LOCUS       NM_012531               1669 bp    mRNA    linear   ROD 23-MAR-2024
DEFINITION  Rattus norvegicus catechol-O-methyltransferase (Comt), mRNA.
ACCESSION   NM_012531
VERSION     NM_012531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1669)
  AUTHORS   Zhou,Y., Song,Z., Chen,S., Yao,F., Liu,J., Ouyang,Z. and Liao,Z.
  TITLE     Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain
            Induced by Tooth Movement
  JOURNAL   Biomed Res Int 2021, 4229491 (2021)
   PUBMED   34725639
  REMARK    GeneRIF: Mechanism of Catechol-O-methyltransferase Regulating
            Orofacial Pain Induced by Tooth Movement.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1669)
  AUTHORS   Oyaci,Y., Aytac,H.M., Pasin,O., Cetinay Aydin,P. and Pehlivan,S.
  TITLE     Detection of altered methylation of MB-COMT promotor and DRD2 gene
            in cannabinoid or synthetic cannabinoid use disorder regarding gene
            variants and clinical parameters
  JOURNAL   J Addict Dis 39 (4), 526-536 (2021)
   PUBMED   33781176
REFERENCE   3  (bases 1 to 1669)
  AUTHORS   Su,Y., DePasquale,M., Liao,G., Buchler,I., Zhang,G., Byers,S.,
            Carr,G.V., Barrow,J. and Wei,H.
  TITLE     Membrane bound catechol-O-methytransferase is the dominant isoform
            for dopamine metabolism in PC12 cells and rat brain
  JOURNAL   Eur J Pharmacol 896, 173909 (2021)
   PUBMED   33503461
  REMARK    GeneRIF: Membrane bound catechol-O-methytransferase is the dominant
            isoform for dopamine metabolism in PC12 cells and rat brain.
REFERENCE   4  (bases 1 to 1669)
  AUTHORS   Deji,C., Li,Y., Chen,Y., Lai,J. and Wei,S.
  TITLE     Association study of Catechol-o-methyltransferase and
            Alpha-1-adrenergic receptor gene polymorphisms with multiple
            phenotypes of heroin use disorder
  JOURNAL   Neurosci Lett 748, 135677 (2021)
   PUBMED   33577997
REFERENCE   5  (bases 1 to 1669)
  AUTHORS   Sonia,J.A., Kabir,T., Islam,M.M.T. and Kabir,Y.
  TITLE     Catechol-O-methyltransferase and dopamine receptor D4 gene
            variants: Possible association with substance abuse in Bangladeshi
            male
  JOURNAL   PLoS One 16 (2), e0246462 (2021)
   PUBMED   33544778
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1669)
  AUTHORS   Ulmanen,I. and Lundstrom,K.
  TITLE     Cell-free synthesis of rat and human catechol O-methyltransferase.
            Insertion of the membrane-bound form into microsomal membranes in
            vitro
  JOURNAL   Eur J Biochem 202 (3), 1013-1020 (1991)
   PUBMED   1765063
REFERENCE   7  (bases 1 to 1669)
  AUTHORS   Salminen,M., Lundstrom,K., Tilgmann,C., Savolainen,R., Kalkkinen,N.
            and Ulmanen,I.
  TITLE     Molecular cloning and characterization of rat liver
            catechol-O-methyltransferase
  JOURNAL   Gene 93 (2), 241-247 (1990)
   PUBMED   2227437
REFERENCE   8  (bases 1 to 1669)
  AUTHORS   Amin,A.M., Creveling,C.R. and Lowe,M.C.
  TITLE     Immunohistochemical localization of catechol methyltransferase in
            normal and cancerous breast tissues of mice and rats
  JOURNAL   J Natl Cancer Inst 70 (2), 337-342 (1983)
   PUBMED   6337293
REFERENCE   9  (bases 1 to 1669)
  AUTHORS   Pazmino,P.A. and Weinshilboum,R.M.
  TITLE     Methyl conjugation in uraemia: catechol-O-methyltransferase
  JOURNAL   Br J Clin Pharmacol 10 (5), 509-518 (1980)
   PUBMED   7437264
REFERENCE   10 (bases 1 to 1669)
  AUTHORS   Parvez,H., Ismahan,G., Parvez,S. and Youdim,M.B.
  TITLE     Developmental changes in the activity of catechol-O-methyl
            transferase in rat and rabbit fetuses
  JOURNAL   J Neural Transm 44 (1-2), 65-75 (1979)
   PUBMED   438804
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK478774.1 and BC081850.1.
