LOCUS       NM_021765               3003 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus COPI coat complex subunit beta 2 (Copb2), mRNA.
ACCESSION   NM_021765
VERSION     NM_021765.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3003)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   2  (bases 1 to 3003)
  AUTHORS   Sharma,A., Yu,C., Leung,C., Trane,A., Lau,M., Utokaparch,S.,
            Shaheen,F., Sheibani,N. and Bernatchez,P.
  TITLE     A new role for the muscle repair protein dysferlin in endothelial
            cell adhesion and angiogenesis
  JOURNAL   Arterioscler Thromb Vasc Biol 30 (11), 2196-2204 (2010)
   PUBMED   20724702
REFERENCE   3  (bases 1 to 3003)
  AUTHORS   Morton,M.J., Farr,G.A., Hull,M., Capendeguy,O., Horisberger,J.D.
            and Caplan,M.J.
  TITLE     Association with {beta}-COP regulates the trafficking of the newly
            synthesized Na,K-ATPase
  JOURNAL   J Biol Chem 285 (44), 33737-33746 (2010)
   PUBMED   20801885
  REMARK    GeneRIF: trafficking of the newly synthesized Na,K-ATPase is
            regulated by association with beta-COP
REFERENCE   4  (bases 1 to 3003)
  AUTHORS   Beck,R., Rawet,M., Wieland,F.T. and Cassel,D.
  TITLE     The COPI system: molecular mechanisms and function
  JOURNAL   FEBS Lett 583 (17), 2701-2709 (2009)
   PUBMED   19631211
  REMARK    Review article
            Erratum:[FEBS Lett. 2009 Nov 3;583(21):3541. Ravet, M [corrected to
            Rawet, M]]
REFERENCE   5  (bases 1 to 3003)
  AUTHORS   Burman,J.L., Bourbonniere,L., Philie,J., Stroh,T., Dejgaard,S.Y.,
            Presley,J.F. and McPherson,P.S.
  TITLE     Scyl1, mutated in a recessive form of spinocerebellar
            neurodegeneration, regulates COPI-mediated retrograde traffic
  JOURNAL   J Biol Chem 283 (33), 22774-22786 (2008)
   PUBMED   18556652
REFERENCE   6  (bases 1 to 3003)
  AUTHORS   Wegmann,D., Hess,P., Baier,C., Wieland,F.T. and Reinhard,C.
  TITLE     Novel isotypic gamma/zeta subunits reveal three coatomer complexes
            in mammals
  JOURNAL   Mol Cell Biol 24 (3), 1070-1080 (2004)
   PUBMED   14729954
REFERENCE   7  (bases 1 to 3003)
  AUTHORS   Adams,L.D., Lemire,J.M. and Schwartz,S.M.
  TITLE     A systematic analysis of 40 random genes in cultured vascular
            smooth muscle subtypes reveals a heterogeneity of gene expression
            and identifies the tight junction gene zonula occludens 2 as a
            marker of epithelioid 'pup' smooth muscle cells and a participant
            in carotid neointimal formation
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (11), 2600-2608 (1999)
   PUBMED   10559001
REFERENCE   8  (bases 1 to 3003)
  AUTHORS   Csukai,M., Chen,C.H., De Matteis,M.A. and Mochly-Rosen,D.
  TITLE     The coatomer protein beta'-COP, a selective binding protein (RACK)
            for protein kinase Cepsilon
  JOURNAL   J Biol Chem 272 (46), 29200-29206 (1997)
   PUBMED   9360998
REFERENCE   9  (bases 1 to 3003)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
REFERENCE   10 (bases 1 to 3003)
  AUTHORS   Harrison-Lavoie,K.J., Lewis,V.A., Hynes,G.M., Collison,K.S.,
            Nutland,E. and Willison,K.R.
