LOCUS       NM_012834               2412 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cartilage oligomeric matrix protein (Comp), mRNA.
ACCESSION   NM_012834
VERSION     NM_012834.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2412)
  AUTHORS   Taglietti,V., Kefi,K., Bronisz-Budzynska,I., Mirciloglu,B.,
            Rodrigues,M., Cardone,N., Coulpier,F., Periou,B., Gentil,C.,
            Goddard,M., Authier,F.J., Pietri-Rouxel,F., Malfatti,E.,
            Lafuste,P., Tiret,L. and Relaix,F.
  TITLE     Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical
            rat model identifies COMP as biomarker of fibrosis
  JOURNAL   Acta Neuropathol Commun 10 (1), 60 (2022)
   PUBMED   35468843
  REMARK    GeneRIF: Duchenne muscular dystrophy trajectory in R-DMDdel52
            preclinical rat model identifies COMP as biomarker of fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2412)
  AUTHORS   Qi,D.D., Liu,Z.H., Wu,D.S. and Huang,Y.F.
  TITLE     A Study on COMP and CTX-II as Molecular Markers for the Diagnosis
            of Intervertebral Disc Degeneration
  JOURNAL   Biomed Res Int 2021, 3371091 (2021)
   PUBMED   34395611
  REMARK    GeneRIF: A Study on COMP and CTX-II as Molecular Markers for the
            Diagnosis of Intervertebral Disc Degeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2412)
  AUTHORS   Jia,Y., Wang,M., Mao,C., Yu,F., Wang,Y., Xiao,R., Jiang,C.,
            Zheng,L., Xu,Q., Zheng,M., Fu,Y., Hu,Q. and Kong,W.
  TITLE     COMP-prohibitin 2 interaction maintains mitochondrial homeostasis
            and controls smooth muscle cell identity
  JOURNAL   Cell Death Dis 9 (6), 676 (2018)
   PUBMED   29867124
  REMARK    GeneRIF: COMP-prohibitin 2 interaction in mitochondria plays an
            important role in maintaining the contractile phenotype of Vascular
            smooth muscle cells by regulating mitochondrial oxidative
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2412)
  AUTHORS   Flowers,S.A., Zieba,A., Ornros,J., Jin,C., Rolfson,O.,
            Bjorkman,L.I., Eisler,T., Kalamajski,S., Kamali-Moghaddam,M. and
            Karlsson,N.G.
  TITLE     Lubricin binds cartilage proteins, cartilage oligomeric matrix
            protein, fibronectin and collagen II at the cartilage surface
  JOURNAL   Sci Rep 7 (1), 13149 (2017)
   PUBMED   29030641
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2412)
  AUTHORS   Yu,H., Jia,Q., Feng,X., Chen,H., Wang,L., Ni,X. and Kong,W.
  TITLE     Hypoxia decrease expression of cartilage oligomeric matrix protein
            to promote phenotype switching of pulmonary arterial smooth muscle
            cells
  JOURNAL   Int J Biochem Cell Biol 91 (Pt A), 37-44 (2017)
   PUBMED   28860005
  REMARK    GeneRIF: COMP could normally have a protective role against PASMC
            phenotype switching
REFERENCE   6  (bases 1 to 2412)
  AUTHORS   Chen,H., Deere,M., Hecht,J.T. and Lawler,J.
  TITLE     Cartilage oligomeric matrix protein is a calcium-binding protein,
            and a mutation in its type 3 repeats causes conformational changes
  JOURNAL   J Biol Chem 275 (34), 26538-26544 (2000)
   PUBMED   10852928
REFERENCE   7  (bases 1 to 2412)
  AUTHORS   Malashkevich,V.N., Kammerer,R.A., Efimov,V.P., Schulthess,T. and
            Engel,J.
  TITLE     The crystal structure of a five-stranded coiled coil in COMP: a
            prototype ion channel?
  JOURNAL   Science 274 (5288), 761-765 (1996)
   PUBMED   8864111
REFERENCE   8  (bases 1 to 2412)
  AUTHORS   Briggs,M.D., Hoffman,S.M., King,L.M., Olsen,A.S., Mohrenweiser,H.,
            Leroy,J.G., Mortier,G.R., Rimoin,D.L., Lachman,R.S., Gaines,E.S. et
            al.
  TITLE     Pseudoachondroplasia and multiple epiphyseal dysplasia due to
            mutations in the cartilage oligomeric matrix protein gene
  JOURNAL   Nat Genet 10 (3), 330-336 (1995)
   PUBMED   7670472
REFERENCE   9  (bases 1 to 2412)
  AUTHORS   Hecht,J.T., Nelson,L.D., Crowder,E., Wang,Y., Elder,F.F.,
            Harrison,W.R., Francomano,C.A., Prange,C.K., Lennon,G.G., Deere,M.
            et al.
