tggtcagctt ctcgctttgt
      181 atttgctgca gaacgacatg aataatgcaa gatatctttg gaagaggata ccacctgcta
      241 taaagtctgc aaattctgaa cttgggggaa tttggtcagt aggacagcga atctggcaaa
      301 gagacttccc tgggatctat acgaccatca acgcacacca gtggtcagag actgtgcagc
      361 caatcatgga agcccttaga gatgcaacaa ggaggcgtgc ctttgccctg gtctcgcaag
      421 catacacctc cataatcgca gacgactttg cagcctttgt cggacttcct gtggaagagg
      481 ctgtgaaagg tgtgttggaa caaggatggc aggctgactc caccacaaga atggttcttc
      541 ccaggaagcc agcccctgga gccctggatg tttccttgaa caggtttatt cccttatcag
      601 agcctgcccc agttccgcca atccccaacg agcagcagct tgccaggctc accgattacg
      661 tggctttctt ggaaaactga tcgatcactc tgagttcaag attcaccttc aatccctgtc
      721 actggcaaac agacatggag ttttattctg agttcggaac agggtgagca cctctgtgtc
      781 ctttgggtgt gataaaatgc acatagaaga tgaaacgcat tgtacagttt tctcctcaga
      841 cacttttgaa tgtccttgga gcagttttcc tttgtattga tcactttggt tggagccatc
      901 agtattatac agagtttctg tcaaggaccg gactccgaac acaagctgtc ctgcttcaag
      961 tagcgagagg gcgctctggc atacaacaca ctcctgccta gcactggcct ctagctgaag
     1021 tgatggggat ttggggactg ccctgggcgg tgccctaccc acattgtcac tcgtgctctg
     1081 gagaatgtgc tcttcttccc ttcccagaac aaggaatcag tgatgtagaa tcagaaagag
     1141 ccgatggtgg caggtgtctc ctggggagga gcttgtcaat gctatgtttg tcttcccatt
     1201 gtgcaagcat ccattgcatg agacagacag tctgcaatga gaacgcaact taggtgcaga
     1261 tgggaaactc gaagttctga tgcctccttt cagaggaagg gaggagcatg gagtgcagtg
     1321 tgtgctgagg gagctcctga gctgagggcc ggcctgcagc cctcctgctg cgcatcctcc
     1381 tgctgcgcat ccagaccccg tgtagaaaag ctcagtgcat ctctttttgt tctcctatgg
     1441 cagcagccct tgaagatttg agttggttaa tgtatcttca ggttaaaacg gccctggttc
     1501 atttattctg catttgttca ataaatattt aattgaattc gaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa a
//
