LOCUS       NM_001115022             904 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus copper metabolism domain containing 1 (Commd1),
            mRNA.
ACCESSION   NM_001115022
VERSION     NM_001115022.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 904)
  AUTHORS   Bartuzi P, Billadeau DD, Favier R, Rong S, Dekker D, Fedoseienko A,
            Fieten H, Wijers M, Levels JH, Huijkman N, Kloosterhuis N, van der
            Molen H, Brufau G, Groen AK, Elliott AM, Kuivenhoven JA, Plecko B,
            Grangl G, McGaughran J, Horton JD, Burstein E, Hofker MH and van de
            Sluis B.
  TITLE     CCC- and WASH-mediated endosomal sorting of LDLR is required for
            normal clearance of circulating LDL
  JOURNAL   Nat Commun 7, 10961 (2016)
   PUBMED   26965651
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 904)
  AUTHORS   Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne
            DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H,
            Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M,
            McGaughran J, Gecz J, Sluis Bv, Billadeau DD and Burstein E.
  TITLE     COMMD1 is linked to the WASH complex and regulates endosomal
            trafficking of the copper transporter ATP7A
  JOURNAL   Mol Biol Cell 26 (1), 91-103 (2015)
   PUBMED   25355947
REFERENCE   3  (bases 1 to 904)
  AUTHORS   Materia S, Cater MA, Klomp LW, Mercer JF and La Fontaine S.
  TITLE     Clusterin and COMMD1 independently regulate degradation of the
            mammalian copper ATPases ATP7A and ATP7B
  JOURNAL   J Biol Chem 287 (4), 2485-2499 (2012)
   PUBMED   22130675
  REMARK    GeneRIF: Clusterin and COMMD1 independently regulate degradation of
            the mammalian copper ATPases ATP7A and ATP7B.
REFERENCE   4  (bases 1 to 904)
  AUTHORS   Duquette ML, Zhu Q, Taylor ER, Tsay AJ, Shi LZ, Berns MW and
            McGowan CH.
  TITLE     CtIP is required to initiate replication-dependent interstrand
            crosslink repair
  JOURNAL   PLoS Genet 8 (11), e1003050 (2012)
   PUBMED   23144634
REFERENCE   5  (bases 1 to 904)
  AUTHORS   Chang T, Ke Y, Ly K and McDonald FJ.
  TITLE     COMMD1 regulates the delta epithelial sodium channel (deltaENaC)
            through trafficking and ubiquitination
  JOURNAL   Biochem Biophys Res Commun 411 (3), 506-511 (2011)
   PUBMED   21741370
REFERENCE   6  (bases 1 to 904)
  AUTHORS   Maine GN, Mao X, Komarck CM and Burstein E.
  TITLE     COMMD1 promotes the ubiquitination of NF-kappaB subunits through a
            cullin-containing ubiquitin ligase
  JOURNAL   EMBO J 26 (2), 436-447 (2007)
   PUBMED   17183367
REFERENCE   7  (bases 1 to 904)
  AUTHORS   de Bie P, van de Sluis B, Burstein E, Duran KJ, Berger R, Duckett
            CS, Wijmenga C and Klomp LW.
  TITLE     Characterization of COMMD protein-protein interactions in NF-kappaB
            signalling
  JOURNAL   Biochem J 398 (1), 63-71 (2006)
   PUBMED   16573520
REFERENCE   8  (bases 1 to 904)
  AUTHORS   Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck
            CM, Maine GN, Wilkinson JC, Mayo MW and Duckett CS.
  TITLE     COMMD proteins, a novel family of structural and functional
            homologs of MURR1
  JOURNAL   J Biol Chem 280 (23), 22222-22232 (2005)
   PUBMED   15799966
REFERENCE   9  (bases 1 to 904)
  AUTHORS   Biasio W, Chang T, McIntosh CJ and McDonald FJ.
  TITLE     Identification of Murr1 as a regulator of the human delta
            epithelial sodium channel
  JOURNAL   J Biol Chem 279 (7), 5429-5434 (2004)
   PUBMED   14645214
REFERENCE   10 (bases 1 to 904)
  AUTHORS   Burstein E, Ganesh L, Dick RD, van De Sluis B, Wilkinson JC, Klomp
            LW, Wijmenga C, Brewer GJ, Nabel GJ and Duckett CS.
  TITLE     A novel role for XIAP in copper homeostasis through regulation of
            MURR1
  JOURNAL   EMBO J 23 (1), 244-254 (2004)
   PUBMED   14685266
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473996.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132297,
                              SAMD00132302 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..904
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..904
                     /gene="Commd1"
                     /note="copper metabolism domain containing 1"
                     /db_xref="GeneID:289831"
                     /db_xref="RGD:1311771"
     exon            1..329
                     /gene="Commd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..719
                     /gene="Commd1"
                     /note="copper metabolism (Murr1) domain containing 1"
                     /codon_start=1
                     /product="COMM domain-containing protein 1"
                     /protein_id="NP_001108494.1"
                     /db_xref="GeneID:289831"
                     /db_xref="RGD:1311771"
                     /translation="MAGELESCKSLSGLLSGLAQNTFHGHSGITEELLHSQLYPEVPL
                     EEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSEQAAVISKFWKSHKT
                     KIRESLMSQSRWDNGLRGLRWRVDGKSQSRHSTQIHSPVAIIELEFGRSGRESEFLCL
                     EFDEAKVKQILKKLSEVEESISGLMQAA"
     exon            330..611
                     /gene="Commd1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..904
                     /gene="Commd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattggctgt ggtggaagta gtggatgttt atatcgacta gcggaggaac cgggcatcgt
       61 gttccgtggg tgcctttgcc agcttttacg gcccttctcg gcccccgtag cggaccggag
      121 ctcagccgct gggcggcagg ccctccctag ccatggcggg cgagctggag agctgcaagt
      181 ccctgagcgg gctgctgagc ggcctggcac agaacacttt tcacggacac tcgggtatca
      241 ctgaggagct gctgcacagc caactctacc cggaagtgcc actggaggaa ttccgcccct
      301 tcctggcgaa gatgagggga attctcaagt ctattgcatc tgcagacatg gatttcaacc
      361 agttagaggc attcctgacc gctcaaacca agaagcaagg cggcatcacc agtgaacaag
      421 ctgcagtcat ctccaagttt tggaagagcc ataagacaaa aatccgagag agcctcatga
      481 gccagagccg ctgggacaac gggcttcggg gcctgcgctg gagagtggac ggcaagtccc
      541 agtcacggca ctcaactcaa atacacagcc ctgttgccat aatagagctg gaatttggga
      601 gaagtggacg ggaatctgag tttctgtgtc tggagtttga tgaagctaag gtcaagcaga
      661 tcttgaagaa gctgtcagag gtggaagaga gtatcagcgg gctgatgcag gcagcctaac
      721 tgagggaggg aggagcgttg aagtgaaagt gctcacagac tttctccact gaccttttta
      781 aagtcctgct tgcccattgg tgttacaaaa aaacattgta tgcatgtatg aaagtcctca
      841 agaataaata aaaatatatt ttaaaaagtg ggtaaaaaag aggaaaaccc tcaaattcaa
      901 atac
//
