LOCUS       NM_080781               3348 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus COPI coat complex subunit beta 1 (Copb1), mRNA.
ACCESSION   NM_080781
VERSION     NM_080781.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3348)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 3348)
  AUTHORS   Fenton,R.A., Komatsu,S., Ikebe,M., Shea,L.G. and Dobson,J.G. Jr.
  TITLE     Adenoprotection of the heart involves phospholipase C-induced
            activation and translocation of PKC-epsilon to RACK2 in adult rat
            and mouse
  JOURNAL   Am J Physiol Heart Circ Physiol 297 (2), H718-H725 (2009)
   PUBMED   19525381
  REMARK    GeneRIF: A(1)R stimulation of the heart is associated with
            PLC-initiated PKC-epsilon translocation and association with RACK2
REFERENCE   3  (bases 1 to 3348)
  AUTHORS   Takatalo,M.S., Tummers,M., Thesleff,I. and Ronnholm,R.
  TITLE     Novel Golgi protein, GoPro49, is a specific dental follicle marker
  JOURNAL   J Dent Res 88 (6), 534-538 (2009)
   PUBMED   19587158
REFERENCE   4  (bases 1 to 3348)
  AUTHORS   Burman,J.L., Bourbonniere,L., Philie,J., Stroh,T., Dejgaard,S.Y.,
            Presley,J.F. and McPherson,P.S.
  TITLE     Scyl1, mutated in a recessive form of spinocerebellar
            neurodegeneration, regulates COPI-mediated retrograde traffic
  JOURNAL   J Biol Chem 283 (33), 22774-22786 (2008)
   PUBMED   18556652
REFERENCE   5  (bases 1 to 3348)
  AUTHORS   Walker,J.W.
  TITLE     Protein scaffolds, lipid domains and substrate recognition in
            protein kinase C function: implications for rational drug design
  JOURNAL   Handb Exp Pharmacol (186), 185-203 (2008)
   PUBMED   18491053
  REMARK    Review article
REFERENCE   6  (bases 1 to 3348)
  AUTHORS   Zhao,L., Helms,J.B., Brugger,B., Harter,C., Martoglio,B., Graf,R.,
            Brunner,J. and Wieland,F.T.
  TITLE     Direct and GTP-dependent interaction of ADP ribosylation factor 1
            with coatomer subunit beta
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4418-4423 (1997)
   PUBMED   9114004
REFERENCE   7  (bases 1 to 3348)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
REFERENCE   8  (bases 1 to 3348)
  AUTHORS   Faulstich,D., Auerbach,S., Orci,L., Ravazzola,M., Wegchingel,S.,
            Lottspeich,F., Stenbeck,G., Harter,C., Wieland,F.T. and
            Tschochner,H.
  TITLE     Architecture of coatomer: molecular characterization of delta-COP
            and protein interactions within the complex
  JOURNAL   J Cell Biol 135 (1), 53-61 (1996)
   PUBMED   8858162
REFERENCE   9  (bases 1 to 3348)
  AUTHORS   Peter,F., Plutner,H., Zhu,H., Kreis,T.E. and Balch,W.E.
  TITLE     Beta-COP is essential for transport of protein from the endoplasmic
            reticulum to the Golgi in vitro
  JOURNAL   J Cell Biol 122 (6), 1155-1167 (1993)
   PUBMED   8376457
REFERENCE   10 (bases 1 to 3348)
  AUTHORS   Duden,R., Griffiths,G., Frank,R., Argos,P. and Kreis,T.E.
  TITLE     Beta-COP, a 110 kd protein associated with non-clathrin-coated
            vesicles and the Golgi complex, shows homology to beta-adaptin
  JOURNAL   Cell 64 (3), 649-665 (1991)
   PUBMED   1840503
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061882.1.