            
            On Apr 10, 2007 this sequence version replaced NM_012531.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081850.1, EV762632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               CK478774.1         121-262
            143-1669            BC081850.1         1-1527
FEATURES             Location/Qualifiers
     source          1..1669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1669
                     /gene="Comt"
                     /note="catechol-O-methyltransferase"
                     /db_xref="GeneID:24267"
                     /db_xref="RGD:2379"
     exon            1..167
                     /gene="Comt"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..962
                     /gene="Comt"
                     /EC_number="2.1.1.6"
                     /note="catecholamine-O-methyltransferase"
                     /codon_start=1
                     /product="catechol O-methyltransferase"
                     /protein_id="NP_036663.1"
                     /db_xref="GeneID:24267"
                     /db_xref="RGD:2379"
                     /translation="MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIM
                     GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSP
                     SLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNG
                     ASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPG
                     TPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSPDKS"
     exon            168..435
                     /gene="Comt"
                     /inference="alignment:Splign:2.1.0"
     exon            436..629
                     /gene="Comt"
                     /inference="alignment:Splign:2.1.0"
     exon            630..761
                     /gene="Comt"
                     /inference="alignment:Splign:2.1.0"
     exon            762..1644
                     /gene="Comt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccgcgtg ttaaaacccg tgtctgcggc cggaagcgcc cgctggatcc gcgcagcgcc
       61 gccacaatcg ccgccatggt ccgggggcct taggcggtta gggctgccct tcgcgctgcc
      121 tgagccgttc aagcgtcggg atcggacctg tgcgtggcct tgaggagatg ccgttggctg
      181 cagtctcatt gggtctcctg ttgttggccc tcctcctgct cttgcgacac ctgggctggg
      241 gcttggtgac tattttctgg tttgagtacg tgctgcagcc agtccacaac ctgatcatgg
      301 gtgacacaaa ggagcagcgc atcctgcgct acgtgcagca gaatgcaaag cctggagacc
      361 ctcagagcgt cctggaggcc atcgacacct actgcacaca gaaggaatgg gccatgaatg
      421 tgggtgacgc gaaaggccaa atcatggatg cagtgattcg ggagtacagc ccctccctgg
      481 tgctggagct gggagcttac tgtggctact cagcagtgcg aatggctcgc ctgctgcagc
      541 ctggagccag gcttctcacc atggagatga accctgacta cgctgccatc acccagcaaa
      601 tgctgaactt tgcaggccta caggacaaag tcaccatcct caatggggca tcccaggatc
      661 ttatccccca gctgaagaag aagtacgacg tggacacact agacatggtc tttcttgacc
      721 actggaaaga ccgctacctt ccagacacac ttctcctgga gaaatgtggc ctgctgcgca
      781 aggggacagt gctcctagct gacaacgtca tcgtcccggg aacccctgac ttcctggcgt
      841 atgtgagagg gagcagcagc ttcgagtgca cacactacag ctcatacctg gagtacatga
      901 aagttgtaga cggcttggag aaggcaatct accagggtcc aagtagccct gacaagtctt
      961 gatccctcag cctgcccccc tgctcccctt ccagcttctc tctgcgagat gacacacatt
     1021 caatctgacc ctttctatgc tcctggggct tgtcctcggg ggctgtggtt ccagactgtc
     1081 atacactggc acattttaaa ggtagtgagc ccactatgca aaatcacttc aataaccctg
     1141 aaaagcacct atggatgaaa ggctgaattg aggccaaagg tacaatagat cacagcctgc
     1201 ccagcatgca aaaggcctca aggttaatcc tctgcacccg agcctcatgg tctcgctaac
     1261 tagaagagga gatcttcacg gggtttcagt gtgggatccc taggcactgc atcaccagtt
     1321 aggcccagca ggaagtcagc aaactgtaaa tgtccagacg ccaaataaca gcagaggctc
     1381 agagacagta ctgtcactca ctgtccccag cagctcacac cacatctcat ctgaagaatg
     1441 agtcacaagc tttccaggta tggtggtgca cgcctgtcat ccccagtatc caggaggcag
     1501 aggcatcgga gttcagcgcc agcctggtct acataagtga gttccaagac agccagggct
     1561 acgtagaaat actttttaaa aaaagttata acctctttta tattataaaa gaaattaaag
     1621 atctacatat ttggatacaa gaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