  TITLE     Mutations in exon 17B of cartilage oligomeric matrix protein (COMP)
            cause pseudoachondroplasia
  JOURNAL   Nat Genet 10 (3), 325-329 (1995)
   PUBMED   7670471
REFERENCE   10 (bases 1 to 2412)
  AUTHORS   Oldberg,A., Antonsson,P., Lindblom,K. and Heinegard,D.
  TITLE     COMP (cartilage oligomeric matrix protein) is structurally related
            to the thrombospondins
  JOURNAL   J Biol Chem 267 (31), 22346-22350 (1992)
   PUBMED   1429587
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012834.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X72914.1, SRR26643298.71028.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                JAXUCZ010000016.1  19089467-19089548   c
            83-168              JAXUCZ010000016.1  19089167-19089252   c
            169-220             JAXUCZ010000016.1  19088696-19088747   c
            221-390             JAXUCZ010000016.1  19088166-19088335   c
            391-528             JAXUCZ010000016.1  19087284-19087421   c
            529-603             JAXUCZ010000016.1  19087041-19087115   c
            604-762             JAXUCZ010000016.1  19086806-19086964   c
            763-867             JAXUCZ010000016.1  19086620-19086724   c
            868-975             JAXUCZ010000016.1  19086428-19086535   c
            976-1135            JAXUCZ010000016.1  19085912-19086071   c
            1136-1254           JAXUCZ010000016.1  19084443-19084561   c
            1255-1307           JAXUCZ010000016.1  19084270-19084322   c
            1308-1489           JAXUCZ010000016.1  19084004-19084185   c
            1490-1668           JAXUCZ010000016.1  19083637-19083815   c
            1669-1717           JAXUCZ010000016.1  19083481-19083529   c
            1718-1914           JAXUCZ010000016.1  19082983-19083179   c
            1915-2087           JAXUCZ010000016.1  19081884-19082056   c
            2088-2227           JAXUCZ010000016.1  19081431-19081570   c
            2228-2412           JAXUCZ010000016.1  19081172-19081356   c
FEATURES             Location/Qualifiers
     source          1..2412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2412
                     /gene="Comp"
                     /note="cartilage oligomeric matrix protein"
                     /db_xref="GeneID:25304"
                     /db_xref="RGD:2378"
     exon            1..82
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..2274
                     /gene="Comp"
                     /codon_start=1
                     /product="cartilage oligomeric matrix protein precursor"
                     /protein_id="NP_036966.2"
                     /db_xref="GeneID:25304"
                     /db_xref="RGD:2378"
                     /translation="MSPTACVLVLALAALRATGQGQIPLGGDLAPQMLRELQETNAAL
                     QDVRELLRQQVKEITFLKNTVMECDACGMQPARTPGLSVRPVPLCAPGSCFPGVVCTE
                     TATGARCGPCPPGYTGNGSHCTDVNECNAHPCFPRVRCINTSPGFHCEACPPGFSGPT
                     HEGVGLTFAKTNKQVCTDINECETGQHNCVPNSVCVNTRGSFQCGPCQPGFVGDQRSG
                     CQRRGQHFCPDGSPSPCHEKADCILERDGSRSCVCAVGWAGNGLLCGRDTDLDGFPDE
                     KLRCSERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEQDNCPLVRNPDQ
                     RNSDKDKWGDACDNCRSQKNDDQKDTDRDGQGDACDDDIDGDRIRNVADNCPRVPNFD
                     QSDSDGDGVGDACDNCPQKDNPDQRDVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVP
                     NSAQQDSDHDGKGDACDDDDDNDGVPDSRDNCRLVPNPGQEDNDRDGVGDACQGDFDA
                     DKVIDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDP
                     GLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANP
                     FRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTASQVRLLWKDPRNVGWKDKTSYRW
                     FLQHRPQVGYIRVRFYEGPELVADSNVVLDTAMRGGRLGVFCFSQENIIWANLRYRCN
                     DTIPEDYERHRLRRA"
     exon            83..168
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            169..220
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            221..390