            
            On Dec 20, 2003 this sequence version replaced NM_080781.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061882.1, X57228.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3348
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q34"
     gene            1..3348
                     /gene="Copb1"
                     /note="COPI coat complex subunit beta 1"
                     /db_xref="GeneID:114023"
                     /db_xref="RGD:620861"
     exon            1..98
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            99..248
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..3019
                     /gene="Copb1"
                     /note="receptor for activated C-kinase-2; beta-COP;
                     beta-coat protein; coatomer protein complex, subunit beta
                     1"
                     /codon_start=1
                     /product="coatomer subunit beta"
                     /protein_id="NP_542959.1"
                     /db_xref="GeneID:114023"
                     /db_xref="RGD:620861"
                     /translation="MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKK
                     VIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVC
                     DAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIY
                     TIYRNFENLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQT
                     FGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPT
                     AIKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEHPAHERVLQDLVMDILRVLSTPDL
                     EVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSV
                     RFPDMAANVIPVLMEFLSDSNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIK
                     SVKIYRGALWILGEYCSTKEDIQSVMTEVRRSLGEIPIVESEIKKEAGELKPEEEITV
                     GPVQKLVTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIAL
                     RYVALVQEKKKQNSFVAEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECS
                     PLMNDIFNKECRQSLSQMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEM
                     NCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIV
                     LDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGI
                     IFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVN
                     TNVTDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSIFGEDALANVSIEKP
                     VHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSL"
     exon            249..478
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..648
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..763
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..856
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..994
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1114
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1222
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1369
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1515
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1612
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1773
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1894
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2122
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2302
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2447
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2567
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2713
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2803
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2959
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3333
                     /gene="Copb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccaagga ctcagtggag ccgtcgcggc agcggctgtc tggaccggta gtcgacggtc
       61 ctacggttcc ttcccgaccc ccacccccac ggagccagat ttacctggca cctttcgtcc
      121 ttttcatctt gttttgagtt ggttataaac aggaaccatg accgcagctg agaacgtgtg
