LOCUS       NM_001025695            1296 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus COP9 signalosome subunit 5 (Cops5), mRNA.
ACCESSION   NM_001025695 XM_232615
VERSION     NM_001025695.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Guo H, Jing L, Cheng Y, Atsaves V, Lv Y, Wu T, Su R, Zhang Y, Zhang
            R, Liu W, Rassidakis GZ, Wei Y, Nan K and Claret FX.
  TITLE     Down-regulation of the cyclin-dependent kinase inhibitor p57 is
            mediated by Jab1/Csn5 in hepatocarcinogenesis
  JOURNAL   Hepatology 63 (3), 898-913 (2016)
   PUBMED   26606000
REFERENCE   2  (bases 1 to 1296)
  AUTHORS   Jiang P, Wang J, Kang Z, Li D and Zhang D.
  TITLE     Porcine JAB1 significantly enhances apoptosis induced by
            staurosporine
  JOURNAL   Cell Death Dis 4 (10), e823 (2013)
   PUBMED   24091666
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1296)
  AUTHORS   Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, Fan J, Lue H,
            Chen Y, Xiong H, Chagnon F, Bernhagen J, Lolis E, Mor G, Lesur O
            and Bucala R.
  TITLE     The D-dopachrome tautomerase (DDT) gene product is a cytokine and
            functional homolog of macrophage migration inhibitory factor (MIF)
  JOURNAL   Proc Natl Acad Sci U S A 108 (34), E577-E585 (2011)
   PUBMED   21817065
REFERENCE   4  (bases 1 to 1296)
  AUTHORS   Wang H, Song W, Hu T, Zhang N, Miao S, Zong S and Wang L.
  TITLE     Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1
            pathway
  JOURNAL   Cell Mol Life Sci 68 (12), 2129-2139 (2011)
   PUBMED   20978819
REFERENCE   5  (bases 1 to 1296)
  AUTHORS   Granata A, Koo SJ, Haucke V, Schiavo G and Warner TT.
  TITLE     CSN complex controls the stability of selected synaptic proteins
            via a torsinA-dependent process
  JOURNAL   EMBO J 30 (1), 181-193 (2011)
   PUBMED   21102408
REFERENCE   6  (bases 1 to 1296)
  AUTHORS   Luo W, Wang Y, Hanck T, Stricker R and Reiser G.
  TITLE     Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting
            protein, is involved in PAR-2-induced activation of activator
            protein-1
  JOURNAL   J Biol Chem 281 (12), 7927-7936 (2006)
   PUBMED   16410250
REFERENCE   7  (bases 1 to 1296)
  AUTHORS   Malicet C, Hoffmeister A, Moreno S, Closa D, Dagorn JC, Vasseur S
            and Iovanna JL.
  TITLE     Interaction of the stress protein p8 with Jab1 is required for
            Jab1-dependent p27 nuclear-to-cytoplasm translocation
  JOURNAL   Biochem Biophys Res Commun 339 (1), 284-289 (2006)
   PUBMED   16300740
REFERENCE   8  (bases 1 to 1296)
  AUTHORS   Tomoda K, Yoneda-Kato N, Fukumoto A, Yamanaka S and Kato JY.
  TITLE     Multiple functions of Jab1 are required for early embryonic
            development and growth potential in mice
  JOURNAL   J Biol Chem 279 (41), 43013-43018 (2004)
   PUBMED   15299027
REFERENCE   9  (bases 1 to 1296)
  AUTHORS   Oono K, Yoneda T, Manabe T, Yamagishi S, Matsuda S, Hitomi J,
            Miyata S, Mizuno T, Imaizumi K, Katayama T and Tohyama M.
  TITLE     JAB1 participates in unfolded protein responses by association and
            dissociation with IRE1
  JOURNAL   Neurochem Int 45 (5), 765-772 (2004)
   PUBMED   15234121
REFERENCE   10 (bases 1 to 1296)
  AUTHORS   Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M and Deng XW.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098736.1.
            
            On Jul 22, 2005 this sequence version replaced XM_232615.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098736.1, FQ215612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..1296
                     /gene="Cops5"
                     /note="COP9 signalosome subunit 5"
                     /db_xref="GeneID:312916"
                     /db_xref="RGD:1310301"
     exon            1..261
                     /gene="Cops5"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1123
                     /gene="Cops5"
                     /note="COP9 (constitutive photomorphogenic) homolog,
                     subunit 5"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 5"
                     /protein_id="NP_001020866.1"
                     /db_xref="GeneID:312916"
                     /db_xref="RGD:1310301"
                     /translation="MTASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKP
                     WTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEG
                     TETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQ
                     FQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHC
                     KQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQS
                     EAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA
                     "
     exon            262..496
                     /gene="Cops5"
                     /inference="alignment:Splign:2.1.0"
     exon            497..625
                     /gene="Cops5"
                     /inference="alignment:Splign:2.1.0"
     exon            626..691
                     /gene="Cops5"
                     /inference="alignment:Splign:2.1.0"
     exon            692..777
                     /gene="Cops5"
                     /inference="alignment:Splign:2.1.0"
     exon            778..889
                     /gene="Cops5"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1038
                     /gene="Cops5"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1273
                     /gene="Cops5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagagtcta gtgagtgtgc acccgtggtg gggaaggtgc aaagcccgca cgctgaggcc
       61 cagtagaata aagttgcatc ttggttgtgg agactacagc ttctccggtc cctcggccat
      121 gacagcttcc gggagtggta tggcccagaa gacctgggaa ttggccaaca acatgcagga
      181 agcgcagagt atcgatgaaa tctacaaata tgacaaaaaa caacaacaag aaatcctggc
      241 ggcgaaaccc tggactaagg atcaccacta ctttaaatac tgcaaaatct ctgcgttggc
      301 actgctgaaa atggtgatgc atgccaggtc aggaggcaac ctggaggtga tgggtttgat
      361 gctcgggaaa gtggatggag agaccatgat catcatggac agctttgctt tgcctgtaga
      421 gggcactgaa acccgagtaa atgcccaggc tgctgcatac gagtacatgg ctgcatacat
      481 agaaaatgcc aaacaggttg gccgccttga gaatgcaatt ggttggtatc acagccaccc
      541 tggttatggc tgctggctct ccggaattga tgttagtaca cagatgctta accagcagtt
      601 tcaggaacca tttgtagcag tggtgattga cccaaccaga acaatatctg cagggaaggt
      661 gaatcttggc gcctttagga catatccaaa gggctataag cctcctgatg aaggaccttc
      721 agagtaccag actatcccac tcaataaaat agaagatttt ggcgtgcact gcaaacaata
      781 ttatgcctta gaagtctcat atttcaaatc ctctttggat cgtaaactac ttgagctctt
      841 gtggaataaa tactgggtga acaccctgag ttcctctagc ttgcttacca atgctgacta
      901 taccacaggc caggtgtttg atctgtctga gaagttagag cagtcggaag cccagctggg
      961 gcgtgggagt ttcatgttgg gtttagaaac acatgaccgc aagtcagaag acaaacttgc
     1021 caaagctacg agagacagct gtaaaaccac catagaagcc atccatggac tgatgtctca
     1081 ggttattaag gataaactgt ttaatcaaat taacgttgct tagttactgc tgagtactct
     1141 tcctcagagc tggcgtgcgg aaggagaaga agctcaagga acattctaac ccagttacca
     1201 gaactcagat agaagactaa ggtgctgtgt gacgtcctga gtattagcac tgtaataaaa
     1261 ctgtcacatg aaaaaaaaaa aaaaaaaaaa aaaaaa
//