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            391..528
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            529..603
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            604..762
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            763..867
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            868..975
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1135
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1254
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1307
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1489
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1668
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1717
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1914
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2087
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2227
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2412
                     /gene="Comp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgacatga gccccactgc ctgcgttcta gtgctcgccc tggctgcctt gcgggctacc
       61 ggccagggcc agatcccgct gggtggagac ctagccccac agatgcttcg agaactccag
      121 gagactaatg cggcgctgca agacgtgaga gagctcttgc gacagcaggt caaggagatc
      181 accttcctga agaatacggt gatggaatgt gacgcttgcg gaatgcagcc cgcacgcacc
      241 cccggtctga gcgtgcggcc agtgccgctc tgcgcacccg gctcctgctt ccctggcgta
      301 gtctgcacgg agacagctac cggcgcgcgc tgcggcccct gccctccggg ctacaccggc
      361 aacggctcgc actgcaccga cgttaatgag tgcaacgctc acccctgttt cccgcgcgtg
      421 cggtgcatca ataccagccc tggctttcac tgcgaagcct gtccccctgg gttcagcggg
      481 cccacccacg agggtgtggg gctgaccttc gccaagacca acaaacaagt ttgcacagat
      541 attaatgagt gtgagaccgg gcagcacaat tgcgttccca actccgtgtg cgtcaacacc
      601 cggggctcct tccagtgcgg tccctgccag cccggcttcg tgggcgacca gaggtcaggc
      661 tgccagcggc gtgggcaaca cttctgcccc gacgggtcac ccagcccgtg ccatgagaaa
      721 gcagactgta ttttggagcg cgacggctca aggtcctgcg tgtgtgcggt cggctgggcc
      781 ggcaacgggc tcctgtgcgg acgcgacaca gacctggacg gtttcccgga cgagaagctt
      841 cgctgctcag agcgccagtg ccgcaaggac aactgcgtga cggtgcccaa ttcagggcag
      901 gaggatgtgg accgggacgg cattggagat gcttgtgacc cggatgcgga cggggatgga
      961 gtccctaatg agcaagacaa ttgcccgctg gttcgaaacc cagaccagcg caactcggat
     1021 aaagacaagt ggggagatgc ctgcgacaac tgccggtccc agaagaatga tgaccagaaa
     1081 gatacagacc gggatggcca gggcgatgcc tgcgacgacg acatagatgg cgatcgaatc
     1141 cgaaatgtag ctgacaactg tccccgggtg cccaactttg accagagtga cagcgatggt
     1201 gatggtgttg gggatgcctg tgacaattgt ccccagaaag acaacccgga ccagagggac
     1261 gtggaccacg actttgtggg tgatgcctgt gacagtgacc aagaccagga cggggatgga
     1321 caccaagact cccgggacaa ctgccccaca gtacccaaca gtgcccagca ggactcagac
     1381 catgatggca agggtgatgc ctgtgatgat gacgacgaca atgacggagt ccctgacagc
     1441 cgggacaatt gccgcttggt gcccaacccg ggccaagagg acaatgaccg ggatggcgtg
     1501 ggtgacgctt gtcagggtga cttcgatgct gacaaggtta tagacaagat cgatgtgtgc
     1561 cccgagaacg ccgaggtcac tctcaccgac ttcagggcct tccaaacagt tgtgctggac
     1621 cccgagggtg atgcgcagat cgaccccaac tgggtggtgc tcaatcaggg aatggagatc
     1681 gttcagacca tgaacagtga ccctggcctg gctgtgggtt acacggcatt caacggtgta
     1741 gattttgagg gaacgttcca tgtaaacacc gccaccgatg atgactacgc tggcttcatc
     1801 ttcggctatc aagacagctc aagtttctat gtggtcatgt ggaaacagat ggagcagacg
     1861 tactggcagg ccaatccttt ccgggcagtg gctgaaccag ggattcagct caaggctgtc
     1921 aagtcctcta caggtcccgg ggaacagctc cgaaatgcgt tgtggcacac gggggacaca
     1981 gcatcccagg tgcggctgct gtggaaggat cctcgaaatg tgggctggaa ggataagaca
     2041 tcctaccgct ggttcctgca gcaccggcct caagtcggct acatcagggt gcggttctat
     2101 gagggtcctg agctagtagc tgacagcaac gtggtgctgg acacagctat gcgtggtggc
     2161 cgcctgggtg tcttctgctt ctcccaagag aatatcatct gggctaacct gcgctaccgt
     2221 tgcaatgata caatccctga ggactatgag cgtcaccggc tgcggagggc ctagggaccc
     2281 taagaggggc cccgctgacc gatggactgc ggtagcatcg gccacaggtg tctggggggg
     2341 gggggtctgg catctttctg aagggatgtc tggcctgggg aggaaaggca aataaagaat
     2401 gtatgtgggg ga
//