  TITLE     A 102 kDa subunit of a Golgi-associated particle has homology to
            beta subunits of trimeric G proteins
  JOURNAL   EMBO J 12 (7), 2847-2853 (1993)
   PUBMED   8335000
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_021765.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF002705.1, BC088397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000008.1  108040687-108040776
            91-228              JAXUCZ010000008.1  108045022-108045159
            229-315             JAXUCZ010000008.1  108047241-108047327
            316-442             JAXUCZ010000008.1  108047530-108047656
            443-591             JAXUCZ010000008.1  108048455-108048603
            592-738             JAXUCZ010000008.1  108050490-108050636
            739-838             JAXUCZ010000008.1  108051102-108051201
            839-981             JAXUCZ010000008.1  108051862-108052004
            982-1181            JAXUCZ010000008.1  108052206-108052405
            1182-1292           JAXUCZ010000008.1  108053837-108053947
            1293-1381           JAXUCZ010000008.1  108054956-108055044
            1382-1488           JAXUCZ010000008.1  108055132-108055238
            1489-1632           JAXUCZ010000008.1  108055991-108056134
            1633-1763           JAXUCZ010000008.1  108057075-108057205
            1764-1971           JAXUCZ010000008.1  108057494-108057701
            1972-2082           JAXUCZ010000008.1  108059949-108060059
            2083-2297           JAXUCZ010000008.1  108060670-108060884
            2298-2390           JAXUCZ010000008.1  108061520-108061612
            2391-2571           JAXUCZ010000008.1  108061696-108061876
            2572-2640           JAXUCZ010000008.1  108062022-108062090
            2641-2709           JAXUCZ010000008.1  108062243-108062311
            2710-3003           JAXUCZ010000008.1  108062517-108062810
FEATURES             Location/Qualifiers
     source          1..3003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..3003
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /note="COPI coat complex subunit beta 2"
                     /db_xref="GeneID:60384"
                     /db_xref="RGD:628746"
     exon            1..90
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2805
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /note="beta'-COP; beta'-coat protein; beta prime COP;
                     coatomer protein complex, subunit beta 2 (beta prime);
                     coatomer protein complex subunit beta 2"
                     /codon_start=1
                     /product="coatomer subunit beta'"
                     /protein_id="NP_068533.2"
                     /db_xref="GeneID:60384"
                     /db_xref="RGD:628746"
                     /translation="MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNH
                     ETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYI
                     RCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFAS
                     ASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQN
                     KTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWC
                     VASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTE
                     IKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQ
                     EFAWAHDSSEYAIRESNSVVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFY
                     DWENTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTED
                     GIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGY
                     IPKDNRLYLGDKELNIVSYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHF
                     LEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQ
                     FSLAQECLHHAQDYGGLLLLATASGNASMVNKLAEGAERDGKNNVAFMSYFLQGKLDA
                     CLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLF
                     PGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEAKGFQPSRATAQQEPDGK
                     PASSPVIMASQTTHKEEKSFQELEDDLDTMELEDIDTTDINLDEDILDD"
     exon            91..228
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..315
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..442
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            443..591
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            592..738
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..838
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..981
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1181
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1292
