LOCUS       NM_001107129            1173 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus COP9 signalosome subunit 6 (Cops6), mRNA.
ACCESSION   NM_001107129 XM_001066309 XM_222002
VERSION     NM_001107129.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1173)
  AUTHORS   Mei ZL, Wang HB, Hu YH and Xiong L.
  TITLE     CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via
            inhibiting SIRT2
  JOURNAL   Exp Cell Res 396 (1), 112245 (2020)
   PUBMED   32882218
  REMARK    GeneRIF: CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy
            via inhibiting SIRT2.
REFERENCE   2  (bases 1 to 1173)
  AUTHORS   Zhu Y, Li F, Shi W, Zhai C, Wang J, Yan X, Wang Q, Zhang Q, Yang L,
            Gao L and Li M.
  TITLE     COP9 signalosome subunit 6 mediates PDGF -induced pulmonary
            arterial smooth muscle cells proliferation
  JOURNAL   Exp Cell Res 371 (2), 379-388 (2018)
   PUBMED   30180991
  REMARK    GeneRIF: CSN6 mediates PDGF-induced pulmonary arterial smooth
            muscle cells proliferation.
REFERENCE   3  (bases 1 to 1173)
  AUTHORS   Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N and Robinson CV.
  TITLE     Symmetrical modularity of the COP9 signalosome complex suggests its
            multifunctionality
  JOURNAL   Structure 17 (1), 31-40 (2009)
   PUBMED   19141280
REFERENCE   4  (bases 1 to 1173)
  AUTHORS   Fang L, Wang X, Yamoah K, Chen PL, Pan ZQ and Huang L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
REFERENCE   5  (bases 1 to 1173)
  AUTHORS   Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M and Deng XW.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474107.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_222002.3, XM_001066309.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1173
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1173
                     /gene="Cops6"
                     /note="COP9 signalosome subunit 6"
                     /db_xref="GeneID:304343"
                     /db_xref="RGD:1309919"
     exon            1..132
                     /gene="Cops6"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1037
                     /gene="Cops6"
                     /note="COP9 (constitutive photomorphogenic) homolog,
                     subunit 6"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 6"
                     /protein_id="NP_001100599.1"
                     /db_xref="GeneID:304343"
                     /db_xref="RGD:1309919"
                     /translation="MERGGPWLAGAGKMAAAAAAAAAAAAAAANGSGGSSGMEVDAAV
                     PSVMASGVTGSVSVALHPLVILNISDHWIRMRSQEGRPMQVIGALIGKQEGRNIEVMN
                     SFELLSHTVEKKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVC
                     EIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVD
                     HVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILRE
                     AYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQG
                     IGRRMRGLFF"
     exon            133..255
                     /gene="Cops6"
                     /inference="alignment:Splign:2.1.0"
     exon            256..387
                     /gene="Cops6"
                     /inference="alignment:Splign:2.1.0"
     exon            388..476
                     /gene="Cops6"
                     /inference="alignment:Splign:2.1.0"
     exon            477..539
                     /gene="Cops6"
                     /inference="alignment:Splign:2.1.0"
     exon            540..587
                     /gene="Cops6"
                     /inference="alignment:Splign:2.1.0"
     exon            588..702
                     /gene="Cops6"
                     /inference="alignment:Splign:2.1.0"
     exon            703..795
                     /gene="Cops6"
                     /inference="alignment:Splign:2.1.0"
     exon            796..896
                     /gene="Cops6"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1173
                     /gene="Cops6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatggaaag gggcgggccg tggctggcgg gcgcggggaa aatggcggcg gcggcggcgg
       61 cggctgcggc ggcggcggcg gcggcggcga acgggagcgg aggcagcagc ggcatggagg
      121 tggatgcagc agtccccagc gtgatggcct ccggagtgac tgggagtgtt tccgtcgctc
      181 ttcatcccct tgtcatcctc aacatctcag accattggat ccgcatgcgc tcccaggagg
      241 ggcggcctat gcaggtgatt ggggctctga tcgggaagca ggaggggcga aatatcgaag
      301 tgatgaactc ctttgagctg ctgtctcaca ccgtggaaaa gaagattatc attgacaaag
      361 aatattatta caccaaggag gagcagttta aacaggtttt caaggagctg gagtttttgg
      421 gttggtatac cacagggggg ccacctgacc cctcagacat ccacgtccat aagcaggttt
      481 gcgagataat tgagagtcct ctctttctga agttgaaccc tatgaccaag cacacagatc
      541 tgcctgtcag cgtttttgag tctgtcatcg atataatcaa tggagaggcc acaatgctgt
      601 ttgctgaact cacttacact ctggccactg aggaagctga acgtatcggt gtagaccatg
      661 tggcccggat gacagctaca ggcagtgggg agaactccac tgtggctgaa cacctcatag
      721 ctcagcacag cgccatcaag atgctgcaca gccgtgtgaa gctcatttta gagtacgtca
      781 aggcctctga agcaggagag gttcccttca accatgagat cctgcgggag gcctatgccc
      841 tatgccactg tcttccagtt ctcagcactg acaagttcaa gacagacttt tatgatcaat
      901 gcaatgacgt ggggcttatg gcctacctcg gcaccatcac caaaacgtgc aacacaatga
      961 accagtttgt gaacaagttc aacgtcctgt atgaccgaca aggcatcggc aggcggatgc
     1021 ggggactgtt tttctgatga gggctcttgg aagggatgct gtatggggct cagacaactg
     1081 tgccacggga ctgagcactt tccccttaga gaaactcact aataaagaac agccccttag
     1141 cagcccttcc agtggctttg tcctctcagg cac
//
