LOCUS       NM_001025126            2118 bp    mRNA    linear   ROD 08-MAR-2024
DEFINITION  Rattus norvegicus COP1, E3 ubiquitin ligase (Cop1), mRNA.
ACCESSION   NM_001025126 XM_341137
VERSION     NM_001025126.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2118)
  AUTHORS   Cowley,A.W. Jr., Moreno,C., Jacob,H.J., Peterson,C.B., Stingo,F.C.,
            Ahn,K.W., Liu,P., Vannucci,M., Laud,P.W., Reddy,P., Lazar,J.,
            Evans,L., Yang,C., Kurth,T. and Liang,M.
  TITLE     Characterization of biological pathways associated with a 1.37 Mbp
            genomic region protective of hypertension in Dahl S rats
  JOURNAL   Physiol Genomics 46 (11), 398-410 (2014)
   PUBMED   24714719
REFERENCE   2  (bases 1 to 2118)
  AUTHORS   Li,D.Q., Ohshiro,K., Reddy,S.D., Pakala,S.B., Lee,M.H., Zhang,Y.,
            Rayala,S.K. and Kumar,R.
  TITLE     E3 ubiquitin ligase COP1 regulates the stability and functions of
            MTA1
  JOURNAL   Proc Natl Acad Sci U S A 106 (41), 17493-17498 (2009)
   PUBMED   19805145
REFERENCE   3  (bases 1 to 2118)
  AUTHORS   Kato,S., Ding,J., Pisck,E., Jhala,U.S. and Du,K.
  TITLE     COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate
            FoxO1-mediated gene expression
  JOURNAL   J Biol Chem 283 (51), 35464-35473 (2008)
   PUBMED   18815134
  REMARK    GeneRIF: COP1 binds FoxO1, enhances its ubiquitination, and
            promotes its degradation via the ubiquitin-proteasome pathway.
REFERENCE   4  (bases 1 to 2118)
  AUTHORS   Chen,J.L., Lacomis,L., Erdjument-Bromage,H., Tempst,P. and
            Stamnes,M.
  TITLE     Cytosol-derived proteins are sufficient for Arp2/3 recruitment and
            ARF/coatomer-dependent actin polymerization on Golgi membranes
  JOURNAL   FEBS Lett 566 (1-3), 281-286 (2004)
   PUBMED   15147909
REFERENCE   5  (bases 1 to 2118)
  AUTHORS   Wertz,I.E., O'Rourke,K.M., Zhang,Z., Dornan,D., Arnott,D.,
            Deshaies,R.J. and Dixit,V.M.
  TITLE     Human De-etiolated-1 regulates c-Jun by assembling a CUL4A
            ubiquitin ligase
  JOURNAL   Science 303 (5662), 1371-1374 (2004)
   PUBMED   14739464
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091284.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_001428839.1.
