LOCUS       NM_153297               2067 bp    mRNA    linear   ROD 29-APR-2024
DEFINITION  Rattus norvegicus COP9 signalosome subunit 2 (Cops2), transcript
            variant 1, mRNA.
ACCESSION   NM_153297
VERSION     NM_153297.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2067)
  AUTHORS   Alves,C.R.R., Neves,W.D., de Almeida,N.R., Eichelberger,E.J.,
            Jannig,P.R., Voltarelli,V.A., Tobias,G.C., Bechara,L.R.G., de Paula
            Faria,D., Alves,M.J.N., Hagen,L., Sharma,A., Slupphaug,G.,
            Moreira,J.B.N., Wisloff,U., Hirshman,M.F., Negrao,C.E., de
            Castro,G. Jr., Chammas,R., Swoboda,K.J., Ruas,J.L., Goodyear,L.J.
            and Brum,P.C.
  TITLE     Exercise training reverses cancer-induced oxidative stress and
            decrease in muscle COPS2/TRIP15/ALIEN
  JOURNAL   Mol Metab 39, 101012 (2020)
   PUBMED   32408015
  REMARK    GeneRIF: Exercise training reverses cancer-induced oxidative stress
            and decrease in muscle COPS2/TRIP15/ALIEN.
REFERENCE   2  (bases 1 to 2067)
  AUTHORS   Rajan,S., Chu Pham Dang,H., Djambazian,H., Zuzan,H., Fedyshyn,Y.,
            Ketela,T., Moffat,J., Hudson,T.J. and Sladek,R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   3  (bases 1 to 2067)
  AUTHORS   Sharon,M., Mao,H., Boeri Erba,E., Stephens,E., Zheng,N. and
            Robinson,C.V.
  TITLE     Symmetrical modularity of the COP9 signalosome complex suggests its
            multifunctionality
  JOURNAL   Structure 17 (1), 31-40 (2009)
   PUBMED   19141280
REFERENCE   4  (bases 1 to 2067)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
REFERENCE   5  (bases 1 to 2067)
  AUTHORS   Eckey,M., Tenbaum,S.P., Munoz,A. and Baniahmad,A.
  TITLE     Mixed lineage kinase 2 enhances trans-repression of Alien and
            nuclear receptors
  JOURNAL   Mol Cell Endocrinol 213 (1), 71-78 (2003)
   PUBMED   15062575
REFERENCE   6  (bases 1 to 2067)
  AUTHORS   Akiyama,H., Fujisawa,N., Tashiro,Y., Takanabe,N., Sugiyama,A. and
            Tashiro,F.
  TITLE     The role of transcriptional corepressor Nif3l1 in early stage of
            neural differentiation via cooperation with Trip15/CSN2
  JOURNAL   J Biol Chem 278 (12), 10752-10762 (2003)
   PUBMED   12522100
REFERENCE   7  (bases 1 to 2067)
  AUTHORS   Tenbaum,S.P., Juenemann,S., Schlitt,T., Bernal,J., Renkawitz,R.,
            Munoz,A. and Baniahmad,A.
  TITLE     Alien/CSN2 gene expression is regulated by thyroid hormone in rat
            brain
  JOURNAL   Dev Biol 254 (1), 149-160 (2003)
   PUBMED   12606288
REFERENCE   8  (bases 1 to 2067)
  AUTHORS   Akiyama,H., Sugiyama,A., Uzawa,K., Fujisawa,N., Tashiro,Y. and
            Tashiro,F.
  TITLE     Implication of Trip15/CSN2 in early stage of neuronal
            differentiation of P19 embryonal carcinoma cells
  JOURNAL   Brain Res Dev Brain Res 140 (1), 45-56 (2003)
   PUBMED   12524175
  REMARK    GeneRIF: Expressed at an early stage of neuronal differentiaation.