      181 ctatacgtta attaacgtgc caatggactc agaaccccct tctgaaatca gcttaaaaaa
      241 tgacctggag aaaggcgatg tgaagtcaaa gactgaagct ttgaagaaag tgatcattat
      301 gattctgaat ggggaaaagc ttcctggact cctgatgacg atcattcgtt tcgtgctgcc
      361 tcttcaggat cacaccatca aaaagttgct tctggtcttc tgggaaattg ttccgaaaac
      421 aactccagat gggaggctct tacatgaaat gattcttgtg tgtgatgcat acagaaagga
      481 tctccagcat cctaatgagt ttattcgtgg atctactctt cgtttccttt gcaaattgaa
      541 ggaagcagaa ttgctggaac ctctgatgcc tgctatccgt gcttgtttgg aacatcgtca
      601 cagctatgtt aggagaaacg ctgttttggc catctacacc atctacagaa attttgaaaa
      661 tcttatacct gatgctcctg agctgataca tgattttctg gtaaacgaga aggatgcaag
      721 ctgcaaaaga aatgcattta tgatgctcat tcatgcagat caggatcgag ctttggatta
      781 tttaagtaca tgtattgatc aagttcagac atttggagac attctacagt tggttattgt
      841 tgaactaatt tataaggtct gtcatgctaa tccatcagag agggcccgtt tcattcgctg
      901 tatctataac ttactgcagt catctagtcc tgctgtaaaa tacgaagctg ctgggacact
      961 ggtgacactg tcaagtgctc caactgcaat aaaggctgct gctcagtgtt acattgattt
     1021 aattattaag gaaagtgata acaatgtaaa gctcattgtc ctggaccgat tggtagaact
     1081 aaaagagcat cctgctcacg agcgagtcct ccaagatctg gtcatggaca tcctacgagt
     1141 actgagtaca ccagacctag aagtgcgcaa gaaaacgctg cagttagcac tggatcttgt
     1201 ctcatctagg aatgttgaag agttggttat tgtcttgaag aaggaagtaa ttaaaacaaa
     1261 taacgtgtct gagcatgaag acactgacaa ataccgacag cttctcgtgc gaacactgca
     1321 ttcctgctct gtccgatttc cagatatggc tgcaaatgtt attcctgtgc taatggaatt
     1381 tctcagtgac agtaatgaag cagcagctgc tgatgtcttg gagtttgtgc gtgaagccat
     1441 tcagcgcttt gacaacctga gaatgctgat tgttgagaag atgctggaag tcttccatgc
     1501 tattaagtct gtcaagattt atcgaggagc actgtggatc ctgggcgagt actgcagtac
     1561 taaggaagac attcagagtg tgatgactga agtccgcagg tcccttgggg agatcccaat
     1621 cgtagaatca gaaataaaga aagaagctgg cgagttaaaa ccagaagaag aaataactgt
     1681 tgggcccgtt cagaaattgg ttacagagat gggcacctat gctactcaga gtgcactcag
     1741 cagctctaga cctaccaaga aagaagagga cagaccaccc ttgagaggat tcctcctgga
     1801 tggagatttc tttgttgctg cctcccttgc cacaactctg accaagattg cattacgcta
     1861 tgtagcattg gttcaggaga agaaaaagca aaactctttt gttgctgagg ctatgttgct
     1921 tatggcaacc atccttcatt tgggaaaatc ctctcttcct aagaagccaa tcactgatga
     1981 tgatgtagac cgaatttccc tgtgcctcaa ggtcttatct gaatgctcac ctttaatgaa
     2041 tgacattttt aataaggagt gcagacagtc tctttcccaa atgttgtctg ccaaactcga
     2101 agaagagaaa ctatcccaaa agaaagaatc tgaaaagagg aatgtaacag tacagcctga
     2161 tgaccccatt tccttcatgc aactaactgc taagaatgag atgaactgca aggaggatca
     2221 gttccagctg agtttgttgg cagcgatggg taacactcag aggaaagagg cagcagaccc
     2281 cctggcgtcc aaactcaaca aggtcactca gttgacaggt ttctctgatc cagtgtatgc
     2341 agaagcttat gttcatgtca atcagtatga tattgtcctg gatgttcttg ttgtaaacca
     2401 aaccagtgat actttgcaga actgcacatt agagttagct actctagggg atctgaaact
     2461 cgtggaaaaa ccatctcctt tgactcttgc tcctcatgac tttgcgaata ttaaagccaa
     2521 tgtcaaagta gcatcaacag aaaatggaat aattttcggc aatatagttt atgatgtctc
     2581 tggagcagca agtgacagaa actgtgtggt cctcagtgac atccacattg acatcatgga
     2641 ctatatccag cctgcaactt gcactgatgc tgagttccgt cagatgtggg ccgaatttga
     2701 atgggaaaat aaagtgacag ttaacaccaa cgtgactgac ctgaatgatt atttacagca
     2761 catcctcaag tccaccaaca tgaagtgcct gactccagag aaggcccttt ctggctactg
     2821 tggcttcatg gcagccaacc tatatgctcg ctctatattt ggagaggatg cacttgcaaa
     2881 tgtcagcatt gagaagccag ttcaccaggg accagatgct gctgttactg gccatataag
     2941 aattcgtgca aaaagtcagg gaatggcctt gagccttgga gataaaatca acctgtctca
     3001 aaagaagact agtctctaag aatgaacaaa cggtcctcga aagtgtaagg ttaaaattta
     3061 ggtgtgggct gattggactc cgacgttttt gtactctttc atgctttatg tttgtagaat
     3121 ttgagttcat gctgaattca ttccagcccg taatttatag cctttcccct aaatcaagaa
     3181 tgagtttaaa attatagttt gtcttttatc ttaacagttc tgaatgctgt cctcaaagta
     3241 tataaagttc ctcatatgta ccaagaccat tttcacaata aacagatctg ttcataaatt
     3301 tttgttattt tataaataaa ttacttaatt ttaaaaaaaa aaaaaaaa
//