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1381
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1488
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1632
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1763
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1971
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2082
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2297
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2390
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2571
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2640
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2709
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..3003
                     /gene="Copb2"
                     /gene_synonym="p102; Rack2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtccactg ctccgtgggt ctgtgtgttc ttgagtacca gtgtcgctcg gagcctgtga
       61 gaggctgggg ctcggacaat cggagccatg cctcttcgac ttgacatcaa gagaaagcta
      121 actgctaggt ctgatcgggt taagagtgtg gatttgcatc cgactgagcc atggatgctg
      181 gctagtcttt acaatggcag tgtgtgtgtt tggaatcatg aaactcagac gctggtgaag
      241 acctttgaag tgtgtgatct ccctgttcga gctgcgaagt ttgtcgcaag gaagaactgg
      301 gtggtgacag gagcagatga tatgcagatt agagtgttca attataacac cctggagagg
      361 gtgcacatgt ttgaagcaca ctcggattac atccgttgca ttgctgttca tcccacccag
      421 ccgttcattc tcacaagcag tgatgacatg cttattaagc tctgggactg ggacaaaaaa
      481 tggtcttgtt cacaagtgtt tgaaggacac acgcattatg ttatgcagat tgtgataaac
      541 cccaaagata acaatcagtt tgccagtgcc tctctcgaca ggaccatcaa ggtgtggcag
      601 ctgggctctt catcaccaaa cttcacgctg gagggacatg aaaaaggcgt gaattgcatt
      661 gattactaca gtggtggtga taagccatac ctcatttcag gtgcagatga ccggctcgtt
      721 aaaatatggg attatcagaa taaaacttgt gtgcagaccc tggagggaca tgcccagaat
      781 gtgtcatgcg caagcttcca tcctgagctg cccatcatca tcacagggtc agaagacgga
      841 acggtgcgaa tctggcactc cagcacctac cggctggaga gcacactgaa ttacggaatg
      901 gagcgagtgt ggtgtgtggc cagtctgaga ggctccaaca atgtcgctct gggctacgat
      961 gaagggagca tcattgttaa gcttggtcgg gaggaacctg ccatgtccat ggatgccaat
     1021 ggaaagataa tctgggccaa gcattcagag gtccagcagg ccaacctgaa agcaatgggt
     1081 gacaccgaaa ttaaagatgg agaaagactg ccactagcag taaaggatat gggcagctgt
     1141 gaaatatatc cacagaccat tcagcacaat cctaatggga ggtttgtcgt ggtgtgtggt
     1201 gatggagaat atatcatcta cacagcaatg gccttgagaa acaagagctt tggatctgcc
     1261 caggagtttg catgggccca cgattcttca gagtatgcaa taagagaaag caacagtgtt
     1321 gtaaagatat ttaagaactt taaggaaaag aaatcattta aacctgattt tggagctgaa
     1381 agtatctatg ggggcttctt gctgggagtc aggtctgtaa atggcttagc attctatgac
     1441 tgggagaata ccgaactcat ccgcagaatt gaaattcagc ccaagcacat cttctggtct
     1501 gactctggag agctggtctg tattgccacc gaggagtcat tttttattct taaatatctg
     1561 tcagaaaaag tcttggctgc acaggaaacc cacgagggag ttactgagga tggcattgag
     1621 gacgcctttg aggttcttgg tgaaattcag gaaattgtga aaactgggct gtgggtaggt
     1681 gactgcttca tctacacaag ttctgtgaac agattaaact attatgtggg aggcgagatt
     1741 gtcaccattg cccacttgga caggacaatg taccttctgg gctatattcc aaaagacaat
     1801 aggctttatc tgggagataa agaattgaac atagttagct actccctgtt agtttcagtc
     1861 ctggaatacc agactgctgt catgcggagg gatttcagca tggctgataa ggtgctccct
     1921 actatcccca aagaacagag gaccagagtt gcacactttt tggaaaagca gggcttcaag
     1981 cagcaagcac tcacagtatc cacagatcct gaacatcgtt ttgagcttgc tcttcaactt
     2041 ggggagctga aaattgctta ccagttagca gtggaggcag agtcggagca gaagtggaaa
     2101 caacttgccg aacttgccat tagtaaatgt cagttcagcc tagcccagga gtgtttgcac
     2161 catgcccagg actacggtgg tctgctgctc ttggccactg cctctggaaa cgctagtatg
     2221 gtgaacaagc tggcagaagg tgcggagaga gatggcaaaa ataacgtggc attcatgagc
     2281 tattttttac agggcaagct tgatgcttgc ctagagctct tgatcagaac aggaagactc
     2341 ccagaagccg ccttcctggc ccgaacttac ttacccagcc aggtctcaag ggtagtgaag
     2401 ttgtggaggg agaatctctc aaaagtcaac cagaaagcag cagaatccct cgctgacccc
     2461 acagagtatg aaaacctttt ccctggatta aaagaagcct ttgttgttga agaatgggtg
     2521 aaggagacac atgcggatct gtggccagcc aagcagtacc ctcttgtcac gccaaatgaa
     2581 gagagaaatg ttatggaaga ggcaaaaggc tttcagccct caagagccac agctcagcag
     2641 gaacctgatg ggaaacctgc ttctagccca gttatcatgg cctcccaaac cactcacaaa
     2701 gaagaaaaga gtttccagga actagaagat gatttagata ccatggaatt agaggatatt
     2761 gatacaacag acatcaatct ggatgaagat attctggatg actaaagttt gccatttact
     2821 ccagtaagag attatgatgg cacatacaaa tcagtcacca ccaccctgac cagaactgtg
     2881 gcaatccttg ctctgcacac gtaaacaagg aggaacatag ccccttcatc ttcagggcag
     2941 agttttaact gaaacagaca cttgtgcttt tttcatattg tcattaaacc acccctcata
     3001 aaa
//