REFERENCE   9  (bases 1 to 2067)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   10 (bases 1 to 2067)
  AUTHORS   Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R.,
            Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
  TITLE     A novel protein complex involved in signal transduction possessing
            similarities to 26S proteasome subunits
  JOURNAL   FASEB J 12 (6), 469-478 (1998)
   PUBMED   9535219
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_153297.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB081072.1, SRR26643293.18602.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000003.1  133563290-133563493 c
            205-318             JAXUCZ010000003.1  133555935-133556048 c
            319-396             JAXUCZ010000003.1  133554605-133554682 c
            397-522             JAXUCZ010000003.1  133551353-133551478 c
            523-612             JAXUCZ010000003.1  133549183-133549272 c
            613-690             JAXUCZ010000003.1  133548995-133549072 c
            691-865             JAXUCZ010000003.1  133547097-133547271 c
            866-1044            JAXUCZ010000003.1  133546469-133546647 c
            1045-1097           JAXUCZ010000003.1  133546310-133546362 c
            1098-1195           JAXUCZ010000003.1  133543464-133543561 c
            1196-1278           JAXUCZ010000003.1  133542175-133542257 c
            1279-1337           JAXUCZ010000003.1  133541140-133541198 c
            1338-2067           JAXUCZ010000003.1  133538889-133539618 c
FEATURES             Location/Qualifiers
     source          1..2067
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2067
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /note="COP9 signalosome subunit 2"
                     /db_xref="GeneID:261736"
                     /db_xref="RGD:628791"
     exon            1..204
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1482
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /note="isoform 1 is encoded by transcript variant 1; COP9
                     signalosome complex subunit 2; SGN2; TRIP-15; alien
                     homolog; signalosome subunit 2; JAB1-containing
                     signalosome subunit 2; thyroid receptor-interacting
                     protein 15; TR-interacting protein 15; COP9 (constitutive
                     photomorphogenic) homolog, subunit 2; tyroid receptor
                     interacting protein 15"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 2 isoform 1"
                     /protein_id="NP_695209.1"
                     /db_xref="GeneID:261736"
                     /db_xref="RGD:628791"
                     /translation="MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKE
                     DDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSA
                     VTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYL
                     EREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALY
                     EQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTC
                     LKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNH
                     SNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQC
                     ILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA"
     exon            205..318
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            319..396
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            397..522
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            523..612
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            613..690
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            691..865
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1044
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1097
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1195
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1278
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1337
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..2067
                     /gene="Cops2"
                     /gene_synonym="CSN2; Trip15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcgagcgc attggttccg gaatgagctc tctcttctcc aggagagacc ggaagactag
       61 gagaatcggg agtgacgctt ctgggccgcg gagcactgtg ggaggaggct gtctctaatt
      121 tctcctctcc ccctcccccc tccggccaag atgtctgaca tggaggatga tttcatgtgc
      181 gatgatgagg aggactacga cctggaatac tctgaagaca gtaactctga gcccaacgtg
      241 gatttggaaa atcagtacta taattccaaa gcactgaaag aagatgaccc gaaagcagca
      301 ctaagcagct tccaaaaggt tttggaactc gaaggtgaga agggagaatg gggattcaaa
      361 gcgctaaaac agatgatcaa gattaacttc aagctgacaa actttccaga aatgatgaac
      421 agatataagc aactattgac ctatattcgg agtgcagtca ccaggaacta ctctgaaaag
      481 tctattaact ctatccttga ctatatctcc acttctaaac agatggattt actgcaggaa
      541 ttttatgaaa caacactgga agctttgaaa gatgctaaga atgatagact gtggtttaag
      601 acaaacacaa agcttggaaa attatattta gaacgagaag aatatggaaa gcttcaaaaa
      661 attttacgcc agttacatca gtcttgtcag actgatgatg gagaagatga cctgaaaaaa
      721 ggtacccagt tattagaaat ctatgctttg gaaattcaaa tgtacacggc acagaagaac
      781 aacaaaaagc ttaaagcgct ctatgagcaa tcacttcata tcaagtctgc catccctcac
      841 ccactgatca tgggtgtcat cagagaatgt ggtggtaaga tgcacttgag agaaggtgaa
      901 tttgaaaagg cacacactga tttttttgaa gctttcaaga attatgatga atcaggaagc
      961 ccaagacgaa ccacttgttt aaaatatttg gtcttagcaa atatgctaat gaaatcagga
     1021 ataaatccat ttgactcgca agaggccaag ccgtataaaa atgatccaga aattctagca
     1081 atgacaaatt tagtaagtgc ctatcagaac aatgacatca ccgagtttga aaagattctg
     1141 aaaacaaatc acagcaacat catggatgat cctttcataa gagaacacat tgaagagctt
     1201 ttacgaaaca tcagaacaca agtcctcata aagttaatta agccttacac aagaatacat
     1261 attcctttta tttctaagga gctaaacata gacgtagctg atgtggaaag cttgctggtg
     1321 cagtgcatac tggataacac tattcatggc cgaattgatc aagtcaacca gctccttgaa
     1381 ctggatcatc agaagagggg cggtgcccga tatactgcac tagataaatg gaccaaccaa
     1441 ctaaactctc tgaaccaggc tgtggtcagt aaactggctt aacggagagc aagctttgca
     1501 gacgtgctta tggcaacagt gcagagatgc aatccttgcg gactggaaag gcagaactcc
     1561 tgtgggttgg tgtatcctga aagtgactgg agttatggca gaagggcttt tttgatcaac
     1621 tggtttgtgt attgctgctg catttatccc aagaaaaaca gctttaatct ccagaagaaa
     1681 accaaaacac catgggattt atgctgtgtt gacaccttgc cctaaacata caacaccata
     1741 gtaatttgtc atgggcaaca tgaccagaga gatttttgtc atgattttaa atacactgac
     1801 acgctactgt tggttaaatt taaacatgtt gtacctgcag aaattctctc acaaataacc
     1861 tgcaataact tgaaattcat acccttttga acacttcctt ttctcatgta taaatgaaaa
     1921 tgtttgctgc attttgcaaa atgtcaattc tccaaaactg tgtccgtcta cttctgtact
     1981 tgcagctagt gaaggttaga tgacccgtgc cctctgtggt acactgtcac ctagggctca
     2041 agcagcaaaa taaacagtgc agctcag
//