            
            On Jul 1, 2005 this sequence version replaced XM_341137.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2118
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..2118
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /note="COP1, E3 ubiquitin ligase"
                     /db_xref="GeneID:360860"
                     /db_xref="RGD:1304773"
     exon            1..257
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1485
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase RFWD2; ring finger and
                     WD repeat domain 2, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase COP1"
                     /protein_id="NP_001020297.1"
                     /db_xref="GeneID:360860"
                     /db_xref="RGD:1304773"
                     /translation="MSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGPSQ
                     TKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFT
                     RYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYGTVIQDAV
                     DIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRC
                     WSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFG
                     CADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYC
                     LRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKD
                     RKEDDTNEFVSAVCWRALSDGESNVLIAANSQGTIKVLELV"
     exon            258..315
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            316..430
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            431..566
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            567..710
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            711..819
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            820..901
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1018
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1136
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1261
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1422
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1467
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..2094
                     /gene="Cop1"
                     /gene_synonym="Rfwd2; RGD1304773"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttgattt cagattaact ttacttttgt actctatgaa aggtattttt gagaagtttg
       61 aagacaaaag gggactaata aaaagctgag gctagaacag actataatgc tgtacgcttg
      121 cttgatttat acatcctctg tttggactgt gtagagtaac tcatatactt acaatttcag
      181 gagatgagtg gcttgtactc ccccgtcagt gaagatagca cggtgcctca atttgaagct
      241 ccttctccat cgcacagtag cattattgac tctacagaat acagccaacc tccaggcttc
      301 agtgggccgt ctcagacaaa gaaacagcct tggtataaca gcacattagc atcaagacga
      361 aagcgactca ctgctcattt tgaagactta gagcagtgtt atttttctac aaggatgtct
      421 cgtatctcag atgacagtag aactgcaagc cagttagatg aatttcaaga atgcttgtcc
      481 aaatttactc gatataactc tgtaagaccg ttggccacat tgtcttatgc tagtgatctg
      541 tataatggtt ccagcatagt ttctagtatt gaatttgacc gggattgtga ctactttgca
      601 attgctggag ttacaaagaa gattaaagtc tatgaatatg gcacagtcat ccaggatgca
      661 gtggatattc attaccctga gaatgaaatg acctgcaatt ccaaaatcag ctgtatcagt
      721 tggagtagtt accataagaa cctgctagcc agcagtgatt atgaaggcac cgttatacta
      781 tgggatggat tcacaggaca gaggtcaaag gtctatcagg agcatgaaaa gaggtgttgg
      841 agtgtcgact ttaatttgat ggatcccaaa cttctggctt caggttctga tgatgcaaaa
      901 gtgaagcttt ggtccaccaa tttagacaat tctgtggcaa gcatcgaggc aaaagctaat
      961 gtgtgttgtg tgaagttcag cccctcctcc aggtaccatc tggcttttgg ctgtgcagat
     1021 cactgtgtcc actactacga tcttcgtaac actaaacagc caataatggt gttcaagggg
     1081 caccgaaaag cagtgtctta tgccaagttt gtgagtggtg aagaaattgt ctctgcctca
     1141 acagacagcc aactaaaact gtggaatgtg gggaaaccat actgtctacg ttccttcaag
     1201 ggtcatatta atgaaaaaaa ctttgtaggc cttgcttcca atggagatta tatagcttgt
     1261 ggaagtgaga acaactccct ctacctgtac tataaaggac tttctaagac tttgctaact
     1321 tttaagtttg atacagttaa gagtgtatta gataaagacc ggaaagaaga tgacaccaat
     1381 gaatttgtca gtgctgtgtg ttggcgggca ctatcagatg gggagtccaa tgtgctgatt
     1441 gctgctaaca gccagggtac aattaaggtg ctagaattgg tataaagaat ttcctgaagt
     1501 caaattgtgt ttgatccccc caaaagccgt ctgcagctga tgatgagaag agaaagaaat
     1561 ggcatgtgat gtctctccca acgtcgtttg gatgtgttct gagtaccttt tccctccttt
     1621 ttgcctttgg gacattggga atatccagag aattctccgc cgtcagtgta actatgaact
     1681 ttgctgttgg cagtgtggct atctaatttt tgtgataggg aaacaaattc ttttaaataa
     1741 aaataaataa caaaaaaaaa aagtttatcg agccacagct gagctggaaa cacctttgtc
     1801 aggtggagtg agagtctttc gaagaagtag cacttgtggg ctgtacagaa tgttctggct
     1861 ggggctggaa agaggctcgg tgaataagag cactggctgc tcctacagag gatctgggtt
     1921 cagtccccag agtccccagc acctacgtag cagctcactg ccacttatga ttccagtaga
     1981 tctgacctcc tcttctggcc tccttgagca ccaggtatgc atgtggtgca catacaaaca
     2041 tccggacaaa acgctcacac ataaaaatga aaataaatct tattttaaaa caaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaa
//
