LOCUS       NM_139108               1095 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus COMM domain containing 5 (Commd5), mRNA.
ACCESSION   NM_139108
VERSION     NM_139108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1095)
  AUTHORS   Matsuda,H., Hamet,P. and Tremblay,J.
  TITLE     Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) and
            kidney diseases: HCaRG accelerates tubular repair
  JOURNAL   J Nephrol 27 (4), 351-360 (2014)
   PUBMED   24515317
  REMARK    Review article
REFERENCE   2  (bases 1 to 1095)
  AUTHORS   Chen,B.L., Yu,J., Zeng,Z.R., Chu,W.K., Wong,C.Y., Cheng,Y.Y.,
            Sung,J.J., Hu,P.J. and Leung,W.K.
  TITLE     Rosiglitazone suppresses gastric carcinogenesis by up-regulating
            HCaRG expression
  JOURNAL   Oncol Rep 20 (5), 1093-1097 (2008)
   PUBMED   18949406
  REMARK    GeneRIF: The up-regulation of HCaRG may be one of the mechanisms
            underlying the chemopreventive effect of rosiglitazone in gastric
            cancer.
REFERENCE   3  (bases 1 to 1095)
  AUTHORS   El Hader,C., Tremblay,S., Solban,N., Gingras,D., Beliveau,R.,
            Orlov,S.N., Hamet,P. and Tremblay,J.
  TITLE     HCaRG increases renal cell migration by a TGF-alpha autocrine loop
            mechanism
  JOURNAL   Am J Physiol Renal Physiol 289 (6), F1273-F1280 (2005)
   PUBMED   16033922
  REMARK    GeneRIF: data support a role for HCaRG in kidney repair after
            injury through its effect on renal cell migration and TGF-alpha
            secretion
REFERENCE   4  (bases 1 to 1095)
  AUTHORS   Devlin,A.M., Solban,N., Tremblay,S., Gutkowska,J., Schurch,W.,
            Orlov,S.N., Lewanczuk,R., Hamet,P. and Tremblay,J.
  TITLE     HCaRG is a novel regulator of renal epithelial cell growth and
            differentiation causing G2M arrest
  JOURNAL   Am J Physiol Renal Physiol 284 (4), F753-F762 (2003)
   PUBMED   12620924
  REMARK    GeneRIF: HCaRG regulates renal epithelial cell growth and
            differentiation causing G(2)M cell cycle arrest
REFERENCE   5  (bases 1 to 1095)
  AUTHORS   Solban,N., Dumas,P., Gossard,F., Sun,Y., Pravenec,M., Kren,V.,
            Lewanczuk,R., Hamet,P. and Tremblay,J.
  TITLE     Chromosomal mapping of HCaRG, a novel hypertension-related,
            calcium-regulated gene
  JOURNAL   Folia Biol (Praha) 48 (1), 9-14 (2002)
   PUBMED   11871861
  REMARK    GeneRIF: Hcarg localizes to the rat chromosome 7 between the
            markers Mit3 and Mit4. We identified a BglII RFLP between BN.lx and
            SHR rats.
REFERENCE   6  (bases 1 to 1095)
  AUTHORS   Solban,N., Jia,H.P., Richard,S., Tremblay,S., Devlin,A.M., Peng,J.,
            Gossard,F., Guo,D.F., Morel,G., Hamet,P., Lewanczuk,R. and
            Tremblay,J.
  TITLE     HCaRG, a novel calcium-regulated gene coding for a nuclear protein,
            is potentially involved in the regulation of cell proliferation
  JOURNAL   J Biol Chem 275 (41), 32234-32243 (2000)
   PUBMED   10918053
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF290194.1.
            
            [WARNING] On Oct 11, 2024 this sequence was replaced by
            NM_139108.3.
            
            On Feb 21, 2013 this sequence version replaced NM_139108.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF290194.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1095              AF290194.1         6-1100
FEATURES             Location/Qualifiers
     source          1..1095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="SHR"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1095
                     /gene="Commd5"
                     /gene_synonym="Hcarg"
                     /note="COMM domain containing 5"
                     /db_xref="GeneID:245974"
                     /db_xref="RGD:621468"
     exon            1..73
                     /gene="Commd5"
                     /gene_synonym="Hcarg"
                     /inference="alignment:Splign:2.1.0"
     exon            74..1083
                     /gene="Commd5"
                     /gene_synonym="Hcarg"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..801
                     /gene="Commd5"
                     /gene_synonym="Hcarg"
                     /note="hypertension-related calcium-regulated gene
                     protein; hypertension-related, calcium regulated"
                     /codon_start=1
                     /product="COMM domain-containing protein 5"
                     /protein_id="NP_620808.1"
                     /db_xref="GeneID:245974"
                     /db_xref="RGD:621468"
                     /translation="MSALGAAAPYLHHPADSHSGRVSFLGSQPSPEVTAVAQLLKDLD
                     RSTFRKLLKLVVGALHGKDCREAVEQLGASANLSEERLAVLLAGTHTLLQQALRLPPA
                     SLKPDAFQEELQELGIPQDLIGDLASLAFGSQRPLLDSVAQQQGSSLPHVSYFRWRVD
                     VAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPIAKFQELRYSVALVLKEMAELEKKC
                     ERKLQD"
ORIGIN      
        1 agccacagcc agctaccgcg gctaggttcc tccaggtgca gagggcggta aaggcttggt
       61 ttgtatttgt aatgcaactg tggttaggac cttctcttcg gactggtcaa gaaacgggaa
      121 gaaaggatgt ctgctttggg ggctgcagct ccatacttgc accatcccgc tgacagtcac
      181 agtggccggg tcagtttcct gggttcccag ccctctccag aagtgacggc cgtggctcag
      241 ctcttgaagg acttagacag gagcaccttc agaaagttgt tgaaacttgt agtcggggcc
      301 ctgcatggga aagactgcag agaagctgtg gagcaacttg gtgccagcgc caacctgtca
      361 gaagagcgtc tggccgtcct gctggcgggc acacacaccc tgctccagca ggctctccgg
      421 ctgccccctg ctagtctaaa gccagatgcc ttccaggaag agctccagga acttggcatt
      481 cctcaggatc taattggaga tttggccagt ttggcatttg ggagtcaacg ccctcttctc
      541 gactctgtag cccaacagca gggatcctcg ctgcctcacg tgtcttactt ccggtggcgg
      601 gtggacgtgg ccatctcaac cagcgctcag tcccgctccc tgcaaccgag tgttctcatg
      661 cagctgaagc tcacagatgg atctgcacac cgcttcgagg tgcccatagc caaatttcag
      721 gagctgcggt acagtgtagc cttggtcctt aaggagatgg cagaactgga gaagaagtgt
      781 gagcgcaaac tgcaggactg actgaaccct ggtactgtgg gtgctgaagc tggtaccaga
      841 acacagcccc ccactggtga tgagcccaac tccattgagg tcctgcatgt gagaacgtat
      901 tttaagtgaa aagacagcgg gactttcagg ttttgtttta tgagtcaaca gctgggcagg
      961 gtggcacagt ttataatctc agcccttgga agtctgaggc tggagaatgg gaagtgtaag
     1021 ctgggcctgg ctttcatagt gaggctcagt gtcgaattaa agaggtaaag caactattaa
     1081 aaaaaaaaaa aaaaa
//
